inositol phosphate biosynthesis

gomodel:YeastPathways_PWY3O-402

Inositol phosphate biosynthesis in Saccharomyces cerevisiae S288C converts phosphatidylinositol 4,5-bisphosphate and soluble inositol phosphates through inositol tetrakisphosphate, inositol pentakisphosphate, inositol hexakisphosphate, and inositol pyrophosphate intermediates. The source includes the additional diphosphoinositol pentakisphosphate phosphorylation step without assigning its enabling protein.

Pathway type

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

48 nodes · 117 asserted directed edges

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
hydron `CHEBI:15378`	small molecule
ADP(3-) `CHEBI:456216`	small molecule
inositol phosphate biosynthetic process `GO:0032958`	biological process
KCS1 Scer `SGD:S000002424`	protein
1D-myo-inositol 1,4,5-trisphosphate(6-) `CHEBI:203600`	small molecule
cytosol `GO:0005829`	cellular component
1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-) `CHEBI:57627`	small molecule
water `CHEBI:15377`	small molecule
ATP(4-) `CHEBI:30616`	small molecule
IPK1 Scer `SGD:S000002723`	protein
myo-inositol hexakisphosphate(12-) `CHEBI:58130`	small molecule
DDP1 Scer `SGD:S000005689`	protein
1D-myo-inositol bis(diphosphate) tetrakisphosphate `CHEBI:14178`	small molecule
ARG82 Scer `SGD:S000002580`	protein
1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-) `CHEBI:57895`	small molecule
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate `CHEBI:18348`	lipid
5-diphospho-1D-myo-inositol pentakisphosphate(13-) `CHEBI:58628`	small molecule
myo-inositol 1,3,4,5,6-pentakisphosphate `CHEBI:16322`	small molecule
PLC1 Scer `SGD:S000006189`	protein
VIP1 Scer `SGD:S000004402`	protein
1,2-diacyl-sn-glycerol `CHEBI:17815`	lipid
hydrogenphosphate `CHEBI:43474`	small molecule
cytoplasm `GO:0005737`	cellular component
nucleus `GO:0005634`	cellular component
cytoskeleton `GO:0005856`	cellular component
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate(13-) `CHEBI:74946`	small molecule
1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate(13-) `CHEBI:77983`	small molecule
a diphospho-1D-myo-inositol tetrakisphosphate `gomodel:CHEBI_14178_RXN-4941`	small molecule
diphosphoinositol pentakisphosphate `gomodel:CHEBI_62919_RXN3O-786`	small molecule
magnesium(2+) `CHEBI:18420`	cofactor
manganese(2+) `CHEBI:29035`	cofactor
zinc(2+) `CHEBI:29105`	cofactor
calcium(2+) `CHEBI:29108`	cofactor
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.127-RXN`	molecular activity
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,4,5,6)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.151-RXN`	molecular activity
ATP + inositol hexakisphosphate -> ADP + 5-IP7 `gomodel:2.7.1.152-RXN`	molecular activity
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O -> a 1,2-diacyl-sn-glycerol + D-myo-inositol (1,4,5)-trisphosphate + H⁺ `gomodel:3.1.4.11-RXN`	molecular activity
ATP + D-myo-inositol 1,3,4,5,6-pentakisphosphate -> a diphospho-1D-myo-inositol tetrakisphosphate + ADP `gomodel:RXN-4941`	molecular activity
D-myo-inositol (1,4,5,6)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7162`	molecular activity
D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP -> phytate + ADP + H⁺ `gomodel:RXN-7163`	molecular activity
D-myo-inositol (1,3,4,5)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7184`	molecular activity
ATP + 5-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-143`	molecular activity
ATP + inositol hexakisphosphate -> ADP + 1-IP7 `gomodel:RXN3O-258`	molecular activity
diphosphoinositol pentakisphosphate + H₂O -> phytate + phosphate `gomodel:RXN3O-785`	molecular activity
[PP]₂-IP₄ + H₂O -> diphosphoinositol pentakisphosphate + phosphate `gomodel:RXN3O-786`	molecular activity
ATP + 1-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-9819`	molecular activity
inositol pentakisphosphate kinase activity `gomodel:YeastPathways_PWY3O-402/6a4c244800000690`	molecular activity
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + phosphate + H(+) `RHEA:79724`	molecular activity	left to right

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
D-myo-inositol (1,4,5,6)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7162`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7162 RO:0002234 gomodel:CHEBI_15378_RXN-7162. Source location `./YeastPathways_PWY3O-402.json#/facts/0; endpoint types: /individuals/56/type; /individuals/8/type`
ATP + D-myo-inositol 1,3,4,5,6-pentakisphosphate -> a diphospho-1D-myo-inositol tetrakisphosphate + ADP `gomodel:RXN-4941`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-4941 RO:0002234 gomodel:CHEBI_456216_RXN-4941. Source location `./YeastPathways_PWY3O-402.json#/facts/1; endpoint types: /individuals/55/type; /individuals/31/type`
D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP -> phytate + ADP + H⁺ `gomodel:RXN-7163`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7163 RO:0002234 gomodel:CHEBI_456216_RXN-7163. Source location `./YeastPathways_PWY3O-402.json#/facts/2; endpoint types: /individuals/57/type; /individuals/33/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.127-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.127-RXN RO:0002234 gomodel:CHEBI_456216_2.7.1.127-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/3; endpoint types: /individuals/166/type; /individuals/28/type`
D-myo-inositol (1,4,5,6)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7162`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7162 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/4; endpoint types: /individuals/56/type; /individuals/170/type`
KCS1 Scer `SGD:S000002424`	enables	ATP + inositol hexakisphosphate -> ADP + 5-IP7 `gomodel:2.7.1.152-RXN`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.152-RXN RO:0002333 gomodel:MONOMER3O-205_2.7.1.152-RXN_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/5; endpoint types: /individuals/168/type; /individuals/47/type`
