tryptophan degradation

gomodel:YeastPathways_PWY3O-214

Tryptophan degradation in Saccharomyces cerevisiae S288C uses ARO8 or ARO9 aminotransferase activity to form 3-(indol-3-yl)pyruvate from L-tryptophan, decarboxylates 3-(indol-3-yl)pyruvate through ARO10, PDC1, PDC5, or PDC6 indolepyruvate decarboxylase activity to indol-3-ylacetaldehyde and carbon dioxide, and reduces indol-3-ylacetaldehyde with NADH through ADH1, ADH2, ADH3, ADH4, ADH5, or SFA1 indole-3-acetaldehyde reductase activity to tryptophol and NAD.

Pathway type

amino acid degradation

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

48 nodes · 121 asserted directed edges

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
indol-3-ylacetaldehyde `CHEBI:18086`	small molecule
carbon dioxide `CHEBI:16526`	small molecule
NADH(2-) `CHEBI:57945`	small molecule
cytosol `GO:0005829`	cellular component
hydron `CHEBI:15378`	small molecule
L-tryptophan catabolic process `GO:0006569`	biological process
ADH3 Scer `SGD:S000004688`	protein
tryptophol `CHEBI:17890`	small molecule
NAD(1-) `CHEBI:57540`	small molecule
ADH4 Scer `SGD:S000003225`	protein
ADH2 Scer `SGD:S000004918`	protein
2-oxoglutarate(2-) `CHEBI:16810`	small molecule
ADH5 Scer `SGD:S000000349`	protein
ADH1 Scer `SGD:S000005446`	protein
PDC5 Scer `SGD:S000004124`	protein
3-(indol-3-yl)pyruvate `CHEBI:17640`	small molecule
L-glutamate(1-) `CHEBI:29985`	small molecule
ARO9 Scer `SGD:S000001179`	protein
L-phenylalanine zwitterion `CHEBI:58095`	small molecule
L-tryptophan zwitterion `CHEBI:57912`	small molecule
SFA1 Scer `SGD:S000002327`	protein
keto-phenylpyruvate `CHEBI:18005`	small molecule
ARO10 Scer `SGD:S000002788`	protein
PDC6 Scer `SGD:S000003319`	protein
PDC1 Scer `SGD:S000004034`	protein
ARO8 Scer `SGD:S000003170`	protein
mitochondrial matrix `GO:0005759`	cellular component
mitochondrial inner membrane `GO:0005743`	cellular component
mitochondrion `GO:0005739`	cellular component
cytoplasm `GO:0005737`	cellular component
nucleus `GO:0005634`	cellular component
zinc(2+) `CHEBI:29105`	cofactor
iron(2+) `CHEBI:29033`	cofactor
magnesium(2+) `CHEBI:18420`	cofactor
thiamine(1+) diphosphate(3-) `CHEBI:58937`	cofactor
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
indole-3-ethanol + NAD⁺ ← (indol-3-yl)acetaldehyde + NADH + H⁺ `gomodel:1.1.1.190-RXN`	molecular activity
L-tryptophan + 3-phenyl-2-oxopropanoate <=> (indol-3-yl)pyruvate + L-phenylalanine `gomodel:2.6.1.28-RXN`	molecular activity
(indol-3-yl)pyruvate + H⁺ -> CO₂ + (indol-3-yl)acetaldehyde `gomodel:4.1.1.74-RXN`	molecular activity
2-oxoglutarate + L-tryptophan <=> L-glutamate + (indol-3-yl)pyruvate `gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN`	molecular activity
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000621`	molecular activity
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000627`	molecular activity
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000633`	molecular activity
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000660`	molecular activity
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000669`	molecular activity
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000694`	molecular activity
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000701`	molecular activity
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000708`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000708`	has_input	indol-3-ylacetaldehyde `CHEBI:18086`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/0; endpoint types: /individuals/129/type; /individuals/7/type`
(indol-3-yl)pyruvate + H⁺ -> CO₂ + (indol-3-yl)acetaldehyde `gomodel:4.1.1.74-RXN`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:4.1.1.74-RXN RO:0002234 gomodel:CHEBI_16526_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/1; endpoint types: /individuals/43/type; /individuals/2/type`
indole-3-ethanol + NAD⁺ ← (indol-3-yl)acetaldehyde + NADH + H⁺ `gomodel:1.1.1.190-RXN`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:1.1.1.190-RXN RO:0002233 gomodel:CHEBI_57945_1.1.1.190-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/2; endpoint types: /individuals/41/type; /individuals/11/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000633`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000637. Source location `./YeastPathways_PWY3O-214.json#/facts/3; endpoint types: /individuals/61/type; /individuals/64/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000708`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000709. Source location `./YeastPathways_PWY3O-214.json#/facts/4; endpoint types: /individuals/129/type; /individuals/130/type`
2-oxoglutarate + L-tryptophan <=> L-glutamate + (indol-3-yl)pyruvate `gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/5; endpoint types: /individuals/13/type; /individuals/44/type`
