gluconeogenesis I

gomodel:YeastPathways_GLUCONEO-PWY-1

Gluconeogenesis I in Saccharomyces cerevisiae S288C converts malate or pyruvate to oxaloacetate and phosphoenolpyruvate, runs lower glycolytic reactions toward fructose 1,6-bisphosphate, and uses FBP1 and PGI1 activities to produce beta-D-fructofuranose 6-phosphate and D-glucopyranose 6-phosphate.

Pathway type

central carbon metabolism

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

62 nodes · 158 asserted directed edges

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
phosphonatoenolpyruvate `CHEBI:58702`	small molecule
ATP(4-) `CHEBI:30616`	small molecule
D-glucopyranose 6-phosphate `CHEBI:4170`	small molecule
3-phosphonato-D-glyceroyl phosphate(4-) `CHEBI:57604`	small molecule
oxaloacetate(2-) `CHEBI:16452`	small molecule
NAD(1-) `CHEBI:57540`	small molecule
cytosol `GO:0005829`	cellular component
D-glyceraldehyde 3-phosphate(2-) `CHEBI:59776`	small molecule
gluconeogenesis `GO:0006094`	biological process
glycerone phosphate(2-) `CHEBI:57642`	small molecule
beta-D-fructofuranose 6-phosphate(2-) `CHEBI:57634`	small molecule
carbon dioxide `CHEBI:16526`	small molecule
beta-D-fructofuranose 1,6-bisphosphate(4-) `CHEBI:32966`	small molecule
NADH(2-) `CHEBI:57945`	small molecule
hydrogenphosphate `CHEBI:43474`	small molecule
ADP(3-) `CHEBI:456216`	small molecule
GPM1 Scer `SGD:S000001635`	protein
2-phosphonato-D-glycerate(3-) `CHEBI:58289`	small molecule
hydron `CHEBI:15378`	small molecule
pyruvate `CHEBI:15361`	small molecule
hydrogencarbonate `CHEBI:17544`	small molecule
MAE1 Scer `SGD:S000001512`	protein
water `CHEBI:15377`	small molecule
TDH3 Scer `SGD:S000003424`	protein
PGK1 Scer `SGD:S000000605`	protein
MDH2 Scer `SGD:S000005486`	protein
(S)-malate(2-) `CHEBI:15589`	small molecule
ENO2 Scer `SGD:S000001217`	protein
PCK1 Scer `SGD:S000001805`	protein
mitochondrion `GO:0005739`	cellular component
FBP1 Scer `SGD:S000004369`	protein
ENO1 Scer `SGD:S000003486`	protein
PYC2 Scer `SGD:S000000422`	protein
PYC1 Scer `SGD:S000003030`	protein
PGI1 Scer `SGD:S000000400`	protein
3-phosphonato-D-glycerate(3-) `CHEBI:58272`	small molecule
TDH1 Scer `SGD:S000003588`	protein
FBA1 Scer `SGD:S000001543`	protein
TDH2 Scer `SGD:S000003769`	protein
cytoplasm `GO:0005737`	cellular component
mitochondrial outer membrane `GO:0005741`	cellular component
mitochondrial intermembrane space `GO:0005758`	cellular component
mitochondrial matrix `GO:0005759`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
manganese(2+) `CHEBI:29035`	cofactor
biotinate `CHEBI:57586`	cofactor
zinc(2+) `CHEBI:29105`	cofactor
malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	molecular activity
phosphopyruvate hydratase activity `gomodel:2PGADEHYDRAT-RXN`	molecular activity
fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	molecular activity
fructose 1,6-bisphosphate 1-phosphatase activity `gomodel:F16BDEPHOS-RXN`	molecular activity
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	molecular activity
L-malate dehydrogenase (NAD+) activity `gomodel:MALATE-DEH-RXN`	molecular activity
phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	molecular activity
glucose-6-phosphate isomerase activity `gomodel:PGLUCISOM-RXN`	molecular activity
phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	molecular activity
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	molecular activity
phosphoglycerate mutase activity `gomodel:RXN-15513`	molecular activity
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	molecular activity
phosphopyruvate hydratase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125`	molecular activity
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	molecular activity
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	provides_input_for	pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:1.1.1.39-RXN RO:0002413 gomodel:PYRUVATE-CARBOXYLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/0; endpoint types: /individuals/132/type; /individuals/44/type` UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction`
phosphopyruvate hydratase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125`	has_input	phosphonatoenolpyruvate `CHEBI:58702`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 RO:0002233 gomodel:CHEBI_58702_PEPCARBOXYKIN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/1; endpoint types: /individuals/167/type; /individuals/35/type`
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_30616_PYRUVATE-CARBOXYLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/2; endpoint types: /individuals/44/type; /individuals/15/type`
fructose 1,6-bisphosphate 1-phosphatase activity `gomodel:F16BDEPHOS-RXN`	provides_input_for	glucose-6-phosphate isomerase activity `gomodel:PGLUCISOM-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16BDEPHOS-RXN RO:0002413 gomodel:PGLUCISOM-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/3; endpoint types: /individuals/38/type; /individuals/42/type`
phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002233 gomodel:CHEBI_30616_PHOSGLYPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/4; endpoint types: /individuals/43/type; /individuals/14/type`
glucose-6-phosphate isomerase activity `gomodel:PGLUCISOM-RXN`	has_output	D-glucopyranose 6-phosphate `CHEBI:4170`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PGLUCISOM-RXN RO:0002234 gomodel:CHEBI_4170_PGLUCISOM-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/5; endpoint types: /individuals/42/type; /individuals/17/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	has_input	3-phosphonato-D-glyceroyl phosphate(4-) `CHEBI:57604`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002233 gomodel:CHEBI_57604_PHOSGLYPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/6; endpoint types: /individuals/197/type; /individuals/27/type`
L-malate dehydrogenase (NAD+) activity `gomodel:MALATE-DEH-RXN`	has_output	oxaloacetate(2-) `CHEBI:16452`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:MALATE-DEH-RXN RO:0002234 gomodel:CHEBI_16452_MALATE-DEH-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/7; endpoint types: /individuals/40/type; /individuals/8/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005141. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/8; endpoint types: /individuals/179/type; /individuals/182/type`
phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PEPCARBOXYKIN-RXN BFO:0000066 gomodel:reaction_PEPCARBOXYKIN-RXN_location_lociGO_0005829. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/9; endpoint types: /individuals/41/type; /individuals/127/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	has_output	D-glyceraldehyde 3-phosphate(2-) `CHEBI:59776`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002234 gomodel:CHEBI_59776_GAPOXNPHOSPHN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/10; endpoint types: /individuals/39/type; /individuals/36/type`
phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PEPCARBOXYKIN-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/12; endpoint types: /individuals/41/type; /individuals/134/type`
fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	has_input	glycerone phosphate(2-) `CHEBI:57642`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16ALDOLASE-RXN RO:0002233 gomodel:CHEBI_57642_F16ALDOLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/13; endpoint types: /individuals/37/type; /individuals/29/type`
phosphopyruvate hydratase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 BFO:0000066 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005129. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/14; endpoint types: /individuals/167/type; /individuals/170/type`
fructose 1,6-bisphosphate 1-phosphatase activity `gomodel:F16BDEPHOS-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16BDEPHOS-RXN BFO:0000066 gomodel:reaction_F16BDEPHOS-RXN_location_lociGO_0005829. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/15; endpoint types: /individuals/38/type; /individuals/124/type`
glucose-6-phosphate isomerase activity `gomodel:PGLUCISOM-RXN`	has_input	beta-D-fructofuranose 6-phosphate(2-) `CHEBI:57634`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PGLUCISOM-RXN RO:0002233 gomodel:CHEBI_57634_F16BDEPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/16; endpoint types: /individuals/42/type; /individuals/28/type`
phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002234 gomodel:CHEBI_16526_PEPCARBOXYKIN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/17; endpoint types: /individuals/41/type; /individuals/11/type`
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 BFO:0000066 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005112. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/18; endpoint types: /individuals/146/type; /individuals/154/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	provides_input_for	fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002413 gomodel:F16ALDOLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/19; endpoint types: /individuals/179/type; /individuals/37/type`
fructose 1,6-bisphosphate 1-phosphatase activity `gomodel:F16BDEPHOS-RXN`	has_input	beta-D-fructofuranose 1,6-bisphosphate(4-) `CHEBI:32966`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16BDEPHOS-RXN RO:0002233 gomodel:CHEBI_32966_F16ALDOLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/20; endpoint types: /individuals/38/type; /individuals/16/type`
phosphopyruvate hydratase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/21; endpoint types: /individuals/167/type; /individuals/134/type`
phosphopyruvate hydratase activity `gomodel:2PGADEHYDRAT-RXN`	provides_input_for	phosphoglycerate mutase activity `gomodel:RXN-15513`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002413 gomodel:RXN-15513. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/22; endpoint types: /individuals/133/type; /individuals/45/type`
phosphopyruvate hydratase activity `gomodel:2PGADEHYDRAT-RXN`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:2PGADEHYDRAT-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/23; endpoint types: /individuals/133/type; /individuals/134/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	provides_input_for	fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002413 gomodel:F16ALDOLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/24; endpoint types: /individuals/39/type; /individuals/37/type`
fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	has_input	D-glyceraldehyde 3-phosphate(2-) `CHEBI:59776`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16ALDOLASE-RXN RO:0002233 gomodel:CHEBI_59776_GAPOXNPHOSPHN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/26; endpoint types: /individuals/37/type; /individuals/36/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	has_output	D-glyceraldehyde 3-phosphate(2-) `CHEBI:59776`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002234 gomodel:CHEBI_59776_GAPOXNPHOSPHN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/27; endpoint types: /individuals/179/type; /individuals/36/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005162. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/28; endpoint types: /individuals/197/type; /individuals/201/type`
phosphopyruvate hydratase activity `gomodel:2PGADEHYDRAT-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:2PGADEHYDRAT-RXN BFO:0000066 gomodel:reaction_2PGADEHYDRAT-RXN_location_lociGO_0005829. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/29; endpoint types: /individuals/133/type; /individuals/122/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:GAPOXNPHOSPHN-RXN BFO:0000066 gomodel:reaction_GAPOXNPHOSPHN-RXN_location_lociGO_0005829. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/30; endpoint types: /individuals/39/type; /individuals/125/type`
phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002234 gomodel:CHEBI_456216_PHOSGLYPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/31; endpoint types: /individuals/43/type; /individuals/22/type`
GPM1 Scer `SGD:S000001635`	enables	phosphoglycerate mutase activity `gomodel:RXN-15513`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:RXN-15513 RO:0002333 gomodel:YKL152C-MONOMER_RXN-15513_controller. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/32; endpoint types: /individuals/45/type; /individuals/53/type`
phosphopyruvate hydratase activity `gomodel:2PGADEHYDRAT-RXN`	has_output	2-phosphonato-D-glycerate(3-) `CHEBI:58289`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002234 gomodel:CHEBI_58289_2PGADEHYDRAT-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/33; endpoint types: /individuals/133/type; /individuals/34/type`
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_15378_PYRUVATE-CARBOXYLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/34; endpoint types: /individuals/44/type; /individuals/5/type`
fructose 1,6-bisphosphate 1-phosphatase activity `gomodel:F16BDEPHOS-RXN`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16BDEPHOS-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/35; endpoint types: /individuals/38/type; /individuals/134/type`
malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:1.1.1.39-RXN RO:0002234 gomodel:CHEBI_16526_1.1.1.39-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/36; endpoint types: /individuals/132/type; /individuals/10/type` UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction`
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005106. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/37; endpoint types: /individuals/146/type; /individuals/149/type`
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	provides_input_for	phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002413 gomodel:PEPCARBOXYKIN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/38; endpoint types: /individuals/44/type; /individuals/41/type`
fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	has_output	beta-D-fructofuranose 1,6-bisphosphate(4-) `CHEBI:32966`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16ALDOLASE-RXN RO:0002234 gomodel:CHEBI_32966_F16ALDOLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/39; endpoint types: /individuals/37/type; /individuals/16/type`
L-malate dehydrogenase (NAD+) activity `gomodel:MALATE-DEH-RXN`	has_input	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:MALATE-DEH-RXN RO:0002233 gomodel:CHEBI_57540_MALATE-DEH-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/40; endpoint types: /individuals/40/type; /individuals/26/type`
phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002233 gomodel:CHEBI_30616_PEPCARBOXYKIN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/41; endpoint types: /individuals/41/type; /individuals/13/type`
phosphopyruvate hydratase activity `gomodel:2PGADEHYDRAT-RXN`	has_input	phosphonatoenolpyruvate `CHEBI:58702`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002233 gomodel:CHEBI_58702_PEPCARBOXYKIN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/42; endpoint types: /individuals/133/type; /individuals/35/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 BFO:0000066 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005146. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/43; endpoint types: /individuals/179/type; /individuals/185/type`
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	has_input	pyruvate `CHEBI:15361`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002233 gomodel:CHEBI_15361_1.1.1.39-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/44; endpoint types: /individuals/146/type; /individuals/0/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005140. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/45; endpoint types: /individuals/179/type; /individuals/181/type`
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	has_input	hydrogencarbonate `CHEBI:17544`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005105. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/46; endpoint types: /individuals/146/type; /individuals/148/type`
phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	provides_input_for	phosphopyruvate hydratase activity `gomodel:2PGADEHYDRAT-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002413 gomodel:2PGADEHYDRAT-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/47; endpoint types: /individuals/41/type; /individuals/133/type`
glucose-6-phosphate isomerase activity `gomodel:PGLUCISOM-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PGLUCISOM-RXN BFO:0000066 gomodel:reaction_PGLUCISOM-RXN_location_lociGO_0005829. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/48; endpoint types: /individuals/42/type; /individuals/128/type`
glucose-6-phosphate isomerase activity `gomodel:PGLUCISOM-RXN`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PGLUCISOM-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/49; endpoint types: /individuals/42/type; /individuals/134/type`
L-malate dehydrogenase (NAD+) activity `gomodel:MALATE-DEH-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:MALATE-DEH-RXN RO:0002234 gomodel:CHEBI_15378_MALATE-DEH-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/50; endpoint types: /individuals/40/type; /individuals/4/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005142. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/51; endpoint types: /individuals/179/type; /individuals/183/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:GAPOXNPHOSPHN-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/52; endpoint types: /individuals/39/type; /individuals/134/type`
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/54; endpoint types: /individuals/44/type; /individuals/134/type`
malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	has_input	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:1.1.1.39-RXN RO:0002233 gomodel:CHEBI_57540_1.1.1.39-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/56; endpoint types: /individuals/132/type; /individuals/24/type` UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction`
phosphopyruvate hydratase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125`	has_output	2-phosphonato-D-glycerate(3-) `CHEBI:58289`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 RO:0002234 gomodel:CHEBI_58289_2PGADEHYDRAT-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/57; endpoint types: /individuals/167/type; /individuals/34/type`
MAE1 Scer `SGD:S000001512`	enables	malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:1.1.1.39-RXN RO:0002333 gomodel:YKL029C-MONOMER_1.1.1.39-RXN_controller. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/58; endpoint types: /individuals/132/type; /individuals/51/type` UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction`
L-malate dehydrogenase (NAD+) activity `gomodel:MALATE-DEH-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:MALATE-DEH-RXN BFO:0000066 gomodel:reaction_MALATE-DEH-RXN_location_lociGO_0005829. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/59; endpoint types: /individuals/40/type; /individuals/126/type`
phosphopyruvate hydratase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005126. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/60; endpoint types: /individuals/167/type; /individuals/168/type`
TDH3 Scer `SGD:S000003424`	enables	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002333 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005163. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/61; endpoint types: /individuals/197/type; /individuals/202/type`
malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	has_output	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:1.1.1.39-RXN RO:0002234 gomodel:CHEBI_57945_1.1.1.39-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/62; endpoint types: /individuals/132/type; /individuals/30/type` UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction`
phosphoglycerate mutase activity `gomodel:RXN-15513`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:RXN-15513 BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/63; endpoint types: /individuals/45/type; /individuals/134/type`
PGK1 Scer `SGD:S000000605`	enables	phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002333 gomodel:YCR012W-MONOMER_PHOSGLYPHOS-RXN_controller. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/64; endpoint types: /individuals/43/type; /individuals/47/type`
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	has_input	pyruvate `CHEBI:15361`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_15361_1.1.1.39-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/65; endpoint types: /individuals/44/type; /individuals/0/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005139. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/66; endpoint types: /individuals/179/type; /individuals/180/type`