ATP + inositol hexakisphosphate -> ADP + 1-IP7 `gomodel:RXN3O-258`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-258 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/6; endpoint types: /individuals/60/type; /individuals/170/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.127-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.127-RXN RO:0002234 gomodel:CHEBI_15378_2.7.1.127-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/7; endpoint types: /individuals/166/type; /individuals/4/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.127-RXN`	has_input	1D-myo-inositol 1,4,5-trisphosphate(6-) `CHEBI:203600`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.127-RXN RO:0002233 gomodel:CHEBI_203600_3.1.4.11-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/8; endpoint types: /individuals/166/type; /individuals/15/type`
ATP + 1-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-9819`	has_input Corrected the Kcs1-specific IP7/IP8 isomers.	1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate(13-) `CHEBI:74946`	UniProtKB:Q12494 Source assertion: Kcs1 RHEA:37467 adds the 5-position diphosphate to 1-IP7 (CHEBI:74946), producing 1,5-IP8 (CHEBI:77983). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3127/comments/2`
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O -> a 1,2-diacyl-sn-glycerol + D-myo-inositol (1,4,5)-trisphosphate + H⁺ `gomodel:3.1.4.11-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:3.1.4.11-RXN BFO:0000066 gomodel:reaction_3.1.4.11-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-402.json#/facts/10; endpoint types: /individuals/169/type; /individuals/156/type`
D-myo-inositol (1,4,5,6)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7162`	has_input	1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-) `CHEBI:57627`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7162 RO:0002233 gomodel:CHEBI_57627_2.7.1.151-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/11; endpoint types: /individuals/56/type; /individuals/41/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,4,5,6)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.151-RXN`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.151-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/12; endpoint types: /individuals/167/type; /individuals/170/type`
[PP]₂-IP₄ + H₂O -> diphosphoinositol pentakisphosphate + phosphate `gomodel:RXN3O-786`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-786 BFO:0000066 gomodel:reaction_RXN3O-786_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-402.json#/facts/13; endpoint types: /individuals/62/type; /individuals/164/type`
[PP]₂-IP₄ + H₂O -> diphosphoinositol pentakisphosphate + phosphate `gomodel:RXN3O-786`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-786 RO:0002233 gomodel:CHEBI_15377_RXN3O-786. Source location `./YeastPathways_PWY3O-402.json#/facts/14; endpoint types: /individuals/62/type; /individuals/3/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.127-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.127-RXN RO:0002233 gomodel:CHEBI_30616_2.7.1.127-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/15; endpoint types: /individuals/166/type; /individuals/16/type`
IPK1 Scer `SGD:S000002723`	enables	D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP -> phytate + ADP + H⁺ `gomodel:RXN-7163`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7163 RO:0002333 gomodel:YDR315C-MONOMER_RXN-7163_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/16; endpoint types: /individuals/57/type; /individuals/64/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,4,5,6)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.151-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.151-RXN RO:0002234 gomodel:CHEBI_15378_2.7.1.151-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/17; endpoint types: /individuals/167/type; /individuals/5/type`
D-myo-inositol (1,4,5,6)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7162`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7162 RO:0002234 gomodel:CHEBI_456216_RXN-7162. Source location `./YeastPathways_PWY3O-402.json#/facts/18; endpoint types: /individuals/56/type; /individuals/32/type`
ATP + inositol hexakisphosphate -> ADP + 1-IP7 `gomodel:RXN3O-258`	has_input	myo-inositol hexakisphosphate(12-) `CHEBI:58130`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-258 RO:0002233 gomodel:CHEBI_58130_RXN-7163. Source location `./YeastPathways_PWY3O-402.json#/facts/20; endpoint types: /individuals/60/type; /individuals/43/type`
DDP1 Scer `SGD:S000005689`	enables	[PP]₂-IP₄ + H₂O -> diphosphoinositol pentakisphosphate + phosphate `gomodel:RXN3O-786`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-786 RO:0002333 gomodel:YOR163W-MONOMER_RXN3O-786_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/21; endpoint types: /individuals/62/type; /individuals/66/type`
inositol pentakisphosphate kinase activity `gomodel:YeastPathways_PWY3O-402/6a4c244800000690`	has_output Preserved the independently existing native generic PP-InsP4 entity; its former CHEBI:14178 type has two diphosphates and is incorrect.	a diphospho-1D-myo-inositol tetrakisphosphate `gomodel:CHEBI_14178_RXN-4941`	PMID:10827188 Source assertion: Purified yeast inositol hexakisphosphate kinase phosphorylates IP5 to PP-InsP4; this experiment does not establish a unique positional isomer here. Source location `PubMed abstract, purified kinase substrate/product results`
DDP1 Scer `SGD:S000005689`	enables	diphosphoinositol pentakisphosphate + H₂O -> phytate + phosphate `gomodel:RXN3O-785`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-785 RO:0002333 gomodel:YOR163W-MONOMER_RXN3O-785_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/23; endpoint types: /individuals/61/type; /individuals/65/type`
ATP + 1-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-9819`	has_output Corrected the Kcs1-specific IP7/IP8 isomers.	1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate(13-) `CHEBI:77983`	UniProtKB:Q12494 Source assertion: Kcs1 RHEA:37467 adds the 5-position diphosphate to 1-IP7 (CHEBI:74946), producing 1,5-IP8 (CHEBI:77983). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3127/comments/2`
ARG82 Scer `SGD:S000002580`	enables	D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.127-RXN`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.127-RXN RO:0002333 gomodel:MONOMER3O-64_2.7.1.127-RXN_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/26; endpoint types: /individuals/166/type; /individuals/50/type`
