mevalonate pathway

gomodel:YeastPathways_IPPSYN-PWY

The mevalonate pathway in Saccharomyces cerevisiae S288C condenses acetyl-CoA to acetoacetyl-CoA, forms 3-hydroxy-3-methylglutaryl-CoA and mevalonate, phosphorylates mevalonate to 5-diphosphomevalonate, decarboxylates that intermediate to isopentenyl diphosphate, and isomerizes it to prenyl diphosphate.

Pathway type

lipid biosynthesis

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

38 nodes · 63 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
coenzyme A(4-) `CHEBI:57287`	small molecule
(R)-mevalonate `CHEBI:36464`	small molecule
ERG10 Scer `SGD:S000005949`	protein
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) `CHEBI:43074`	small molecule
hydron `CHEBI:15378`	small molecule
ERG12 Scer `SGD:S000004821`	protein
isopentenyl diphosphate(3-) `CHEBI:128769`	small molecule
(R)-5-diphosphonatomevalonate(4-) `CHEBI:57557`	small molecule
cytosol `GO:0005829`	cellular component
isoprenoid biosynthetic process `GO:0008299`	biological process
ADP(3-) `CHEBI:456216`	small molecule
MVD1 Scer `SGD:S000005326`	protein
IDI1 Scer `SGD:S000006038`	protein
hydrogenphosphate `CHEBI:43474`	small molecule
ATP(4-) `CHEBI:30616`	small molecule
acetyl-CoA(4-) `CHEBI:57288`	small molecule
(R)-5-phosphonatomevalonate(3-) `CHEBI:58146`	small molecule
HMG2 Scer `SGD:S000004442`	protein
acetoacetyl-CoA(4-) `CHEBI:57286`	small molecule
ERG8 Scer `SGD:S000004833`	protein
HMG1 Scer `SGD:S000004540`	protein
NADP(3-) `CHEBI:58349`	small molecule
NADPH(4-) `CHEBI:57783`	small molecule
prenyl diphosphate(3-) `CHEBI:57623`	small molecule
ERG13 Scer `SGD:S000004595`	protein
carbon dioxide `CHEBI:16526`	small molecule
water `CHEBI:15377`	small molecule
cytoplasm `GO:0005737`	cellular component
endoplasmic reticulum membrane `GO:0005789`	cellular component
nuclear envelope `GO:0005635`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
hydroxymethylglutaryl-CoA reductase (NADPH) activity `gomodel:1.1.1.34-RXN`	molecular activity
acetyl-CoA C-acetyltransferase activity `gomodel:ACETYL-COA-ACETYLTRANSFER-RXN`	molecular activity
diphosphomevalonate decarboxylase activity `gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN`	molecular activity
hydroxymethylglutaryl-CoA synthase activity `gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN`	molecular activity
isopentenyl-diphosphate delta-isomerase activity `gomodel:IPPISOM-RXN`	molecular activity
mevalonate kinase activity `gomodel:MEVALONATE-KINASE-RXN`	molecular activity
phosphomevalonate kinase activity `gomodel:PHOSPHOMEVALONATE-KINASE-RXN`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
hydroxymethylglutaryl-CoA synthase activity `gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN`	has_output	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_57287_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/0; endpoint types: /individuals/28/type; /individuals/19/type`
mevalonate kinase activity `gomodel:MEVALONATE-KINASE-RXN`	has_input	(R)-mevalonate `CHEBI:36464`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002233 gomodel:CHEBI_36464_1.1.1.34-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/1; endpoint types: /individuals/30/type; /individuals/10/type`
ERG10 Scer `SGD:S000005949`	enables	acetyl-CoA C-acetyltransferase activity `gomodel:ACETYL-COA-ACETYLTRANSFER-RXN`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN RO:0002333 gomodel:YPL028W-MONOMER_ACETYL-COA-ACETYLTRANSFER-RXN_controller. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/2; endpoint types: /individuals/0/type; /individuals/38/type`
hydroxymethylglutaryl-CoA reductase (NADPH) activity `gomodel:1.1.1.34-RXN`	has_input	(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) `CHEBI:43074`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:1.1.1.34-RXN RO:0002233 gomodel:CHEBI_43074_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/3; endpoint types: /individuals/94/type; /individuals/11/type`
hydroxymethylglutaryl-CoA synthase activity `gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_15378_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/4; endpoint types: /individuals/28/type; /individuals/4/type`
ERG12 Scer `SGD:S000004821`	enables	mevalonate kinase activity `gomodel:MEVALONATE-KINASE-RXN`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002333 gomodel:YMR208W-MONOMER_MEVALONATE-KINASE-RXN_controller. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/5; endpoint types: /individuals/30/type; /individuals/35/type`
diphosphomevalonate decarboxylase activity `gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN`	has_output	isopentenyl diphosphate(3-) `CHEBI:128769`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_128769_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/6; endpoint types: /individuals/27/type; /individuals/1/type`
diphosphomevalonate decarboxylase activity `gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN`	has_input	(R)-5-diphosphonatomevalonate(4-) `CHEBI:57557`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_57557_PHOSPHOMEVALONATE-KINASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/7; endpoint types: /individuals/27/type; /individuals/22/type`
