phosphatidylinositol phosphate biosynthesis
gomodel:YeastPathways_PWY3O-242
Phosphatidylinositol phosphate biosynthesis in Saccharomyces cerevisiae S288C uses phosphatidylinositol kinases and phosphatidylinositol phosphate phosphatases to interconvert phosphatidylinositol, phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 3,5-bisphosphate, and phosphatidylinositol 4,5-bisphosphate.
- Pathway type
- lipid biosynthesis
- Organism scope
Pathway network
58 nodes · 239 asserted directed edges
Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.
- Reaction / activity
- Chemical / cofactor
- Protein / complex
- Cell / process context
- Solid arrow: mechanistic relation
- Dashed arrow: membership, location or cofactor relation
Components and activities
| Node | Kind or role | Source direction |
|---|---|---|
Saccharomyces cerevisiae S288CNCBITaxon:559292 | taxon | |
FAB1 ScerSGD:S000001915 | protein | |
ADP(3-)CHEBI:456216 | small molecule | |
hydronCHEBI:15378 | small molecule | |
MSS4 ScerSGD:S000002616 | protein | |
SAC1 ScerSGD:S000001695 | protein | |
cytosolGO:0005829 | cellular component | |
phosphatidylinositol phosphate biosynthetic processGO:0046854 | biological process | |
1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 | lipid | |
FIG4 ScerSGD:S000005269 | protein | |
1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 | small molecule | |
1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 | lipid | |
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphateCHEBI:16851 | lipid | |
hydrogenphosphateCHEBI:43474 | small molecule | |
YMR1 ScerSGD:S000003871 | protein | |
waterCHEBI:15377 | small molecule | |
INP52 ScerSGD:S000005050 | protein | |
ATP(4-)CHEBI:30616 | small molecule | |
LSB6 ScerSGD:S000003636 | protein | |
VPS34 ScerSGD:S000004230 | protein | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphateCHEBI:18348 | lipid | |
INP51 ScerSGD:S000001264 | protein | |
STT4 ScerSGD:S000004296 | protein | |
INP53 ScerSGD:S000005635 | protein | |
INP54 ScerSGD:S000005426 | protein | |
PIK1 ScerSGD:S000005211 | protein | |
vacuolar membraneGO:0005774 | cellular component | |
endosome membraneGO:0010008 | cellular component | |
plasma membraneGO:0005886 | cellular component | |
endoplasmic reticulum membraneGO:0005789 | cellular component | |
Golgi membraneGO:0000139 | cellular component | |
cytoplasmGO:0005737 | cellular component | |
actin cortical patchGO:0030479 | cellular component | |
trans-Golgi network membraneGO:0032588 | cellular component | |
nucleusGO:0005634 | cellular component | |
trans-Golgi networkGO:0005802 | cellular component | |
magnesium(2+)CHEBI:18420 | cofactor | |
manganese(2+)CHEBI:29035 | cofactor | |
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | molecular activity | |
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | molecular activity | |
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | molecular activity | |
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | molecular activity | |
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN | molecular activity | |
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | molecular activity | |
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | molecular activity | |
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 | molecular activity | |
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | molecular activity | |
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 | molecular activity | |
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | molecular activity | |
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | molecular activity | |
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 | molecular activity | |
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 | molecular activity | |
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 | molecular activity | |
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 | molecular activity | |
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 | molecular activity | |
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 | molecular activity | |
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | molecular activity | |
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | molecular activity | |
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 | molecular activity |
Mechanistic edges
| Subject | Predicate and description | Object | Evidence |
|---|---|---|---|
FAB1 ScerSGD:S000001915 | enables | a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | has_output | ADP(3-)CHEBI:456216 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | has_output | hydronCHEBI:15378 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 |
|
MSS4 ScerSGD:S000002616 | enables | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | has_output | ADP(3-)CHEBI:456216 |
|
SAC1 ScerSGD:S000001695 | enables | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 | has_input | 1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 |
|
FIG4 ScerSGD:S000005269 | enables | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | has_input | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | has_output | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | has_output | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphateCHEBI:16851 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 | has_input | 1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 | has_output | hydrogenphosphateCHEBI:43474 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 | has_input | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphateCHEBI:16851 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | has_input | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphateCHEBI:16851 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 | has_output | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 | has_output | hydrogenphosphateCHEBI:43474 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 | has_output | hydrogenphosphateCHEBI:43474 |
|
SAC1 ScerSGD:S000001695 | enables | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 | has_input | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 | has_output | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
|
YMR1 ScerSGD:S000003871 | enables | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | provides_input_for | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 | has_input | waterCHEBI:15377 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | has_output | hydrogenphosphateCHEBI:43474 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 |
|
INP52 ScerSGD:S000005050 | enables | a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | provides_input_for | 1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | provides_input_for | 1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 | has_output | hydrogenphosphateCHEBI:43474 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 | has_input | waterCHEBI:15377 |
