hexaprenyl diphosphate biosynthesis

gomodel:YeastPathways_HEXPPSYN-PWY-2

Hexaprenyl diphosphate biosynthesis in Saccharomyces cerevisiae S288C condenses dimethylallyl diphosphate with isopentenyl diphosphate through geranyl, farnesyl, geranylgeranyl, and pentaprenyl diphosphate intermediates to form all-trans-hexaprenyl diphosphate for ubiquinone biosynthesis.

Pathway type

cofactor biosynthesis

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

23 nodes · 44 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
2-trans,6-trans-farnesyl diphosphate(3-) `CHEBI:175763`	small molecule
ubiquinone biosynthetic process `GO:0006744`	biological process
diphosphoric acid `CHEBI:29888`	small molecule
protein `gomodel:YeastPathways_HEXPPSYN-PWY-2/65692e7e00001766`	protein
isopentenyl diphosphate(3-) `CHEBI:128769`	small molecule
prenyl diphosphate(3-) `CHEBI:57623`	small molecule
all-trans-pentaprenyl diphosphate(3-) `CHEBI:57907`	small molecule
2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) `CHEBI:58756`	small molecule
cytosol `GO:0005829`	cellular component
ERG20 Scer `SGD:S000003703`	protein
BTS1 Scer `SGD:S000005990`	protein
all-trans-hexaprenyl diphosphate(3-) `CHEBI:58179`	lipid
geranyl diphosphate(3-) `CHEBI:58057`	small molecule
COQ1 Scer `SGD:S000000207`	protein
mitochondrion `GO:0005739`	cellular component
cytoplasm `GO:0005737`	cellular component
mitochondrial inner membrane `GO:0005743`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
geranylgeranyl diphosphate synthase activity `gomodel:FARNESYLTRANSTRANSFERASE-RXN`	molecular activity
(2E,6E)-farnesyl diphosphate synthase activity `gomodel:FPPSYN-RXN`	molecular activity
dimethylallyltranstransferase activity `gomodel:GPPSYN-RXN`	molecular activity
geranylfarnesyl diphosphate synthase activity `gomodel:RXN-8813`	molecular activity
hexaprenyl diphosphate synthase activity `gomodel:RXN3O-9805`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
geranylgeranyl diphosphate synthase activity `gomodel:FARNESYLTRANSTRANSFERASE-RXN`	has_input	2-trans,6-trans-farnesyl diphosphate(3-) `CHEBI:175763`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_175763_FPPSYN-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/0; endpoint types: /individuals/16/type; /individuals/5/type`
hexaprenyl diphosphate synthase activity `gomodel:RXN3O-9805`	part_of	ubiquinone biosynthetic process `GO:0006744`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN3O-9805 BFO:0000050 gomodel:YeastPathways_HEXPPSYN-PWY-2/YeastPathways_HEXPPSYN-PWY-2. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/1; endpoint types: /individuals/20/type; /individuals/54/type`
dimethylallyltranstransferase activity `gomodel:GPPSYN-RXN`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:GPPSYN-RXN RO:0002234 gomodel:CHEBI_29888_GPPSYN-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/2; endpoint types: /individuals/18/type; /individuals/8/type`
protein `gomodel:YeastPathways_HEXPPSYN-PWY-2/65692e7e00001766`	enables	geranylfarnesyl diphosphate synthase activity `gomodel:RXN-8813`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN-8813 RO:0002333 gomodel:YeastPathways_HEXPPSYN-PWY-2/65692e7e00001766. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/3; endpoint types: /individuals/19/type; /individuals/59/type`
dimethylallyltranstransferase activity `gomodel:GPPSYN-RXN`	has_input	isopentenyl diphosphate(3-) `CHEBI:128769`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:GPPSYN-RXN RO:0002233 gomodel:CHEBI_128769_GPPSYN-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/4; endpoint types: /individuals/18/type; /individuals/2/type`
dimethylallyltranstransferase activity `gomodel:GPPSYN-RXN`	has_input	prenyl diphosphate(3-) `CHEBI:57623`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:GPPSYN-RXN RO:0002233 gomodel:CHEBI_57623_GPPSYN-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/5; endpoint types: /individuals/18/type; /individuals/11/type`
dimethylallyltranstransferase activity `gomodel:GPPSYN-RXN`	part_of	ubiquinone biosynthetic process `GO:0006744`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:GPPSYN-RXN BFO:0000050 gomodel:YeastPathways_HEXPPSYN-PWY-2/YeastPathways_HEXPPSYN-PWY-2. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/6; endpoint types: /individuals/18/type; /individuals/54/type`
geranylfarnesyl diphosphate synthase activity `gomodel:RXN-8813`	has_output	all-trans-pentaprenyl diphosphate(3-) `CHEBI:57907`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN-8813 RO:0002234 gomodel:CHEBI_57907_RXN-8813. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/7; endpoint types: /individuals/19/type; /individuals/12/type`
geranylfarnesyl diphosphate synthase activity `gomodel:RXN-8813`	has_input	2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) `CHEBI:58756`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN-8813 RO:0002233 gomodel:CHEBI_58756_FARNESYLTRANSTRANSFERASE-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/8; endpoint types: /individuals/19/type; /individuals/15/type`
