dolichyl glucosyl phosphate biosynthesis

gomodel:YeastPathways_PWY3O-1565

Dolichyl glucosyl phosphate biosynthesis in Saccharomyces cerevisiae S288C converts D-glucopyranose 6-phosphate to alpha-D-glucose 1-phosphate through PGM1 or PGM2 phosphoglucomutase activity, couples alpha-D-glucose 1-phosphate with UTP through UGP1 or YHL012W to form UDP-alpha-D-glucose, and uses ALG5 to transfer glucose from UDP-alpha-D-glucose to dolichyl phosphate, producing dolichyl beta-D-glucosyl phosphate and UDP.

Pathway type

glycan biosynthesis

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

25 nodes · 45 asserted directed edges

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Chemical / cofactor
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Cell / process context
Solid arrow: mechanistic relation
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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
UDP-alpha-D-glucose(2-) `CHEBI:58885`	small molecule
D-glucopyranose 6-phosphate `CHEBI:4170`	small molecule
UTP(4-) `CHEBI:46398`	small molecule
carbohydrate biosynthetic process `GO:0016051`	biological process
hydron `CHEBI:15378`	small molecule
UDP(3-) `CHEBI:58223`	small molecule
diphosphoric acid `CHEBI:29888`	small molecule
ALG5 Scer `SGD:S000006148`	protein
alpha-D-glucose 1-phosphate(2-) `CHEBI:58601`	small molecule
UGP1 Scer `SGD:S000001518`	protein
dolichyl beta-D-glucosyl phosphate(1-) `CHEBI:57525`	small molecule
cytosol `GO:0005829`	cellular component
PGM2 Scer `SGD:S000004711`	protein
PGM1 Scer `SGD:S000001610`	protein
YHL012W Scer `SGD:S000001004`	protein
dolichyl phosphate `CHEBI:16214`	lipid
endoplasmic reticulum membrane `GO:0005789`	cellular component
cytoplasm `GO:0005737`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
zinc(2+) `CHEBI:29105`	cofactor
UDP-α-D-glucose + a dolichyl phosphate -> a dolichyl β-D-glucosyl phosphate + UDP `gomodel:2.4.1.117-RXN`	molecular activity
α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	molecular activity
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	molecular activity
phosphoglucomutase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003247`	molecular activity
UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
UDP-α-D-glucose + a dolichyl phosphate -> a dolichyl β-D-glucosyl phosphate + UDP `gomodel:2.4.1.117-RXN`	has_input	UDP-alpha-D-glucose(2-) `CHEBI:58885`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:2.4.1.117-RXN RO:0002233 gomodel:CHEBI_58885_GLUC1PURIDYLTRANS-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/0; endpoint types: /individuals/32/type; /individuals/8/type`
phosphoglucomutase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003247`	has_input	D-glucopyranose 6-phosphate `CHEBI:4170`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 RO:0002233 gomodel:YeastPathways_PWY3O-1565/6a4c244800003248. Source location `./YeastPathways_PWY3O-1565.json#/facts/1; endpoint types: /individuals/36/type; /individuals/37/type`
UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	has_input	UTP(4-) `CHEBI:46398`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002233 gomodel:YeastPathways_PWY3O-1565/6a4c244800003260. Source location `./YeastPathways_PWY3O-1565.json#/facts/2; endpoint types: /individuals/46/type; /individuals/48/type`
α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	part_of	carbohydrate biosynthetic process `GO:0016051`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:GLUC1PURIDYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-1565/YeastPathways_PWY3O-1565. Source location `./YeastPathways_PWY3O-1565.json#/facts/3; endpoint types: /individuals/9/type; /individuals/33/type`
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	part_of	carbohydrate biosynthetic process `GO:0016051`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-1565/YeastPathways_PWY3O-1565. Source location `./YeastPathways_PWY3O-1565.json#/facts/4; endpoint types: /individuals/10/type; /individuals/33/type`
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	provides_input_for	UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002413 gomodel:YeastPathways_PWY3O-1565/6a4c244800003258. Source location `./YeastPathways_PWY3O-1565.json#/facts/5; endpoint types: /individuals/10/type; /individuals/46/type`
UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	has_output	UDP-alpha-D-glucose(2-) `CHEBI:58885`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002234 gomodel:CHEBI_58885_GLUC1PURIDYLTRANS-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/6; endpoint types: /individuals/46/type; /individuals/8/type`
α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_15378_GLUC1PURIDYLTRANS-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/7; endpoint types: /individuals/9/type; /individuals/0/type`