MDH2 Scer `SGD:S000005486`	enables	L-malate dehydrogenase (NAD+) activity `gomodel:MALATE-DEH-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:MALATE-DEH-RXN RO:0002333 gomodel:YeastPathways_GLUCONEO-PWY-1/6690711d00001653. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/67; endpoint types: /individuals/40/type; /individuals/217/type`
phosphoglycerate mutase activity `gomodel:RXN-15513`	provides_input_for	phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:RXN-15513 RO:0002413 gomodel:PHOSGLYPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/68; endpoint types: /individuals/45/type; /individuals/43/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 BFO:0000066 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005165. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/69; endpoint types: /individuals/197/type; /individuals/203/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002233 gomodel:CHEBI_57945_GAPOXNPHOSPHN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/71; endpoint types: /individuals/39/type; /individuals/31/type`
fructose 1,6-bisphosphate 1-phosphatase activity `gomodel:F16BDEPHOS-RXN`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16BDEPHOS-RXN RO:0002234 gomodel:CHEBI_43474_F16BDEPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/72; endpoint types: /individuals/38/type; /individuals/18/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002234 gomodel:CHEBI_57540_GAPOXNPHOSPHN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/73; endpoint types: /individuals/39/type; /individuals/25/type`
L-malate dehydrogenase (NAD+) activity `gomodel:MALATE-DEH-RXN`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:MALATE-DEH-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/74; endpoint types: /individuals/40/type; /individuals/134/type`
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	provides_input_for	phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002413 gomodel:PEPCARBOXYKIN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/75; endpoint types: /individuals/146/type; /individuals/41/type`
fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16ALDOLASE-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/76; endpoint types: /individuals/37/type; /individuals/134/type`
ENO2 Scer `SGD:S000001217`	enables	phosphopyruvate hydratase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 RO:0002333 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005127. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/77; endpoint types: /individuals/167/type; /individuals/169/type`
fructose 1,6-bisphosphate 1-phosphatase activity `gomodel:F16BDEPHOS-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16BDEPHOS-RXN RO:0002233 gomodel:CHEBI_15377_F16BDEPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/78; endpoint types: /individuals/38/type; /individuals/2/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005161. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/79; endpoint types: /individuals/197/type; /individuals/200/type`
phosphopyruvate hydratase activity `gomodel:2PGADEHYDRAT-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002233 gomodel:CHEBI_15377_2PGADEHYDRAT-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/80; endpoint types: /individuals/133/type; /individuals/1/type`
PCK1 Scer `SGD:S000001805`	enables	phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002333 gomodel:YKR097W-MONOMER_PEPCARBOXYKIN-RXN_controller. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/81; endpoint types: /individuals/41/type; /individuals/54/type`
phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	has_output	3-phosphonato-D-glyceroyl phosphate(4-) `CHEBI:57604`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002234 gomodel:CHEBI_57604_PHOSGLYPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/83; endpoint types: /individuals/43/type; /individuals/27/type`
malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	occurs_in	mitochondrion `GO:0005739`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:1.1.1.39-RXN BFO:0000066 gomodel:YeastPathways_GLUCONEO-PWY-1/6690711d00001647. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/84; endpoint types: /individuals/132/type; /individuals/215/type` UniProtKB:P36013 Source assertion: UniProtKB:P36013 describes the corresponding catalytic function in the mitochondrion; this projection applies to the activity enabled by SGD:S000001512. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3501/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction`
fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	provides_input_for	fructose 1,6-bisphosphate 1-phosphatase activity `gomodel:F16BDEPHOS-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16ALDOLASE-RXN RO:0002413 gomodel:F16BDEPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/85; endpoint types: /individuals/37/type; /individuals/38/type`
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	has_output	oxaloacetate(2-) `CHEBI:16452`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005108. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/86; endpoint types: /individuals/146/type; /individuals/151/type`
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN BFO:0000066 gomodel:reaction_PYRUVATE-CARBOXYLASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/87; endpoint types: /individuals/44/type; /individuals/130/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002234 gomodel:CHEBI_43474_GAPOXNPHOSPHN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/88; endpoint types: /individuals/39/type; /individuals/19/type`
malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:1.1.1.39-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/90; endpoint types: /individuals/132/type; /individuals/134/type` UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002233 gomodel:CHEBI_15378_GAPOXNPHOSPHN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/91; endpoint types: /individuals/39/type; /individuals/3/type`
phosphoglycerate mutase activity `gomodel:RXN-15513`	has_input	2-phosphonato-D-glycerate(3-) `CHEBI:58289`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:RXN-15513 RO:0002233 gomodel:CHEBI_58289_2PGADEHYDRAT-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/92; endpoint types: /individuals/45/type; /individuals/34/type`
FBP1 Scer `SGD:S000004369`	enables	fructose 1,6-bisphosphate 1-phosphatase activity `gomodel:F16BDEPHOS-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16BDEPHOS-RXN RO:0002333 gomodel:YLR377C-MONOMER_F16BDEPHOS-RXN_controller. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/93; endpoint types: /individuals/38/type; /individuals/55/type`
phosphoglycerate mutase activity `gomodel:RXN-15513`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:RXN-15513 BFO:0000066 gomodel:reaction_RXN-15513_location_lociGO_0005829. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/94; endpoint types: /individuals/45/type; /individuals/131/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	has_input	3-phosphonato-D-glyceroyl phosphate(4-) `CHEBI:57604`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002233 gomodel:CHEBI_57604_PHOSGLYPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/95; endpoint types: /individuals/39/type; /individuals/27/type`
phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	has_input	oxaloacetate(2-) `CHEBI:16452`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002233 gomodel:CHEBI_16452_MALATE-DEH-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/97; endpoint types: /individuals/41/type; /individuals/8/type`
ENO1 Scer `SGD:S000003486`	enables	phosphopyruvate hydratase activity `gomodel:2PGADEHYDRAT-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:2PGADEHYDRAT-RXN RO:0002333 gomodel:YGR254W-MONOMER_2PGADEHYDRAT-RXN_controller. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/98; endpoint types: /individuals/133/type; /individuals/49/type`
PYC2 Scer `SGD:S000000422`	enables	pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002333 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005110. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/99; endpoint types: /individuals/146/type; /individuals/153/type`
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005109. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/100; endpoint types: /individuals/146/type; /individuals/152/type`
L-malate dehydrogenase (NAD+) activity `gomodel:MALATE-DEH-RXN`	has_input	(S)-malate(2-) `CHEBI:15589`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:MALATE-DEH-RXN RO:0002233 gomodel:CHEBI_15589_MALATE-DEH-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/101; endpoint types: /individuals/40/type; /individuals/7/type`
PYC1 Scer `SGD:S000003030`	enables	pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002333 gomodel:YGL062W-MONOMER_PYRUVATE-CARBOXYLASE-RXN_controller. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/102; endpoint types: /individuals/44/type; /individuals/48/type`
phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	provides_input_for	phosphopyruvate hydratase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002413 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/103; endpoint types: /individuals/41/type; /individuals/167/type`
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005104. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/104; endpoint types: /individuals/146/type; /individuals/147/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	has_output	D-glyceraldehyde 3-phosphate(2-) `CHEBI:59776`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002234 gomodel:CHEBI_59776_GAPOXNPHOSPHN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/105; endpoint types: /individuals/197/type; /individuals/36/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	provides_input_for	fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002413 gomodel:F16ALDOLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/107; endpoint types: /individuals/197/type; /individuals/37/type`
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_43474_PYRUVATE-CARBOXYLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/108; endpoint types: /individuals/44/type; /individuals/20/type`
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	has_output	oxaloacetate(2-) `CHEBI:16452`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_16452_PYRUVATE-CARBOXYLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/109; endpoint types: /individuals/44/type; /individuals/9/type`
phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	provides_input_for	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002413 gomodel:GAPOXNPHOSPHN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/110; endpoint types: /individuals/43/type; /individuals/39/type`
L-malate dehydrogenase (NAD+) activity `gomodel:MALATE-DEH-RXN`	provides_input_for	phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:MALATE-DEH-RXN RO:0002413 gomodel:PEPCARBOXYKIN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/111; endpoint types: /individuals/40/type; /individuals/41/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/112; endpoint types: /individuals/179/type; /individuals/134/type`
fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16ALDOLASE-RXN BFO:0000066 gomodel:reaction_F16ALDOLASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/113; endpoint types: /individuals/37/type; /individuals/123/type`
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	has_input	hydrogencarbonate `CHEBI:17544`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_17544_PYRUVATE-CARBOXYLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/114; endpoint types: /individuals/44/type; /individuals/12/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	has_input	3-phosphonato-D-glyceroyl phosphate(4-) `CHEBI:57604`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002233 gomodel:CHEBI_57604_PHOSGLYPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/115; endpoint types: /individuals/179/type; /individuals/27/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005160. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/116; endpoint types: /individuals/197/type; /individuals/199/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 RO:0002233 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005159. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/117; endpoint types: /individuals/197/type; /individuals/198/type`
PGI1 Scer `SGD:S000000400`	enables	glucose-6-phosphate isomerase activity `gomodel:PGLUCISOM-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PGLUCISOM-RXN RO:0002333 gomodel:YBR196C-MONOMER_PGLUCISOM-RXN_controller. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/118; endpoint types: /individuals/42/type; /individuals/46/type`
phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PHOSGLYPHOS-RXN BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/119; endpoint types: /individuals/43/type; /individuals/134/type`
phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	provides_input_for	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002413 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/120; endpoint types: /individuals/43/type; /individuals/197/type`
pyruvate carboxylase activity `gomodel:PYRUVATE-CARBOXYLASE-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PYRUVATE-CARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_456216_PYRUVATE-CARBOXYLASE-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/121; endpoint types: /individuals/44/type; /individuals/23/type`
malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	has_output	pyruvate `CHEBI:15361`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:1.1.1.39-RXN RO:0002234 gomodel:CHEBI_15361_1.1.1.39-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/122; endpoint types: /individuals/132/type; /individuals/0/type` UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction`
malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	provides_input_for	pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:1.1.1.39-RXN RO:0002413 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/123; endpoint types: /individuals/132/type; /individuals/146/type` UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction`
phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PHOSGLYPHOS-RXN BFO:0000066 gomodel:reaction_PHOSGLYPHOS-RXN_location_lociGO_0005829. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/124; endpoint types: /individuals/43/type; /individuals/129/type`
phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	has_input	3-phosphonato-D-glycerate(3-) `CHEBI:58272`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002233 gomodel:CHEBI_58272_RXN-15513. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/125; endpoint types: /individuals/43/type; /individuals/33/type`
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005158 BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/126; endpoint types: /individuals/197/type; /individuals/134/type`
TDH1 Scer `SGD:S000003588`	enables	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:GAPOXNPHOSPHN-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:GAPOXNPHOSPHN-RXN RO:0002333 gomodel:YJL052W-MONOMER_GAPOXNPHOSPHN-RXN_controller. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/127; endpoint types: /individuals/39/type; /individuals/50/type`
phosphoglycerate kinase activity `gomodel:PHOSGLYPHOS-RXN`	provides_input_for	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PHOSGLYPHOS-RXN RO:0002413 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/128; endpoint types: /individuals/43/type; /individuals/179/type`
L-malate dehydrogenase (NAD+) activity `gomodel:MALATE-DEH-RXN`	has_output	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:MALATE-DEH-RXN RO:0002234 gomodel:CHEBI_57945_MALATE-DEH-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/129; endpoint types: /individuals/40/type; /individuals/32/type`
FBA1 Scer `SGD:S000001543`	enables	fructose-bisphosphate aldolase activity `gomodel:F16ALDOLASE-RXN`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16ALDOLASE-RXN RO:0002333 gomodel:YKL060C-MONOMER_F16ALDOLASE-RXN_controller. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/130; endpoint types: /individuals/37/type; /individuals/52/type`
fructose 1,6-bisphosphate 1-phosphatase activity `gomodel:F16BDEPHOS-RXN`	has_output	beta-D-fructofuranose 6-phosphate(2-) `CHEBI:57634`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:F16BDEPHOS-RXN RO:0002234 gomodel:CHEBI_57634_F16BDEPHOS-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/131; endpoint types: /individuals/38/type; /individuals/28/type`
malate dehydrogenase (oxaloacetate-decarboxylating) (NAD+) activity `gomodel:1.1.1.39-RXN`	has_input	(S)-malate(2-) `CHEBI:15589`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:1.1.1.39-RXN RO:0002233 gomodel:CHEBI_15589_1.1.1.39-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/132; endpoint types: /individuals/132/type; /individuals/6/type` UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates oxidative decarboxylation of malate to pyruvate, carbon dioxide and NADH. The separate imported oxaloacetate-producing MAE1 activity is excluded. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3501/comments/1/reaction`
phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002234 gomodel:CHEBI_456216_PEPCARBOXYKIN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/133; endpoint types: /individuals/41/type; /individuals/21/type`
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	part_of	gluconeogenesis `GO:0006094`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 BFO:0000050 gomodel:YeastPathways_GLUCONEO-PWY-1/YeastPathways_GLUCONEO-PWY-1. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/134; endpoint types: /individuals/146/type; /individuals/134/type`
phosphoglycerate mutase activity `gomodel:RXN-15513`	has_output	3-phosphonato-D-glycerate(3-) `CHEBI:58272`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:RXN-15513 RO:0002234 gomodel:CHEBI_58272_RXN-15513. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/135; endpoint types: /individuals/45/type; /individuals/33/type`
phosphopyruvate hydratase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125`	provides_input_for	phosphoglycerate mutase activity `gomodel:RXN-15513`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005125 RO:0002413 gomodel:RXN-15513. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/136; endpoint types: /individuals/167/type; /individuals/45/type`
TDH2 Scer `SGD:S000003769`	enables	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005138 RO:0002333 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005143. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/137; endpoint types: /individuals/179/type; /individuals/184/type`
pyruvate carboxylase activity `gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005103 RO:0002234 gomodel:YeastPathways_GLUCONEO-PWY-1/6a4c244800005107. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/138; endpoint types: /individuals/146/type; /individuals/150/type`
phosphoenolpyruvate carboxykinase (ATP) activity `gomodel:PEPCARBOXYKIN-RXN`	has_output	phosphonatoenolpyruvate `CHEBI:58702`	gomodel:YeastPathways_GLUCONEO-PWY-1 Source assertion: The model asserts gomodel:PEPCARBOXYKIN-RXN RO:0002234 gomodel:CHEBI_58702_PEPCARBOXYKIN-RXN. Source location `./YeastPathways_GLUCONEO-PWY-1.json#/facts/139; endpoint types: /individuals/41/type; /individuals/35/type`
GPM1 Scer `SGD:S000001635`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P00950 Source assertion: UniProtKB:P00950 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00950 Source assertion: UniProtKB:P00950 has the exact SGD cross-reference SGD:S000001635. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GPM1 Scer `SGD:S000001635`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:16962558) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	mitochondrial outer membrane `GO:0005741`	UniProtKB:P00950 Source assertion: UniProtKB:P00950 annotates location Mitochondrion outer membrane (SL-0172). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00950 Source assertion: UniProtKB:P00950 has the exact SGD cross-reference SGD:S000001635. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GPM1 Scer `SGD:S000001635`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22984289)	mitochondrial intermembrane space `GO:0005758`	UniProtKB:P00950 Source assertion: UniProtKB:P00950 annotates location Mitochondrion intermembrane space (SL-0169). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00950 Source assertion: UniProtKB:P00950 has the exact SGD cross-reference SGD:S000001635. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/51/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