ATP + D-myo-inositol 1,3,4,5,6-pentakisphosphate -> a diphospho-1D-myo-inositol tetrakisphosphate + ADP `gomodel:RXN-4941`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-4941 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/27; endpoint types: /individuals/55/type; /individuals/170/type`
ARG82 Scer `SGD:S000002580`	enables	ATP + D-myo-inositol 1,3,4,5,6-pentakisphosphate -> a diphospho-1D-myo-inositol tetrakisphosphate + ADP `gomodel:RXN-4941`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-4941 RO:0002333 gomodel:MONOMER3O-64_RXN-4941_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/28; endpoint types: /individuals/55/type; /individuals/52/type`
ATP + inositol hexakisphosphate -> ADP + 1-IP7 `gomodel:RXN3O-258`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-258 RO:0002233 gomodel:CHEBI_30616_RXN3O-258. Source location `./YeastPathways_PWY3O-402.json#/facts/29; endpoint types: /individuals/60/type; /individuals/24/type`
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O -> a 1,2-diacyl-sn-glycerol + D-myo-inositol (1,4,5)-trisphosphate + H⁺ `gomodel:3.1.4.11-RXN`	has_output	1D-myo-inositol 1,4,5-trisphosphate(6-) `CHEBI:203600`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:3.1.4.11-RXN RO:0002234 gomodel:CHEBI_203600_3.1.4.11-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/30; endpoint types: /individuals/169/type; /individuals/15/type`
ATP + inositol hexakisphosphate -> ADP + 1-IP7 `gomodel:RXN3O-258`	has_output Corrected experimentally established Vip1 1-position specificity.	1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate(13-) `CHEBI:74946`	UniProtKB:Q06685 Source assertion: Vip1 adds a diphosphate at inositol position 1: RHEA:37459 produces CHEBI:74946 from inositol hexakisphosphate. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2794/comments/1` PMID:32303658 Source assertion: Crystallography of the Saccharomyces cerevisiae Vip1 kinase product establishes 1-IP7; the old 4/6-IP7 assignment is incorrect. Source location `https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7196807/fullTextXML [sha256:3e4daf11de27f7571fd524187c26585c63365169c80143be547437354180a0c9] //sec[@id='s3']/p`
D-myo-inositol (1,3,4,5)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7184`	has_input	1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-) `CHEBI:57895`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7184 RO:0002233 gomodel:CHEBI_57895_2.7.1.127-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/32; endpoint types: /individuals/58/type; /individuals/42/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,4,5,6)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.151-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.151-RXN RO:0002233 gomodel:CHEBI_30616_2.7.1.151-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/33; endpoint types: /individuals/167/type; /individuals/17/type`
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O -> a 1,2-diacyl-sn-glycerol + D-myo-inositol (1,4,5)-trisphosphate + H⁺ `gomodel:3.1.4.11-RXN`	has_input	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate `CHEBI:18348`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:3.1.4.11-RXN RO:0002233 gomodel:CHEBI_18348_3.1.4.11-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/34; endpoint types: /individuals/169/type; /individuals/14/type`
ARG82 Scer `SGD:S000002580`	enables	D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,4,5,6)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.151-RXN`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.151-RXN RO:0002333 gomodel:MONOMER3O-64_2.7.1.151-RXN_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/35; endpoint types: /individuals/167/type; /individuals/51/type`
ATP + 1-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-9819`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-9819 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/36; endpoint types: /individuals/63/type; /individuals/170/type`
D-myo-inositol (1,3,4,5)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7184`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7184 RO:0002234 gomodel:CHEBI_456216_RXN-7184. Source location `./YeastPathways_PWY3O-402.json#/facts/37; endpoint types: /individuals/58/type; /individuals/34/type`
ATP + 5-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-143`	has_input	5-diphospho-1D-myo-inositol pentakisphosphate(13-) `CHEBI:58628`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-143 RO:0002233 gomodel:CHEBI_58628_2.7.1.152-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/38; endpoint types: /individuals/59/type; /individuals/45/type`
[PP]₂-IP₄ + H₂O -> diphosphoinositol pentakisphosphate + phosphate `gomodel:RXN3O-786`	has_input Retained supported generic DDP1 substrates and products without imposing unsupported pyrophosphate positions.	1D-myo-inositol bis(diphosphate) tetrakisphosphate `CHEBI:14178`	UniProtKB:Q99321 Source assertion: DDP1 hydrolyzes beta-phosphates from diphosphoinositol pentakisphosphate and bis(diphosphoinositol) tetrakisphosphate. This assertion does not identify a positional isomer. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3200/comments/0`
ATP + D-myo-inositol 1,3,4,5,6-pentakisphosphate -> a diphospho-1D-myo-inositol tetrakisphosphate + ADP `gomodel:RXN-4941`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-4941 RO:0002233 gomodel:CHEBI_30616_RXN-4941. Source location `./YeastPathways_PWY3O-402.json#/facts/40; endpoint types: /individuals/55/type; /individuals/19/type`
D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP -> phytate + ADP + H⁺ `gomodel:RXN-7163`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7163 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/41; endpoint types: /individuals/57/type; /individuals/170/type`
D-myo-inositol (1,3,4,5)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7184`	has_output	myo-inositol 1,3,4,5,6-pentakisphosphate `CHEBI:16322`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7184 RO:0002234 gomodel:CHEBI_16322_RXN-7184. Source location `./YeastPathways_PWY3O-402.json#/facts/42; endpoint types: /individuals/58/type; /individuals/12/type`
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O -> a 1,2-diacyl-sn-glycerol + D-myo-inositol (1,4,5)-trisphosphate + H⁺ `gomodel:3.1.4.11-RXN`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:3.1.4.11-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/43; endpoint types: /individuals/169/type; /individuals/170/type`
