valine degradation

gomodel:YeastPathways_PWY3O-4105

Valine degradation in Saccharomyces cerevisiae S288C transaminates L-valine to 3-methyl-2-oxobutanoate, decarboxylates 3-methyl-2-oxobutanoate to isobutyraldehyde, and reduces isobutyraldehyde with NADH to isobutanol.

Pathway type

amino acid degradation

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

43 nodes · 125 asserted directed edges

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
carbon dioxide `CHEBI:16526`	small molecule
L-valine catabolic process `GO:0006574`	biological process
isobutyraldehyde `CHEBI:48943`	small molecule
3-methyl-2-oxobutanoate `CHEBI:11851`	lipid
ADH2 Scer `SGD:S000004918`	protein
cytosol `GO:0005829`	cellular component
isobutanol `CHEBI:46645`	small molecule
PDC1 Scer `SGD:S000004034`	protein
BAT1 Scer `SGD:S000001251`	protein
NADH(2-) `CHEBI:57945`	small molecule
L-glutamate(1-) `CHEBI:29985`	small molecule
ADH5 Scer `SGD:S000000349`	protein
2-oxoglutarate(2-) `CHEBI:16810`	small molecule
PDC6 Scer `SGD:S000003319`	protein
NAD(1-) `CHEBI:57540`	small molecule
ADH1 Scer `SGD:S000005446`	protein
ADH4 Scer `SGD:S000003225`	protein
L-valine zwitterion `CHEBI:57762`	small molecule
SFA1 Scer `SGD:S000002327`	protein
ADH3 Scer `SGD:S000004688`	protein
BAT2 Scer `SGD:S000003909`	protein
PDC5 Scer `SGD:S000004124`	protein
cytoplasm `GO:0005737`	cellular component
nucleus `GO:0005634`	cellular component
mitochondrial matrix `GO:0005759`	cellular component
mitochondrion `GO:0005739`	cellular component
mitochondrial inner membrane `GO:0005743`	cellular component
zinc(2+) `CHEBI:29105`	cofactor
magnesium(2+) `CHEBI:18420`	cofactor
thiamine(1+) diphosphate(3-) `CHEBI:58937`	cofactor
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
iron(2+) `CHEBI:29033`	cofactor
L-valine + 2-oxoglutarate <=> L-glutamate + 3-methyl-2-oxobutanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN`	molecular activity
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	molecular activity
isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	molecular activity
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	molecular activity
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	molecular activity
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003163`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003183`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003202. Source location `./YeastPathways_PWY3O-4105.json#/facts/0; endpoint types: /individuals/50/type; /individuals/124/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003113. Source location `./YeastPathways_PWY3O-4105.json#/facts/1; endpoint types: /individuals/50/type; /individuals/51/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003142. Source location `./YeastPathways_PWY3O-4105.json#/facts/2; endpoint types: /individuals/10/type; /individuals/76/type`
L-valine + 2-oxoglutarate <=> L-glutamate + 3-methyl-2-oxobutanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN`	provides_input_for	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003112. Source location `./YeastPathways_PWY3O-4105.json#/facts/3; endpoint types: /individuals/0/type; /individuals/50/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	provides_input_for	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003112. Source location `./YeastPathways_PWY3O-4105.json#/facts/4; endpoint types: /individuals/36/type; /individuals/50/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003163`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/5; endpoint types: /individuals/92/type; /individuals/33/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003163`	has_input	isobutyraldehyde `CHEBI:48943`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/6; endpoint types: /individuals/92/type; /individuals/6/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/7; endpoint types: /individuals/124/type; /individuals/33/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003125. Source location `./YeastPathways_PWY3O-4105.json#/facts/8; endpoint types: /individuals/60/type; /individuals/61/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	has_input	isobutyraldehyde `CHEBI:48943`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/9; endpoint types: /individuals/124/type; /individuals/6/type`
L-valine + 2-oxoglutarate <=> L-glutamate + 3-methyl-2-oxobutanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN`	provides_input_for	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003124. Source location `./YeastPathways_PWY3O-4105.json#/facts/10; endpoint types: /individuals/0/type; /individuals/60/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	has_input	3-methyl-2-oxobutanoate `CHEBI:11851`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002233 gomodel:CHEBI_11851_BRANCHED-CHAINAMINOTRANSFERVAL-RXN. Source location `./YeastPathways_PWY3O-4105.json#/facts/11; endpoint types: /individuals/50/type; /individuals/1/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003163`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003163. Source location `./YeastPathways_PWY3O-4105.json#/facts/12; endpoint types: /individuals/50/type; /individuals/92/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	has_output	isobutyraldehyde `CHEBI:48943`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002234 gomodel:CHEBI_48943_RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/13; endpoint types: /individuals/60/type; /individuals/6/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/14; endpoint types: /individuals/76/type; /individuals/33/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	has_input	isobutyraldehyde `CHEBI:48943`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/15; endpoint types: /individuals/76/type; /individuals/6/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/16; endpoint types: /individuals/36/type; /individuals/33/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	has_input	isobutyraldehyde `CHEBI:48943`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/17; endpoint types: /individuals/140/type; /individuals/6/type`