phosphomevalonate kinase activity `gomodel:PHOSPHOMEVALONATE-KINASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN BFO:0000066 gomodel:reaction_PHOSPHOMEVALONATE-KINASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/8; endpoint types: /individuals/31/type; /individuals/93/type`
acetyl-CoA C-acetyltransferase activity `gomodel:ACETYL-COA-ACETYLTRANSFER-RXN`	part_of	isoprenoid biosynthetic process `GO:0008299`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/9; endpoint types: /individuals/0/type; /individuals/95/type`
phosphomevalonate kinase activity `gomodel:PHOSPHOMEVALONATE-KINASE-RXN`	has_output	(R)-5-diphosphonatomevalonate(4-) `CHEBI:57557`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN RO:0002234 gomodel:CHEBI_57557_PHOSPHOMEVALONATE-KINASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/10; endpoint types: /individuals/31/type; /individuals/22/type`
isopentenyl-diphosphate delta-isomerase activity `gomodel:IPPISOM-RXN`	part_of	isoprenoid biosynthetic process `GO:0008299`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:IPPISOM-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/11; endpoint types: /individuals/29/type; /individuals/95/type`
mevalonate kinase activity `gomodel:MEVALONATE-KINASE-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002234 gomodel:CHEBI_456216_MEVALONATE-KINASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/12; endpoint types: /individuals/30/type; /individuals/14/type`
acetyl-CoA C-acetyltransferase activity `gomodel:ACETYL-COA-ACETYLTRANSFER-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN BFO:0000066 gomodel:reaction_ACETYL-COA-ACETYLTRANSFER-RXN_location_lociGO_0005829. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/13; endpoint types: /individuals/0/type; /individuals/88/type`
MVD1 Scer `SGD:S000005326`	enables	diphosphomevalonate decarboxylase activity `gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002333 gomodel:YNR043W-MONOMER_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN_controller. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/15; endpoint types: /individuals/27/type; /individuals/37/type`
hydroxymethylglutaryl-CoA synthase activity `gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN`	has_output	(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) `CHEBI:43074`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_43074_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/16; endpoint types: /individuals/28/type; /individuals/11/type`
diphosphomevalonate decarboxylase activity `gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN`	part_of	isoprenoid biosynthetic process `GO:0008299`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/17; endpoint types: /individuals/27/type; /individuals/95/type`
hydroxymethylglutaryl-CoA synthase activity `gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN BFO:0000066 gomodel:reaction_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/18; endpoint types: /individuals/28/type; /individuals/90/type`
hydroxymethylglutaryl-CoA reductase (NADPH) activity `gomodel:1.1.1.34-RXN`	has_output	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:1.1.1.34-RXN RO:0002234 gomodel:CHEBI_57287_1.1.1.34-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/19; endpoint types: /individuals/94/type; /individuals/17/type`
IDI1 Scer `SGD:S000006038`	enables	isopentenyl-diphosphate delta-isomerase activity `gomodel:IPPISOM-RXN`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:IPPISOM-RXN RO:0002333 gomodel:YPL117C-MONOMER_IPPISOM-RXN_controller. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/20; endpoint types: /individuals/29/type; /individuals/39/type`
diphosphomevalonate decarboxylase activity `gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_43474_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/21; endpoint types: /individuals/27/type; /individuals/12/type`
mevalonate kinase activity `gomodel:MEVALONATE-KINASE-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002233 gomodel:CHEBI_30616_MEVALONATE-KINASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/22; endpoint types: /individuals/30/type; /individuals/8/type`
hydroxymethylglutaryl-CoA synthase activity `gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN`	has_input	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57288_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/23; endpoint types: /individuals/28/type; /individuals/21/type`
phosphomevalonate kinase activity `gomodel:PHOSPHOMEVALONATE-KINASE-RXN`	has_input	(R)-5-phosphonatomevalonate(3-) `CHEBI:58146`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN RO:0002233 gomodel:CHEBI_58146_MEVALONATE-KINASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/24; endpoint types: /individuals/31/type; /individuals/25/type`
