L-tyrosine degradation III

gomodel:YeastPathways_PWY3O-4108

L-tyrosine degradation III in Saccharomyces cerevisiae S288C uses tyrosine aminotransferase, phenylpyruvate decarboxylase, and alcohol dehydrogenase activities to convert L-tyrosine through 3-(4-hydroxyphenyl)pyruvate and (4-hydroxyphenyl)acetaldehyde to 2-(4-hydroxyphenyl)ethanol.

Pathway type

l tyrosine degradation iii

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

44 nodes · 121 asserted directed edges

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
L-tyrosine catabolic process `GO:0006572`	biological process
ARO8 Scer `SGD:S000003170`	protein
hydron `CHEBI:15378`	small molecule
2-(4-hydroxyphenyl)ethanol `CHEBI:1879`	small molecule
NADH(2-) `CHEBI:57945`	small molecule
NAD(1-) `CHEBI:57540`	small molecule
cytosol `GO:0005829`	cellular component
ADH3 Scer `SGD:S000004688`	protein
L-glutamate(1-) `CHEBI:29985`	small molecule
ADH5 Scer `SGD:S000000349`	protein
3-(4-hydroxyphenyl)pyruvate `CHEBI:36242`	small molecule
carbon dioxide `CHEBI:16526`	small molecule
ADH2 Scer `SGD:S000004918`	protein
ARO9 Scer `SGD:S000001179`	protein
(4-hydroxyphenyl)acetaldehyde `CHEBI:15621`	small molecule
2-oxoglutarate(2-) `CHEBI:16810`	small molecule
ADH1 Scer `SGD:S000005446`	protein
PDC1 Scer `SGD:S000004034`	protein
L-tyrosine zwitterion `CHEBI:58315`	small molecule
ADH4 Scer `SGD:S000003225`	protein
PDC6 Scer `SGD:S000003319`	protein
L-alanine zwitterion `CHEBI:57972`	small molecule
pyruvate `CHEBI:15361`	small molecule
PDC5 Scer `SGD:S000004124`	protein
cytoplasm `GO:0005737`	cellular component
mitochondrial matrix `GO:0005759`	cellular component
mitochondrial inner membrane `GO:0005743`	cellular component
nucleus `GO:0005634`	cellular component
mitochondrion `GO:0005739`	cellular component
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
zinc(2+) `CHEBI:29105`	cofactor
magnesium(2+) `CHEBI:18420`	cofactor
thiamine(1+) diphosphate(3-) `CHEBI:58937`	cofactor
iron(2+) `CHEBI:29033`	cofactor
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	molecular activity
4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	molecular activity
L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	molecular activity
L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	molecular activity
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	molecular activity
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	part_of	L-tyrosine catabolic process `GO:0006572`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108. Source location `./YeastPathways_PWY3O-4108.json#/facts/0; endpoint types: /individuals/104/type; /individuals/48/type`
L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	provides_input_for	3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4157 RO:0002413 gomodel:4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/1; endpoint types: /individuals/16/type; /individuals/47/type`
ARO8 Scer `SGD:S000003170`	enables	L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000639. Source location `./YeastPathways_PWY3O-4108.json#/facts/2; endpoint types: /individuals/17/type; /individuals/49/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN RO:0002233 gomodel:CHEBI_15378_4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/3; endpoint types: /individuals/47/type; /individuals/1/type`
4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	part_of	L-tyrosine catabolic process `GO:0006572`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4113 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108. Source location `./YeastPathways_PWY3O-4108.json#/facts/4; endpoint types: /individuals/15/type; /individuals/48/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	has_output	2-(4-hydroxyphenyl)ethanol `CHEBI:1879`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000692. Source location `./YeastPathways_PWY3O-4108.json#/facts/5; endpoint types: /individuals/91/type; /individuals/95/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000679. Source location `./YeastPathways_PWY3O-4108.json#/facts/6; endpoint types: /individuals/84/type; /individuals/86/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000691. Source location `./YeastPathways_PWY3O-4108.json#/facts/7; endpoint types: /individuals/91/type; /individuals/94/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677. Source location `./YeastPathways_PWY3O-4108.json#/facts/8; endpoint types: /individuals/69/type; /individuals/84/type`
L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4157 BFO:0000066 gomodel:reaction_RXN3O-4157_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4108.json#/facts/9; endpoint types: /individuals/16/type; /individuals/45/type`
ADH3 Scer `SGD:S000004688`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000747. Source location `./YeastPathways_PWY3O-4108.json#/facts/10; endpoint types: /individuals/91/type; /individuals/137/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	provides_input_for	4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002413 gomodel:RXN3O-4113. Source location `./YeastPathways_PWY3O-4108.json#/facts/11; endpoint types: /individuals/54/type; /individuals/15/type`