MAE1 Scer `SGD:S000001512`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14576278); ECO:0000269 (PubMed:9603875)	mitochondrial matrix `GO:0005759`	UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3501/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P36013 Source assertion: UniProtKB:P36013 has the exact SGD cross-reference SGD:S000001512. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3501/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
TDH3 Scer `SGD:S000003424`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	cytoplasm `GO:0005737`	UniProtKB:P00359 Source assertion: UniProtKB:P00359 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00359 Source assertion: UniProtKB:P00359 has the exact SGD cross-reference SGD:S000003424. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
TDH3 Scer `SGD:S000003424`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	mitochondrion `GO:0005739`	UniProtKB:P00359 Source assertion: UniProtKB:P00359 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/comments/2/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00359 Source assertion: UniProtKB:P00359 has the exact SGD cross-reference SGD:S000003424. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/25/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PGK1 Scer `SGD:S000000605`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	cytoplasm `GO:0005737`	UniProtKB:P00560 Source assertion: UniProtKB:P00560 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00560 Source assertion: UniProtKB:P00560 has the exact SGD cross-reference SGD:S000000605. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PGK1 Scer `SGD:S000000605`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	mitochondrion `GO:0005739`	UniProtKB:P00560 Source assertion: UniProtKB:P00560 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00560 Source assertion: UniProtKB:P00560 has the exact SGD cross-reference SGD:S000000605. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/35/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
MDH2 Scer `SGD:S000005486`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	cytoplasm `GO:0005737`	UniProtKB:P22133 Source assertion: UniProtKB:P22133 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/571/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P22133 Source assertion: UniProtKB:P22133 has the exact SGD cross-reference SGD:S000005486. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/571/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ENO2 Scer `SGD:S000001217`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	cytoplasm `GO:0005737`	UniProtKB:P00925 Source assertion: UniProtKB:P00925 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/47/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00925 Source assertion: UniProtKB:P00925 has the exact SGD cross-reference SGD:S000001217. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/47/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ENO1 Scer `SGD:S000003486`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	cytoplasm `GO:0005737`	UniProtKB:P00924 Source assertion: UniProtKB:P00924 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/46/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00924 Source assertion: UniProtKB:P00924 has the exact SGD cross-reference SGD:S000003486. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/46/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PYC2 Scer `SGD:S000000422`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	cytoplasm `GO:0005737`	UniProtKB:P32327 Source assertion: UniProtKB:P32327 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/866/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P32327 Source assertion: UniProtKB:P32327 has the exact SGD cross-reference SGD:S000000422. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/866/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PYC1 Scer `SGD:S000003030`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	cytoplasm `GO:0005737`	UniProtKB:P11154 Source assertion: UniProtKB:P11154 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/322/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P11154 Source assertion: UniProtKB:P11154 has the exact SGD cross-reference SGD:S000003030. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/322/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PGI1 Scer `SGD:S000000400`	located_in Physical protein location from reviewed UniProt. ECO:0000250 (UniProtKB:P78917)	cytosol `GO:0005829`	UniProtKB:P12709 Source assertion: UniProtKB:P12709 annotates location Cytoplasm, cytosol (SL-0091). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/351/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P12709 Source assertion: UniProtKB:P12709 has the exact SGD cross-reference SGD:S000000400. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/351/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
TDH1 Scer `SGD:S000003588`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11502169)	cytoplasm `GO:0005737`	UniProtKB:P00360 Source assertion: UniProtKB:P00360 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/26/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00360 Source assertion: UniProtKB:P00360 has the exact SGD cross-reference SGD:S000003588. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/26/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
TDH2 Scer `SGD:S000003769`	located_in Physical protein location from reviewed UniProt. ECO:0000250 (UniProtKB:P00360)	cytoplasm `GO:0005737`	UniProtKB:P00358 Source assertion: UniProtKB:P00358 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/24/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00358 Source assertion: UniProtKB:P00358 has the exact SGD cross-reference SGD:S000003769. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/24/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
MAE1 Scer `SGD:S000001512`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P23368) Divalent metal cations. Prefers magnesium or manganese. UniProt note evidence: ECO:0000250 (UniProtKB:P23368)	magnesium(2+) `CHEBI:18420`	UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3501/comments/0/cofactors/0; /results/3501/comments/0/note` UniProtKB:P36013 Source assertion: UniProtKB:P36013 has the exact SGD cross-reference SGD:S000001512. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3501/uniProtKBCrossReferences/0`
MAE1 Scer `SGD:S000001512`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P23368) Divalent metal cations. Prefers magnesium or manganese. UniProt note evidence: ECO:0000250 (UniProtKB:P23368)	manganese(2+) `CHEBI:29035`	UniProtKB:P36013 Source assertion: UniProtKB:P36013 annotates CHEBI:29035 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3501/comments/0/cofactors/1; /results/3501/comments/0/note` UniProtKB:P36013 Source assertion: UniProtKB:P36013 has the exact SGD cross-reference SGD:S000001512. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3501/uniProtKBCrossReferences/0`