HMG2 Scer `SGD:S000004442`	enables	hydroxymethylglutaryl-CoA reductase (NADPH) activity `gomodel:1.1.1.34-RXN`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:1.1.1.34-RXN RO:0002333 gomodel:YLR450W-MONOMER_1.1.1.34-RXN_controller. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/25; endpoint types: /individuals/94/type; /individuals/32/type`
mevalonate kinase activity `gomodel:MEVALONATE-KINASE-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002234 gomodel:CHEBI_15378_MEVALONATE-KINASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/26; endpoint types: /individuals/30/type; /individuals/5/type`
hydroxymethylglutaryl-CoA synthase activity `gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN`	has_input	acetoacetyl-CoA(4-) `CHEBI:57286`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57286_ACETYL-COA-ACETYLTRANSFER-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/27; endpoint types: /individuals/28/type; /individuals/16/type`
ERG8 Scer `SGD:S000004833`	enables	phosphomevalonate kinase activity `gomodel:PHOSPHOMEVALONATE-KINASE-RXN`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN RO:0002333 gomodel:YMR220W-MONOMER_PHOSPHOMEVALONATE-KINASE-RXN_controller. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/28; endpoint types: /individuals/31/type; /individuals/36/type`
phosphomevalonate kinase activity `gomodel:PHOSPHOMEVALONATE-KINASE-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN RO:0002233 gomodel:CHEBI_30616_PHOSPHOMEVALONATE-KINASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/29; endpoint types: /individuals/31/type; /individuals/9/type`
isopentenyl-diphosphate delta-isomerase activity `gomodel:IPPISOM-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:IPPISOM-RXN BFO:0000066 gomodel:reaction_IPPISOM-RXN_location_lociGO_0005829. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/30; endpoint types: /individuals/29/type; /individuals/91/type`
acetyl-CoA C-acetyltransferase activity `gomodel:ACETYL-COA-ACETYLTRANSFER-RXN`	has_output	acetoacetyl-CoA(4-) `CHEBI:57286`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_57286_ACETYL-COA-ACETYLTRANSFER-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/31; endpoint types: /individuals/0/type; /individuals/16/type`
phosphomevalonate kinase activity `gomodel:PHOSPHOMEVALONATE-KINASE-RXN`	part_of	isoprenoid biosynthetic process `GO:0008299`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/32; endpoint types: /individuals/31/type; /individuals/95/type`
HMG1 Scer `SGD:S000004540`	enables	hydroxymethylglutaryl-CoA reductase (NADPH) activity `gomodel:1.1.1.34-RXN`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:1.1.1.34-RXN RO:0002333 gomodel:YML075C-MONOMER_1.1.1.34-RXN_controller. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/33; endpoint types: /individuals/94/type; /individuals/33/type`
phosphomevalonate kinase activity `gomodel:PHOSPHOMEVALONATE-KINASE-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:PHOSPHOMEVALONATE-KINASE-RXN RO:0002234 gomodel:CHEBI_456216_PHOSPHOMEVALONATE-KINASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/34; endpoint types: /individuals/31/type; /individuals/15/type`
acetyl-CoA C-acetyltransferase activity `gomodel:ACETYL-COA-ACETYLTRANSFER-RXN`	has_input	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN RO:0002233 gomodel:CHEBI_57288_ACETYL-COA-ACETYLTRANSFER-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/35; endpoint types: /individuals/0/type; /individuals/20/type`
hydroxymethylglutaryl-CoA reductase (NADPH) activity `gomodel:1.1.1.34-RXN`	has_output	(R)-mevalonate `CHEBI:36464`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:1.1.1.34-RXN RO:0002234 gomodel:CHEBI_36464_1.1.1.34-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/36; endpoint types: /individuals/94/type; /individuals/10/type`
isopentenyl-diphosphate delta-isomerase activity `gomodel:IPPISOM-RXN`	has_input	isopentenyl diphosphate(3-) `CHEBI:128769`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:IPPISOM-RXN RO:0002233 gomodel:CHEBI_128769_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/37; endpoint types: /individuals/29/type; /individuals/1/type`
hydroxymethylglutaryl-CoA reductase (NADPH) activity `gomodel:1.1.1.34-RXN`	has_output	NADP(3-) `CHEBI:58349`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:1.1.1.34-RXN RO:0002234 gomodel:CHEBI_58349_1.1.1.34-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/38; endpoint types: /individuals/94/type; /individuals/26/type`
hydroxymethylglutaryl-CoA reductase (NADPH) activity `gomodel:1.1.1.34-RXN`	has_input	NADPH(4-) `CHEBI:57783`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:1.1.1.34-RXN RO:0002233 gomodel:CHEBI_57783_1.1.1.34-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/39; endpoint types: /individuals/94/type; /individuals/24/type`
hydroxymethylglutaryl-CoA reductase (NADPH) activity `gomodel:1.1.1.34-RXN`	part_of	isoprenoid biosynthetic process `GO:0008299`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:1.1.1.34-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/40; endpoint types: /individuals/94/type; /individuals/95/type`