ADH3 Scer `SGD:S000004688`	enables	indole-3-ethanol + NAD⁺ ← (indol-3-yl)acetaldehyde + NADH + H⁺ `gomodel:1.1.1.190-RXN`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:1.1.1.190-RXN RO:0002333 gomodel:YMR083W-MONOMER_1.1.1.190-RXN_controller. Source location `./YeastPathways_PWY3O-214.json#/facts/6; endpoint types: /individuals/41/type; /individuals/15/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000660`	has_output	tryptophol `CHEBI:17890`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000664. Source location `./YeastPathways_PWY3O-214.json#/facts/7; endpoint types: /individuals/87/type; /individuals/91/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000660`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000663. Source location `./YeastPathways_PWY3O-214.json#/facts/8; endpoint types: /individuals/87/type; /individuals/90/type`
L-tryptophan + 3-phenyl-2-oxopropanoate <=> (indol-3-yl)pyruvate + L-phenylalanine `gomodel:2.6.1.28-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:2.6.1.28-RXN BFO:0000066 gomodel:reaction_2.6.1.28-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-214.json#/facts/9; endpoint types: /individuals/42/type; /individuals/38/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000669`	has_input	indol-3-ylacetaldehyde `CHEBI:18086`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/10; endpoint types: /individuals/94/type; /individuals/7/type`
ADH4 Scer `SGD:S000003225`	enables	indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000694`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000717. Source location `./YeastPathways_PWY3O-214.json#/facts/11; endpoint types: /individuals/117/type; /individuals/137/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000708`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000712. Source location `./YeastPathways_PWY3O-214.json#/facts/12; endpoint types: /individuals/129/type; /individuals/133/type`
(indol-3-yl)pyruvate + H⁺ -> CO₂ + (indol-3-yl)acetaldehyde `gomodel:4.1.1.74-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:4.1.1.74-RXN BFO:0000066 gomodel:reaction_4.1.1.74-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-214.json#/facts/13; endpoint types: /individuals/43/type; /individuals/39/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000694`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000695. Source location `./YeastPathways_PWY3O-214.json#/facts/14; endpoint types: /individuals/117/type; /individuals/118/type`
(indol-3-yl)pyruvate + H⁺ -> CO₂ + (indol-3-yl)acetaldehyde `gomodel:4.1.1.74-RXN`	has_output	indol-3-ylacetaldehyde `CHEBI:18086`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:4.1.1.74-RXN RO:0002234 gomodel:CHEBI_18086_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/15; endpoint types: /individuals/43/type; /individuals/7/type`
ADH2 Scer `SGD:S000004918`	enables	indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000660`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000666. Source location `./YeastPathways_PWY3O-214.json#/facts/16; endpoint types: /individuals/87/type; /individuals/92/type`
L-tryptophan + 3-phenyl-2-oxopropanoate <=> (indol-3-yl)pyruvate + L-phenylalanine `gomodel:2.6.1.28-RXN`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:2.6.1.28-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/17; endpoint types: /individuals/42/type; /individuals/44/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000621`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/18; endpoint types: /individuals/51/type; /individuals/44/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000627`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000629. Source location `./YeastPathways_PWY3O-214.json#/facts/19; endpoint types: /individuals/56/type; /individuals/58/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000701`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000703. Source location `./YeastPathways_PWY3O-214.json#/facts/20; endpoint types: /individuals/123/type; /individuals/125/type`
indole-3-ethanol + NAD⁺ ← (indol-3-yl)acetaldehyde + NADH + H⁺ `gomodel:1.1.1.190-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:1.1.1.190-RXN RO:0002233 gomodel:CHEBI_15378_1.1.1.190-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/22; endpoint types: /individuals/41/type; /individuals/0/type`