D-myo-inositol (1,3,4,5)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7184`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7184 RO:0002233 gomodel:CHEBI_30616_RXN-7184. Source location `./YeastPathways_PWY3O-402.json#/facts/44; endpoint types: /individuals/58/type; /individuals/22/type`
D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP -> phytate + ADP + H⁺ `gomodel:RXN-7163`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7163 RO:0002233 gomodel:CHEBI_30616_RXN-7163. Source location `./YeastPathways_PWY3O-402.json#/facts/45; endpoint types: /individuals/57/type; /individuals/21/type`
ATP + D-myo-inositol 1,3,4,5,6-pentakisphosphate -> a diphospho-1D-myo-inositol tetrakisphosphate + ADP `gomodel:RXN-4941`	has_output Preserved the independently existing native generic PP-InsP4 entity; its former CHEBI:14178 type has two diphosphates and is incorrect.	a diphospho-1D-myo-inositol tetrakisphosphate `gomodel:CHEBI_14178_RXN-4941`	PMID:11311242 Source assertion: Purified Arg82 phosphorylates IP5 to two PP-InsP4 isomers: one diphosphate plus four monophosphates, not bis(diphosphate) InsP4. Source location `PubMed abstract, purified kinase substrate/product results`
PLC1 Scer `SGD:S000006189`	enables	a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O -> a 1,2-diacyl-sn-glycerol + D-myo-inositol (1,4,5)-trisphosphate + H⁺ `gomodel:3.1.4.11-RXN`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:3.1.4.11-RXN RO:0002333 gomodel:YPL268W-MONOMER_3.1.4.11-RXN_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/47; endpoint types: /individuals/169/type; /individuals/67/type`
ATP + inositol hexakisphosphate -> ADP + 5-IP7 `gomodel:2.7.1.152-RXN`	has_input	myo-inositol hexakisphosphate(12-) `CHEBI:58130`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.152-RXN RO:0002233 gomodel:CHEBI_58130_RXN-7163. Source location `./YeastPathways_PWY3O-402.json#/facts/48; endpoint types: /individuals/168/type; /individuals/43/type`
diphosphoinositol pentakisphosphate + H₂O -> phytate + phosphate `gomodel:RXN3O-785`	has_input Retained supported generic DDP1 substrates and products without imposing unsupported pyrophosphate positions.	diphosphoinositol pentakisphosphate `gomodel:CHEBI_62919_RXN3O-786`	UniProtKB:Q99321 Source assertion: DDP1 hydrolyzes beta-phosphates from diphosphoinositol pentakisphosphate and bis(diphosphoinositol) tetrakisphosphate. This assertion does not identify a positional isomer. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3200/comments/0`
D-myo-inositol (1,3,4,5)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7184`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7184 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/50; endpoint types: /individuals/58/type; /individuals/170/type`
diphosphoinositol pentakisphosphate + H₂O -> phytate + phosphate `gomodel:RXN3O-785`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-785 RO:0002233 gomodel:CHEBI_15377_RXN3O-785. Source location `./YeastPathways_PWY3O-402.json#/facts/51; endpoint types: /individuals/61/type; /individuals/2/type`
D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP -> phytate + ADP + H⁺ `gomodel:RXN-7163`	has_input	myo-inositol 1,3,4,5,6-pentakisphosphate `CHEBI:16322`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7163 RO:0002233 gomodel:CHEBI_16322_RXN-7184. Source location `./YeastPathways_PWY3O-402.json#/facts/54; endpoint types: /individuals/57/type; /individuals/12/type`
ATP + 1-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-9819`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-9819 RO:0002233 gomodel:CHEBI_30616_RXN3O-9819. Source location `./YeastPathways_PWY3O-402.json#/facts/55; endpoint types: /individuals/63/type; /individuals/25/type`
inositol pentakisphosphate kinase activity `gomodel:YeastPathways_PWY3O-402/6a4c244800000690`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 RO:0002233 gomodel:YeastPathways_PWY3O-402/6a4c244800000691. Source location `./YeastPathways_PWY3O-402.json#/facts/56; endpoint types: /individuals/171/type; /individuals/172/type`
ATP + inositol hexakisphosphate -> ADP + 1-IP7 `gomodel:RXN3O-258`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-258 RO:0002234 gomodel:CHEBI_456216_RXN3O-258. Source location `./YeastPathways_PWY3O-402.json#/facts/57; endpoint types: /individuals/60/type; /individuals/36/type`
ATP + inositol hexakisphosphate -> ADP + 5-IP7 `gomodel:2.7.1.152-RXN`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.152-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/58; endpoint types: /individuals/168/type; /individuals/170/type`
D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP -> phytate + ADP + H⁺ `gomodel:RXN-7163`	has_output	myo-inositol hexakisphosphate(12-) `CHEBI:58130`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7163 RO:0002234 gomodel:CHEBI_58130_RXN-7163. Source location `./YeastPathways_PWY3O-402.json#/facts/59; endpoint types: /individuals/57/type; /individuals/43/type`
D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP -> phytate + ADP + H⁺ `gomodel:RXN-7163`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7163 RO:0002234 gomodel:CHEBI_15378_RXN-7163. Source location `./YeastPathways_PWY3O-402.json#/facts/60; endpoint types: /individuals/57/type; /individuals/9/type`
[PP]₂-IP₄ + H₂O -> diphosphoinositol pentakisphosphate + phosphate `gomodel:RXN3O-786`	has_output Retained supported generic DDP1 substrates and products without imposing unsupported pyrophosphate positions.	diphosphoinositol pentakisphosphate `gomodel:CHEBI_62919_RXN3O-786`	UniProtKB:Q99321 Source assertion: DDP1 hydrolyzes beta-phosphates from diphosphoinositol pentakisphosphate and bis(diphosphoinositol) tetrakisphosphate. This assertion does not identify a positional isomer. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3200/comments/0`
D-myo-inositol (1,3,4,5)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7184`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7184 RO:0002234 gomodel:CHEBI_15378_RXN-7184. Source location `./YeastPathways_PWY3O-402.json#/facts/62; endpoint types: /individuals/58/type; /individuals/10/type`
