phospholipid biosynthesis

gomodel:YeastPathways_PHOSLIPSYN2-PWY-1

Phospholipid biosynthesis in Saccharomyces cerevisiae S288C routes CDP-diacylglycerol to phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine, and cardiolipin through CDP-diacylglycerol-serine O-phosphatidyltransferase, phosphatidylserine decarboxylase, phosphatidylethanolamine methyltransferase, phosphatidylglycerophosphate synthase, phosphatidylglycerophosphatase, and cardiolipin synthase activities.

Pathway type

lipid biosynthesis

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

50 nodes · 89 asserted directed edges

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
S-adenosyl-L-methionine zwitterion `CHEBI:59789`	small molecule
phosphatidylethanolamine `CHEBI:16038`	lipid
water `CHEBI:15377`	small molecule
3-sn-phosphatidyl-L-serine `CHEBI:11750`	lipid
phospholipid biosynthetic process `GO:0008654`	biological process
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) `CHEBI:64716`	small molecule
cardiolipin(2-) `CHEBI:62237`	small molecule
cytosol `GO:0005829`	cellular component
phosphatidyl-N,N-dimethylethanolamine `CHEBI:17152`	lipid
PSD2 Scer `SGD:S000003402`	protein
carbon dioxide `CHEBI:16526`	small molecule
L-serine zwitterion `CHEBI:33384`	small molecule
PSD1 Scer `SGD:S000005113`	protein
hydron `CHEBI:15378`	small molecule
OPI3 Scer `SGD:S000003834`	protein
hydrogenphosphate `CHEBI:43474`	small molecule
1,2-diacyl-sn-glycero-3-phosphocholine(1+) `CHEBI:16110`	small molecule
phosphatidyl-N-methylethanolamine `CHEBI:15958`	lipid
1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate `CHEBI:37393`	lipid
S-adenosyl-L-homocysteine zwitterion `CHEBI:57856`	small molecule
cytidine 5'-monophosphate(2-) `CHEBI:60377`	small molecule
sn-glycerol 3-phosphate(2-) `CHEBI:57597`	small molecule
PGS1 Scer `SGD:S000000510`	protein
GEP4 Scer `SGD:S000001142`	protein
CRD1 Scer `SGD:S000002301`	protein
CHO1 Scer `SGD:S000000828`	protein
CHO2 Scer `SGD:S000003389`	protein
CDP-diacylglycerol `CHEBI:17962`	lipid
Golgi membrane `GO:0000139`	cellular component
endosome membrane `GO:0010008`	cellular component
mitochondrial inner membrane `GO:0005743`	cellular component
lipid droplet `GO:0005811`	cellular component
endoplasmic reticulum membrane `GO:0005789`	cellular component
mitochondrial membrane `GO:0031966`	cellular component
mitochondrion `GO:0005739`	cellular component
mitochondrial outer membrane `GO:0005741`	cellular component
CDP-diacylglycerol(2-) `CHEBI:58332`	lipid
pyruvoyl group `CHEBI:45360`	cofactor
calcium(2+) `CHEBI:29108`	cofactor
magnesium(2+) `CHEBI:18420`	cofactor
manganese(2+) `CHEBI:29035`	cofactor
phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	molecular activity
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:2.1.1.71-RXN`	molecular activity
cardiolipin synthase (CMP-forming) activity `gomodel:CARDIOLIPSYN-RXN`	molecular activity
phosphatidylglycerophosphatase activity `gomodel:PGPPHOSPHA-RXN`	molecular activity
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity `gomodel:PHOSPHAGLYPSYN-RXN`	molecular activity
phosphatidylserine decarboxylase activity `gomodel:PHOSPHASERDECARB-RXN`	molecular activity
CDP-diacylglycerol-serine O-phosphatidyltransferase activity `gomodel:PHOSPHASERSYN-RXN`	molecular activity
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:RXN3O-349`	molecular activity
phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:2.1.1.71-RXN`	has_input	S-adenosyl-L-methionine zwitterion `CHEBI:59789`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.71-RXN RO:0002233 gomodel:CHEBI_59789_2.1.1.71-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/0; endpoint types: /individuals/101/type; /individuals/24/type`
phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	has_input	phosphatidylethanolamine `CHEBI:16038`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.17-RXN RO:0002233 gomodel:CHEBI_16038_PHOSPHASERDECARB-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/1; endpoint types: /individuals/100/type; /individuals/9/type`
phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	provides_input_for	phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002413 gomodel:2.1.1.17-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/2; endpoint types: /individuals/111/type; /individuals/100/type`
phosphatidylglycerophosphatase activity `gomodel:PGPPHOSPHA-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PGPPHOSPHA-RXN RO:0002233 gomodel:CHEBI_15377_PGPPHOSPHA-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/3; endpoint types: /individuals/30/type; /individuals/2/type`
phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	has_input	3-sn-phosphatidyl-L-serine `CHEBI:11750`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002233 gomodel:CHEBI_11750_PHOSPHASERSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/4; endpoint types: /individuals/111/type; /individuals/1/type`
cardiolipin synthase (CMP-forming) activity `gomodel:CARDIOLIPSYN-RXN`	part_of	phospholipid biosynthetic process `GO:0008654`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:CARDIOLIPSYN-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/5; endpoint types: /individuals/0/type; /individuals/102/type`
