carnitine shuttle

gomodel:YeastPathways_PWY3O-4

The carnitine shuttle in Saccharomyces cerevisiae S288C uses CAT2, YAT1, and YAT2 carnitine O-acetyltransferase activities to interconvert acetyl-CoA and (R)-carnitine with O-acetyl-L-carnitine and coenzyme A.

Pathway type

carnitine shuttle

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

Read the source YAML

Pathway network

16 nodes · 32 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

Show at full size (scroll to explore)

Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
CAT2 Scer `SGD:S000004506`	protein
acetyl-CoA(4-) `CHEBI:57288`	small molecule
YAT1 Scer `SGD:S000000080`	protein
(R)-carnitine `CHEBI:16347`	small molecule
O-acetyl-L-carnitine `CHEBI:57589`	lipid
coenzyme A(4-) `CHEBI:57287`	small molecule
carnitine shuttle `GO:0006853`	biological process
YAT2 Scer `SGD:S000000826`	protein
cytosol `GO:0005829`	cellular component
mitochondrial inner membrane `GO:0005743`	cellular component
peroxisome `GO:0005777`	cellular component
cytoplasm `GO:0005737`	cellular component
L-carnitine + acetyl-CoA <=> O-acetyl-L-carnitine + coenzyme A `gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN`	molecular activity
L-carnitine_{[mitochondrial lumen]} + acetyl-CoA_{[mitochondrial lumen]} <- O-acetyl-L-carnitine_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} `gomodel:RXN3O-37`	molecular activity
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000733`	molecular activity
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000742`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
CAT2 Scer `SGD:S000004506`	enables	L-carnitine + acetyl-CoA <=> O-acetyl-L-carnitine + coenzyme A `gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002333 gomodel:YML042W-MONOMER_CARNITINE-O-ACETYLTRANSFERASE-RXN_controller. Source location `./YeastPathways_PWY3O-4.json#/facts/0; endpoint types: /individuals/0/type; /individuals/10/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000742`	has_input	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002233 gomodel:YeastPathways_PWY3O-4/6a46ef0600000744. Source location `./YeastPathways_PWY3O-4.json#/facts/1; endpoint types: /individuals/33/type; /individuals/35/type`
YAT1 Scer `SGD:S000000080`	enables	carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000733`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002333 gomodel:YeastPathways_PWY3O-4/6a46ef0600000739. Source location `./YeastPathways_PWY3O-4.json#/facts/2; endpoint types: /individuals/26/type; /individuals/31/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000742`	has_input	(R)-carnitine `CHEBI:16347`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002233 gomodel:YeastPathways_PWY3O-4/6a46ef0600000743. Source location `./YeastPathways_PWY3O-4.json#/facts/3; endpoint types: /individuals/33/type; /individuals/34/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000742`	has_output	O-acetyl-L-carnitine `CHEBI:57589`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002234 gomodel:YeastPathways_PWY3O-4/6a46ef0600000746. Source location `./YeastPathways_PWY3O-4.json#/facts/4; endpoint types: /individuals/33/type; /individuals/37/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000742`	has_output	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002234 gomodel:YeastPathways_PWY3O-4/6a46ef0600000745. Source location `./YeastPathways_PWY3O-4.json#/facts/5; endpoint types: /individuals/33/type; /individuals/36/type`
L-carnitine + acetyl-CoA <=> O-acetyl-L-carnitine + coenzyme A `gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN`	part_of	carnitine shuttle `GO:0006853`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4/YeastPathways_PWY3O-4. Source location `./YeastPathways_PWY3O-4.json#/facts/6; endpoint types: /individuals/0/type; /individuals/25/type`
L-carnitine_{[mitochondrial lumen]} + acetyl-CoA_{[mitochondrial lumen]} <- O-acetyl-L-carnitine_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} `gomodel:RXN3O-37`	has_input	O-acetyl-L-carnitine `CHEBI:57589`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:RXN3O-37 RO:0002233 gomodel:CHEBI_57589_RXN3O-37. Source location `./YeastPathways_PWY3O-4.json#/facts/7; endpoint types: /individuals/9/type; /individuals/8/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000742`	part_of	carnitine shuttle `GO:0006853`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 BFO:0000050 gomodel:YeastPathways_PWY3O-4/YeastPathways_PWY3O-4. Source location `./YeastPathways_PWY3O-4.json#/facts/8; endpoint types: /individuals/33/type; /individuals/25/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000733`	has_input	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002233 gomodel:YeastPathways_PWY3O-4/6a46ef0600000735. Source location `./YeastPathways_PWY3O-4.json#/facts/9; endpoint types: /individuals/26/type; /individuals/28/type`