indole-3-ethanol + NAD⁺ ← (indol-3-yl)acetaldehyde + NADH + H⁺ `gomodel:1.1.1.190-RXN`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:1.1.1.190-RXN RO:0002234 gomodel:CHEBI_57540_1.1.1.190-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/23; endpoint types: /individuals/41/type; /individuals/9/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000621`	has_output	indol-3-ylacetaldehyde `CHEBI:18086`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 RO:0002234 gomodel:CHEBI_18086_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/24; endpoint types: /individuals/51/type; /individuals/7/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000694`	has_output	tryptophol `CHEBI:17890`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000698. Source location `./YeastPathways_PWY3O-214.json#/facts/25; endpoint types: /individuals/117/type; /individuals/121/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000621`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000623. Source location `./YeastPathways_PWY3O-214.json#/facts/26; endpoint types: /individuals/51/type; /individuals/53/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000701`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/27; endpoint types: /individuals/123/type; /individuals/44/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000694`	has_input	indol-3-ylacetaldehyde `CHEBI:18086`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/28; endpoint types: /individuals/117/type; /individuals/7/type`
indole-3-ethanol + NAD⁺ ← (indol-3-yl)acetaldehyde + NADH + H⁺ `gomodel:1.1.1.190-RXN`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:1.1.1.190-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/29; endpoint types: /individuals/41/type; /individuals/44/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000627`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/30; endpoint types: /individuals/56/type; /individuals/44/type`
2-oxoglutarate + L-tryptophan <=> L-glutamate + (indol-3-yl)pyruvate `gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN`	has_output	L-glutamate(1-) `CHEBI:29985`	UniProtKB:P53090 Source assertion: UniProtKB:P53090 transaminates an aromatic L-amino acid with 2-oxoglutarate to the corresponding oxo acid and L-glutamate (RHEA:17533); correct the swapped glutamate/2-oxoglutarate sides. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2112/comments/1/reaction`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000701`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000702. Source location `./YeastPathways_PWY3O-214.json#/facts/32; endpoint types: /individuals/123/type; /individuals/124/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000694`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/33; endpoint types: /individuals/117/type; /individuals/44/type`
ADH5 Scer `SGD:S000000349`	enables	indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000701`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000716. Source location `./YeastPathways_PWY3O-214.json#/facts/34; endpoint types: /individuals/123/type; /individuals/136/type`
ADH1 Scer `SGD:S000005446`	enables	indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000669`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000676. Source location `./YeastPathways_PWY3O-214.json#/facts/35; endpoint types: /individuals/94/type; /individuals/99/type`
PDC5 Scer `SGD:S000004124`	enables	indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000627`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000632. Source location `./YeastPathways_PWY3O-214.json#/facts/36; endpoint types: /individuals/56/type; /individuals/60/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000633`	has_input	3-(indol-3-yl)pyruvate `CHEBI:17640`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 RO:0002233 gomodel:CHEBI_17640_2.6.1.28-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/37; endpoint types: /individuals/61/type; /individuals/4/type`
2-oxoglutarate + L-tryptophan <=> L-glutamate + (indol-3-yl)pyruvate `gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN`	has_input	2-oxoglutarate(2-) `CHEBI:16810`	UniProtKB:P53090 Source assertion: UniProtKB:P53090 transaminates an aromatic L-amino acid with 2-oxoglutarate to the corresponding oxo acid and L-glutamate (RHEA:17533); correct the swapped glutamate/2-oxoglutarate sides. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2112/comments/1/reaction`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000660`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/39; endpoint types: /individuals/87/type; /individuals/44/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000621`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000625. Source location `./YeastPathways_PWY3O-214.json#/facts/40; endpoint types: /individuals/51/type; /individuals/54/type`
ARO9 Scer `SGD:S000001179`	enables	L-tryptophan + 3-phenyl-2-oxopropanoate <=> (indol-3-yl)pyruvate + L-phenylalanine `gomodel:2.6.1.28-RXN`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:2.6.1.28-RXN RO:0002333 gomodel:YHR137W-MONOMER_2.6.1.28-RXN_controller. Source location `./YeastPathways_PWY3O-214.json#/facts/42; endpoint types: /individuals/42/type; /individuals/14/type`