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phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 | has_input | waterCHEBI:15377 |
|
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | has_input | waterCHEBI:15377 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | has_output | ADP(3-)CHEBI:456216 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | has_input | ATP(4-)CHEBI:30616 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | has_output | ADP(3-)CHEBI:456216 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN |
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LSB6 ScerSGD:S000003636 | enables | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN |
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phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 | has_input | waterCHEBI:15377 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 | has_output | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | has_output | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
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molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN |
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phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | has_output | 1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 |
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phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | has_output | hydrogenphosphateCHEBI:43474 |
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phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | provides_input_for | 1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | occurs_in | cytosolGO:0005829 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | occurs_in | cytosolGO:0005829 |
|
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | has_output | hydronCHEBI:15378 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 | has_output | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | has_input | waterCHEBI:15377 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 |
|
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | has_input | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphateCHEBI:16851 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | has_input | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
|
VPS34 ScerSGD:S000004230 | enables | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 | has_input | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphateCHEBI:18348 |
|
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN |
|
INP51 ScerSGD:S000001264 | enables | a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN |
|
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | has_output | hydrogenphosphateCHEBI:43474 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 | has_input | waterCHEBI:15377 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | has_input | ATP(4-)CHEBI:30616 |
|
STT4 ScerSGD:S000004296 | enables | 1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | provides_input_for | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 | occurs_in | cytosolGO:0005829 |
|
INP53 ScerSGD:S000005635 | enables | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN | has_output | hydrogenphosphateCHEBI:43474 |
|
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | has_input | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 | has_output | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
|
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | has_input | ATP(4-)CHEBI:30616 |
|
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN | has_output | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | provides_input_for | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 |
|
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | has_output | 1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | has_input | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphateCHEBI:16851 |
|
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | provides_input_for | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 | has_input | waterCHEBI:15377 |
|
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | has_output | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | provides_input_for | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 |
|
INP52 ScerSGD:S000005050 | enables | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | has_input | waterCHEBI:15377 |
|
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | has_output | 1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | occurs_in | cytosolGO:0005829 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 | has_output | 1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | has_input | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | has_output | hydronCHEBI:15378 |
|
INP54 ScerSGD:S000005426 | enables | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | has_output | ADP(3-)CHEBI:456216 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 | has_input | waterCHEBI:15377 |
|
INP53 ScerSGD:S000005635 | enables | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | has_input | ATP(4-)CHEBI:30616 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 | has_input | waterCHEBI:15377 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 | provides_input_for | 1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 | has_output | hydrogenphosphateCHEBI:43474 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 | has_input | 1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 |
|
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
INP52 ScerSGD:S000005050 | enables | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN |
|
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN | has_input | waterCHEBI:15377 |
|
INP52 ScerSGD:S000005050 | enables | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | provides_input_for | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | has_input | ATP(4-)CHEBI:30616 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 |
|
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN | has_input | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphateCHEBI:18348 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 | has_input | waterCHEBI:15377 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 | has_input | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphateCHEBI:18348 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 | occurs_in | cytosolGO:0005829 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | has_output | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 | has_output | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 | provides_input_for | 1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 | has_output | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 | has_input | waterCHEBI:15377 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 | has_output | hydrogenphosphateCHEBI:43474 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 |