UDP-α-D-glucose + a dolichyl phosphate -> a dolichyl β-D-glucosyl phosphate + UDP `gomodel:2.4.1.117-RXN`	has_output	UDP(3-) `CHEBI:58223`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:2.4.1.117-RXN RO:0002234 gomodel:CHEBI_58223_2.4.1.117-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/8; endpoint types: /individuals/32/type; /individuals/6/type`
α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002234 gomodel:CHEBI_29888_GLUC1PURIDYLTRANS-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/9; endpoint types: /individuals/9/type; /individuals/2/type`
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	provides_input_for	α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002413 gomodel:GLUC1PURIDYLTRANS-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/10; endpoint types: /individuals/10/type; /individuals/9/type`
phosphoglucomutase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003247`	provides_input_for	UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 RO:0002413 gomodel:YeastPathways_PWY3O-1565/6a4c244800003258. Source location `./YeastPathways_PWY3O-1565.json#/facts/11; endpoint types: /individuals/36/type; /individuals/46/type`
ALG5 Scer `SGD:S000006148`	enables	UDP-α-D-glucose + a dolichyl phosphate -> a dolichyl β-D-glucosyl phosphate + UDP `gomodel:2.4.1.117-RXN`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:2.4.1.117-RXN RO:0002333 gomodel:YPL227C-MONOMER_2.4.1.117-RXN_controller. Source location `./YeastPathways_PWY3O-1565.json#/facts/12; endpoint types: /individuals/32/type; /individuals/12/type`
α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	has_input	UTP(4-) `CHEBI:46398`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_46398_GLUC1PURIDYLTRANS-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/13; endpoint types: /individuals/9/type; /individuals/4/type`
UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002234 gomodel:YeastPathways_PWY3O-1565/6a4c244800003261. Source location `./YeastPathways_PWY3O-1565.json#/facts/14; endpoint types: /individuals/46/type; /individuals/49/type`
phosphoglucomutase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003247`	has_output	alpha-D-glucose 1-phosphate(2-) `CHEBI:58601`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 RO:0002234 gomodel:CHEBI_58601_PHOSPHOGLUCMUT-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/15; endpoint types: /individuals/36/type; /individuals/7/type`
UGP1 Scer `SGD:S000001518`	enables	α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002333 gomodel:YKL035W-MONOMER_GLUC1PURIDYLTRANS-RXN_controller. Source location `./YeastPathways_PWY3O-1565.json#/facts/16; endpoint types: /individuals/9/type; /individuals/11/type`
UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	part_of	carbohydrate biosynthetic process `GO:0016051`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 BFO:0000050 gomodel:YeastPathways_PWY3O-1565/YeastPathways_PWY3O-1565. Source location `./YeastPathways_PWY3O-1565.json#/facts/17; endpoint types: /individuals/46/type; /individuals/33/type`
UDP-α-D-glucose + a dolichyl phosphate -> a dolichyl β-D-glucosyl phosphate + UDP `gomodel:2.4.1.117-RXN`	has_output	dolichyl beta-D-glucosyl phosphate(1-) `CHEBI:57525`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:2.4.1.117-RXN RO:0002234 gomodel:CHEBI_57525_2.4.1.117-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/18; endpoint types: /individuals/32/type; /individuals/5/type`
α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	provides_input_for	UDP-α-D-glucose + a dolichyl phosphate -> a dolichyl β-D-glucosyl phosphate + UDP `gomodel:2.4.1.117-RXN`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002413 gomodel:2.4.1.117-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/19; endpoint types: /individuals/9/type; /individuals/32/type`
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	has_output	alpha-D-glucose 1-phosphate(2-) `CHEBI:58601`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002234 gomodel:CHEBI_58601_PHOSPHOGLUCMUT-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/20; endpoint types: /individuals/10/type; /individuals/7/type`
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	has_input	D-glucopyranose 6-phosphate `CHEBI:4170`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002233 gomodel:CHEBI_4170_PHOSPHOGLUCMUT-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/22; endpoint types: /individuals/10/type; /individuals/3/type`
PGM2 Scer `SGD:S000004711`	enables	phosphoglucomutase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003247`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 RO:0002333 gomodel:YeastPathways_PWY3O-1565/6a4c244800003250. Source location `./YeastPathways_PWY3O-1565.json#/facts/23; endpoint types: /individuals/36/type; /individuals/38/type`