ADH2 Scer `SGD:S000004918`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003146. Source location `./YeastPathways_PWY3O-4105.json#/facts/18; endpoint types: /individuals/76/type; /individuals/80/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003117. Source location `./YeastPathways_PWY3O-4105.json#/facts/19; endpoint types: /individuals/50/type; /individuals/53/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	has_output	3-methyl-2-oxobutanoate `CHEBI:11851`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002234 gomodel:CHEBI_11851_BRANCHED-CHAINAMINOTRANSFERVAL-RXN. Source location `./YeastPathways_PWY3O-4105.json#/facts/20; endpoint types: /individuals/36/type; /individuals/1/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	has_output	isobutyraldehyde `CHEBI:48943`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 RO:0002234 gomodel:CHEBI_48943_RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/21; endpoint types: /individuals/10/type; /individuals/6/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	has_output	isobutanol `CHEBI:46645`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003205. Source location `./YeastPathways_PWY3O-4105.json#/facts/22; endpoint types: /individuals/124/type; /individuals/127/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003183`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003183. Source location `./YeastPathways_PWY3O-4105.json#/facts/23; endpoint types: /individuals/60/type; /individuals/108/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/24; endpoint types: /individuals/60/type; /individuals/33/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	provides_input_for	isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:RXN3O-4141. Source location `./YeastPathways_PWY3O-4105.json#/facts/25; endpoint types: /individuals/10/type; /individuals/11/type`
PDC1 Scer `SGD:S000004034`	enables	3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6690711d00000712. Source location `./YeastPathways_PWY3O-4105.json#/facts/26; endpoint types: /individuals/10/type; /individuals/156/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003142. Source location `./YeastPathways_PWY3O-4105.json#/facts/27; endpoint types: /individuals/60/type; /individuals/76/type`
BAT1 Scer `SGD:S000001251`	enables	L-valine + 2-oxoglutarate <=> L-glutamate + 3-methyl-2-oxobutanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002333 gomodel:YHR208W-MONOMER_BRANCHED-CHAINAMINOTRANSFERVAL-RXN_controller. Source location `./YeastPathways_PWY3O-4105.json#/facts/28; endpoint types: /individuals/0/type; /individuals/12/type`
L-valine + 2-oxoglutarate <=> L-glutamate + 3-methyl-2-oxobutanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/29; endpoint types: /individuals/0/type; /individuals/33/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003163`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003163. Source location `./YeastPathways_PWY3O-4105.json#/facts/30; endpoint types: /individuals/60/type; /individuals/92/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003209. Source location `./YeastPathways_PWY3O-4105.json#/facts/31; endpoint types: /individuals/124/type; /individuals/129/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	provides_input_for	isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:RXN3O-4141. Source location `./YeastPathways_PWY3O-4105.json#/facts/32; endpoint types: /individuals/50/type; /individuals/11/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003183`	has_output	isobutanol `CHEBI:46645`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003186. Source location `./YeastPathways_PWY3O-4105.json#/facts/34; endpoint types: /individuals/108/type; /individuals/111/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003220. Source location `./YeastPathways_PWY3O-4105.json#/facts/35; endpoint types: /individuals/60/type; /individuals/140/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003221. Source location `./YeastPathways_PWY3O-4105.json#/facts/36; endpoint types: /individuals/140/type; /individuals/141/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	has_output	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003100. Source location `./YeastPathways_PWY3O-4105.json#/facts/37; endpoint types: /individuals/36/type; /individuals/39/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003183`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003183. Source location `./YeastPathways_PWY3O-4105.json#/facts/38; endpoint types: /individuals/10/type; /individuals/108/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	has_output	isobutanol `CHEBI:46645`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003145. Source location `./YeastPathways_PWY3O-4105.json#/facts/39; endpoint types: /individuals/76/type; /individuals/79/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 BFO:0000066 gomodel:reaction_RXN3O-4133_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4105.json#/facts/40; endpoint types: /individuals/10/type; /individuals/31/type`
ADH5 Scer `SGD:S000000349`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003207. Source location `./YeastPathways_PWY3O-4105.json#/facts/41; endpoint types: /individuals/124/type; /individuals/128/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003163`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003164. Source location `./YeastPathways_PWY3O-4105.json#/facts/42; endpoint types: /individuals/92/type; /individuals/93/type`