L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	has_output	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_29985_TYROSINE-AMINOTRANSFERASE-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/12; endpoint types: /individuals/17/type; /individuals/7/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 BFO:0000066 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000687. Source location `./YeastPathways_PWY3O-4108.json#/facts/13; endpoint types: /individuals/84/type; /individuals/90/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000702. Source location `./YeastPathways_PWY3O-4108.json#/facts/14; endpoint types: /individuals/97/type; /individuals/100/type`
ADH5 Scer `SGD:S000000349`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000719. Source location `./YeastPathways_PWY3O-4108.json#/facts/15; endpoint types: /individuals/104/type; /individuals/109/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 BFO:0000066 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000666. Source location `./YeastPathways_PWY3O-4108.json#/facts/16; endpoint types: /individuals/69/type; /individuals/73/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000700. Source location `./YeastPathways_PWY3O-4108.json#/facts/17; endpoint types: /individuals/97/type; /individuals/98/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	has_input	3-(4-hydroxyphenyl)pyruvate `CHEBI:36242`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002233 gomodel:CHEBI_36242_RXN3O-4157. Source location `./YeastPathways_PWY3O-4108.json#/facts/18; endpoint types: /individuals/69/type; /individuals/8/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	has_output	2-(4-hydroxyphenyl)ethanol `CHEBI:1879`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000714. Source location `./YeastPathways_PWY3O-4108.json#/facts/19; endpoint types: /individuals/104/type; /individuals/108/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000663. Source location `./YeastPathways_PWY3O-4108.json#/facts/20; endpoint types: /individuals/69/type; /individuals/71/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000713. Source location `./YeastPathways_PWY3O-4108.json#/facts/21; endpoint types: /individuals/104/type; /individuals/107/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN BFO:0000066 gomodel:reaction_4.1.1.80-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4108.json#/facts/22; endpoint types: /individuals/47/type; /individuals/43/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000711. Source location `./YeastPathways_PWY3O-4108.json#/facts/23; endpoint types: /individuals/104/type; /individuals/105/type`
ADH2 Scer `SGD:S000004918`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000683. Source location `./YeastPathways_PWY3O-4108.json#/facts/24; endpoint types: /individuals/84/type; /individuals/89/type`
L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	has_output	3-(4-hydroxyphenyl)pyruvate `CHEBI:36242`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4157 RO:0002234 gomodel:CHEBI_36242_RXN3O-4157. Source location `./YeastPathways_PWY3O-4108.json#/facts/25; endpoint types: /individuals/16/type; /individuals/8/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688. Source location `./YeastPathways_PWY3O-4108.json#/facts/26; endpoint types: /individuals/69/type; /individuals/91/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710. Source location `./YeastPathways_PWY3O-4108.json#/facts/27; endpoint types: /individuals/69/type; /individuals/104/type`
4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4113 BFO:0000066 gomodel:reaction_RXN3O-4113_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4108.json#/facts/28; endpoint types: /individuals/15/type; /individuals/44/type`
ARO9 Scer `SGD:S000001179`	enables	L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4157 RO:0002333 gomodel:YHR137W-MONOMER_RXN3O-4157_controller. Source location `./YeastPathways_PWY3O-4108.json#/facts/29; endpoint types: /individuals/16/type; /individuals/18/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000712. Source location `./YeastPathways_PWY3O-4108.json#/facts/30; endpoint types: /individuals/104/type; /individuals/106/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	has_input	3-(4-hydroxyphenyl)pyruvate `CHEBI:36242`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002233 gomodel:CHEBI_36242_RXN3O-4157. Source location `./YeastPathways_PWY3O-4108.json#/facts/31; endpoint types: /individuals/54/type; /individuals/8/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699. Source location `./YeastPathways_PWY3O-4108.json#/facts/32; endpoint types: /individuals/47/type; /individuals/97/type`
L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	part_of	L-tyrosine catabolic process `GO:0006572`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4157 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108. Source location `./YeastPathways_PWY3O-4108.json#/facts/33; endpoint types: /individuals/16/type; /individuals/48/type`