PGM1 Scer `SGD:S000001610`	enables	α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002333 gomodel:YeastPathways_PWY3O-1565/6690711d00000641. Source location `./YeastPathways_PWY3O-1565.json#/facts/24; endpoint types: /individuals/10/type; /individuals/63/type`
YHL012W Scer `SGD:S000001004`	enables	UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002333 gomodel:YeastPathways_PWY3O-1565/6a4c244800003263. Source location `./YeastPathways_PWY3O-1565.json#/facts/25; endpoint types: /individuals/46/type; /individuals/50/type`
phosphoglucomutase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003247`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 BFO:0000066 gomodel:YeastPathways_PWY3O-1565/6a4c244800003251. Source location `./YeastPathways_PWY3O-1565.json#/facts/26; endpoint types: /individuals/36/type; /individuals/39/type`
phosphoglucomutase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003247`	provides_input_for	α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 RO:0002413 gomodel:GLUC1PURIDYLTRANS-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/27; endpoint types: /individuals/36/type; /individuals/9/type`
UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	has_input	alpha-D-glucose 1-phosphate(2-) `CHEBI:58601`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002233 gomodel:CHEBI_58601_PHOSPHOGLUCMUT-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/28; endpoint types: /individuals/46/type; /individuals/7/type`
α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	has_output	UDP-alpha-D-glucose(2-) `CHEBI:58885`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002234 gomodel:CHEBI_58885_GLUC1PURIDYLTRANS-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/29; endpoint types: /individuals/9/type; /individuals/8/type`
UDP-α-D-glucose + a dolichyl phosphate -> a dolichyl β-D-glucosyl phosphate + UDP `gomodel:2.4.1.117-RXN`	has_input	dolichyl phosphate `CHEBI:16214`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:2.4.1.117-RXN RO:0002233 gomodel:CHEBI_16214_2.4.1.117-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/30; endpoint types: /individuals/32/type; /individuals/1/type`
α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	has_input	alpha-D-glucose 1-phosphate(2-) `CHEBI:58601`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:GLUC1PURIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_58601_PHOSPHOGLUCMUT-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/31; endpoint types: /individuals/9/type; /individuals/7/type`
α-D-glucopyranose 1-phosphate + UTP + H⁺ -> UDP-α-D-glucose + diphosphate `gomodel:GLUC1PURIDYLTRANS-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:GLUC1PURIDYLTRANS-RXN BFO:0000066 gomodel:reaction_GLUC1PURIDYLTRANS-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-1565.json#/facts/32; endpoint types: /individuals/9/type; /individuals/30/type`
UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002233 gomodel:YeastPathways_PWY3O-1565/6a4c244800003259. Source location `./YeastPathways_PWY3O-1565.json#/facts/33; endpoint types: /individuals/46/type; /individuals/47/type`
phosphoglucomutase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003247`	part_of	carbohydrate biosynthetic process `GO:0016051`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003247 BFO:0000050 gomodel:YeastPathways_PWY3O-1565/YeastPathways_PWY3O-1565. Source location `./YeastPathways_PWY3O-1565.json#/facts/34; endpoint types: /individuals/36/type; /individuals/33/type`
UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	provides_input_for	UDP-α-D-glucose + a dolichyl phosphate -> a dolichyl β-D-glucosyl phosphate + UDP `gomodel:2.4.1.117-RXN`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 RO:0002413 gomodel:2.4.1.117-RXN. Source location `./YeastPathways_PWY3O-1565.json#/facts/35; endpoint types: /individuals/46/type; /individuals/32/type`
UTP:glucose-1-phosphate uridylyltransferase activity `gomodel:YeastPathways_PWY3O-1565/6a4c244800003258`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-1565/6a4c244800003258 BFO:0000066 gomodel:YeastPathways_PWY3O-1565/6a4c244800003264. Source location `./YeastPathways_PWY3O-1565.json#/facts/36; endpoint types: /individuals/46/type; /individuals/51/type`
UDP-α-D-glucose + a dolichyl phosphate -> a dolichyl β-D-glucosyl phosphate + UDP `gomodel:2.4.1.117-RXN`	part_of	carbohydrate biosynthetic process `GO:0016051`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:2.4.1.117-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-1565/YeastPathways_PWY3O-1565. Source location `./YeastPathways_PWY3O-1565.json#/facts/37; endpoint types: /individuals/32/type; /individuals/33/type`