diphosphomevalonate decarboxylase activity `gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_456216_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/41; endpoint types: /individuals/27/type; /individuals/13/type`
acetyl-CoA C-acetyltransferase activity `gomodel:ACETYL-COA-ACETYLTRANSFER-RXN`	has_output	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:ACETYL-COA-ACETYLTRANSFER-RXN RO:0002234 gomodel:CHEBI_57287_ACETYL-COA-ACETYLTRANSFER-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/42; endpoint types: /individuals/0/type; /individuals/18/type`
isopentenyl-diphosphate delta-isomerase activity `gomodel:IPPISOM-RXN`	has_output	prenyl diphosphate(3-) `CHEBI:57623`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:IPPISOM-RXN RO:0002234 gomodel:CHEBI_57623_IPPISOM-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/43; endpoint types: /individuals/29/type; /individuals/23/type`
hydroxymethylglutaryl-CoA reductase (NADPH) activity `gomodel:1.1.1.34-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:1.1.1.34-RXN RO:0002233 gomodel:CHEBI_15378_1.1.1.34-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/44; endpoint types: /individuals/94/type; /individuals/3/type`
mevalonate kinase activity `gomodel:MEVALONATE-KINASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:MEVALONATE-KINASE-RXN BFO:0000066 gomodel:reaction_MEVALONATE-KINASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/45; endpoint types: /individuals/30/type; /individuals/92/type`
diphosphomevalonate decarboxylase activity `gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN BFO:0000066 gomodel:reaction_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/46; endpoint types: /individuals/27/type; /individuals/89/type`
hydroxymethylglutaryl-CoA synthase activity `gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN`	part_of	isoprenoid biosynthetic process `GO:0008299`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/47; endpoint types: /individuals/28/type; /individuals/95/type`
ERG13 Scer `SGD:S000004595`	enables	hydroxymethylglutaryl-CoA synthase activity `gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002333 gomodel:YML126C-MONOMER_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN_controller. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/48; endpoint types: /individuals/28/type; /individuals/34/type`
mevalonate kinase activity `gomodel:MEVALONATE-KINASE-RXN`	part_of	isoprenoid biosynthetic process `GO:0008299`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:MEVALONATE-KINASE-RXN BFO:0000050 gomodel:YeastPathways_IPPSYN-PWY/YeastPathways_IPPSYN-PWY. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/49; endpoint types: /individuals/30/type; /individuals/95/type`
diphosphomevalonate decarboxylase activity `gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002234 gomodel:CHEBI_16526_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/50; endpoint types: /individuals/27/type; /individuals/6/type`
mevalonate kinase activity `gomodel:MEVALONATE-KINASE-RXN`	has_output	(R)-5-phosphonatomevalonate(3-) `CHEBI:58146`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:MEVALONATE-KINASE-RXN RO:0002234 gomodel:CHEBI_58146_MEVALONATE-KINASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/51; endpoint types: /individuals/30/type; /individuals/25/type`
hydroxymethylglutaryl-CoA synthase activity `gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_15377_HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/52; endpoint types: /individuals/28/type; /individuals/2/type`
diphosphomevalonate decarboxylase activity `gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_IPPSYN-PWY Source assertion: The model asserts gomodel:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN RO:0002233 gomodel:CHEBI_30616_DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN. Source location `./YeastPathways_IPPSYN-PWY.json#/facts/53; endpoint types: /individuals/27/type; /individuals/7/type`
ERG10 Scer `SGD:S000005949`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:5571830)	cytosol `GO:0005829`	UniProtKB:P41338 Source assertion: UniProtKB:P41338 annotates location Cytoplasm, cytosol (SL-0091). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1800/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P41338 Source assertion: UniProtKB:P41338 has the exact SGD cross-reference SGD:S000005949. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1800/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ERG12 Scer `SGD:S000004821`	located_in Physical protein location from reviewed UniProt. ECO:0000305 (PubMed:1645230)	cytosol `GO:0005829`	UniProtKB:P07277 Source assertion: UniProtKB:P07277 annotates location Cytoplasm, cytosol (SL-0091). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/183/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07277 Source assertion: UniProtKB:P07277 has the exact SGD cross-reference SGD:S000004821. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