phosphatidylglycerophosphatase activity `gomodel:PGPPHOSPHA-RXN`	has_output	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) `CHEBI:64716`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PGPPHOSPHA-RXN RO:0002234 gomodel:CHEBI_64716_PGPPHOSPHA-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/6; endpoint types: /individuals/30/type; /individuals/29/type`
CDP-diacylglycerol-serine O-phosphatidyltransferase activity `gomodel:PHOSPHASERSYN-RXN`	has_output	3-sn-phosphatidyl-L-serine `CHEBI:11750`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002234 gomodel:CHEBI_11750_PHOSPHASERSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/8; endpoint types: /individuals/33/type; /individuals/1/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:RXN3O-349`	part_of	phospholipid biosynthetic process `GO:0008654`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:RXN3O-349 BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/9; endpoint types: /individuals/34/type; /individuals/102/type`
phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	part_of	phospholipid biosynthetic process `GO:0008654`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/10; endpoint types: /individuals/111/type; /individuals/102/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:RXN3O-349`	has_input	phosphatidyl-N,N-dimethylethanolamine `CHEBI:17152`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:RXN3O-349 RO:0002233 gomodel:CHEBI_17152_2.1.1.71-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/12; endpoint types: /individuals/34/type; /individuals/12/type`
PSD2 Scer `SGD:S000003402`	enables	phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002333 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007488. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/13; endpoint types: /individuals/111/type; /individuals/114/type`
phosphatidylserine decarboxylase activity `gomodel:PHOSPHASERDECARB-RXN`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002234 gomodel:CHEBI_16526_PHOSPHASERDECARB-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/14; endpoint types: /individuals/32/type; /individuals/11/type`
CDP-diacylglycerol-serine O-phosphatidyltransferase activity `gomodel:PHOSPHASERSYN-RXN`	has_input	L-serine zwitterion `CHEBI:33384`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002233 gomodel:CHEBI_33384_PHOSPHASERSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/15; endpoint types: /individuals/33/type; /individuals/16/type`
PSD1 Scer `SGD:S000005113`	enables	phosphatidylserine decarboxylase activity `gomodel:PHOSPHASERDECARB-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002333 gomodel:YNL169C-MONOMER_PHOSPHASERDECARB-RXN_controller. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/16; endpoint types: /individuals/32/type; /individuals/41/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:2.1.1.71-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.71-RXN RO:0002234 gomodel:CHEBI_15378_2.1.1.71-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/17; endpoint types: /individuals/101/type; /individuals/4/type`
phosphatidylserine decarboxylase activity `gomodel:PHOSPHASERDECARB-RXN`	part_of	phospholipid biosynthetic process `GO:0008654`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERDECARB-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/18; endpoint types: /individuals/32/type; /individuals/102/type`
OPI3 Scer `SGD:S000003834`	enables	phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:2.1.1.71-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.71-RXN RO:0002333 gomodel:YJR073C-MONOMER_2.1.1.71-RXN_controller. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/19; endpoint types: /individuals/101/type; /individuals/39/type`
phosphatidylglycerophosphatase activity `gomodel:PGPPHOSPHA-RXN`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PGPPHOSPHA-RXN RO:0002234 gomodel:CHEBI_43474_PGPPHOSPHA-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/20; endpoint types: /individuals/30/type; /individuals/18/type`
phosphatidylserine decarboxylase activity `gomodel:PHOSPHASERDECARB-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002233 gomodel:CHEBI_15378_PHOSPHASERDECARB-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/21; endpoint types: /individuals/32/type; /individuals/6/type`
CDP-diacylglycerol-serine O-phosphatidyltransferase activity `gomodel:PHOSPHASERSYN-RXN`	provides_input_for	phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002413 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/22; endpoint types: /individuals/33/type; /individuals/111/type`
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity `gomodel:PHOSPHAGLYPSYN-RXN`	part_of	phospholipid biosynthetic process `GO:0008654`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHAGLYPSYN-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/23; endpoint types: /individuals/31/type; /individuals/102/type`