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-1565 Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN BFO:0000066 gomodel:reaction_PHOSPHOGLUCMUT-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-1565.json#/facts/38; endpoint types: /individuals/10/type; /individuals/31/type`
ALG5 Scer `SGD:S000006148`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8076653) Topology: Single-pass membrane protein. Source qualification: Its interaction with the substrate UDP-glucose may occur at the cytoplasmic side of the ER, whereas the steps utilizing dolichyl beta-D-glucosyl phosphate take place in the lumen of the ER	endoplasmic reticulum membrane `GO:0005789`	UniProtKB:P40350 Source assertion: UniProtKB:P40350 annotates location Endoplasmic reticulum membrane (SL-0097). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3740/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P40350 Source assertion: UniProtKB:P40350 has the exact SGD cross-reference SGD:S000006148. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3740/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PGM2 Scer `SGD:S000004711`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8385141)	cytoplasm `GO:0005737`	UniProtKB:P37012 Source assertion: UniProtKB:P37012 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1251/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P37012 Source assertion: UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1251/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PGM1 Scer `SGD:S000001610`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P33401 Source assertion: UniProtKB:P33401 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1085/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P33401 Source assertion: UniProtKB:P33401 has the exact SGD cross-reference SGD:S000001610. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1085/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
UDP-α-D-glucose + a dolichyl phosphate -> a dolichyl β-D-glucosyl phosphate + UDP `gomodel:2.4.1.117-RXN`	occurs_in Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:8076653). Alternative isoenzymes may function elsewhere.	endoplasmic reticulum membrane `GO:0005789`	UniProtKB:P40350 Source assertion: UniProtKB:P40350 describes the corresponding catalytic function in the endoplasmic reticulum membrane; this projection applies to the activity enabled by SGD:S000006148. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3740/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PGM2 Scer `SGD:S000004711`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805) Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor. UniProt note evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805)	magnesium(2+) `CHEBI:18420`	UniProtKB:P37012 Source assertion: UniProtKB:P37012 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/comments/0/cofactors/0; /results/1251/comments/0/note` UniProtKB:P37012 Source assertion: UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/uniProtKBCrossReferences/0`
PGM2 Scer `SGD:S000004711`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805) Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor. UniProt note evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805)	zinc(2+) `CHEBI:29105`	UniProtKB:P37012 Source assertion: UniProtKB:P37012 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/comments/0/cofactors/1; /results/1251/comments/0/note` UniProtKB:P37012 Source assertion: UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/uniProtKBCrossReferences/0`
PGM1 Scer `SGD:S000001610`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00949) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00949)	magnesium(2+) `CHEBI:18420`	UniProtKB:P33401 Source assertion: UniProtKB:P33401 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1085/comments/0/cofactors/0; /results/1085/comments/0/note` UniProtKB:P33401 Source assertion: UniProtKB:P33401 has the exact SGD cross-reference SGD:S000001610. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1085/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY3O-1565 SGD GO-CAM dolichyl glucosyl phosphate biosynthesis - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-1565.json)
UniProtKB:P40350 Reviewed UniProtKB P40350 location annotations (source version: UniProt release 2026_03)
UniProtKB:P37012 Reviewed UniProtKB P37012 location annotations (source version: UniProt release 2026_03)
UniProtKB:P33401 Reviewed UniProtKB P33401 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 5 activity location assignments and 5 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 4 independently supported location edges and quarantined 1 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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