IDI1 Scer `SGD:S000006038`	located_in Physical protein location from reviewed UniProt. ECO:0000305	cytoplasm `GO:0005737`	UniProtKB:P15496 Source assertion: UniProtKB:P15496 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/417/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P15496 Source assertion: UniProtKB:P15496 has the exact SGD cross-reference SGD:S000006038. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/417/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
HMG2 Scer `SGD:S000004442`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:8744950) Topology: Multi-pass membrane protein.	endoplasmic reticulum membrane `GO:0005789`	UniProtKB:P12684 Source assertion: UniProtKB:P12684 annotates location Endoplasmic reticulum membrane (SL-0097). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/347/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P12684 Source assertion: UniProtKB:P12684 has the exact SGD cross-reference SGD:S000004442. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/347/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
HMG2 Scer `SGD:S000004442`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nuclear envelope `GO:0005635`	UniProtKB:P12684 Source assertion: UniProtKB:P12684 annotates location Nucleus envelope (SL-0178). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/347/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P12684 Source assertion: UniProtKB:P12684 has the exact SGD cross-reference SGD:S000004442. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/347/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ERG8 Scer `SGD:S000004833`	located_in Physical protein location from reviewed UniProt. ECO:0000305 (PubMed:1846667)	cytoplasm `GO:0005737`	UniProtKB:P24521 Source assertion: UniProtKB:P24521 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3348/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P24521 Source assertion: UniProtKB:P24521 has the exact SGD cross-reference SGD:S000004833. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3348/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
HMG1 Scer `SGD:S000004540`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:8744950) Topology: Multi-pass membrane protein.	endoplasmic reticulum membrane `GO:0005789`	UniProtKB:P12683 Source assertion: UniProtKB:P12683 annotates location Endoplasmic reticulum membrane (SL-0097). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/346/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P12683 Source assertion: UniProtKB:P12683 has the exact SGD cross-reference SGD:S000004540. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/346/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
HMG1 Scer `SGD:S000004540`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nuclear envelope `GO:0005635`	UniProtKB:P12683 Source assertion: UniProtKB:P12683 annotates location Nucleus envelope (SL-0178). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/346/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P12683 Source assertion: UniProtKB:P12683 has the exact SGD cross-reference SGD:S000004540. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/346/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ERG12 Scer `SGD:S000004821`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P17256)	magnesium(2+) `CHEBI:18420`	UniProtKB:P07277 Source assertion: UniProtKB:P07277 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/183/comments/0/cofactors/0` UniProtKB:P07277 Source assertion: UniProtKB:P07277 has the exact SGD cross-reference SGD:S000004821. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/183/uniProtKBCrossReferences/0`
IDI1 Scer `SGD:S000006038`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q46822) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q46822)	magnesium(2+) `CHEBI:18420`	UniProtKB:P15496 Source assertion: UniProtKB:P15496 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/417/comments/0/cofactors/0; /results/417/comments/0/note` UniProtKB:P15496 Source assertion: UniProtKB:P15496 has the exact SGD cross-reference SGD:S000006038. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/417/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_IPPSYN-PWY SGD GO-CAM mevalonate pathway model (source version: Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_IPPSYN-PWY.json)
UniProtKB:P41338 Reviewed UniProtKB P41338 location annotations (source version: UniProt release 2026_03)
UniProtKB:P07277 Reviewed UniProtKB P07277 location annotations (source version: UniProt release 2026_03)
UniProtKB:P15496 Reviewed UniProtKB P15496 location annotations (source version: UniProt release 2026_03)
UniProtKB:P12684 Reviewed UniProtKB P12684 location annotations (source version: UniProt release 2026_03)
UniProtKB:P24521 Reviewed UniProtKB P24521 location annotations (source version: UniProt release 2026_03)
UniProtKB:P12683 Reviewed UniProtKB P12683 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 7 activity location assignments and 8 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 8 independently supported location edges and quarantined 1 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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