L-tryptophan + 3-phenyl-2-oxopropanoate <=> (indol-3-yl)pyruvate + L-phenylalanine `gomodel:2.6.1.28-RXN`	has_output	L-phenylalanine zwitterion `CHEBI:58095`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:2.6.1.28-RXN RO:0002234 gomodel:CHEBI_58095_2.6.1.28-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/43; endpoint types: /individuals/42/type; /individuals/12/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000621`	has_input	3-(indol-3-yl)pyruvate `CHEBI:17640`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 RO:0002233 gomodel:CHEBI_17640_2.6.1.28-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/44; endpoint types: /individuals/51/type; /individuals/4/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000669`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000677. Source location `./YeastPathways_PWY3O-214.json#/facts/45; endpoint types: /individuals/94/type; /individuals/100/type`
L-tryptophan + 3-phenyl-2-oxopropanoate <=> (indol-3-yl)pyruvate + L-phenylalanine `gomodel:2.6.1.28-RXN`	has_input	L-tryptophan zwitterion `CHEBI:57912`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:2.6.1.28-RXN RO:0002233 gomodel:CHEBI_57912_TRYPTOPHAN-AMINOTRANSFERASE-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/46; endpoint types: /individuals/42/type; /individuals/10/type`
2-oxoglutarate + L-tryptophan <=> L-glutamate + (indol-3-yl)pyruvate `gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN BFO:0000066 gomodel:reaction_TRYPTOPHAN-AMINOTRANSFERASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-214.json#/facts/47; endpoint types: /individuals/13/type; /individuals/40/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000708`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/48; endpoint types: /individuals/129/type; /individuals/44/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000627`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000631. Source location `./YeastPathways_PWY3O-214.json#/facts/49; endpoint types: /individuals/56/type; /individuals/59/type`
indole-3-ethanol + NAD⁺ ← (indol-3-yl)acetaldehyde + NADH + H⁺ `gomodel:1.1.1.190-RXN`	has_output	tryptophol `CHEBI:17890`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:1.1.1.190-RXN RO:0002234 gomodel:CHEBI_17890_1.1.1.190-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/50; endpoint types: /individuals/41/type; /individuals/5/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000633`	has_output	indol-3-ylacetaldehyde `CHEBI:18086`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 RO:0002234 gomodel:CHEBI_18086_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/51; endpoint types: /individuals/61/type; /individuals/7/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000627`	has_input	3-(indol-3-yl)pyruvate `CHEBI:17640`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 RO:0002233 gomodel:CHEBI_17640_2.6.1.28-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/52; endpoint types: /individuals/56/type; /individuals/4/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000708`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000710. Source location `./YeastPathways_PWY3O-214.json#/facts/53; endpoint types: /individuals/129/type; /individuals/131/type`
indole-3-ethanol + NAD⁺ ← (indol-3-yl)acetaldehyde + NADH + H⁺ `gomodel:1.1.1.190-RXN`	has_input	indol-3-ylacetaldehyde `CHEBI:18086`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:1.1.1.190-RXN RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/54; endpoint types: /individuals/41/type; /individuals/7/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000660`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000661. Source location `./YeastPathways_PWY3O-214.json#/facts/55; endpoint types: /individuals/87/type; /individuals/88/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000669`	has_output	tryptophol `CHEBI:17890`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000673. Source location `./YeastPathways_PWY3O-214.json#/facts/56; endpoint types: /individuals/94/type; /individuals/98/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000660`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000662. Source location `./YeastPathways_PWY3O-214.json#/facts/57; endpoint types: /individuals/87/type; /individuals/89/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000669`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000672. Source location `./YeastPathways_PWY3O-214.json#/facts/58; endpoint types: /individuals/94/type; /individuals/97/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000708`	has_output	tryptophol `CHEBI:17890`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000711. Source location `./YeastPathways_PWY3O-214.json#/facts/59; endpoint types: /individuals/129/type; /individuals/132/type`