YAT2 Scer `SGD:S000000826`	enables	carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000742`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002333 gomodel:YeastPathways_PWY3O-4/6a46ef0600000749. Source location `./YeastPathways_PWY3O-4.json#/facts/10; endpoint types: /individuals/33/type; /individuals/38/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000733`	has_output	O-acetyl-L-carnitine `CHEBI:57589`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002234 gomodel:YeastPathways_PWY3O-4/6a46ef0600000737. Source location `./YeastPathways_PWY3O-4.json#/facts/12; endpoint types: /individuals/26/type; /individuals/30/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000733`	has_output	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002234 gomodel:YeastPathways_PWY3O-4/6a46ef0600000736. Source location `./YeastPathways_PWY3O-4.json#/facts/13; endpoint types: /individuals/26/type; /individuals/29/type`
L-carnitine_{[mitochondrial lumen]} + acetyl-CoA_{[mitochondrial lumen]} <- O-acetyl-L-carnitine_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} `gomodel:RXN3O-37`	part_of	carnitine shuttle `GO:0006853`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:RXN3O-37 BFO:0000050 gomodel:YeastPathways_PWY3O-4/YeastPathways_PWY3O-4. Source location `./YeastPathways_PWY3O-4.json#/facts/14; endpoint types: /individuals/9/type; /individuals/25/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000733`	part_of	carnitine shuttle `GO:0006853`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 BFO:0000050 gomodel:YeastPathways_PWY3O-4/YeastPathways_PWY3O-4. Source location `./YeastPathways_PWY3O-4.json#/facts/15; endpoint types: /individuals/26/type; /individuals/25/type`
L-carnitine + acetyl-CoA <=> O-acetyl-L-carnitine + coenzyme A `gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN`	has_output	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_57287_CARNITINE-O-ACETYLTRANSFERASE-RXN. Source location `./YeastPathways_PWY3O-4.json#/facts/16; endpoint types: /individuals/0/type; /individuals/3/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000733`	causally_upstream_of	L-carnitine_{[mitochondrial lumen]} + acetyl-CoA_{[mitochondrial lumen]} <- O-acetyl-L-carnitine_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} `gomodel:RXN3O-37`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002411 gomodel:RXN3O-37. Source location `./YeastPathways_PWY3O-4.json#/facts/17; endpoint types: /individuals/26/type; /individuals/9/type`
L-carnitine + acetyl-CoA <=> O-acetyl-L-carnitine + coenzyme A `gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN`	has_output	O-acetyl-L-carnitine `CHEBI:57589`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_57589_CARNITINE-O-ACETYLTRANSFERASE-RXN. Source location `./YeastPathways_PWY3O-4.json#/facts/18; endpoint types: /individuals/0/type; /individuals/7/type`
L-carnitine_{[mitochondrial lumen]} + acetyl-CoA_{[mitochondrial lumen]} <- O-acetyl-L-carnitine_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} `gomodel:RXN3O-37`	has_output	(R)-carnitine `CHEBI:16347`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:RXN3O-37 RO:0002234 gomodel:CHEBI_16347_RXN3O-37. Source location `./YeastPathways_PWY3O-4.json#/facts/19; endpoint types: /individuals/9/type; /individuals/2/type`
L-carnitine + acetyl-CoA <=> O-acetyl-L-carnitine + coenzyme A `gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN`	has_input	(R)-carnitine `CHEBI:16347`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_16347_CARNITINE-O-ACETYLTRANSFERASE-RXN. Source location `./YeastPathways_PWY3O-4.json#/facts/20; endpoint types: /individuals/0/type; /individuals/1/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000733`	has_input	(R)-carnitine `CHEBI:16347`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000733 RO:0002233 gomodel:YeastPathways_PWY3O-4/6a46ef0600000734. Source location `./YeastPathways_PWY3O-4.json#/facts/21; endpoint types: /individuals/26/type; /individuals/27/type`
L-carnitine + acetyl-CoA <=> O-acetyl-L-carnitine + coenzyme A `gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN`	has_input	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_57288_CARNITINE-O-ACETYLTRANSFERASE-RXN. Source location `./YeastPathways_PWY3O-4.json#/facts/22; endpoint types: /individuals/0/type; /individuals/5/type`
CAT2 Scer `SGD:S000004506`	enables	L-carnitine_{[mitochondrial lumen]} + acetyl-CoA_{[mitochondrial lumen]} <- O-acetyl-L-carnitine_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} `gomodel:RXN3O-37`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:RXN3O-37 RO:0002333 gomodel:YML042W-MONOMER_RXN3O-37_controller. Source location `./YeastPathways_PWY3O-4.json#/facts/23; endpoint types: /individuals/9/type; /individuals/11/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000742`	causally_upstream_of	L-carnitine_{[mitochondrial lumen]} + acetyl-CoA_{[mitochondrial lumen]} <- O-acetyl-L-carnitine_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} `gomodel:RXN3O-37`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 RO:0002411 gomodel:RXN3O-37. Source location `./YeastPathways_PWY3O-4.json#/facts/25; endpoint types: /individuals/33/type; /individuals/9/type`
