6-hydroxymethyl-dihydropterin diphosphate biosynthesis I

gomodel:YeastPathways_PWY-6147

6-hydroxymethyl-dihydropterin diphosphate biosynthesis I in Saccharomyces cerevisiae S288C converts GTP to (7,8-dihydropterin-6-yl)methyl diphosphate through FOL2-catalyzed GTP cyclohydrolase I activity, 7,8-dihydroneopterin triphosphate pyrophosphohydrolase, 7,8-dihydroneopterin 3'-phosphate dephosphorylation, and FOL1-catalyzed aldolase and diphosphokinase activities.

Pathway type

folate biosynthesis

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

27 nodes · 41 asserted directed edges

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Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one `CHEBI:44841`	small molecule
cytosol `GO:0005829`	cellular component
diphosphoric acid `CHEBI:29888`	small molecule
protein `gomodel:YeastPathways_PWY-6147/6a6bcaed00000919`	protein
folic acid biosynthetic process `GO:0046656`	biological process
hydron `CHEBI:15378`	small molecule
7,8-dihydroneopterin 3'-phosphate(2-) `CHEBI:58762`	small molecule
7,8-dihydroneopterin `CHEBI:17001`	small molecule
(7,8-dihydropterin-6-yl)methyl diphosphate `CHEBI:73083`	small molecule
adenosine 5'-monophosphate(2-) `CHEBI:456215`	small molecule
7,8-dihydroneopterin 3'-triphosphate(4-) `CHEBI:58462`	small molecule
glycolaldehyde `CHEBI:17071`	small molecule
protein `gomodel:YeastPathways_PWY-6147/6a6bcaed00000922`	protein
hydrogenphosphate `CHEBI:43474`	small molecule
FOL2 Scer `SGD:S000003499`	protein
formate `CHEBI:15740`	small molecule
ATP(4-) `CHEBI:30616`	small molecule
water `CHEBI:15377`	small molecule
FOL1 Scer `SGD:S000005200`	protein
GTP(4-) `CHEBI:37565`	small molecule
mitochondrial membrane `GO:0031966`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN`	molecular activity
GTP cyclohydrolase I activity `gomodel:GTP-CYCLOHYDRO-I-RXN`	molecular activity
dihydroneopterin aldolase activity `gomodel:H2NEOPTERINALDOL-RXN`	molecular activity
dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	molecular activity
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity `gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity `gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN`	has_input	2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one `CHEBI:44841`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002233 gomodel:CHEBI_44841_H2NEOPTERINALDOL-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/0; endpoint types: /individuals/22/type; /individuals/13/type`
dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN BFO:0000066 gomodel:reaction_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY-6147.json#/facts/1; endpoint types: /individuals/21/type; /individuals/59/type`
dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002234 gomodel:CHEBI_29888_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/2; endpoint types: /individuals/21/type; /individuals/9/type`
dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	provides_input_for	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002413 gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/3; endpoint types: /individuals/21/type; /individuals/18/type`
GTP cyclohydrolase I activity `gomodel:GTP-CYCLOHYDRO-I-RXN`	provides_input_for	dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002413 gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/4; endpoint types: /individuals/19/type; /individuals/21/type`
protein `gomodel:YeastPathways_PWY-6147/6a6bcaed00000919`	enables	dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002333 gomodel:YeastPathways_PWY-6147/6a6bcaed00000919. Source location `./YeastPathways_PWY-6147.json#/facts/5; endpoint types: /individuals/21/type; /individuals/66/type`
GTP cyclohydrolase I activity `gomodel:GTP-CYCLOHYDRO-I-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN BFO:0000066 gomodel:reaction_GTP-CYCLOHYDRO-I-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY-6147.json#/facts/6; endpoint types: /individuals/19/type; /individuals/57/type`
dihydroneopterin aldolase activity `gomodel:H2NEOPTERINALDOL-RXN`	part_of	folic acid biosynthetic process `GO:0046656`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINALDOL-RXN BFO:0000050 gomodel:YeastPathways_PWY-6147/YeastPathways_PWY-6147. Source location `./YeastPathways_PWY-6147.json#/facts/7; endpoint types: /individuals/20/type; /individuals/61/type`
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity `gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002234 gomodel:CHEBI_15378_H2PTERIDINEPYROPHOSPHOKIN-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/9; endpoint types: /individuals/22/type; /individuals/5/type`
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN`	has_input	7,8-dihydroneopterin 3'-phosphate(2-) `CHEBI:58762`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002233 gomodel:CHEBI_58762_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/10; endpoint types: /individuals/18/type; /individuals/16/type`
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN`	part_of	folic acid biosynthetic process `GO:0046656`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN BFO:0000050 gomodel:YeastPathways_PWY-6147/YeastPathways_PWY-6147. Source location `./YeastPathways_PWY-6147.json#/facts/11; endpoint types: /individuals/18/type; /individuals/61/type`
dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	part_of	folic acid biosynthetic process `GO:0046656`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN BFO:0000050 gomodel:YeastPathways_PWY-6147/YeastPathways_PWY-6147. Source location `./YeastPathways_PWY-6147.json#/facts/12; endpoint types: /individuals/21/type; /individuals/61/type`
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity `gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN`	part_of	folic acid biosynthetic process `GO:0046656`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN BFO:0000050 gomodel:YeastPathways_PWY-6147/YeastPathways_PWY-6147. Source location `./YeastPathways_PWY-6147.json#/facts/13; endpoint types: /individuals/22/type; /individuals/61/type`
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN`	has_output	7,8-dihydroneopterin `CHEBI:17001`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002234 gomodel:CHEBI_17001_DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/14; endpoint types: /individuals/18/type; /individuals/7/type`
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity `gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN`	has_output	(7,8-dihydropterin-6-yl)methyl diphosphate `CHEBI:73083`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002234 gomodel:CHEBI_73083_H2PTERIDINEPYROPHOSPHOKIN-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/15; endpoint types: /individuals/22/type; /individuals/17/type`
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity `gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN`	has_output	adenosine 5'-monophosphate(2-) `CHEBI:456215`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002234 gomodel:CHEBI_456215_H2PTERIDINEPYROPHOSPHOKIN-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/16; endpoint types: /individuals/22/type; /individuals/14/type`
dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	has_input	7,8-dihydroneopterin 3'-triphosphate(4-) `CHEBI:58462`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002233 gomodel:CHEBI_58462_GTP-CYCLOHYDRO-I-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/17; endpoint types: /individuals/21/type; /individuals/15/type`
dihydroneopterin aldolase activity `gomodel:H2NEOPTERINALDOL-RXN`	has_output	glycolaldehyde `CHEBI:17071`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINALDOL-RXN RO:0002234 gomodel:CHEBI_17071_H2NEOPTERINALDOL-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/18; endpoint types: /individuals/20/type; /individuals/8/type`
dihydroneopterin aldolase activity `gomodel:H2NEOPTERINALDOL-RXN`	has_output	2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one `CHEBI:44841`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINALDOL-RXN RO:0002234 gomodel:CHEBI_44841_H2NEOPTERINALDOL-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/19; endpoint types: /individuals/20/type; /individuals/13/type`
protein `gomodel:YeastPathways_PWY-6147/6a6bcaed00000922`	enables	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002333 gomodel:YeastPathways_PWY-6147/6a6bcaed00000922. Source location `./YeastPathways_PWY-6147.json#/facts/20; endpoint types: /individuals/18/type; /individuals/68/type`
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002234 gomodel:CHEBI_43474_DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/21; endpoint types: /individuals/18/type; /individuals/12/type`
FOL2 Scer `SGD:S000003499`	enables	GTP cyclohydrolase I activity `gomodel:GTP-CYCLOHYDRO-I-RXN`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002333 gomodel:YGR267C-MONOMER_GTP-CYCLOHYDRO-I-RXN_controller. Source location `./YeastPathways_PWY-6147.json#/facts/22; endpoint types: /individuals/19/type; /individuals/23/type`
GTP cyclohydrolase I activity `gomodel:GTP-CYCLOHYDRO-I-RXN`	has_output	formate `CHEBI:15740`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002234 gomodel:CHEBI_15740_GTP-CYCLOHYDRO-I-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/23; endpoint types: /individuals/19/type; /individuals/6/type`
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity `gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002233 gomodel:CHEBI_30616_H2PTERIDINEPYROPHOSPHOKIN-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/24; endpoint types: /individuals/22/type; /individuals/10/type`
dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	has_output	7,8-dihydroneopterin 3'-phosphate(2-) `CHEBI:58762`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002234 gomodel:CHEBI_58762_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/25; endpoint types: /individuals/21/type; /individuals/16/type`
dihydroneopterin aldolase activity `gomodel:H2NEOPTERINALDOL-RXN`	provides_input_for	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity `gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINALDOL-RXN RO:0002413 gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/26; endpoint types: /individuals/20/type; /individuals/22/type`
GTP cyclohydrolase I activity `gomodel:GTP-CYCLOHYDRO-I-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002233 gomodel:CHEBI_15377_GTP-CYCLOHYDRO-I-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/27; endpoint types: /individuals/19/type; /individuals/1/type`
dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002234 gomodel:CHEBI_15378_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/28; endpoint types: /individuals/21/type; /individuals/4/type`
GTP cyclohydrolase I activity `gomodel:GTP-CYCLOHYDRO-I-RXN`	part_of	folic acid biosynthetic process `GO:0046656`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN BFO:0000050 gomodel:YeastPathways_PWY-6147/YeastPathways_PWY-6147. Source location `./YeastPathways_PWY-6147.json#/facts/29; endpoint types: /individuals/19/type; /individuals/61/type`
FOL1 Scer `SGD:S000005200`	enables	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity `gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2PTERIDINEPYROPHOSPHOKIN-RXN RO:0002333 gomodel:YNL256W-MONOMER_H2PTERIDINEPYROPHOSPHOKIN-RXN_controller. Source location `./YeastPathways_PWY-6147.json#/facts/30; endpoint types: /individuals/22/type; /individuals/25/type`
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN BFO:0000066 gomodel:reaction_DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY-6147.json#/facts/31; endpoint types: /individuals/18/type; /individuals/56/type`
GTP cyclohydrolase I activity `gomodel:GTP-CYCLOHYDRO-I-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002234 gomodel:CHEBI_15378_GTP-CYCLOHYDRO-I-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/32; endpoint types: /individuals/19/type; /individuals/3/type`
dihydroneopterin triphosphate pyrophosphohydrolase activity `gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN RO:0002233 gomodel:CHEBI_15377_H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/33; endpoint types: /individuals/21/type; /individuals/2/type`
dihydroneopterin aldolase activity `gomodel:H2NEOPTERINALDOL-RXN`	has_input	7,8-dihydroneopterin `CHEBI:17001`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINALDOL-RXN RO:0002233 gomodel:CHEBI_17001_DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/34; endpoint types: /individuals/20/type; /individuals/7/type`
GTP cyclohydrolase I activity `gomodel:GTP-CYCLOHYDRO-I-RXN`	has_output	7,8-dihydroneopterin 3'-triphosphate(4-) `CHEBI:58462`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002234 gomodel:CHEBI_58462_GTP-CYCLOHYDRO-I-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/35; endpoint types: /individuals/19/type; /individuals/15/type`
GTP cyclohydrolase I activity `gomodel:GTP-CYCLOHYDRO-I-RXN`	has_input	GTP(4-) `CHEBI:37565`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:GTP-CYCLOHYDRO-I-RXN RO:0002233 gomodel:CHEBI_37565_GTP-CYCLOHYDRO-I-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/37; endpoint types: /individuals/19/type; /individuals/11/type`
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002233 gomodel:CHEBI_15377_DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/38; endpoint types: /individuals/18/type; /individuals/0/type`
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN`	provides_input_for	dihydroneopterin aldolase activity `gomodel:H2NEOPTERINALDOL-RXN`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN RO:0002413 gomodel:H2NEOPTERINALDOL-RXN. Source location `./YeastPathways_PWY-6147.json#/facts/39; endpoint types: /individuals/18/type; /individuals/20/type`
FOL1 Scer `SGD:S000005200`	enables	dihydroneopterin aldolase activity `gomodel:H2NEOPTERINALDOL-RXN`	gomodel:YeastPathways_PWY-6147 Source assertion: The model asserts gomodel:H2NEOPTERINALDOL-RXN RO:0002333 gomodel:YNL256W-MONOMER_H2NEOPTERINALDOL-RXN_controller. Source location `./YeastPathways_PWY-6147.json#/facts/40; endpoint types: /individuals/20/type; /individuals/24/type`
FOL1 Scer `SGD:S000005200`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14576278); ECO:0000269 (PubMed:15169867)	mitochondrial membrane `GO:0031966`	UniProtKB:P53848 Source assertion: UniProtKB:P53848 annotates location Mitochondrion membrane (SL-0171). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2262/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P53848 Source assertion: UniProtKB:P53848 has the exact SGD cross-reference SGD:S000005200. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2262/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FOL1 Scer `SGD:S000005200`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P0AC13)	magnesium(2+) `CHEBI:18420`	UniProtKB:P53848 Source assertion: UniProtKB:P53848 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2262/comments/0/cofactors/0` UniProtKB:P53848 Source assertion: UniProtKB:P53848 has the exact SGD cross-reference SGD:S000005200. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2262/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY-6147 GO-CAM 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I model YeastPathways_PWY-6147 (source version: Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY-6147.json)
UniProtKB:P53848 Reviewed UniProtKB P53848 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 5 activity location assignments and 2 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 1 independently supported location edges and quarantined 2 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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