geranylfarnesyl diphosphate synthase activity `gomodel:RXN-8813`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN-8813 BFO:0000066 gomodel:reaction_RXN-8813_location_lociGO_0005829. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/9; endpoint types: /individuals/19/type; /individuals/53/type`
geranylgeranyl diphosphate synthase activity `gomodel:FARNESYLTRANSTRANSFERASE-RXN`	has_input	isopentenyl diphosphate(3-) `CHEBI:128769`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_128769_FARNESYLTRANSTRANSFERASE-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/10; endpoint types: /individuals/16/type; /individuals/0/type`
dimethylallyltranstransferase activity `gomodel:GPPSYN-RXN`	provides_input_for	(2E,6E)-farnesyl diphosphate synthase activity `gomodel:FPPSYN-RXN`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:GPPSYN-RXN RO:0002413 gomodel:FPPSYN-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/11; endpoint types: /individuals/18/type; /individuals/17/type`
(2E,6E)-farnesyl diphosphate synthase activity `gomodel:FPPSYN-RXN`	has_output	2-trans,6-trans-farnesyl diphosphate(3-) `CHEBI:175763`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FPPSYN-RXN RO:0002234 gomodel:CHEBI_175763_FPPSYN-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/12; endpoint types: /individuals/17/type; /individuals/5/type`
ERG20 Scer `SGD:S000003703`	enables	(2E,6E)-farnesyl diphosphate synthase activity `gomodel:FPPSYN-RXN`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FPPSYN-RXN RO:0002333 gomodel:YJL167W-MONOMER_FPPSYN-RXN_controller. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/13; endpoint types: /individuals/17/type; /individuals/22/type`
geranylgeranyl diphosphate synthase activity `gomodel:FARNESYLTRANSTRANSFERASE-RXN`	part_of	ubiquinone biosynthetic process `GO:0006744`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_HEXPPSYN-PWY-2/YeastPathways_HEXPPSYN-PWY-2. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/14; endpoint types: /individuals/16/type; /individuals/54/type`
geranylgeranyl diphosphate synthase activity `gomodel:FARNESYLTRANSTRANSFERASE-RXN`	has_output	2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) `CHEBI:58756`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_58756_FARNESYLTRANSTRANSFERASE-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/15; endpoint types: /individuals/16/type; /individuals/15/type`
geranylfarnesyl diphosphate synthase activity `gomodel:RXN-8813`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN-8813 RO:0002234 gomodel:CHEBI_29888_RXN-8813. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/16; endpoint types: /individuals/19/type; /individuals/9/type`
hexaprenyl diphosphate synthase activity `gomodel:RXN3O-9805`	has_input	isopentenyl diphosphate(3-) `CHEBI:128769`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN3O-9805 RO:0002233 gomodel:CHEBI_128769_RXN3O-9805. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/17; endpoint types: /individuals/20/type; /individuals/4/type`
BTS1 Scer `SGD:S000005990`	enables	geranylgeranyl diphosphate synthase activity `gomodel:FARNESYLTRANSTRANSFERASE-RXN`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002333 gomodel:YPL069C-MONOMER_FARNESYLTRANSTRANSFERASE-RXN_controller. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/18; endpoint types: /individuals/16/type; /individuals/24/type`
hexaprenyl diphosphate synthase activity `gomodel:RXN3O-9805`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN3O-9805 RO:0002234 gomodel:CHEBI_29888_RXN3O-9805. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/19; endpoint types: /individuals/20/type; /individuals/10/type`
hexaprenyl diphosphate synthase activity `gomodel:RXN3O-9805`	has_output	all-trans-hexaprenyl diphosphate(3-) `CHEBI:58179`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN3O-9805 RO:0002234 gomodel:CHEBI_58179_RXN3O-9805. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/20; endpoint types: /individuals/20/type; /individuals/14/type`
geranylgeranyl diphosphate synthase activity `gomodel:FARNESYLTRANSTRANSFERASE-RXN`	provides_input_for	geranylfarnesyl diphosphate synthase activity `gomodel:RXN-8813`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002413 gomodel:RXN-8813. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/21; endpoint types: /individuals/16/type; /individuals/19/type`
(2E,6E)-farnesyl diphosphate synthase activity `gomodel:FPPSYN-RXN`	has_input	geranyl diphosphate(3-) `CHEBI:58057`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FPPSYN-RXN RO:0002233 gomodel:CHEBI_58057_GPPSYN-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/22; endpoint types: /individuals/17/type; /individuals/13/type`
dimethylallyltranstransferase activity `gomodel:GPPSYN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:GPPSYN-RXN BFO:0000066 gomodel:reaction_GPPSYN-RXN_location_lociGO_0005829. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/23; endpoint types: /individuals/18/type; /individuals/52/type`