CDP-diacylglycerol-serine O-phosphatidyltransferase activity `gomodel:PHOSPHASERSYN-RXN`	part_of	phospholipid biosynthetic process `GO:0008654`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERSYN-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/25; endpoint types: /individuals/33/type; /individuals/102/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:2.1.1.71-RXN`	part_of	phospholipid biosynthetic process `GO:0008654`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.71-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/26; endpoint types: /individuals/101/type; /individuals/102/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:2.1.1.71-RXN`	has_output	phosphatidyl-N,N-dimethylethanolamine `CHEBI:17152`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.71-RXN RO:0002234 gomodel:CHEBI_17152_2.1.1.71-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/27; endpoint types: /individuals/101/type; /individuals/12/type`
phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002234 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007487. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/28; endpoint types: /individuals/111/type; /individuals/113/type`
phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	has_input	S-adenosyl-L-methionine zwitterion `CHEBI:59789`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.17-RXN RO:0002233 gomodel:CHEBI_59789_2.1.1.17-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/29; endpoint types: /individuals/100/type; /individuals/23/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:2.1.1.71-RXN`	provides_input_for	phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:RXN3O-349`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.71-RXN RO:0002413 gomodel:RXN3O-349. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/30; endpoint types: /individuals/101/type; /individuals/34/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:RXN3O-349`	has_output	1,2-diacyl-sn-glycero-3-phosphocholine(1+) `CHEBI:16110`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:RXN3O-349 RO:0002234 gomodel:CHEBI_16110_RXN3O-349. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/32; endpoint types: /individuals/34/type; /individuals/10/type`
phosphatidylglycerophosphatase activity `gomodel:PGPPHOSPHA-RXN`	part_of	phospholipid biosynthetic process `GO:0008654`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PGPPHOSPHA-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/33; endpoint types: /individuals/30/type; /individuals/102/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:2.1.1.71-RXN`	has_input	phosphatidyl-N-methylethanolamine `CHEBI:15958`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.71-RXN RO:0002233 gomodel:CHEBI_15958_2.1.1.17-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/34; endpoint types: /individuals/101/type; /individuals/8/type`
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity `gomodel:PHOSPHAGLYPSYN-RXN`	has_output	1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate `CHEBI:37393`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002234 gomodel:CHEBI_37393_PHOSPHAGLYPSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/35; endpoint types: /individuals/31/type; /individuals/17/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:RXN3O-349`	has_output	S-adenosyl-L-homocysteine zwitterion `CHEBI:57856`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:RXN3O-349 RO:0002234 gomodel:CHEBI_57856_RXN3O-349. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/36; endpoint types: /individuals/34/type; /individuals/22/type`
phosphatidylserine decarboxylase activity `gomodel:PHOSPHASERDECARB-RXN`	provides_input_for	phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002413 gomodel:2.1.1.17-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/37; endpoint types: /individuals/32/type; /individuals/100/type`
phosphatidylglycerophosphatase activity `gomodel:PGPPHOSPHA-RXN`	has_input	1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate `CHEBI:37393`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PGPPHOSPHA-RXN RO:0002233 gomodel:CHEBI_37393_PHOSPHAGLYPSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/39; endpoint types: /individuals/30/type; /individuals/17/type`
CDP-diacylglycerol-serine O-phosphatidyltransferase activity `gomodel:PHOSPHASERSYN-RXN`	has_output	cytidine 5'-monophosphate(2-) `CHEBI:60377`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002234 gomodel:CHEBI_60377_PHOSPHASERSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/40; endpoint types: /individuals/33/type; /individuals/27/type`
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity `gomodel:PHOSPHAGLYPSYN-RXN`	has_input	sn-glycerol 3-phosphate(2-) `CHEBI:57597`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002233 gomodel:CHEBI_57597_PHOSPHAGLYPSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/41; endpoint types: /individuals/31/type; /individuals/19/type`
PGS1 Scer `SGD:S000000510`	enables	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity `gomodel:PHOSPHAGLYPSYN-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002333 gomodel:YCL004W-MONOMER_PHOSPHAGLYPSYN-RXN_controller. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/43; endpoint types: /individuals/31/type; /individuals/35/type`
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity `gomodel:PHOSPHAGLYPSYN-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002234 gomodel:CHEBI_15378_PHOSPHAGLYPSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/44; endpoint types: /individuals/31/type; /individuals/5/type`