L-valine + 2-oxoglutarate <=> L-glutamate + 3-methyl-2-oxobutanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN`	has_input	2-oxoglutarate(2-) `CHEBI:16810`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002233 gomodel:CHEBI_16810_BRANCHED-CHAINAMINOTRANSFERVAL-RXN. Source location `./YeastPathways_PWY3O-4105.json#/facts/43; endpoint types: /individuals/0/type; /individuals/3/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003183`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003184. Source location `./YeastPathways_PWY3O-4105.json#/facts/44; endpoint types: /individuals/108/type; /individuals/109/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	has_input	2-oxoglutarate(2-) `CHEBI:16810`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003099. Source location `./YeastPathways_PWY3O-4105.json#/facts/45; endpoint types: /individuals/36/type; /individuals/38/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 RO:0002234 gomodel:CHEBI_16526_RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/46; endpoint types: /individuals/10/type; /individuals/2/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	provides_input_for	3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002413 gomodel:RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/47; endpoint types: /individuals/36/type; /individuals/10/type`
isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	has_output	isobutanol `CHEBI:46645`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4141 RO:0002234 gomodel:CHEBI_46645_RXN3O-4141. Source location `./YeastPathways_PWY3O-4105.json#/facts/48; endpoint types: /individuals/11/type; /individuals/5/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	provides_input_for	isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:RXN3O-4141. Source location `./YeastPathways_PWY3O-4105.json#/facts/50; endpoint types: /individuals/60/type; /individuals/11/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003183`	has_input	isobutyraldehyde `CHEBI:48943`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/51; endpoint types: /individuals/108/type; /individuals/6/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003183`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/52; endpoint types: /individuals/108/type; /individuals/33/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	has_output	isobutyraldehyde `CHEBI:48943`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002234 gomodel:CHEBI_48943_RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/53; endpoint types: /individuals/50/type; /individuals/6/type`
PDC6 Scer `SGD:S000003319`	enables	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003115. Source location `./YeastPathways_PWY3O-4105.json#/facts/54; endpoint types: /individuals/50/type; /individuals/52/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003220. Source location `./YeastPathways_PWY3O-4105.json#/facts/55; endpoint types: /individuals/10/type; /individuals/140/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	has_input	3-methyl-2-oxobutanoate `CHEBI:11851`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 RO:0002233 gomodel:CHEBI_11851_BRANCHED-CHAINAMINOTRANSFERVAL-RXN. Source location `./YeastPathways_PWY3O-4105.json#/facts/56; endpoint types: /individuals/10/type; /individuals/1/type`
isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	has_input	isobutyraldehyde `CHEBI:48943`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4141 RO:0002233 gomodel:CHEBI_48943_RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/57; endpoint types: /individuals/11/type; /individuals/6/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003226. Source location `./YeastPathways_PWY3O-4105.json#/facts/58; endpoint types: /individuals/140/type; /individuals/145/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003163`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003165. Source location `./YeastPathways_PWY3O-4105.json#/facts/59; endpoint types: /individuals/92/type; /individuals/94/type`
ADH1 Scer `SGD:S000005446`	enables	isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4141 RO:0002333 gomodel:YOL086C-MONOMER_RXN3O-4141_controller. Source location `./YeastPathways_PWY3O-4105.json#/facts/60; endpoint types: /individuals/11/type; /individuals/13/type`
L-valine + 2-oxoglutarate <=> L-glutamate + 3-methyl-2-oxobutanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN`	has_output	3-methyl-2-oxobutanoate `CHEBI:11851`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002234 gomodel:CHEBI_11851_BRANCHED-CHAINAMINOTRANSFERVAL-RXN. Source location `./YeastPathways_PWY3O-4105.json#/facts/61; endpoint types: /individuals/0/type; /individuals/1/type`
isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4141 BFO:0000066 gomodel:reaction_RXN3O-4141_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4105.json#/facts/62; endpoint types: /individuals/11/type; /individuals/32/type`
isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4141 RO:0002234 gomodel:CHEBI_57540_RXN3O-4141. Source location `./YeastPathways_PWY3O-4105.json#/facts/63; endpoint types: /individuals/11/type; /individuals/7/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003203. Source location `./YeastPathways_PWY3O-4105.json#/facts/64; endpoint types: /individuals/124/type; /individuals/125/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003183`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003185. Source location `./YeastPathways_PWY3O-4105.json#/facts/65; endpoint types: /individuals/108/type; /individuals/110/type`