2-oxoglutarate + L-tryptophan <=> L-glutamate + (indol-3-yl)pyruvate `gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN`	has_output	3-(indol-3-yl)pyruvate `CHEBI:17640`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_17640_2.6.1.28-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/60; endpoint types: /individuals/13/type; /individuals/4/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000669`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000670. Source location `./YeastPathways_PWY3O-214.json#/facts/61; endpoint types: /individuals/94/type; /individuals/95/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000660`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000668. Source location `./YeastPathways_PWY3O-214.json#/facts/62; endpoint types: /individuals/87/type; /individuals/93/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000708`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000714. Source location `./YeastPathways_PWY3O-214.json#/facts/63; endpoint types: /individuals/129/type; /individuals/134/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000669`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000671. Source location `./YeastPathways_PWY3O-214.json#/facts/64; endpoint types: /individuals/94/type; /individuals/96/type`
SFA1 Scer `SGD:S000002327`	enables	indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000708`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000708 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000715. Source location `./YeastPathways_PWY3O-214.json#/facts/65; endpoint types: /individuals/129/type; /individuals/135/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000669`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000669 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/66; endpoint types: /individuals/94/type; /individuals/44/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000633`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000634. Source location `./YeastPathways_PWY3O-214.json#/facts/67; endpoint types: /individuals/61/type; /individuals/62/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000701`	has_input	indol-3-ylacetaldehyde `CHEBI:18086`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/68; endpoint types: /individuals/123/type; /individuals/7/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000701`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000705. Source location `./YeastPathways_PWY3O-214.json#/facts/69; endpoint types: /individuals/123/type; /individuals/127/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000694`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000696. Source location `./YeastPathways_PWY3O-214.json#/facts/70; endpoint types: /individuals/117/type; /individuals/119/type`
(indol-3-yl)pyruvate + H⁺ -> CO₂ + (indol-3-yl)acetaldehyde `gomodel:4.1.1.74-RXN`	has_input	3-(indol-3-yl)pyruvate `CHEBI:17640`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:4.1.1.74-RXN RO:0002233 gomodel:CHEBI_17640_2.6.1.28-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/71; endpoint types: /individuals/43/type; /individuals/4/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000633`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/72; endpoint types: /individuals/61/type; /individuals/44/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000627`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000628. Source location `./YeastPathways_PWY3O-214.json#/facts/73; endpoint types: /individuals/56/type; /individuals/57/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000621`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 RO:0002233 gomodel:YeastPathways_PWY3O-214/65692e7e00000622. Source location `./YeastPathways_PWY3O-214.json#/facts/74; endpoint types: /individuals/51/type; /individuals/52/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000633`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000635. Source location `./YeastPathways_PWY3O-214.json#/facts/75; endpoint types: /individuals/61/type; /individuals/63/type`
L-tryptophan + 3-phenyl-2-oxopropanoate <=> (indol-3-yl)pyruvate + L-phenylalanine `gomodel:2.6.1.28-RXN`	has_input	keto-phenylpyruvate `CHEBI:18005`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:2.6.1.28-RXN RO:0002233 gomodel:CHEBI_18005_2.6.1.28-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/76; endpoint types: /individuals/42/type; /individuals/6/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000660`	has_input	indol-3-ylacetaldehyde `CHEBI:18086`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000660 RO:0002233 gomodel:CHEBI_18086_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/77; endpoint types: /individuals/87/type; /individuals/7/type`