GEP4 Scer `SGD:S000001142`	enables	phosphatidylglycerophosphatase activity `gomodel:PGPPHOSPHA-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PGPPHOSPHA-RXN RO:0002333 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007476. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/45; endpoint types: /individuals/30/type; /individuals/103/type`
phosphatidylserine decarboxylase activity `gomodel:PHOSPHASERDECARB-RXN`	has_input	3-sn-phosphatidyl-L-serine `CHEBI:11750`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002233 gomodel:CHEBI_11750_PHOSPHASERSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/46; endpoint types: /individuals/32/type; /individuals/1/type`
phosphatidylglycerophosphatase activity `gomodel:PGPPHOSPHA-RXN`	provides_input_for	cardiolipin synthase (CMP-forming) activity `gomodel:CARDIOLIPSYN-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PGPPHOSPHA-RXN RO:0002413 gomodel:CARDIOLIPSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/47; endpoint types: /individuals/30/type; /individuals/0/type`
CRD1 Scer `SGD:S000002301`	enables	cardiolipin synthase (CMP-forming) activity `gomodel:CARDIOLIPSYN-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:CARDIOLIPSYN-RXN RO:0002333 gomodel:YDL142C-MONOMER_CARDIOLIPSYN-RXN_controller. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/48; endpoint types: /individuals/0/type; /individuals/36/type`
CHO1 Scer `SGD:S000000828`	enables	CDP-diacylglycerol-serine O-phosphatidyltransferase activity `gomodel:PHOSPHASERSYN-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002333 gomodel:YER026C-MONOMER_PHOSPHASERSYN-RXN_controller. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/49; endpoint types: /individuals/33/type; /individuals/37/type`
phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.17-RXN RO:0002234 gomodel:CHEBI_15378_2.1.1.17-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/50; endpoint types: /individuals/100/type; /individuals/3/type`
phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	provides_input_for	phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:2.1.1.71-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.17-RXN RO:0002413 gomodel:2.1.1.71-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/51; endpoint types: /individuals/100/type; /individuals/101/type`
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity `gomodel:PHOSPHAGLYPSYN-RXN`	has_output	cytidine 5'-monophosphate(2-) `CHEBI:60377`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002234 gomodel:CHEBI_60377_PHOSPHAGLYPSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/52; endpoint types: /individuals/31/type; /individuals/26/type`
CHO2 Scer `SGD:S000003389`	enables	phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.17-RXN RO:0002333 gomodel:YGR157W-MONOMER_2.1.1.17-RXN_controller. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/53; endpoint types: /individuals/100/type; /individuals/38/type`
phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	has_output	phosphatidylethanolamine `CHEBI:16038`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002234 gomodel:CHEBI_16038_PHOSPHASERDECARB-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/54; endpoint types: /individuals/111/type; /individuals/9/type`
phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485 RO:0002233 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007486. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/55; endpoint types: /individuals/111/type; /individuals/112/type`
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity `gomodel:PHOSPHAGLYPSYN-RXN`	has_input	CDP-diacylglycerol `CHEBI:17962`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002233 gomodel:CHEBI_17962_PHOSPHAGLYPSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/56; endpoint types: /individuals/31/type; /individuals/14/type`
phosphatidylserine decarboxylase activity `gomodel:PHOSPHASERDECARB-RXN`	has_output	phosphatidylethanolamine `CHEBI:16038`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERDECARB-RXN RO:0002234 gomodel:CHEBI_16038_PHOSPHASERDECARB-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/57; endpoint types: /individuals/32/type; /individuals/9/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:RXN3O-349`	has_input	S-adenosyl-L-methionine zwitterion `CHEBI:59789`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:RXN3O-349 RO:0002233 gomodel:CHEBI_59789_RXN3O-349. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/58; endpoint types: /individuals/34/type; /individuals/25/type`
phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	has_output	phosphatidyl-N-methylethanolamine `CHEBI:15958`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.17-RXN RO:0002234 gomodel:CHEBI_15958_2.1.1.17-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/59; endpoint types: /individuals/100/type; /individuals/8/type`
CDP-diacylglycerol-serine O-phosphatidyltransferase activity `gomodel:PHOSPHASERSYN-RXN`	has_input	CDP-diacylglycerol `CHEBI:17962`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002233 gomodel:CHEBI_17962_PHOSPHASERSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/62; endpoint types: /individuals/33/type; /individuals/15/type`
phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:2.1.1.71-RXN`	has_output	S-adenosyl-L-homocysteine zwitterion `CHEBI:57856`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.71-RXN RO:0002234 gomodel:CHEBI_57856_2.1.1.71-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/64; endpoint types: /individuals/101/type; /individuals/21/type`
OPI3 Scer `SGD:S000003834`	enables	phosphatidyl-N-methylethanolamine N-methyltransferase activity `gomodel:RXN3O-349`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:RXN3O-349 RO:0002333 gomodel:YJR073C-MONOMER_RXN3O-349_controller. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/65; endpoint types: /individuals/34/type; /individuals/40/type`
phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	part_of	phospholipid biosynthetic process `GO:0008654`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.17-RXN BFO:0000050 gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/YeastPathways_PHOSLIPSYN2-PWY-1. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/66; endpoint types: /individuals/100/type; /individuals/102/type`
CDP-diacylglycerol-serine O-phosphatidyltransferase activity `gomodel:PHOSPHASERSYN-RXN`	provides_input_for	phosphatidylserine decarboxylase activity `gomodel:PHOSPHASERDECARB-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002413 gomodel:PHOSPHASERDECARB-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/69; endpoint types: /individuals/33/type; /individuals/32/type`
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity `gomodel:PHOSPHAGLYPSYN-RXN`	provides_input_for	phosphatidylglycerophosphatase activity `gomodel:PGPPHOSPHA-RXN`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHAGLYPSYN-RXN RO:0002413 gomodel:PGPPHOSPHA-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/71; endpoint types: /individuals/31/type; /individuals/30/type`
phosphatidylethanolamine N-methyltransferase activity `gomodel:2.1.1.17-RXN`	has_output	S-adenosyl-L-homocysteine zwitterion `CHEBI:57856`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:2.1.1.17-RXN RO:0002234 gomodel:CHEBI_57856_2.1.1.17-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/72; endpoint types: /individuals/100/type; /individuals/20/type`
CDP-diacylglycerol-serine O-phosphatidyltransferase activity `gomodel:PHOSPHASERSYN-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 Source assertion: The model asserts gomodel:PHOSPHASERSYN-RXN RO:0002234 gomodel:CHEBI_15378_PHOSPHASERSYN-RXN. Source location `./YeastPathways_PHOSLIPSYN2-PWY-1.json#/facts/73; endpoint types: /individuals/33/type; /individuals/7/type`
PSD2 Scer `SGD:S000003402`	located_in Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:7890739) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	Golgi membrane `GO:0000139`	UniProtKB:P53037 Source assertion: UniProtKB:P53037 annotates location Golgi apparatus membrane (SL-0134). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P53037 Source assertion: UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PSD2 Scer `SGD:S000003402`	located_in Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:20016005) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side.	endosome membrane `GO:0010008`	UniProtKB:P53037 Source assertion: UniProtKB:P53037 annotates location Endosome membrane (SL-0100). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P53037 Source assertion: UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PSD1 Scer `SGD:S000005113`	located_in Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03208); ECO:0000269 (PubMed:14576278); ECO:0000269 (PubMed:22984266); ECO:0000269 (PubMed:23124206); ECO:0000269 (PubMed:29290583); ECO:0000269 (PubMed:3005242); ECO:0000269 (PubMed:33718843); ECO:0000305 (PubMed:34818062); molecular form: Phosphatidylserine decarboxylase 1 beta chain. Topology: Single-pass membrane protein. Orientation: Intermembrane side.	mitochondrial inner membrane `GO:0005743`	UniProtKB:P39006 Source assertion: UniProtKB:P39006 annotates location Mitochondrion inner membrane (SL-0168); molecular form: Phosphatidylserine decarboxylase 1 beta chain. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P39006 Source assertion: UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P39006 Source assertion: UniProtKB:P39006 annotates location Mitochondrion inner membrane (SL-0168); molecular form: Phosphatidylserine decarboxylase 1 alpha chain. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PSD1 Scer `SGD:S000005113`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:34818062) Source qualification: Localizes to sites of lipid droplet formation on the endoplasmic reticulum membrane	lipid droplet `GO:0005811`	UniProtKB:P39006 Source assertion: UniProtKB:P39006 annotates location Lipid droplet (SL-0154). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/3/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P39006 Source assertion: UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PSD1 Scer `SGD:S000005113`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:29290583); ECO:0000269 (PubMed:34818062) Source qualification: Localizes to sites of lipid droplet formation on the endoplasmic reticulum membrane	endoplasmic reticulum membrane `GO:0005789`	UniProtKB:P39006 Source assertion: UniProtKB:P39006 annotates location Endoplasmic reticulum membrane (SL-0097). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/3/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P39006 Source assertion: UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