ADH4 Scer `SGD:S000003225`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003183`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003183 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003188. Source location `./YeastPathways_PWY3O-4105.json#/facts/66; endpoint types: /individuals/108/type; /individuals/112/type`
L-valine + 2-oxoglutarate <=> L-glutamate + 3-methyl-2-oxobutanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN`	has_output	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002234 gomodel:CHEBI_29985_BRANCHED-CHAINAMINOTRANSFERVAL-RXN. Source location `./YeastPathways_PWY3O-4105.json#/facts/67; endpoint types: /individuals/0/type; /individuals/4/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003202. Source location `./YeastPathways_PWY3O-4105.json#/facts/68; endpoint types: /individuals/10/type; /individuals/124/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003143. Source location `./YeastPathways_PWY3O-4105.json#/facts/69; endpoint types: /individuals/76/type; /individuals/77/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003222. Source location `./YeastPathways_PWY3O-4105.json#/facts/70; endpoint types: /individuals/140/type; /individuals/142/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003103. Source location `./YeastPathways_PWY3O-4105.json#/facts/71; endpoint types: /individuals/36/type; /individuals/41/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003163`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003163. Source location `./YeastPathways_PWY3O-4105.json#/facts/72; endpoint types: /individuals/10/type; /individuals/92/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003220. Source location `./YeastPathways_PWY3O-4105.json#/facts/73; endpoint types: /individuals/50/type; /individuals/140/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/74; endpoint types: /individuals/50/type; /individuals/33/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	has_input	3-methyl-2-oxobutanoate `CHEBI:11851`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002233 gomodel:CHEBI_11851_BRANCHED-CHAINAMINOTRANSFERVAL-RXN. Source location `./YeastPathways_PWY3O-4105.json#/facts/75; endpoint types: /individuals/60/type; /individuals/1/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003144. Source location `./YeastPathways_PWY3O-4105.json#/facts/76; endpoint types: /individuals/76/type; /individuals/78/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003142 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003152. Source location `./YeastPathways_PWY3O-4105.json#/facts/77; endpoint types: /individuals/76/type; /individuals/81/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	provides_input_for	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003124. Source location `./YeastPathways_PWY3O-4105.json#/facts/78; endpoint types: /individuals/36/type; /individuals/60/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/79; endpoint types: /individuals/140/type; /individuals/33/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003202 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003204. Source location `./YeastPathways_PWY3O-4105.json#/facts/80; endpoint types: /individuals/124/type; /individuals/126/type`
L-valine + 2-oxoglutarate <=> L-glutamate + 3-methyl-2-oxobutanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN`	has_input	L-valine zwitterion `CHEBI:57762`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002233 gomodel:CHEBI_57762_BRANCHED-CHAINAMINOTRANSFERVAL-RXN. Source location `./YeastPathways_PWY3O-4105.json#/facts/82; endpoint types: /individuals/0/type; /individuals/8/type`
3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4133 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/83; endpoint types: /individuals/10/type; /individuals/33/type`
isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4141 RO:0002233 gomodel:CHEBI_57945_RXN3O-4141. Source location `./YeastPathways_PWY3O-4105.json#/facts/84; endpoint types: /individuals/11/type; /individuals/9/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 BFO:0000066 gomodel:YeastPathways_PWY3O-4105/6a4c244800003129. Source location `./YeastPathways_PWY3O-4105.json#/facts/85; endpoint types: /individuals/60/type; /individuals/63/type`
SFA1 Scer `SGD:S000002327`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003225. Source location `./YeastPathways_PWY3O-4105.json#/facts/86; endpoint types: /individuals/140/type; /individuals/144/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003163`	has_output	isobutanol `CHEBI:46645`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003166. Source location `./YeastPathways_PWY3O-4105.json#/facts/87; endpoint types: /individuals/92/type; /individuals/95/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003142`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003142. Source location `./YeastPathways_PWY3O-4105.json#/facts/88; endpoint types: /individuals/50/type; /individuals/76/type`
ADH3 Scer `SGD:S000004688`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003163`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003163 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003167. Source location `./YeastPathways_PWY3O-4105.json#/facts/89; endpoint types: /individuals/92/type; /individuals/96/type`
L-valine + 2-oxoglutarate <=> L-glutamate + 3-methyl-2-oxobutanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN`	provides_input_for	3-methyl-2-oxobutanoate -> isobutanal + CO₂ `gomodel:RXN3O-4133`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERVAL-RXN RO:0002413 gomodel:RXN3O-4133. Source location `./YeastPathways_PWY3O-4105.json#/facts/90; endpoint types: /individuals/0/type; /individuals/10/type`