COQ1 Scer `SGD:S000000207`	enables	hexaprenyl diphosphate synthase activity `gomodel:RXN3O-9805`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN3O-9805 RO:0002333 gomodel:YBR003W-MONOMER_RXN3O-9805_controller. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/24; endpoint types: /individuals/20/type; /individuals/21/type` UniProtKB:P18900 Source assertion: UniProtKB:P18900 is the yeast mitochondrial hexaprenyl pyrophosphate synthase COQ1; the native RXN3O-9805 product is hexaprenyl diphosphate, not heptaprenyl diphosphate. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3319/proteinDescription/recommendedName`
geranylfarnesyl diphosphate synthase activity `gomodel:RXN-8813`	has_input	isopentenyl diphosphate(3-) `CHEBI:128769`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN-8813 RO:0002233 gomodel:CHEBI_128769_RXN-8813. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/25; endpoint types: /individuals/19/type; /individuals/3/type`
hexaprenyl diphosphate synthase activity `gomodel:RXN3O-9805`	occurs_in	mitochondrion `GO:0005739`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN3O-9805 BFO:0000066 gomodel:YeastPathways_HEXPPSYN-PWY-2/65692e7e00001769. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/26; endpoint types: /individuals/20/type; /individuals/62/type`
geranylfarnesyl diphosphate synthase activity `gomodel:RXN-8813`	part_of	ubiquinone biosynthetic process `GO:0006744`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN-8813 BFO:0000050 gomodel:YeastPathways_HEXPPSYN-PWY-2/YeastPathways_HEXPPSYN-PWY-2. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/27; endpoint types: /individuals/19/type; /individuals/54/type`
(2E,6E)-farnesyl diphosphate synthase activity `gomodel:FPPSYN-RXN`	part_of	ubiquinone biosynthetic process `GO:0006744`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FPPSYN-RXN BFO:0000050 gomodel:YeastPathways_HEXPPSYN-PWY-2/YeastPathways_HEXPPSYN-PWY-2. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/28; endpoint types: /individuals/17/type; /individuals/54/type`
(2E,6E)-farnesyl diphosphate synthase activity `gomodel:FPPSYN-RXN`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FPPSYN-RXN RO:0002234 gomodel:CHEBI_29888_FPPSYN-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/29; endpoint types: /individuals/17/type; /individuals/7/type`
hexaprenyl diphosphate synthase activity `gomodel:RXN3O-9805`	has_input	all-trans-pentaprenyl diphosphate(3-) `CHEBI:57907`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN3O-9805 RO:0002233 gomodel:CHEBI_57907_RXN-8813. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/30; endpoint types: /individuals/20/type; /individuals/12/type`
(2E,6E)-farnesyl diphosphate synthase activity `gomodel:FPPSYN-RXN`	provides_input_for	geranylgeranyl diphosphate synthase activity `gomodel:FARNESYLTRANSTRANSFERASE-RXN`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FPPSYN-RXN RO:0002413 gomodel:FARNESYLTRANSTRANSFERASE-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/31; endpoint types: /individuals/17/type; /individuals/16/type`
(2E,6E)-farnesyl diphosphate synthase activity `gomodel:FPPSYN-RXN`	has_input	isopentenyl diphosphate(3-) `CHEBI:128769`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FPPSYN-RXN RO:0002233 gomodel:CHEBI_128769_FPPSYN-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/32; endpoint types: /individuals/17/type; /individuals/1/type`
dimethylallyltranstransferase activity `gomodel:GPPSYN-RXN`	has_output	geranyl diphosphate(3-) `CHEBI:58057`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:GPPSYN-RXN RO:0002234 gomodel:CHEBI_58057_GPPSYN-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/33; endpoint types: /individuals/18/type; /individuals/13/type`
geranylgeranyl diphosphate synthase activity `gomodel:FARNESYLTRANSTRANSFERASE-RXN`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_29888_FARNESYLTRANSTRANSFERASE-RXN. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/34; endpoint types: /individuals/16/type; /individuals/6/type`
geranylfarnesyl diphosphate synthase activity `gomodel:RXN-8813`	provides_input_for	hexaprenyl diphosphate synthase activity `gomodel:RXN3O-9805`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:RXN-8813 RO:0002413 gomodel:RXN3O-9805. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/35; endpoint types: /individuals/19/type; /individuals/20/type`
ERG20 Scer `SGD:S000003703`	enables	dimethylallyltranstransferase activity `gomodel:GPPSYN-RXN`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:GPPSYN-RXN RO:0002333 gomodel:YJL167W-MONOMER_GPPSYN-RXN_controller. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/36; endpoint types: /individuals/18/type; /individuals/23/type`
geranylgeranyl diphosphate synthase activity `gomodel:FARNESYLTRANSTRANSFERASE-RXN`	occurs_in	mitochondrion `GO:0005739`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FARNESYLTRANSTRANSFERASE-RXN BFO:0000066 gomodel:YeastPathways_HEXPPSYN-PWY-2/65692e7e00001772. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/37; endpoint types: /individuals/16/type; /individuals/64/type`