|
SAC1 ScerSGD:S000001695 | enables | phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 |
|
molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 | has_input | waterCHEBI:15377 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006151 | has_output | hydrogenphosphateCHEBI:43474 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | has_input | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 | has_output | hydrogenphosphateCHEBI:43474 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006061 | has_input | 1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 |
|
phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006096 | occurs_in | cytosolGO:0005829 |
|
1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | has_output | hydronCHEBI:15378 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | part_of | phosphatidylinositol phosphate biosynthetic processGO:0046854 |
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a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | has_output | hydronCHEBI:15378 |
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a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | has_output | 1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 | has_input | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphateCHEBI:18348 |
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phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 | has_output | hydrogenphosphateCHEBI:43474 |
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a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | has_output | hydrogenphosphateCHEBI:43474 |
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a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | has_output | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
|
INP53 ScerSGD:S000005635 | enables | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005927 |
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a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | provides_input_for | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006024 |
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phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | has_output | hydrogenphosphateCHEBI:43474 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | has_output | ADP(3-)CHEBI:456216 |
|
a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | has_input | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
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1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 | has_output | hydronCHEBI:15378 |
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a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | has_input | 1-phosphatidyl-1D-myo-inositol 4-phosphateCHEBI:17526 |
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a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-KINASE-RXN | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 |
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a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | has_input | 1-phosphatidyl-1D-myo-inositol 3-phosphateCHEBI:17283 |
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phosphatidylinositol-3-phosphate phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006079 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP -> 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + H+gomodel:2.7.1.150-RXN | provides_input_for | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 |
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molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 | has_output | 1-phosphatidyl-1D-myo-inositol(1-)CHEBI:57880 |
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a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP -> a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+gomodel:2.7.1.68-RXN | has_output | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphateCHEBI:18348 |
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a 1-phosphatidyl-1D-myo-inositol + ATP -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+gomodel:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN | has_input | ATP(4-)CHEBI:30616 |
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PIK1 ScerSGD:S000005211 | enables | 1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005962 |
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INP53 ScerSGD:S000005635 | enables | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006132 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | provides_input_for | 1-phosphatidylinositol 4-kinase activitygomodel:YeastPathways_PWY3O-242/6a4c244800005984 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006043 | provides_input_for | a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 |
|
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN | provides_input_for | molecular_functiongomodel:YeastPathways_PWY3O-242/6a4c244800005945 |
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FAB1 ScerSGD:S000001915 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11889142); ECO:0000269 (PubMed:18653468); ECO:0000269 (PubMed:19037259); ECO:0000269 (PubMed:9763421) Topology: Peripheral membrane protein. Source qualification: Localization to the vacuole membrane requires VAC14 and FIG4 | vacuolar membraneGO:0005774 |
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FAB1 ScerSGD:S000001915 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11889142); ECO:0000269 (PubMed:9763421) Topology: Peripheral membrane protein. Source qualification: Localization to the vacuole membrane requires VAC14 and FIG4 | endosome membraneGO:0010008 |
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MSS4 ScerSGD:S000002616 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22562153) Topology: Peripheral membrane protein. Source qualification: Forms dynamic oligomeric patches at the cell membrane (PubMed:22562153). Localization to the cell membrane is dependent on its ability to bind substrate (PubMed:22562153) | plasma membraneGO:0005886 |
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SAC1 ScerSGD:S000001695 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11514624); ECO:0000269 (PubMed:11792713); ECO:0000269 (PubMed:8314848) Topology: Multi-pass membrane protein. | endoplasmic reticulum membraneGO:0005789 |
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SAC1 ScerSGD:S000001695 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8314848) Topology: Multi-pass membrane protein. | Golgi membraneGO:0000139 |
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FIG4 ScerSGD:S000005269 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11950935); ECO:0000269 (PubMed:14528018); ECO:0000269 (PubMed:18653468); ECO:0000269 (PubMed:19037259) Topology: Peripheral membrane protein. Source qualification: Localized to the limiting membrane of the vacuole. Localization requires VAC14 and FAB1 | vacuolar membraneGO:0005774 |
