chitin biosynthesis

gomodel:YeastPathways_PWY3O-15

Saccharomyces cerevisiae S288C chitin biosynthesis route in which CHS1, CHS2, and CHS3 chitin synthase activities convert UDP-N-acetyl-alpha-D-glucosamine to chitin and UDP.

Pathway type

cell wall biosynthesis

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

Read the source YAML

Pathway network

15 nodes · 29 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Other participant
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

Show at full size (scroll to explore)

Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
chitin `CHEBI:17029`	participant
CHS3 Scer `SGD:S000000227`	protein
CHS1 Scer `SGD:S000005136`	protein
cytosol `GO:0005829`	cellular component
UDP(3-) `CHEBI:58223`	small molecule
chitin biosynthetic process `GO:0006031`	biological process
UDP-N-acetyl-alpha-D-glucosamine(2-) `CHEBI:57705`	small molecule
CHS2 Scer `SGD:S000000242`	protein
plasma membrane `GO:0005886`	cellular component
cellular bud neck `GO:0005935`	cellular component
cytoplasmic vesicle membrane `GO:0030659`	cellular component
membrane `GO:0016020`	cellular component
UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	molecular activity
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	molecular activity
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	has_output	chitin `CHEBI:17029`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002234 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-15.json#/facts/0; endpoint types: /individuals/13/type; /individuals/0/type`
UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	provides_input_for	chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871. Source location `./YeastPathways_PWY3O-15.json#/facts/1; endpoint types: /individuals/3/type; /individuals/13/type`
CHS3 Scer `SGD:S000000227`	enables	chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002333 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000895. Source location `./YeastPathways_PWY3O-15.json#/facts/2; endpoint types: /individuals/25/type; /individuals/28/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	has_output	chitin `CHEBI:17029`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002234 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-15.json#/facts/3; endpoint types: /individuals/25/type; /individuals/0/type`
CHS1 Scer `SGD:S000005136`	enables	UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002333 gomodel:YNL192W-MONOMER_CHITIN-SYNTHASE-RXN_controller. Source location `./YeastPathways_PWY3O-15.json#/facts/4; endpoint types: /individuals/3/type; /individuals/4/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	provides_input_for	UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002413 gomodel:CHITIN-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-15.json#/facts/5; endpoint types: /individuals/13/type; /individuals/3/type`
UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	has_output	UDP(3-) `CHEBI:58223`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_58223_CHITIN-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-15.json#/facts/7; endpoint types: /individuals/3/type; /individuals/2/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	provides_input_for	chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002413 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891. Source location `./YeastPathways_PWY3O-15.json#/facts/8; endpoint types: /individuals/13/type; /individuals/25/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	part_of	chitin biosynthetic process `GO:0006031`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 BFO:0000050 gomodel:YeastPathways_PWY3O-15/YeastPathways_PWY3O-15. Source location `./YeastPathways_PWY3O-15.json#/facts/9; endpoint types: /individuals/25/type; /individuals/12/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	has_input	chitin `CHEBI:17029`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002233 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-15.json#/facts/11; endpoint types: /individuals/13/type; /individuals/0/type`
UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	has_output	chitin `CHEBI:17029`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-15.json#/facts/12; endpoint types: /individuals/3/type; /individuals/0/type`
UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	has_input	UDP-N-acetyl-alpha-D-glucosamine(2-) `CHEBI:57705`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57705_CHITIN-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-15.json#/facts/13; endpoint types: /individuals/3/type; /individuals/1/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	has_output	UDP(3-) `CHEBI:58223`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002234 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000893. Source location `./YeastPathways_PWY3O-15.json#/facts/14; endpoint types: /individuals/25/type; /individuals/27/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	has_input	chitin `CHEBI:17029`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002233 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-15.json#/facts/15; endpoint types: /individuals/25/type; /individuals/0/type`
UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	provides_input_for	chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891. Source location `./YeastPathways_PWY3O-15.json#/facts/16; endpoint types: /individuals/3/type; /individuals/25/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	provides_input_for	UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002413 gomodel:CHITIN-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-15.json#/facts/17; endpoint types: /individuals/25/type; /individuals/3/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	has_input	UDP-N-acetyl-alpha-D-glucosamine(2-) `CHEBI:57705`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002233 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000872. Source location `./YeastPathways_PWY3O-15.json#/facts/18; endpoint types: /individuals/13/type; /individuals/14/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	has_output	UDP(3-) `CHEBI:58223`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002234 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000873. Source location `./YeastPathways_PWY3O-15.json#/facts/19; endpoint types: /individuals/13/type; /individuals/15/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	part_of	chitin biosynthetic process `GO:0006031`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 BFO:0000050 gomodel:YeastPathways_PWY3O-15/YeastPathways_PWY3O-15. Source location `./YeastPathways_PWY3O-15.json#/facts/20; endpoint types: /individuals/13/type; /individuals/12/type`
UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	part_of	chitin biosynthetic process `GO:0006031`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:CHITIN-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-15/YeastPathways_PWY3O-15. Source location `./YeastPathways_PWY3O-15.json#/facts/22; endpoint types: /individuals/3/type; /individuals/12/type`
UDP-N-acetyl-α-D-glucosamine + [1,4-(N-acetyl-β-D-glucosaminyl)]_n -> UDP + [1,4-(N-acetyl-β-D-glucosaminyl)]_(n+1) `gomodel:CHITIN-SYNTHASE-RXN`	has_input	chitin `CHEBI:17029`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:CHITIN-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_17029_CHITIN-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-15.json#/facts/23; endpoint types: /individuals/3/type; /individuals/0/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	provides_input_for	chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002413 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871. Source location `./YeastPathways_PWY3O-15.json#/facts/24; endpoint types: /individuals/25/type; /individuals/13/type`
chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891`	has_input	UDP-N-acetyl-alpha-D-glucosamine(2-) `CHEBI:57705`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000891 RO:0002233 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000892. Source location `./YeastPathways_PWY3O-15.json#/facts/25; endpoint types: /individuals/25/type; /individuals/26/type`
CHS2 Scer `SGD:S000000242`	enables	chitin synthase activity `gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871`	gomodel:YeastPathways_PWY3O-15 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-15/6a6bcaed00000871 RO:0002333 gomodel:YeastPathways_PWY3O-15/6a6bcaed00000875. Source location `./YeastPathways_PWY3O-15.json#/facts/26; endpoint types: /individuals/13/type; /individuals/16/type`
CHS3 Scer `SGD:S000000227`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12928491); ECO:0000269 (PubMed:17519287); ECO:0000269 (PubMed:28346351) Topology: Multi-pass membrane protein. Source qualification: Localizes to a ring on the surface of cells about to undergo bud emergence and in the mother-bud neck of small-budded cells (PubMed:8909536). Delocalized throughout the plasma membrane during heat shock (PubMed:12928491). Also localizes to intracellular membrane-bound particles called chitosomes, proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum (PubMed:12928491, PubMed:8970154)	plasma membrane `GO:0005886`	UniProtKB:P29465 Source assertion: UniProtKB:P29465 annotates location Cell membrane (SL-0039). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P29465 Source assertion: UniProtKB:P29465 has the exact SGD cross-reference SGD:S000000227. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CHS3 Scer `SGD:S000000227`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16818716); ECO:0000269 (PubMed:28346351); ECO:0000269 (PubMed:8909536) Source qualification: Localizes to a ring on the surface of cells about to undergo bud emergence and in the mother-bud neck of small-budded cells (PubMed:8909536). Delocalized throughout the plasma membrane during heat shock (PubMed:12928491). Also localizes to intracellular membrane-bound particles called chitosomes, proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum (PubMed:12928491, PubMed:8970154)	cellular bud neck `GO:0005935`	UniProtKB:P29465 Source assertion: UniProtKB:P29465 annotates location Bud neck (SL-0029). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P29465 Source assertion: UniProtKB:P29465 has the exact SGD cross-reference SGD:S000000227. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CHS3 Scer `SGD:S000000227`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12928491); ECO:0000269 (PubMed:28346351); ECO:0000269 (PubMed:8970154) Topology: Multi-pass membrane protein. Source qualification: Localizes to a ring on the surface of cells about to undergo bud emergence and in the mother-bud neck of small-budded cells (PubMed:8909536). Delocalized throughout the plasma membrane during heat shock (PubMed:12928491). Also localizes to intracellular membrane-bound particles called chitosomes, proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum (PubMed:12928491, PubMed:8970154)	cytoplasmic vesicle membrane `GO:0030659`	UniProtKB:P29465 Source assertion: UniProtKB:P29465 annotates location Cytoplasmic vesicle membrane (SL-0089). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P29465 Source assertion: UniProtKB:P29465 has the exact SGD cross-reference SGD:S000000227. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/813/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CHS1 Scer `SGD:S000005136`	located_in Physical protein location from reviewed UniProt. ECO:0000305 (PubMed:2523889) Topology: Multi-pass membrane protein.	plasma membrane `GO:0005886`	UniProtKB:P08004 Source assertion: UniProtKB:P08004 annotates location Cell membrane (SL-0039). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/198/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P08004 Source assertion: UniProtKB:P08004 has the exact SGD cross-reference SGD:S000005136. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/198/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CHS2 Scer `SGD:S000000242`	located_in Physical protein location from reviewed UniProt. ECO:0000305 Topology: Multi-pass membrane protein.	membrane `GO:0016020`	UniProtKB:P14180 Source assertion: UniProtKB:P14180 annotates location Membrane (SL-0162). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/382/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P14180 Source assertion: UniProtKB:P14180 has the exact SGD cross-reference SGD:S000000242. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/382/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`

References

gomodel:YeastPathways_PWY3O-15 SGD GO-CAM chitin biosynthesis - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-08-05; member ./YeastPathways_PWY3O-15.json)
UniProtKB:P29465 Reviewed UniProtKB P29465 location annotations (source version: UniProt release 2026_03)
UniProtKB:P08004 Reviewed UniProtKB P08004 location annotations (source version: UniProt release 2026_03)
UniProtKB:P14180 Reviewed UniProtKB P14180 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 3 activity location assignments and 3 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 5 independently supported location edges and quarantined 3 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
Read this curation session