OPI3 Scer `SGD:S000003834`	located_in Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03216); ECO:0000269 (PubMed:14562095) Topology: Multi-pass membrane protein.	endoplasmic reticulum membrane `GO:0005789`	UniProtKB:P05375 Source assertion: UniProtKB:P05375 annotates location Endoplasmic reticulum membrane (SL-0097). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/106/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P05375 Source assertion: UniProtKB:P05375 has the exact SGD cross-reference SGD:S000003834. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/106/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
OPI3 Scer `SGD:S000003834`	located_in Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03216); ECO:0000269 (PubMed:14576278) Topology: Multi-pass membrane protein.	mitochondrial membrane `GO:0031966`	UniProtKB:P05375 Source assertion: UniProtKB:P05375 annotates location Mitochondrion membrane (SL-0171). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/106/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P05375 Source assertion: UniProtKB:P05375 has the exact SGD cross-reference SGD:S000003834. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/106/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PGS1 Scer `SGD:S000000510`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:9545322); ECO:0000269 (PubMed:9799363)	mitochondrion `GO:0005739`	UniProtKB:P25578 Source assertion: UniProtKB:P25578 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3372/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P25578 Source assertion: UniProtKB:P25578 has the exact SGD cross-reference SGD:S000000510. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3372/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GEP4 Scer `SGD:S000001142`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:20485265) Topology: Peripheral membrane protein. Orientation: Matrix side.	mitochondrial inner membrane `GO:0005743`	UniProtKB:P38812 Source assertion: UniProtKB:P38812 annotates location Mitochondrion inner membrane (SL-0168). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3637/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38812 Source assertion: UniProtKB:P38812 has the exact SGD cross-reference SGD:S000001142. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3637/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CRD1 Scer `SGD:S000002301`	located_in Physical protein location from reviewed UniProt. ECO:0000305 (PubMed:9442089) Topology: Multi-pass membrane protein.	mitochondrial inner membrane `GO:0005743`	UniProtKB:Q07560 Source assertion: UniProtKB:Q07560 annotates location Mitochondrion inner membrane (SL-0168). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2821/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q07560 Source assertion: UniProtKB:Q07560 has the exact SGD cross-reference SGD:S000002301. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2821/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CHO1 Scer `SGD:S000000828`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Multi-pass membrane protein.	endoplasmic reticulum membrane `GO:0005789`	UniProtKB:P08456 Source assertion: UniProtKB:P08456 annotates location Endoplasmic reticulum membrane (SL-0097). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P08456 Source assertion: UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CHO1 Scer `SGD:S000000828`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:3005242) Topology: Multi-pass membrane protein.	mitochondrial outer membrane `GO:0005741`	UniProtKB:P08456 Source assertion: UniProtKB:P08456 annotates location Mitochondrion outer membrane (SL-0172). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P08456 Source assertion: UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/205/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CHO2 Scer `SGD:S000003389`	located_in Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03217); ECO:0000269 (PubMed:14562095) Topology: Multi-pass membrane protein.	endoplasmic reticulum membrane `GO:0005789`	UniProtKB:P05374 Source assertion: UniProtKB:P05374 annotates location Endoplasmic reticulum membrane (SL-0097). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/105/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P05374 Source assertion: UniProtKB:P05374 has the exact SGD cross-reference SGD:S000003389. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/105/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