L-tryptophan + 3-phenyl-2-oxopropanoate <=> (indol-3-yl)pyruvate + L-phenylalanine `gomodel:2.6.1.28-RXN`	has_output	3-(indol-3-yl)pyruvate `CHEBI:17640`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:2.6.1.28-RXN RO:0002234 gomodel:CHEBI_17640_2.6.1.28-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/78; endpoint types: /individuals/42/type; /individuals/4/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000701`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 BFO:0000066 gomodel:YeastPathways_PWY3O-214/65692e7e00000707. Source location `./YeastPathways_PWY3O-214.json#/facts/79; endpoint types: /individuals/123/type; /individuals/128/type`
ARO10 Scer `SGD:S000002788`	enables	(indol-3-yl)pyruvate + H⁺ -> CO₂ + (indol-3-yl)acetaldehyde `gomodel:4.1.1.74-RXN`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:4.1.1.74-RXN RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000619. Source location `./YeastPathways_PWY3O-214.json#/facts/80; endpoint types: /individuals/43/type; /individuals/49/type`
PDC6 Scer `SGD:S000003319`	enables	indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000621`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000621 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000626. Source location `./YeastPathways_PWY3O-214.json#/facts/81; endpoint types: /individuals/51/type; /individuals/55/type`
(indol-3-yl)pyruvate + H⁺ -> CO₂ + (indol-3-yl)acetaldehyde `gomodel:4.1.1.74-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:4.1.1.74-RXN RO:0002233 gomodel:CHEBI_15378_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/82; endpoint types: /individuals/43/type; /individuals/1/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000701`	has_output	tryptophol `CHEBI:17890`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000701 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000704. Source location `./YeastPathways_PWY3O-214.json#/facts/83; endpoint types: /individuals/123/type; /individuals/126/type`
PDC1 Scer `SGD:S000004034`	enables	indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000633`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000633 RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000638. Source location `./YeastPathways_PWY3O-214.json#/facts/84; endpoint types: /individuals/61/type; /individuals/65/type`
2-oxoglutarate + L-tryptophan <=> L-glutamate + (indol-3-yl)pyruvate `gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN`	has_input	L-tryptophan zwitterion `CHEBI:57912`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57912_TRYPTOPHAN-AMINOTRANSFERASE-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/85; endpoint types: /individuals/13/type; /individuals/10/type`
ARO8 Scer `SGD:S000003170`	enables	2-oxoglutarate + L-tryptophan <=> L-glutamate + (indol-3-yl)pyruvate `gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:TRYPTOPHAN-AMINOTRANSFERASE-RXN RO:0002333 gomodel:YeastPathways_PWY3O-214/65692e7e00000611. Source location `./YeastPathways_PWY3O-214.json#/facts/86; endpoint types: /individuals/13/type; /individuals/45/type`
indole-3-acetaldehyde reductase (NADH) activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000694`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000694 RO:0002234 gomodel:YeastPathways_PWY3O-214/65692e7e00000697. Source location `./YeastPathways_PWY3O-214.json#/facts/87; endpoint types: /individuals/117/type; /individuals/120/type`
indolepyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-214/65692e7e00000627`	has_output	indol-3-ylacetaldehyde `CHEBI:18086`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-214/65692e7e00000627 RO:0002234 gomodel:CHEBI_18086_4.1.1.74-RXN. Source location `./YeastPathways_PWY3O-214.json#/facts/88; endpoint types: /individuals/56/type; /individuals/7/type`
(indol-3-yl)pyruvate + H⁺ -> CO₂ + (indol-3-yl)acetaldehyde `gomodel:4.1.1.74-RXN`	part_of	L-tryptophan catabolic process `GO:0006569`	gomodel:YeastPathways_PWY3O-214 Source assertion: The model asserts gomodel:4.1.1.74-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-214/YeastPathways_PWY3O-214. Source location `./YeastPathways_PWY3O-214.json#/facts/89; endpoint types: /individuals/43/type; /individuals/44/type`