[PP]₂-IP₄ + H₂O -> diphosphoinositol pentakisphosphate + phosphate `gomodel:RXN3O-786`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-786 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/63; endpoint types: /individuals/62/type; /individuals/170/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.127-RXN`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.127-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/64; endpoint types: /individuals/166/type; /individuals/170/type`
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O -> a 1,2-diacyl-sn-glycerol + D-myo-inositol (1,4,5)-trisphosphate + H⁺ `gomodel:3.1.4.11-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:3.1.4.11-RXN RO:0002233 gomodel:CHEBI_15377_3.1.4.11-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/65; endpoint types: /individuals/169/type; /individuals/1/type`
ATP + 1-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-9819`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-9819 RO:0002234 gomodel:CHEBI_456216_RXN3O-9819. Source location `./YeastPathways_PWY3O-402.json#/facts/66; endpoint types: /individuals/63/type; /individuals/37/type`
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O -> a 1,2-diacyl-sn-glycerol + D-myo-inositol (1,4,5)-trisphosphate + H⁺ `gomodel:3.1.4.11-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:3.1.4.11-RXN RO:0002234 gomodel:CHEBI_15378_3.1.4.11-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/67; endpoint types: /individuals/169/type; /individuals/7/type`
VIP1 Scer `SGD:S000004402`	enables	ATP + 5-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-143`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-143 RO:0002333 gomodel:MONOMER3O-224_RXN3O-143_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/68; endpoint types: /individuals/59/type; /individuals/48/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,4,5,6)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.151-RXN`	has_input	1D-myo-inositol 1,4,5-trisphosphate(6-) `CHEBI:203600`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.151-RXN RO:0002233 gomodel:CHEBI_203600_3.1.4.11-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/69; endpoint types: /individuals/167/type; /individuals/15/type`
ATP + inositol hexakisphosphate -> ADP + 5-IP7 `gomodel:2.7.1.152-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.152-RXN BFO:0000066 gomodel:reaction_2.7.1.152-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-402.json#/facts/70; endpoint types: /individuals/168/type; /individuals/155/type`
ATP + inositol hexakisphosphate -> ADP + 5-IP7 `gomodel:2.7.1.152-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.152-RXN RO:0002233 gomodel:CHEBI_30616_2.7.1.152-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/71; endpoint types: /individuals/168/type; /individuals/18/type`
VIP1 Scer `SGD:S000004402`	enables	ATP + inositol hexakisphosphate -> ADP + 1-IP7 `gomodel:RXN3O-258`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-258 RO:0002333 gomodel:MONOMER3O-224_RXN3O-258_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/72; endpoint types: /individuals/60/type; /individuals/49/type`
diphosphoinositol pentakisphosphate + H₂O -> phytate + phosphate `gomodel:RXN3O-785`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-785 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/73; endpoint types: /individuals/61/type; /individuals/170/type`
ARG82 Scer `SGD:S000002580`	enables	D-myo-inositol (1,3,4,5)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7184`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7184 RO:0002333 gomodel:MONOMER3O-64_RXN-7184_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/74; endpoint types: /individuals/58/type; /individuals/54/type`
ATP + inositol hexakisphosphate -> ADP + 5-IP7 `gomodel:2.7.1.152-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.152-RXN RO:0002234 gomodel:CHEBI_456216_2.7.1.152-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/75; endpoint types: /individuals/168/type; /individuals/30/type`
diphosphoinositol pentakisphosphate + H₂O -> phytate + phosphate `gomodel:RXN3O-785`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-785 BFO:0000066 gomodel:reaction_RXN3O-785_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-402.json#/facts/76; endpoint types: /individuals/61/type; /individuals/163/type`
a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H₂O -> a 1,2-diacyl-sn-glycerol + D-myo-inositol (1,4,5)-trisphosphate + H⁺ `gomodel:3.1.4.11-RXN`	has_output	1,2-diacyl-sn-glycerol `CHEBI:17815`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:3.1.4.11-RXN RO:0002234 gomodel:CHEBI_17815_3.1.4.11-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/77; endpoint types: /individuals/169/type; /individuals/13/type`
diphosphoinositol pentakisphosphate + H₂O -> phytate + phosphate `gomodel:RXN3O-785`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-785 RO:0002234 gomodel:CHEBI_43474_RXN3O-785. Source location `./YeastPathways_PWY3O-402.json#/facts/79; endpoint types: /individuals/61/type; /individuals/26/type`
inositol pentakisphosphate kinase activity `gomodel:YeastPathways_PWY3O-402/6a4c244800000690`	has_input	myo-inositol 1,3,4,5,6-pentakisphosphate `CHEBI:16322`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 RO:0002233 gomodel:CHEBI_16322_RXN-7184. Source location `./YeastPathways_PWY3O-402.json#/facts/80; endpoint types: /individuals/171/type; /individuals/12/type`
inositol pentakisphosphate kinase activity `gomodel:YeastPathways_PWY3O-402/6a4c244800000690`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 RO:0002234 gomodel:YeastPathways_PWY3O-402/6a4c244800000692. Source location `./YeastPathways_PWY3O-402.json#/facts/81; endpoint types: /individuals/171/type; /individuals/173/type`
inositol pentakisphosphate kinase activity `gomodel:YeastPathways_PWY3O-402/6a4c244800000690`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/82; endpoint types: /individuals/171/type; /individuals/170/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,4,5,6)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.151-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.151-RXN RO:0002234 gomodel:CHEBI_456216_2.7.1.151-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/83; endpoint types: /individuals/167/type; /individuals/29/type`