phosphatidylserine decarboxylase activity `gomodel:PHOSPHASERDECARB-RXN`	occurs_in Activity compartment supported by an inspected functional annotation. ECO:0000255 (HAMAP-Rule:MF_03208); ECO:0000269 (PubMed:11294902); ECO:0000269 (PubMed:17976194); ECO:0000269 (PubMed:23045528); ECO:0000269 (PubMed:23124206); ECO:0000269 (PubMed:25829489); ECO:0000269 (PubMed:29290583); ECO:0000269 (PubMed:30926815); ECO:0000269 (PubMed:34818062); ECO:0000269 (PubMed:8227017); ECO:0000269 (PubMed:8407984); ECO:0000269 (PubMed:8530379). Alternative isoenzymes may function elsewhere.	mitochondrion `GO:0005739`	UniProtKB:P39006 Source assertion: UniProtKB:P39006 describes the corresponding catalytic function in the mitochondrion; this projection applies to the activity enabled by SGD:S000005113. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1539/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	occurs_in Activity compartment supported by an inspected functional annotation. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:11294902); ECO:0000269 (PubMed:20016005); ECO:0000269 (PubMed:24366873); ECO:0000269 (PubMed:7890739); ECO:0000269 (PubMed:7890740). Alternative isoenzymes may function elsewhere.	Golgi membrane `GO:0000139`	UniProtKB:P53037 Source assertion: UniProtKB:P53037 describes the corresponding catalytic function in the Golgi membrane; this projection applies to the activity enabled by SGD:S000003402. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
phosphatidylserine decarboxylase activity `gomodel:YeastPathways_PHOSLIPSYN2-PWY-1/6a4c244800007485`	occurs_in Activity compartment supported by an inspected functional annotation. ECO:0000255 (HAMAP-Rule:MF_03209); ECO:0000269 (PubMed:11294902); ECO:0000269 (PubMed:20016005); ECO:0000269 (PubMed:24366873); ECO:0000269 (PubMed:7890739); ECO:0000269 (PubMed:7890740). Alternative isoenzymes may function elsewhere.	endosome membrane `GO:0010008`	UniProtKB:P53037 Source assertion: UniProtKB:P53037 describes the corresponding catalytic function in the endosome membrane; this projection applies to the activity enabled by SGD:S000003402. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2090/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
cardiolipin synthase (CMP-forming) activity `gomodel:CARDIOLIPSYN-RXN`	has_input Yeast CRD1 is the CMP-forming cardiolipin synthase: CDP-diacylglycerol and phosphatidylglycerol are inputs; cardiolipin, CMP and H+ are outputs. The imported bacterial glycerol-forming chemistry is superseded.	CDP-diacylglycerol(2-) `CHEBI:58332`	UniProtKB:Q07560 Source assertion: a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+) Source location `https://rest.uniprot.org/uniprotkb/Q07560.json [sha256:4776cb2392de0f791dccac79c1e4ce3b203239abfb46d2dcab9ae4ffada2c30d] #/comments/1/reaction`
cardiolipin synthase (CMP-forming) activity `gomodel:CARDIOLIPSYN-RXN`	has_input Yeast CRD1 is the CMP-forming cardiolipin synthase: CDP-diacylglycerol and phosphatidylglycerol are inputs; cardiolipin, CMP and H+ are outputs. The imported bacterial glycerol-forming chemistry is superseded.	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) `CHEBI:64716`	UniProtKB:Q07560 Source assertion: a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+) Source location `https://rest.uniprot.org/uniprotkb/Q07560.json [sha256:4776cb2392de0f791dccac79c1e4ce3b203239abfb46d2dcab9ae4ffada2c30d] #/comments/1/reaction`
cardiolipin synthase (CMP-forming) activity `gomodel:CARDIOLIPSYN-RXN`	has_output Yeast CRD1 is the CMP-forming cardiolipin synthase: CDP-diacylglycerol and phosphatidylglycerol are inputs; cardiolipin, CMP and H+ are outputs. The imported bacterial glycerol-forming chemistry is superseded.	cardiolipin(2-) `CHEBI:62237`	UniProtKB:Q07560 Source assertion: a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+) Source location `https://rest.uniprot.org/uniprotkb/Q07560.json [sha256:4776cb2392de0f791dccac79c1e4ce3b203239abfb46d2dcab9ae4ffada2c30d] #/comments/1/reaction`
cardiolipin synthase (CMP-forming) activity `gomodel:CARDIOLIPSYN-RXN`	has_output Yeast CRD1 is the CMP-forming cardiolipin synthase: CDP-diacylglycerol and phosphatidylglycerol are inputs; cardiolipin, CMP and H+ are outputs. The imported bacterial glycerol-forming chemistry is superseded.	cytidine 5'-monophosphate(2-) `CHEBI:60377`	UniProtKB:Q07560 Source assertion: a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+) Source location `https://rest.uniprot.org/uniprotkb/Q07560.json [sha256:4776cb2392de0f791dccac79c1e4ce3b203239abfb46d2dcab9ae4ffada2c30d] #/comments/1/reaction`
cardiolipin synthase (CMP-forming) activity `gomodel:CARDIOLIPSYN-RXN`	has_output Yeast CRD1 is the CMP-forming cardiolipin synthase: CDP-diacylglycerol and phosphatidylglycerol are inputs; cardiolipin, CMP and H+ are outputs. The imported bacterial glycerol-forming chemistry is superseded.	hydron `CHEBI:15378`	UniProtKB:Q07560 Source assertion: a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+) Source location `https://rest.uniprot.org/uniprotkb/Q07560.json [sha256:4776cb2392de0f791dccac79c1e4ce3b203239abfb46d2dcab9ae4ffada2c30d] #/comments/1/reaction`
PSD2 Scer `SGD:S000003402`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: ECO:0000250 (UniProtKB:P0A8K1); ECO:0000255 (HAMAP-Rule:MF_03209) Binds 1 pyruvoyl group covalently per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P0A8K1); ECO:0000255 (HAMAP-Rule:MF_03209)	pyruvoyl group `CHEBI:45360`	CHEBI:45360 Source assertion: ChEBI labels CHEBI:45360 as pyruvoyl group. Source location `chebi.obo [Term] id: CHEBI:45360; name: pyruvoyl group` UniProtKB:P53037 Source assertion: UniProtKB:P53037 cross-references CHEBI:15361, but its note specifies a covalently bound pyruvoyl group; that group is projected to CHEBI:45360. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/comments/0/cofactors/0; /results/2090/comments/0/note` UniProtKB:P53037 Source assertion: UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/uniProtKBCrossReferences/0`