BAT2 Scer `SGD:S000003909`	enables	L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003101. Source location `./YeastPathways_PWY3O-4105.json#/facts/91; endpoint types: /individuals/36/type; /individuals/40/type`
PDC5 Scer `SGD:S000004124`	enables	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002333 gomodel:YeastPathways_PWY3O-4105/6a4c244800003128. Source location `./YeastPathways_PWY3O-4105.json#/facts/92; endpoint types: /individuals/60/type; /individuals/62/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003220`	has_output	isobutanol `CHEBI:46645`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003220 RO:0002234 gomodel:YeastPathways_PWY3O-4105/6a4c244800003223. Source location `./YeastPathways_PWY3O-4105.json#/facts/93; endpoint types: /individuals/140/type; /individuals/143/type`
isobutanal + NADH -> isobutanol + NAD⁺ `gomodel:RXN3O-4141`	part_of	L-valine catabolic process `GO:0006574`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:RXN3O-4141 BFO:0000050 gomodel:YeastPathways_PWY3O-4105/YeastPathways_PWY3O-4105. Source location `./YeastPathways_PWY3O-4105.json#/facts/94; endpoint types: /individuals/11/type; /individuals/33/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003112`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003183`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003112 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003183. Source location `./YeastPathways_PWY3O-4105.json#/facts/95; endpoint types: /individuals/50/type; /individuals/108/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003124`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003202`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003124 RO:0002413 gomodel:YeastPathways_PWY3O-4105/6a4c244800003202. Source location `./YeastPathways_PWY3O-4105.json#/facts/96; endpoint types: /individuals/60/type; /individuals/124/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4105/6a4c244800003097`	has_input	L-valine zwitterion `CHEBI:57762`	gomodel:YeastPathways_PWY3O-4105 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4105/6a4c244800003097 RO:0002233 gomodel:YeastPathways_PWY3O-4105/6a4c244800003098. Source location `./YeastPathways_PWY3O-4105.json#/facts/97; endpoint types: /individuals/36/type; /individuals/37/type`
ADH2 Scer `SGD:S000004918`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2937632)	cytoplasm `GO:0005737`	UniProtKB:P00331 Source assertion: UniProtKB:P00331 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00331 Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC1 Scer `SGD:S000004034`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC1 Scer `SGD:S000004034`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
BAT1 Scer `SGD:S000001251`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21267457); ECO:0000269 (PubMed:8798704)	mitochondrial matrix `GO:0005759`	UniProtKB:P38891 Source assertion: UniProtKB:P38891 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1497/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38891 Source assertion: UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1497/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH5 Scer `SGD:S000000349`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P38113 Source assertion: UniProtKB:P38113 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38113 Source assertion: UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC6 Scer `SGD:S000003319`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH1 Scer `SGD:S000005446`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	cytoplasm `GO:0005737`	UniProtKB:P00330 Source assertion: UniProtKB:P00330 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00330 Source assertion: UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH4 Scer `SGD:S000003225`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	mitochondrion `GO:0005739`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
SFA1 Scer `SGD:S000002327`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P32771 Source assertion: UniProtKB:P32771 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P32771 Source assertion: UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
SFA1 Scer `SGD:S000002327`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	mitochondrion `GO:0005739`	UniProtKB:P32771 Source assertion: UniProtKB:P32771 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P32771 Source assertion: UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH3 Scer `SGD:S000004688`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1101965); ECO:0000269 (PubMed:2188098); ECO:0000269 (PubMed:2943982)	mitochondrial matrix `GO:0005759`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH3 Scer `SGD:S000004688`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	mitochondrial inner membrane `GO:0005743`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates location Mitochondrion inner membrane (SL-0168). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
BAT2 Scer `SGD:S000003909`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21267457); ECO:0000269 (PubMed:8798704)	cytoplasm `GO:0005737`	UniProtKB:P47176 Source assertion: UniProtKB:P47176 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1987/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P47176 Source assertion: UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1987/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC5 Scer `SGD:S000004124`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC5 Scer `SGD:S000004124`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH2 Scer `SGD:S000004918`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P00331 Source assertion: UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note` UniProtKB:P00331 Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0`