PGK1 Scer `SGD:S000000605`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00558)	magnesium(2+) `CHEBI:18420`	UniProtKB:P00560 Source assertion: UniProtKB:P00560 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/35/comments/0/cofactors/0` UniProtKB:P00560 Source assertion: UniProtKB:P00560 has the exact SGD cross-reference SGD:S000000605. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/35/uniProtKBCrossReferences/0`
ENO2 Scer `SGD:S000001217`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified Mg(2+) is required for catalysis and for stabilizing the dimer.	magnesium(2+) `CHEBI:18420`	UniProtKB:P00925 Source assertion: UniProtKB:P00925 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/47/comments/0/cofactors/0; /results/47/comments/0/note` UniProtKB:P00925 Source assertion: UniProtKB:P00925 has the exact SGD cross-reference SGD:S000001217. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/47/uniProtKBCrossReferences/0`
FBP1 Scer `SGD:S000004369`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00636) Binds 3 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00636)	magnesium(2+) `CHEBI:18420`	UniProtKB:P09201 Source assertion: UniProtKB:P09201 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/222/comments/0/cofactors/0; /results/222/comments/0/note` UniProtKB:P09201 Source assertion: UniProtKB:P09201 has the exact SGD cross-reference SGD:S000004369. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/222/uniProtKBCrossReferences/0`
ENO1 Scer `SGD:S000003486`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:8605183) Mg(2+) is required for catalysis and for stabilizing the dimer. UniProt note evidence: ECO:0000269 (PubMed:8605183)	magnesium(2+) `CHEBI:18420`	UniProtKB:P00924 Source assertion: UniProtKB:P00924 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/46/comments/0/cofactors/0; /results/46/comments/0/note` UniProtKB:P00924 Source assertion: UniProtKB:P00924 has the exact SGD cross-reference SGD:S000003486. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/46/uniProtKBCrossReferences/0`
PYC2 Scer `SGD:S000000422`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	biotinate `CHEBI:57586`	UniProtKB:P32327 Source assertion: UniProtKB:P32327 annotates CHEBI:57586 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/comments/0/cofactors/0` UniProtKB:P32327 Source assertion: UniProtKB:P32327 has the exact SGD cross-reference SGD:S000000422. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/uniProtKBCrossReferences/0`
PYC2 Scer `SGD:S000000422`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	zinc(2+) `CHEBI:29105`	UniProtKB:P32327 Source assertion: UniProtKB:P32327 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/comments/1/cofactors/0` UniProtKB:P32327 Source assertion: UniProtKB:P32327 has the exact SGD cross-reference SGD:S000000422. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/866/uniProtKBCrossReferences/0`
PYC1 Scer `SGD:S000003030`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	biotinate `CHEBI:57586`	UniProtKB:P11154 Source assertion: UniProtKB:P11154 annotates CHEBI:57586 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/comments/0/cofactors/0` UniProtKB:P11154 Source assertion: UniProtKB:P11154 has the exact SGD cross-reference SGD:S000003030. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/uniProtKBCrossReferences/0`
PYC1 Scer `SGD:S000003030`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	zinc(2+) `CHEBI:29105`	UniProtKB:P11154 Source assertion: UniProtKB:P11154 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/comments/1/cofactors/0` UniProtKB:P11154 Source assertion: UniProtKB:P11154 has the exact SGD cross-reference SGD:S000003030. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/322/uniProtKBCrossReferences/0`
FBA1 Scer `SGD:S000001543`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. UniProt note evidence: ECO:0000250	zinc(2+) `CHEBI:29105`	UniProtKB:P14540 Source assertion: UniProtKB:P14540 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/387/comments/0/cofactors/0; /results/387/comments/0/note` UniProtKB:P14540 Source assertion: UniProtKB:P14540 has the exact SGD cross-reference SGD:S000001543. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/387/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_GLUCONEO-PWY-1 SGD GO-CAM gluconeogenesis I model (source version: Pinned Noctua JSON archive; model date 2026-07-20; member ./YeastPathways_GLUCONEO-PWY-1.json)
UniProtKB:P00950 Reviewed UniProtKB P00950 location annotations (source version: UniProt release 2026_03)
UniProtKB:P36013 Reviewed UniProtKB P36013 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00359 Reviewed UniProtKB P00359 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00560 Reviewed UniProtKB P00560 location annotations (source version: UniProt release 2026_03)
UniProtKB:P22133 Reviewed UniProtKB P22133 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00925 Reviewed UniProtKB P00925 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00924 Reviewed UniProtKB P00924 location annotations (source version: UniProt release 2026_03)
UniProtKB:P32327 Reviewed UniProtKB P32327 location annotations (source version: UniProt release 2026_03)
UniProtKB:P11154 Reviewed UniProtKB P11154 location annotations (source version: UniProt release 2026_03)
UniProtKB:P12709 Reviewed UniProtKB P12709 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00360 Reviewed UniProtKB P00360 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00358 Reviewed UniProtKB P00358 location annotations (source version: UniProt release 2026_03)
UniProtKB:P09201 UniProtKB P09201 cofactor annotations (source version: 2026_03)
UniProtKB:P14540 UniProtKB P14540 cofactor annotations (source version: 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T07:05:26Z Codex; edited; Exclude spurious nondecarboxylating MAE1 duplicate; retain independently supported MAE1 malic-enzyme branch and genuine MDH2 activity.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 16 activity location assignments and 15 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 16 independently supported location edges and quarantined 0 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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2026-10-05T07:05:26Z Codex
- EDIT — Exclude spurious nondecarboxylating MAE1 duplicate; retain independently supported MAE1 malic-enzyme branch and genuine MDH2 activity.
  User-authorized full causal graph curation. Exclude spurious nondecarboxylating MAE1 duplicate; retain independently supported MAE1 malic-enzyme branch and genuine MDH2 activity. Independent UniProt release2026_03 annotations, Rhea139 and ChEBI255 were inspected; primary literature was checked for the taxon/function distinctions. Exact source pointers and superseded edge assertions are retained in reports/causal_graph_review/gocam-chemical-corrections.json. Native schema validation and focused biochemical regression tests were run. Shared final rendering and full gates are performed by the coordinating agent.
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