ARG82 Scer `SGD:S000002580`	enables	D-myo-inositol (1,4,5,6)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7162`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7162 RO:0002333 gomodel:MONOMER3O-64_RXN-7162_controller. Source location `./YeastPathways_PWY3O-402.json#/facts/85; endpoint types: /individuals/56/type; /individuals/53/type`
ATP + 5-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-143`	part_of	inositol phosphate biosynthetic process `GO:0032958`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-143 BFO:0000050 gomodel:YeastPathways_PWY3O-402/YeastPathways_PWY3O-402. Source location `./YeastPathways_PWY3O-402.json#/facts/86; endpoint types: /individuals/59/type; /individuals/170/type`
ATP + 5-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-143`	has_output Corrected 1,5-bis(diphosphate) positions; the former 5,6 isomer is unsupported.	1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate(13-) `CHEBI:77983`	UniProtKB:Q06685 Source assertion: Vip1 RHEA:10276 phosphorylates 5-IP7 to 1,5-IP8 (CHEBI:77983), consuming ATP and a proton. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2794/comments/2`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,3,4,5)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.127-RXN`	has_output	1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-) `CHEBI:57895`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.127-RXN RO:0002234 gomodel:CHEBI_57895_2.7.1.127-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/89; endpoint types: /individuals/166/type; /individuals/42/type`
inositol pentakisphosphate kinase activity `gomodel:YeastPathways_PWY3O-402/6a4c244800000690`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 BFO:0000066 gomodel:YeastPathways_PWY3O-402/6a4c244800000696. Source location `./YeastPathways_PWY3O-402.json#/facts/90; endpoint types: /individuals/171/type; /individuals/176/type`
D-myo-inositol (1,4,5,6)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7162`	has_output	myo-inositol 1,3,4,5,6-pentakisphosphate `CHEBI:16322`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7162 RO:0002234 gomodel:CHEBI_16322_RXN-7162. Source location `./YeastPathways_PWY3O-402.json#/facts/91; endpoint types: /individuals/56/type; /individuals/11/type`
D-myo-inositol (1,4,5,6)-tetrakisphosphate + ATP -> D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H⁺ `gomodel:RXN-7162`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-7162 RO:0002233 gomodel:CHEBI_30616_RXN-7162. Source location `./YeastPathways_PWY3O-402.json#/facts/92; endpoint types: /individuals/56/type; /individuals/20/type`
ATP + inositol hexakisphosphate -> ADP + 5-IP7 `gomodel:2.7.1.152-RXN`	has_output	5-diphospho-1D-myo-inositol pentakisphosphate(13-) `CHEBI:58628`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.152-RXN RO:0002234 gomodel:CHEBI_58628_2.7.1.152-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/94; endpoint types: /individuals/168/type; /individuals/45/type`
ATP + 5-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-143`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-143 RO:0002233 gomodel:CHEBI_30616_RXN3O-143. Source location `./YeastPathways_PWY3O-402.json#/facts/95; endpoint types: /individuals/59/type; /individuals/23/type`
D-myo-inositol (1,4,5)-trisphosphate + ATP -> D-myo-inositol (1,4,5,6)-tetrakisphosphate + ADP + H⁺ `gomodel:2.7.1.151-RXN`	has_output	1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-) `CHEBI:57627`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:2.7.1.151-RXN RO:0002234 gomodel:CHEBI_57627_2.7.1.151-RXN. Source location `./YeastPathways_PWY3O-402.json#/facts/96; endpoint types: /individuals/167/type; /individuals/41/type`
[PP]₂-IP₄ + H₂O -> diphosphoinositol pentakisphosphate + phosphate `gomodel:RXN3O-786`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-786 RO:0002234 gomodel:CHEBI_43474_RXN3O-786. Source location `./YeastPathways_PWY3O-402.json#/facts/97; endpoint types: /individuals/62/type; /individuals/27/type`
ATP + 1-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-9819`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-9819 BFO:0000066 gomodel:reaction_RXN3O-9819_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-402.json#/facts/98; endpoint types: /individuals/63/type; /individuals/165/type`
ATP + D-myo-inositol 1,3,4,5,6-pentakisphosphate -> a diphospho-1D-myo-inositol tetrakisphosphate + ADP `gomodel:RXN-4941`	has_input	myo-inositol 1,3,4,5,6-pentakisphosphate `CHEBI:16322`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN-4941 RO:0002233 gomodel:CHEBI_16322_RXN-7184. Source location `./YeastPathways_PWY3O-402.json#/facts/99; endpoint types: /individuals/55/type; /individuals/12/type`
ATP + 5-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-143`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-143 RO:0002234 gomodel:CHEBI_456216_RXN3O-143. Source location `./YeastPathways_PWY3O-402.json#/facts/100; endpoint types: /individuals/59/type; /individuals/35/type`
ATP + 5-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-143`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-143 BFO:0000066 gomodel:reaction_RXN3O-143_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-402.json#/facts/101; endpoint types: /individuals/59/type; /individuals/161/type`
diphosphoinositol pentakisphosphate + H₂O -> phytate + phosphate `gomodel:RXN3O-785`	has_output	myo-inositol hexakisphosphate(12-) `CHEBI:58130`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-785 RO:0002234 gomodel:CHEBI_58130_RXN3O-785. Source location `./YeastPathways_PWY3O-402.json#/facts/102; endpoint types: /individuals/61/type; /individuals/44/type`
KCS1 Scer `SGD:S000002424`	enables	inositol pentakisphosphate kinase activity `gomodel:YeastPathways_PWY3O-402/6a4c244800000690`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-402/6a4c244800000690 RO:0002333 gomodel:YeastPathways_PWY3O-402/6a4c244800000695. Source location `./YeastPathways_PWY3O-402.json#/facts/103; endpoint types: /individuals/171/type; /individuals/175/type`
ATP + inositol hexakisphosphate -> ADP + 1-IP7 `gomodel:RXN3O-258`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-402 Source assertion: The model asserts gomodel:RXN3O-258 BFO:0000066 gomodel:reaction_RXN3O-258_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-402.json#/facts/104; endpoint types: /individuals/60/type; /individuals/162/type`