ADH3 Scer `SGD:S000004688`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1101965); ECO:0000269 (PubMed:2188098); ECO:0000269 (PubMed:2943982)	mitochondrial matrix `GO:0005759`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH3 Scer `SGD:S000004688`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	mitochondrial inner membrane `GO:0005743`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates location Mitochondrion inner membrane (SL-0168). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH4 Scer `SGD:S000003225`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	mitochondrion `GO:0005739`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH2 Scer `SGD:S000004918`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2937632)	cytoplasm `GO:0005737`	UniProtKB:P00331 Source assertion: UniProtKB:P00331 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00331 Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH5 Scer `SGD:S000000349`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P38113 Source assertion: UniProtKB:P38113 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38113 Source assertion: UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH1 Scer `SGD:S000005446`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	cytoplasm `GO:0005737`	UniProtKB:P00330 Source assertion: UniProtKB:P00330 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00330 Source assertion: UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC5 Scer `SGD:S000004124`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC5 Scer `SGD:S000004124`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARO9 Scer `SGD:S000001179`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P38840 Source assertion: UniProtKB:P38840 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38840 Source assertion: UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
SFA1 Scer `SGD:S000002327`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P32771 Source assertion: UniProtKB:P32771 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P32771 Source assertion: UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
SFA1 Scer `SGD:S000002327`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	mitochondrion `GO:0005739`	UniProtKB:P32771 Source assertion: UniProtKB:P32771 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P32771 Source assertion: UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARO10 Scer `SGD:S000002788`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2752/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2752/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC6 Scer `SGD:S000003319`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC1 Scer `SGD:S000004034`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC1 Scer `SGD:S000004034`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARO8 Scer `SGD:S000003170`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P53090 Source assertion: UniProtKB:P53090 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P53090 Source assertion: UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH3 Scer `SGD:S000004688`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/comments/0/cofactors/0; /results/161/comments/0/note` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/uniProtKBCrossReferences/0`
ADH4 Scer `SGD:S000003225`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	zinc(2+) `CHEBI:29105`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/0; /results/302/comments/0/note` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0`
ADH4 Scer `SGD:S000003225`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	iron(2+) `CHEBI:29033`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates CHEBI:29033 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/1; /results/302/comments/0/note` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0`
ADH2 Scer `SGD:S000004918`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P00331 Source assertion: UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note` UniProtKB:P00331 Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0`
ADH5 Scer `SGD:S000000349`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P38113 Source assertion: UniProtKB:P38113 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/comments/0/cofactors/0; /results/3563/comments/0/note` UniProtKB:P38113 Source assertion: UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/uniProtKBCrossReferences/0`
ADH1 Scer `SGD:S000005446`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849)	zinc(2+) `CHEBI:29105`	UniProtKB:P00330 Source assertion: UniProtKB:P00330 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note` UniProtKB:P00330 Source assertion: UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/uniProtKBCrossReferences/0`
PDC5 Scer `SGD:S000004124`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	magnesium(2+) `CHEBI:18420`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/0/cofactors/0; /results/439/comments/0/note` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0`
PDC5 Scer `SGD:S000004124`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/1/cofactors/0; /results/439/comments/1/note` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0`