L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	part_of	L-tyrosine catabolic process `GO:0006572`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108. Source location `./YeastPathways_PWY3O-4108.json#/facts/34; endpoint types: /individuals/17/type; /individuals/48/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688. Source location `./YeastPathways_PWY3O-4108.json#/facts/35; endpoint types: /individuals/47/type; /individuals/91/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710. Source location `./YeastPathways_PWY3O-4108.json#/facts/36; endpoint types: /individuals/54/type; /individuals/104/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	has_input	(4-hydroxyphenyl)acetaldehyde `CHEBI:15621`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 RO:0002233 gomodel:CHEBI_15621_4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/37; endpoint types: /individuals/104/type; /individuals/3/type`
4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4113 RO:0002233 gomodel:CHEBI_15378_RXN3O-4113. Source location `./YeastPathways_PWY3O-4108.json#/facts/38; endpoint types: /individuals/15/type; /individuals/2/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	part_of	L-tyrosine catabolic process `GO:0006572`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108. Source location `./YeastPathways_PWY3O-4108.json#/facts/39; endpoint types: /individuals/84/type; /individuals/48/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699. Source location `./YeastPathways_PWY3O-4108.json#/facts/40; endpoint types: /individuals/69/type; /individuals/97/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699. Source location `./YeastPathways_PWY3O-4108.json#/facts/41; endpoint types: /individuals/54/type; /individuals/97/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688. Source location `./YeastPathways_PWY3O-4108.json#/facts/42; endpoint types: /individuals/54/type; /individuals/91/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	part_of	L-tyrosine catabolic process `GO:0006572`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108. Source location `./YeastPathways_PWY3O-4108.json#/facts/43; endpoint types: /individuals/47/type; /individuals/48/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000680. Source location `./YeastPathways_PWY3O-4108.json#/facts/44; endpoint types: /individuals/84/type; /individuals/87/type`
L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	has_input	2-oxoglutarate(2-) `CHEBI:16810`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_16810_TYROSINE-AMINOTRANSFERASE-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/45; endpoint types: /individuals/17/type; /individuals/5/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710 BFO:0000066 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000720. Source location `./YeastPathways_PWY3O-4108.json#/facts/46; endpoint types: /individuals/104/type; /individuals/110/type`
L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	has_output	3-(4-hydroxyphenyl)pyruvate `CHEBI:36242`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002234 gomodel:CHEBI_36242_TYROSINE-AMINOTRANSFERASE-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/47; endpoint types: /individuals/17/type; /individuals/9/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000689. Source location `./YeastPathways_PWY3O-4108.json#/facts/48; endpoint types: /individuals/91/type; /individuals/92/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000646. Source location `./YeastPathways_PWY3O-4108.json#/facts/49; endpoint types: /individuals/54/type; /individuals/56/type`
4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4113 RO:0002234 gomodel:CHEBI_57540_RXN3O-4113. Source location `./YeastPathways_PWY3O-4108.json#/facts/50; endpoint types: /individuals/15/type; /individuals/10/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000645. Source location `./YeastPathways_PWY3O-4108.json#/facts/51; endpoint types: /individuals/54/type; /individuals/55/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	part_of	L-tyrosine catabolic process `GO:0006572`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108. Source location `./YeastPathways_PWY3O-4108.json#/facts/52; endpoint types: /individuals/54/type; /individuals/48/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000678. Source location `./YeastPathways_PWY3O-4108.json#/facts/53; endpoint types: /individuals/84/type; /individuals/85/type`