KCS1 Scer `SGD:S000002424`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:Q12494 Source assertion: UniProtKB:Q12494 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3127/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q12494 Source assertion: UniProtKB:Q12494 has the exact SGD cross-reference SGD:S000002424. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
IPK1 Scer `SGD:S000002723`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10390371)	nucleus `GO:0005634`	UniProtKB:Q06667 Source assertion: UniProtKB:Q06667 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4206/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q06667 Source assertion: UniProtKB:Q06667 has the exact SGD cross-reference SGD:S000002723. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/4206/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
DDP1 Scer `SGD:S000005689`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:Q99321 Source assertion: UniProtKB:Q99321 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3200/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q99321 Source assertion: UniProtKB:Q99321 has the exact SGD cross-reference SGD:S000005689. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3200/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
DDP1 Scer `SGD:S000005689`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:Q99321 Source assertion: UniProtKB:Q99321 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3200/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q99321 Source assertion: UniProtKB:Q99321 has the exact SGD cross-reference SGD:S000005689. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3200/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARG82 Scer `SGD:S000002580`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10632874); ECO:0000269 (PubMed:16123124); ECO:0000269 (PubMed:3311884)	nucleus `GO:0005634`	UniProtKB:P07250 Source assertion: UniProtKB:P07250 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/164/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07250 Source assertion: UniProtKB:P07250 has the exact SGD cross-reference SGD:S000002580. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/164/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
VIP1 Scer `SGD:S000004402`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:Q06685 Source assertion: UniProtKB:Q06685 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2794/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q06685 Source assertion: UniProtKB:Q06685 has the exact SGD cross-reference SGD:S000004402. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2794/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
VIP1 Scer `SGD:S000004402`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoskeleton `GO:0005856`	UniProtKB:Q06685 Source assertion: UniProtKB:Q06685 annotates location Cytoplasm, cytoskeleton (SL-0090). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2794/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q06685 Source assertion: UniProtKB:Q06685 has the exact SGD cross-reference SGD:S000004402. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2794/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ATP + 5-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-143`	has_input	hydron `CHEBI:15378`	UniProtKB:Q06685 Source assertion: Vip1 RHEA:10276 phosphorylates 5-IP7 to 1,5-IP8 (CHEBI:77983), consuming ATP and a proton. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2794/comments/2`
ATP + 1-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-9819`	has_input	hydron `CHEBI:15378`	UniProtKB:Q12494 Source assertion: Kcs1 RHEA:37467 adds the 5-position diphosphate to 1-IP7 (CHEBI:74946), producing 1,5-IP8 (CHEBI:77983). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3127/comments/2`
KCS1 Scer `SGD:S000002424`	enables	ATP + 1-IP7 + H(+) -> ADP + 1,5-IP8 `gomodel:RXN3O-9819`	UniProtKB:Q12494 Source assertion: Kcs1 RHEA:37467 adds the 5-position diphosphate to 1-IP7 (CHEBI:74946), producing 1,5-IP8 (CHEBI:77983). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/3127/comments/2`
VIP1 Scer `SGD:S000004402`	enables In-vitro recombinant pyrophosphatase-domain activity; no cellular flux or S. pombe phenotype is projected onto S. cerevisiae.	1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + phosphate + H(+) `RHEA:79724`	PMID:32303658 Source assertion: The recombinant S. cerevisiae Vip1 pyrophosphatase domain hydrolyzes 1-IP7 but not 3-IP7 in vitro. This is domain-assay evidence, not an assertion of physiological flux. Source location `https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7196807/fullTextXML [sha256:3e4daf11de27f7571fd524187c26585c63365169c80143be547437354180a0c9] //sec[@id='s5']/p[2]; //sec[@id='s5']/p[3]; //fig[@id='fig03']; Table 2`
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + phosphate + H(+) `RHEA:79724`	has_input	1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate(13-) `CHEBI:74946`	RHEA:79724 Source assertion: RHEA:79724 hydrolyzes 1-IP7 and water to inositol hexakisphosphate, phosphate and a proton. Source location `Rhea release 139 RDF: 79724 side 79723_L; contains/compound/accession CHEBI:74946`
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + phosphate + H(+) `RHEA:79724`	has_input	water `CHEBI:15377`	RHEA:79724 Source assertion: RHEA:79724 hydrolyzes 1-IP7 and water to inositol hexakisphosphate, phosphate and a proton. Source location `Rhea release 139 RDF: 79724 side 79723_L; contains/compound/accession CHEBI:15377`
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + phosphate + H(+) `RHEA:79724`	has_output	myo-inositol hexakisphosphate(12-) `CHEBI:58130`	RHEA:79724 Source assertion: RHEA:79724 hydrolyzes 1-IP7 and water to inositol hexakisphosphate, phosphate and a proton. Source location `Rhea release 139 RDF: 79724 side 79723_R; contains/compound/accession CHEBI:58130`
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + phosphate + H(+) `RHEA:79724`	has_output	hydrogenphosphate `CHEBI:43474`	RHEA:79724 Source assertion: RHEA:79724 hydrolyzes 1-IP7 and water to inositol hexakisphosphate, phosphate and a proton. Source location `Rhea release 139 RDF: 79724 side 79723_R; contains/compound/accession CHEBI:43474`