ARO9 Scer `SGD:S000001179`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O84395)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P38840 Source assertion: UniProtKB:P38840 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/comments/0/cofactors/0` UniProtKB:P38840 Source assertion: UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/uniProtKBCrossReferences/0`
SFA1 Scer `SGD:S000002327`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06525) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06525)	zinc(2+) `CHEBI:29105`	UniProtKB:P32771 Source assertion: UniProtKB:P32771 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/comments/0/cofactors/0; /results/990/comments/0/note` UniProtKB:P32771 Source assertion: UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/uniProtKBCrossReferences/0`
ARO10 Scer `SGD:S000002788`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250	magnesium(2+) `CHEBI:18420`	UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/0/cofactors/0; /results/2752/comments/0/note` UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0`
ARO10 Scer `SGD:S000002788`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/1/cofactors/0; /results/2752/comments/1/note` UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0`
PDC6 Scer `SGD:S000003319`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	magnesium(2+) `CHEBI:18420`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/0/cofactors/0; /results/742/comments/0/note` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0`
PDC6 Scer `SGD:S000003319`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/1/cofactors/0; /results/742/comments/1/note` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0`
PDC1 Scer `SGD:S000004034`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	magnesium(2+) `CHEBI:18420`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/0/cofactors/0; /results/127/comments/0/note` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0`
PDC1 Scer `SGD:S000004034`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/1/cofactors/0; /results/127/comments/1/note` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0`
ARO8 Scer `SGD:S000003170`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P53090 Source assertion: UniProtKB:P53090 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/comments/0/cofactors/0` UniProtKB:P53090 Source assertion: UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY3O-214 SGD GO-CAM tryptophan degradation - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2024-07-12; member ./YeastPathways_PWY3O-214.json)
UniProtKB:P07246 Reviewed UniProtKB P07246 location annotations (source version: UniProt release 2026_03)
UniProtKB:P10127 Reviewed UniProtKB P10127 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00331 Reviewed UniProtKB P00331 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38113 Reviewed UniProtKB P38113 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00330 Reviewed UniProtKB P00330 location annotations (source version: UniProt release 2026_03)
UniProtKB:P16467 Reviewed UniProtKB P16467 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38840 Reviewed UniProtKB P38840 location annotations (source version: UniProt release 2026_03)
UniProtKB:P32771 Reviewed UniProtKB P32771 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q06408 Reviewed UniProtKB Q06408 location annotations (source version: UniProt release 2026_03)
UniProtKB:P26263 Reviewed UniProtKB P26263 location annotations (source version: UniProt release 2026_03)
UniProtKB:P06169 Reviewed UniProtKB P06169 location annotations (source version: UniProt release 2026_03)
UniProtKB:P53090 Reviewed UniProtKB P53090 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T07:05:26Z Codex; edited; Repair ARO8 amino-group donor/acceptor sides without changing pathway direction or tryptophan identity.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 12 activity location assignments and 12 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 16 independently supported location edges and quarantined 2 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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2026-10-05T07:05:26Z Codex
- EDIT — Repair ARO8 amino-group donor/acceptor sides without changing pathway direction or tryptophan identity.
  User-authorized full causal graph curation. Repair ARO8 amino-group donor/acceptor sides without changing pathway direction or tryptophan identity. Independent UniProt release2026_03 annotations, Rhea139 and ChEBI255 were inspected; primary literature was checked for the taxon/function distinctions. Exact source pointers and superseded edge assertions are retained in reports/causal_graph_review/gocam-chemical-corrections.json. Native schema validation and focused biochemical regression tests were run. Shared final rendering and full gates are performed by the coordinating agent.
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