(2E,6E)-farnesyl diphosphate synthase activity `gomodel:FPPSYN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_HEXPPSYN-PWY-2 Source assertion: The model asserts gomodel:FPPSYN-RXN BFO:0000066 gomodel:reaction_FPPSYN-RXN_location_lociGO_0005829. Source location `./YeastPathways_HEXPPSYN-PWY-2.json#/facts/38; endpoint types: /individuals/17/type; /individuals/51/type`
BTS1 Scer `SGD:S000005990`	located_in Physical protein location from reviewed UniProt. ECO:0000250	cytoplasm `GO:0005737`	UniProtKB:Q12051 Source assertion: UniProtKB:Q12051 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2964/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q12051 Source assertion: UniProtKB:Q12051 has the exact SGD cross-reference SGD:S000005990. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2964/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
COQ1 Scer `SGD:S000000207`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Peripheral membrane protein. Orientation: Matrix side.	mitochondrial inner membrane `GO:0005743`	UniProtKB:P18900 Source assertion: UniProtKB:P18900 annotates location Mitochondrion inner membrane (SL-0168). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3319/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P18900 Source assertion: UniProtKB:P18900 has the exact SGD cross-reference SGD:S000000207. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3319/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ERG20 Scer `SGD:S000003703`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q12051) Binds 2 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q12051)	magnesium(2+) `CHEBI:18420`	UniProtKB:P08524 Source assertion: UniProtKB:P08524 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/209/comments/0/cofactors/0; /results/209/comments/0/note` UniProtKB:P08524 Source assertion: UniProtKB:P08524 has the exact SGD cross-reference SGD:S000003703. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/209/uniProtKBCrossReferences/0`
BTS1 Scer `SGD:S000005990`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17535895) Binds 2 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:17535895)	magnesium(2+) `CHEBI:18420`	UniProtKB:Q12051 Source assertion: UniProtKB:Q12051 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2964/comments/0/cofactors/0; /results/2964/comments/0/note` UniProtKB:Q12051 Source assertion: UniProtKB:Q12051 has the exact SGD cross-reference SGD:S000005990. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2964/uniProtKBCrossReferences/0`
COQ1 Scer `SGD:S000000207`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 2 Mg(2+) ions per subunit. UniProt note evidence: ECO:0000250	magnesium(2+) `CHEBI:18420`	UniProtKB:P18900 Source assertion: UniProtKB:P18900 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3319/comments/0/cofactors/0; /results/3319/comments/0/note` UniProtKB:P18900 Source assertion: UniProtKB:P18900 has the exact SGD cross-reference SGD:S000000207. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3319/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_HEXPPSYN-PWY-2 GO-CAM hexaprenyl diphosphate biosynthesis model YeastPathways_HEXPPSYN-PWY-2 (source version: Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_HEXPPSYN-PWY-2.json)
UniProtKB:Q12051 Reviewed UniProtKB Q12051 location annotations (source version: UniProt release 2026_03)
UniProtKB:P18900 Reviewed UniProtKB P18900 location annotations (source version: UniProt release 2026_03)
UniProtKB:P08524 UniProtKB P08524 cofactor annotations (source version: 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T07:05:26Z Codex; edited; Correct imported heptaprenyl label to hexaprenyl; chemical endpoints and COQ1 assignment unchanged.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 5 activity location assignments and 3 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 2 independently supported location edges and quarantined 0 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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2026-10-05T07:05:26Z Codex
- EDIT — Correct imported heptaprenyl label to hexaprenyl; chemical endpoints and COQ1 assignment unchanged.
  User-authorized full causal graph curation. Correct imported heptaprenyl label to hexaprenyl; chemical endpoints and COQ1 assignment unchanged. Independent UniProt release2026_03 annotations, Rhea139 and ChEBI255 were inspected; primary literature was checked for the taxon/function distinctions. Exact source pointers and superseded edge assertions are retained in reports/causal_graph_review/gocam-chemical-final-supplement.json. Native schema validation and focused biochemical regression tests were run. Shared final rendering and full gates are performed by the coordinating agent.
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