ADH1 Scer `SGD:S000005446`	enables	4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4113 RO:0002333 gomodel:YOL086C-MONOMER_RXN3O-4113_controller. Source location `./YeastPathways_PWY3O-4108.json#/facts/54; endpoint types: /individuals/15/type; /individuals/19/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677. Source location `./YeastPathways_PWY3O-4108.json#/facts/55; endpoint types: /individuals/47/type; /individuals/84/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	part_of	L-tyrosine catabolic process `GO:0006572`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108. Source location `./YeastPathways_PWY3O-4108.json#/facts/56; endpoint types: /individuals/97/type; /individuals/48/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	has_output	(4-hydroxyphenyl)acetaldehyde `CHEBI:15621`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002234 gomodel:CHEBI_15621_4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/57; endpoint types: /individuals/54/type; /individuals/3/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	part_of	L-tyrosine catabolic process `GO:0006572`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108. Source location `./YeastPathways_PWY3O-4108.json#/facts/58; endpoint types: /individuals/91/type; /individuals/48/type`
PDC1 Scer `SGD:S000004034`	enables	3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN RO:0002333 gomodel:YeastPathways_PWY3O-4108/6690711d00000256. Source location `./YeastPathways_PWY3O-4108.json#/facts/59; endpoint types: /individuals/47/type; /individuals/156/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	has_input	(4-hydroxyphenyl)acetaldehyde `CHEBI:15621`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002233 gomodel:CHEBI_15621_4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/60; endpoint types: /individuals/97/type; /individuals/3/type`
L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	has_input	L-tyrosine zwitterion `CHEBI:58315`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4157 RO:0002233 gomodel:CHEBI_58315_RXN3O-4157. Source location `./YeastPathways_PWY3O-4108.json#/facts/61; endpoint types: /individuals/16/type; /individuals/13/type`
ADH4 Scer `SGD:S000003225`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000706. Source location `./YeastPathways_PWY3O-4108.json#/facts/62; endpoint types: /individuals/97/type; /individuals/102/type`
PDC6 Scer `SGD:S000003319`	enables	4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000665. Source location `./YeastPathways_PWY3O-4108.json#/facts/63; endpoint types: /individuals/69/type; /individuals/72/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	has_output	2-(4-hydroxyphenyl)ethanol `CHEBI:1879`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000703. Source location `./YeastPathways_PWY3O-4108.json#/facts/64; endpoint types: /individuals/97/type; /individuals/101/type`
L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	has_output	L-alanine zwitterion `CHEBI:57972`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4157 RO:0002234 gomodel:CHEBI_57972_RXN3O-4157. Source location `./YeastPathways_PWY3O-4108.json#/facts/65; endpoint types: /individuals/16/type; /individuals/12/type`
4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4113 RO:0002233 gomodel:CHEBI_57945_RXN3O-4113. Source location `./YeastPathways_PWY3O-4108.json#/facts/66; endpoint types: /individuals/15/type; /individuals/11/type`
L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	provides_input_for	4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661. Source location `./YeastPathways_PWY3O-4108.json#/facts/67; endpoint types: /individuals/17/type; /individuals/69/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000699 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000701. Source location `./YeastPathways_PWY3O-4108.json#/facts/68; endpoint types: /individuals/97/type; /individuals/99/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	has_input	3-(4-hydroxyphenyl)pyruvate `CHEBI:36242`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN RO:0002233 gomodel:CHEBI_36242_RXN3O-4157. Source location `./YeastPathways_PWY3O-4108.json#/facts/69; endpoint types: /individuals/47/type; /individuals/8/type`
L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	provides_input_for	4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644. Source location `./YeastPathways_PWY3O-4108.json#/facts/70; endpoint types: /individuals/17/type; /individuals/54/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	has_input	(4-hydroxyphenyl)acetaldehyde `CHEBI:15621`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002233 gomodel:CHEBI_15621_4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/71; endpoint types: /individuals/84/type; /individuals/3/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000690. Source location `./YeastPathways_PWY3O-4108.json#/facts/72; endpoint types: /individuals/91/type; /individuals/93/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	provides_input_for	4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002413 gomodel:RXN3O-4113. Source location `./YeastPathways_PWY3O-4108.json#/facts/74; endpoint types: /individuals/69/type; /individuals/15/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN RO:0002234 gomodel:CHEBI_16526_4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/75; endpoint types: /individuals/47/type; /individuals/4/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688`	has_input	(4-hydroxyphenyl)acetaldehyde `CHEBI:15621`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000688 RO:0002233 gomodel:CHEBI_15621_4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/76; endpoint types: /individuals/91/type; /individuals/3/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002233 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000662. Source location `./YeastPathways_PWY3O-4108.json#/facts/77; endpoint types: /individuals/69/type; /individuals/70/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	has_output	(4-hydroxyphenyl)acetaldehyde `CHEBI:15621`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN RO:0002234 gomodel:CHEBI_15621_4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/78; endpoint types: /individuals/47/type; /individuals/3/type`