PSD2 Scer `SGD:S000003402`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU00041)	calcium(2+) `CHEBI:29108`	UniProtKB:P53037 Source assertion: UniProtKB:P53037 annotates CHEBI:29108 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/comments/1/cofactors/0` UniProtKB:P53037 Source assertion: UniProtKB:P53037 has the exact SGD cross-reference SGD:S000003402. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2090/uniProtKBCrossReferences/0`
PSD1 Scer `SGD:S000005113`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The cofactor note explicitly describes a covalently bound pyruvoyl group; use the exact group class rather than free pyruvate. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03208) Binds 1 pyruvoyl group covalently per subunit. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03208)	pyruvoyl group `CHEBI:45360`	CHEBI:45360 Source assertion: ChEBI labels CHEBI:45360 as pyruvoyl group. Source location `chebi.obo [Term] id: CHEBI:45360; name: pyruvoyl group` UniProtKB:P39006 Source assertion: UniProtKB:P39006 cross-references CHEBI:15361, but its note specifies a covalently bound pyruvoyl group; that group is projected to CHEBI:45360. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1539/comments/0/cofactors/0; /results/1539/comments/0/note` UniProtKB:P39006 Source assertion: UniProtKB:P39006 has the exact SGD cross-reference SGD:S000005113. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1539/uniProtKBCrossReferences/0`
CRD1 Scer `SGD:S000002301`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The caution corrects the historical species attribution of a sequence; the current reviewed yeast entry and magnesium annotation remain applicable. UniProt evidence: ECO:0000269 (PubMed:2171667)	magnesium(2+) `CHEBI:18420`	UniProtKB:Q07560 Source assertion: UniProtKB:Q07560 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2821/comments/0/cofactors/0` UniProtKB:Q07560 Source assertion: UniProtKB:Q07560 has the exact SGD cross-reference SGD:S000002301. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2821/uniProtKBCrossReferences/0`
CHO1 Scer `SGD:S000000828`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6088519); ECO:0000269 (PubMed:6274497) Divalent metal cations; Mn(2+) or Mg(2+). UniProt note evidence: ECO:0000269 (PubMed:6088519)	manganese(2+) `CHEBI:29035`	UniProtKB:P08456 Source assertion: UniProtKB:P08456 annotates CHEBI:29035 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/comments/0/cofactors/0; /results/205/comments/0/note` UniProtKB:P08456 Source assertion: UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/uniProtKBCrossReferences/0`
CHO1 Scer `SGD:S000000828`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6088519) Divalent metal cations; Mn(2+) or Mg(2+). UniProt note evidence: ECO:0000269 (PubMed:6088519)	magnesium(2+) `CHEBI:18420`	UniProtKB:P08456 Source assertion: UniProtKB:P08456 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/comments/0/cofactors/1; /results/205/comments/0/note` UniProtKB:P08456 Source assertion: UniProtKB:P08456 has the exact SGD cross-reference SGD:S000000828. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/205/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PHOSLIPSYN2-PWY-1 SGD GO-CAM phospholipid biosynthesis model (source version: Pinned Noctua JSON archive; model date 2026-07-23; member ./YeastPathways_PHOSLIPSYN2-PWY-1.json)
UniProtKB:P53037 Reviewed UniProtKB P53037 location annotations (source version: UniProt release 2026_03)
UniProtKB:P39006 Reviewed UniProtKB P39006 location annotations (source version: UniProt release 2026_03)
UniProtKB:P05375 Reviewed UniProtKB P05375 location annotations (source version: UniProt release 2026_03)
UniProtKB:P25578 Reviewed UniProtKB P25578 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38812 Reviewed UniProtKB P38812 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q07560 Reviewed UniProtKB Q07560 location annotations (source version: UniProt release 2026_03)
UniProtKB:P08456 Reviewed UniProtKB P08456 location annotations (source version: UniProt release 2026_03)
UniProtKB:P05374 Reviewed UniProtKB P05374 location annotations (source version: UniProt release 2026_03)
CHEBI:45360 ChEBI CHEBI:45360: pyruvoyl group (source version: ChEBI release 255)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:53:32Z Codex; review-catalytic-function; Reconciled native GO-CAM chemistry with independently reviewed enzyme specificity, direction, physiological scope and source cautions; superseded facts remain in the function review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 9 activity location assignments and 8 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 16 independently supported location edges and quarantined 9 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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