L-carnitine_{[mitochondrial lumen]} + acetyl-CoA_{[mitochondrial lumen]} <- O-acetyl-L-carnitine_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} `gomodel:RXN3O-37`	has_output	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:RXN3O-37 RO:0002234 gomodel:CHEBI_57288_RXN3O-37. Source location `./YeastPathways_PWY3O-4.json#/facts/26; endpoint types: /individuals/9/type; /individuals/6/type`
carnitine O-acetyltransferase activity `gomodel:YeastPathways_PWY3O-4/6a46ef0600000742`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4/6a46ef0600000742 BFO:0000066 gomodel:YeastPathways_PWY3O-4/6a46ef0600000750. Source location `./YeastPathways_PWY3O-4.json#/facts/27; endpoint types: /individuals/33/type; /individuals/39/type`
L-carnitine + acetyl-CoA <=> O-acetyl-L-carnitine + coenzyme A `gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN`	causally_upstream_of	L-carnitine_{[mitochondrial lumen]} + acetyl-CoA_{[mitochondrial lumen]} <- O-acetyl-L-carnitine_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} `gomodel:RXN3O-37`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:CARNITINE-O-ACETYLTRANSFERASE-RXN RO:0002411 gomodel:RXN3O-37. Source location `./YeastPathways_PWY3O-4.json#/facts/28; endpoint types: /individuals/0/type; /individuals/9/type`
L-carnitine_{[mitochondrial lumen]} + acetyl-CoA_{[mitochondrial lumen]} <- O-acetyl-L-carnitine_{[mitochondrial lumen]} + coenzyme A_{[mitochondrial lumen]} `gomodel:RXN3O-37`	has_input	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_PWY3O-4 Source assertion: The model asserts gomodel:RXN3O-37 RO:0002233 gomodel:CHEBI_57287_RXN3O-37. Source location `./YeastPathways_PWY3O-4.json#/facts/29; endpoint types: /individuals/9/type; /individuals/4/type`
CAT2 Scer `SGD:S000004506`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source; molecular form: Isoform Mitochondrial. Topology: Peripheral membrane protein. Orientation: Matrix side.	mitochondrial inner membrane `GO:0005743`	UniProtKB:P32796 Source assertion: UniProtKB:P32796 annotates location Mitochondrion inner membrane (SL-0168); molecular form: Isoform Mitochondrial. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1002/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P32796 Source assertion: UniProtKB:P32796 has the exact SGD cross-reference SGD:S000004506. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1002/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
CAT2 Scer `SGD:S000004506`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:7628448); molecular form: Isoform Peroxisomal.	peroxisome `GO:0005777`	UniProtKB:P32796 Source assertion: UniProtKB:P32796 annotates location Peroxisome (SL-0204); molecular form: Isoform Peroxisomal. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1002/comments/2/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P32796 Source assertion: UniProtKB:P32796 has the exact SGD cross-reference SGD:S000004506. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1002/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
YAT1 Scer `SGD:S000000080`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Peripheral membrane protein. Orientation: Intermembrane side.	mitochondrial inner membrane `GO:0005743`	UniProtKB:P80235 Source assertion: UniProtKB:P80235 annotates location Mitochondrion inner membrane (SL-0168). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4032/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P80235 Source assertion: UniProtKB:P80235 has the exact SGD cross-reference SGD:S000000080. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4032/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
YAT2 Scer `SGD:S000000826`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:18427809)	cytoplasm `GO:0005737`	UniProtKB:P40017 Source assertion: UniProtKB:P40017 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3704/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P40017 Source assertion: UniProtKB:P40017 has the exact SGD cross-reference SGD:S000000826. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3704/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`

References

gomodel:YeastPathways_PWY3O-4 SGD GO-CAM carnitine shuttle - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-4.json)
UniProtKB:P32796 Reviewed UniProtKB P32796 location annotations (source version: UniProt release 2026_03)
UniProtKB:P80235 Reviewed UniProtKB P80235 location annotations (source version: UniProt release 2026_03)
UniProtKB:P40017 Reviewed UniProtKB P40017 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 4 activity location assignments and 3 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 4 independently supported location edges and quarantined 2 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
Read this curation session