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YMR1 ScerSGD:S000003871 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095) | cytoplasmGO:0005737 |
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INP52 ScerSGD:S000005050 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11094088); ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:15798181); ECO:0000269 (PubMed:16406366) | actin cortical patchGO:0030479 |
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LSB6 ScerSGD:S000003636 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12361950) Topology: Peripheral membrane protein. Source qualification: Located at both the plasma and vacuolar membrane | plasma membraneGO:0005886 |
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LSB6 ScerSGD:S000003636 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12361950); ECO:0000269 (PubMed:12523934) Topology: Peripheral membrane protein. Source qualification: Located at both the plasma and vacuolar membrane | vacuolar membraneGO:0005774 |
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VPS34 ScerSGD:S000004230 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11157979) Topology: Peripheral membrane protein. | trans-Golgi network membraneGO:0032588 |
|
VPS34 ScerSGD:S000004230 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11157979) Topology: Peripheral membrane protein. | endosome membraneGO:0010008 |
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INP51 ScerSGD:S000001264 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095) | actin cortical patchGO:0030479 |
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INP53 ScerSGD:S000005635 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11094088); ECO:0000269 (PubMed:14562095) Source qualification: Cytoplasmic punctate structures. Hyperosmotic stress causes translocation to actin patches | cytoplasmGO:0005737 |
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INP54 ScerSGD:S000005426 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11116155) Topology: Peripheral membrane protein. Orientation: Cytoplasmic side. | endoplasmic reticulum membraneGO:0005789 |
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PIK1 ScerSGD:S000005211 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8194527) | nucleusGO:0005634 |
|
PIK1 ScerSGD:S000005211 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:19898464) | trans-Golgi networkGO:0005802 |
|
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphategomodel:RXN-10938 | occurs_in Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:11950935); ECO:0000269 (PubMed:14528018); ECO:0000269 (PubMed:16492811); ECO:0000269 (PubMed:19037259). Alternative isoenzymes may function elsewhere. | vacuolar membraneGO:0005774 |
|
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphategomodel:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN | occurs_in | cytosolGO:0005829 |
|
a 1-phosphatidyl-1D-myo-inositol 4-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN-10961 | occurs_in | cytosolGO:0005829 |
|
a 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O -> a 1-phosphatidyl-1D-myo-inositol + phosphategomodel:RXN3O-364 | occurs_in | cytosolGO:0005829 |
|
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006005 | occurs_in | cytosolGO:0005829 |
|
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activitygomodel:YeastPathways_PWY3O-242/6a4c244800006112 | occurs_in | cytosolGO:0005829 |
|
FAB1 ScerSGD:S000001915 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified | magnesium(2+)CHEBI:18420 |
|
FAB1 ScerSGD:S000001915 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified | manganese(2+)CHEBI:29035 |
|
FIG4 ScerSGD:S000005269 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:14528018) | magnesium(2+)CHEBI:18420 |
|
INP52 ScerSGD:S000005050 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU01427) | magnesium(2+)CHEBI:18420 |
|
LSB6 ScerSGD:S000003636 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12361950) | magnesium(2+)CHEBI:18420 |
|
LSB6 ScerSGD:S000003636 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12361950) | manganese(2+)CHEBI:29035 |
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INP51 ScerSGD:S000001264 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU01427) | magnesium(2+)CHEBI:18420 |
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INP53 ScerSGD:S000005635 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU01427) | magnesium(2+)CHEBI:18420 |
|
INP54 ScerSGD:S000005426 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000255 (PROSITE-ProRule:PRU01427) | magnesium(2+)CHEBI:18420 |
|
References
gomodel:YeastPathways_PWY3O-242SGD GO-CAM phosphatidylinositol phosphate biosynthesis - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_PWY3O-242.json)UniProtKB:P34756Reviewed UniProtKB P34756 location annotations (source version: UniProt release 2026_03)UniProtKB:P38994Reviewed UniProtKB P38994 location annotations (source version: UniProt release 2026_03)UniProtKB:P32368Reviewed UniProtKB P32368 location annotations (source version: UniProt release 2026_03)UniProtKB:P42837Reviewed UniProtKB P42837 location annotations (source version: UniProt release 2026_03)UniProtKB:P47147Reviewed UniProtKB P47147 location annotations (source version: UniProt release 2026_03)UniProtKB:P50942Reviewed UniProtKB P50942 location annotations (source version: UniProt release 2026_03)UniProtKB:P42951Reviewed UniProtKB P42951 location annotations (source version: UniProt release 2026_03)UniProtKB:P22543Reviewed UniProtKB P22543 location annotations (source version: UniProt release 2026_03)UniProtKB:P40559Reviewed UniProtKB P40559 location annotations (source version: UniProt release 2026_03)UniProtKB:Q12271Reviewed UniProtKB Q12271 location annotations (source version: UniProt release 2026_03)UniProtKB:Q08227Reviewed UniProtKB Q08227 location annotations (source version: UniProt release 2026_03)UniProtKB:P39104Reviewed UniProtKB P39104 location annotations (source version: UniProt release 2026_03)
Curation history
- Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
- Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
Reviewed all 21 activity location assignments and 13 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 18 independently supported location edges and quarantined 15 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
- Codex
- EDIT — Retain compatible native cytosol assertions for cytoplasmic actin-patch enzymes
During final compartment review, restored five native INP51/INP52 activity cytosol facts because their independent location annotation is explicitly Cytoplasm, cytoskeleton, actin patch. Cytoskeletal localization is not an organellar contradiction. The final source-exclusion ledger has163 quarantined facts across85 yeast records. Added a regression fixture for this distinction; all five location-curation tests pass.
- EDIT — Retain compatible native cytosol assertions for cytoplasmic actin-patch enzymes