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + phosphate + H(+) `RHEA:79724`	has_output	hydron `CHEBI:15378`	RHEA:79724 Source assertion: RHEA:79724 hydrolyzes 1-IP7 and water to inositol hexakisphosphate, phosphate and a proton. Source location `Rhea release 139 RDF: 79724 side 79723_R; contains/compound/accession CHEBI:15378`
DDP1 Scer `SGD:S000005689`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10085096); ECO:0000269 (PubMed:31175919); ECO:0000269 (PubMed:33893105) Binds 3 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:O95989); ECO:0000305 (PubMed:33893105)	magnesium(2+) `CHEBI:18420`	UniProtKB:Q99321 Source assertion: UniProtKB:Q99321 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/comments/0/cofactors/0; /results/3200/comments/0/note` UniProtKB:Q99321 Source assertion: UniProtKB:Q99321 has the exact SGD cross-reference SGD:S000005689. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/uniProtKBCrossReferences/0`
DDP1 Scer `SGD:S000005689`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10085096) Binds 3 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:O95989); ECO:0000305 (PubMed:33893105)	manganese(2+) `CHEBI:29035`	UniProtKB:Q99321 Source assertion: UniProtKB:Q99321 annotates CHEBI:29035 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/comments/0/cofactors/1; /results/3200/comments/0/note` UniProtKB:Q99321 Source assertion: UniProtKB:Q99321 has the exact SGD cross-reference SGD:S000005689. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/uniProtKBCrossReferences/0`
DDP1 Scer `SGD:S000005689`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:31175919) Binds 3 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:O95989); ECO:0000305 (PubMed:33893105)	zinc(2+) `CHEBI:29105`	UniProtKB:Q99321 Source assertion: UniProtKB:Q99321 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/comments/0/cofactors/2; /results/3200/comments/0/note` UniProtKB:Q99321 Source assertion: UniProtKB:Q99321 has the exact SGD cross-reference SGD:S000005689. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3200/uniProtKBCrossReferences/0`
PLC1 Scer `SGD:S000006189`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:8395015)	calcium(2+) `CHEBI:29108`	UniProtKB:P32383 Source assertion: UniProtKB:P32383 annotates CHEBI:29108 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/898/comments/0/cofactors/0` UniProtKB:P32383 Source assertion: UniProtKB:P32383 has the exact SGD cross-reference SGD:S000006189. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/898/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY3O-402 SGD GO-CAM lower-level Noctua edge JSON for inositol phosphate biosynthesis - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_PWY3O-402.json)
UniProtKB:Q12494 Reviewed UniProtKB Q12494 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q06667 Reviewed UniProtKB Q06667 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q99321 Reviewed UniProtKB Q99321 location annotations (source version: UniProt release 2026_03)
UniProtKB:P07250 Reviewed UniProtKB P07250 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q06685 Reviewed UniProtKB Q06685 location annotations (source version: UniProt release 2026_03)
PMID:32303658 Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling
PMID:11311242 The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activity
PMID:10827188 The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis
RHEA:79724 Rhea 1-IP7 hydrolysis reaction (source version: 139)
UniProtKB:P32383 UniProtKB P32383 cofactor annotations (source version: 2026_03)
PMID:17050532 Crystal Structure of Inositol Phosphate Multikinase 2 and Implications for Substrate Specificity

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T19:29:52Z Codex; adversarial-scientific-correction; Excluded ARG82 calcium cofactor assertion after primary PMID:17050532 crystal-contact review. Retained the original assertion in the scientific correction ledger and the independently supported PLC1 calcium relation. No replacement metal is inferred.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 14 activity location assignments and 6 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 7 independently supported location edges and quarantined 6 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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2026-10-05T07:03:09Z Codex
- EDIT — Correct inositol phosphate regioisomers and preserve experimentally bounded activities
  Reviewed all14 original activities against UniProt2026_03,Rhea139,and primary studies11311242,10827188,32303658. Corrected Vip1/Kcs1 1-IP7 and1,5-IP8 identities; restored Kcs1 enabler and charged-reaction protons; preserved native generic PP-InsP4 products instead of incorrect bisdiphosphate ChEBI and kept DDP1 regioselectivity unspecified. Rejected misleading CHEBI187038 label because its source structure is hexakisphosphate. Added qualified recombinant S.cerevisiae Vip1 domain1-IP7 hydrolysis RHEA79724 from primary Fig3A,Table2; no physiological flux or S.pombe phenotype inferred. Full edge exclusions and source evidence in reports/causal_graph_review/folate-inositol-chemistry-review.json. Semantic validation and six independent chemistry tests passed.
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2026-10-05T19:31:18Z Codex
- EDIT — Excluded ARG82 calcium cofactor assertion after primary PMID:17050532 crystal-contact review. Retained the original assertion in the scientific correction ledger and the independently supported PLC1 calcium relation. No replacement metal is inferred.
  Excluded ARG82 calcium cofactor assertion after primary PMID:17050532 crystal-contact review. Retained the original assertion in the scientific correction ledger and the independently supported PLC1 calcium relation. No replacement metal is inferred. Original source assertions and review scope are preserved in reports/causal_graph_review/adversarial-scientific-corrections.json. Validated the changed record against the closed schema and added focused regression checks; repository-wide validation and generated artifacts are handled in the integration step.
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