PDC1 Scer `SGD:S000004034`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	magnesium(2+) `CHEBI:18420`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/0/cofactors/0; /results/127/comments/0/note` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0`
PDC1 Scer `SGD:S000004034`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/1/cofactors/0; /results/127/comments/1/note` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0`
BAT1 Scer `SGD:S000001251`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Disputed growth phenotypes do not address PLP binding; retain the similarity-based PLP annotation. UniProt evidence: ECO:0000250 (UniProtKB:P0AB80)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P38891 Source assertion: UniProtKB:P38891 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/comments/0/cofactors/0` UniProtKB:P38891 Source assertion: UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/uniProtKBCrossReferences/0`
ADH5 Scer `SGD:S000000349`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P38113 Source assertion: UniProtKB:P38113 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/comments/0/cofactors/0; /results/3563/comments/0/note` UniProtKB:P38113 Source assertion: UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/uniProtKBCrossReferences/0`
PDC6 Scer `SGD:S000003319`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	magnesium(2+) `CHEBI:18420`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/0/cofactors/0; /results/742/comments/0/note` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0`
PDC6 Scer `SGD:S000003319`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/1/cofactors/0; /results/742/comments/1/note` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0`
ADH1 Scer `SGD:S000005446`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849)	zinc(2+) `CHEBI:29105`	UniProtKB:P00330 Source assertion: UniProtKB:P00330 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note` UniProtKB:P00330 Source assertion: UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/uniProtKBCrossReferences/0`
ADH4 Scer `SGD:S000003225`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	zinc(2+) `CHEBI:29105`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/0; /results/302/comments/0/note` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0`
ADH4 Scer `SGD:S000003225`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	iron(2+) `CHEBI:29033`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates CHEBI:29033 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/1; /results/302/comments/0/note` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0`
SFA1 Scer `SGD:S000002327`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06525) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06525)	zinc(2+) `CHEBI:29105`	UniProtKB:P32771 Source assertion: UniProtKB:P32771 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/comments/0/cofactors/0; /results/990/comments/0/note` UniProtKB:P32771 Source assertion: UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/uniProtKBCrossReferences/0`
ADH3 Scer `SGD:S000004688`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/comments/0/cofactors/0; /results/161/comments/0/note` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/uniProtKBCrossReferences/0`
BAT2 Scer `SGD:S000003909`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P47176 Source assertion: UniProtKB:P47176 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/comments/0/cofactors/0` UniProtKB:P47176 Source assertion: UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/uniProtKBCrossReferences/0`
PDC5 Scer `SGD:S000004124`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	magnesium(2+) `CHEBI:18420`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/0/cofactors/0; /results/439/comments/0/note` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0`
PDC5 Scer `SGD:S000004124`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/1/cofactors/0; /results/439/comments/1/note` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY3O-4105 SGD GO-CAM valine degradation pathway PWY3O-4105 (source version: Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4105.json)
UniProtKB:P00331 Reviewed UniProtKB P00331 location annotations (source version: UniProt release 2026_03)
UniProtKB:P06169 Reviewed UniProtKB P06169 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38891 Reviewed UniProtKB P38891 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38113 Reviewed UniProtKB P38113 location annotations (source version: UniProt release 2026_03)
UniProtKB:P26263 Reviewed UniProtKB P26263 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00330 Reviewed UniProtKB P00330 location annotations (source version: UniProt release 2026_03)
UniProtKB:P10127 Reviewed UniProtKB P10127 location annotations (source version: UniProt release 2026_03)
UniProtKB:P32771 Reviewed UniProtKB P32771 location annotations (source version: UniProt release 2026_03)
UniProtKB:P07246 Reviewed UniProtKB P07246 location annotations (source version: UniProt release 2026_03)
UniProtKB:P47176 Reviewed UniProtKB P47176 location annotations (source version: UniProt release 2026_03)
UniProtKB:P16467 Reviewed UniProtKB P16467 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 11 activity location assignments and 11 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 15 independently supported location edges and quarantined 3 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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