4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	has_output	2-(4-hydroxyphenyl)ethanol `CHEBI:1879`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4113 RO:0002234 gomodel:CHEBI_1879_RXN3O-4113. Source location `./YeastPathways_PWY3O-4108.json#/facts/80; endpoint types: /individuals/15/type; /individuals/6/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 BFO:0000066 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000650. Source location `./YeastPathways_PWY3O-4108.json#/facts/81; endpoint types: /individuals/54/type; /individuals/58/type`
4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	has_input	(4-hydroxyphenyl)acetaldehyde `CHEBI:15621`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4113 RO:0002233 gomodel:CHEBI_15621_4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/82; endpoint types: /individuals/15/type; /individuals/3/type`
L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN BFO:0000066 gomodel:reaction_TYROSINE-AMINOTRANSFERASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4108.json#/facts/83; endpoint types: /individuals/17/type; /individuals/46/type`
L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	has_input	pyruvate `CHEBI:15361`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4157 RO:0002233 gomodel:CHEBI_15361_RXN3O-4157. Source location `./YeastPathways_PWY3O-4108.json#/facts/84; endpoint types: /individuals/16/type; /individuals/0/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	has_output	(4-hydroxyphenyl)acetaldehyde `CHEBI:15621`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 RO:0002234 gomodel:CHEBI_15621_4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/85; endpoint types: /individuals/69/type; /individuals/3/type`
PDC5 Scer `SGD:S000004124`	enables	4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002333 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000649. Source location `./YeastPathways_PWY3O-4108.json#/facts/86; endpoint types: /individuals/54/type; /individuals/57/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677. Source location `./YeastPathways_PWY3O-4108.json#/facts/87; endpoint types: /individuals/54/type; /individuals/84/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	provides_input_for	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000710. Source location `./YeastPathways_PWY3O-4108.json#/facts/88; endpoint types: /individuals/47/type; /individuals/104/type`
L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	provides_input_for	4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4157 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000644. Source location `./YeastPathways_PWY3O-4108.json#/facts/89; endpoint types: /individuals/16/type; /individuals/54/type`
L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	provides_input_for	3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002413 gomodel:4.1.1.80-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/90; endpoint types: /individuals/17/type; /individuals/47/type`
L-tyrosine + 2-oxoglutarate <=> 3-(4-hydroxyphenyl)pyruvate + L-glutamate `gomodel:TYROSINE-AMINOTRANSFERASE-RXN`	has_input	L-tyrosine zwitterion `CHEBI:58315`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:TYROSINE-AMINOTRANSFERASE-RXN RO:0002233 gomodel:CHEBI_58315_TYROSINE-AMINOTRANSFERASE-RXN. Source location `./YeastPathways_PWY3O-4108.json#/facts/91; endpoint types: /individuals/17/type; /individuals/14/type`
L-tyrosine + pyruvate <=> 3-(4-hydroxyphenyl)pyruvate + L-alanine `gomodel:RXN3O-4157`	provides_input_for	4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:RXN3O-4157 RO:0002413 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661. Source location `./YeastPathways_PWY3O-4108.json#/facts/92; endpoint types: /individuals/16/type; /individuals/69/type`
4-hydroxyphenylpyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661`	part_of	L-tyrosine catabolic process `GO:0006572`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000661 BFO:0000050 gomodel:YeastPathways_PWY3O-4108/YeastPathways_PWY3O-4108. Source location `./YeastPathways_PWY3O-4108.json#/facts/93; endpoint types: /individuals/69/type; /individuals/48/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677`	has_output	2-(4-hydroxyphenyl)ethanol `CHEBI:1879`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000677 RO:0002234 gomodel:YeastPathways_PWY3O-4108/6a6bcaed00000681. Source location `./YeastPathways_PWY3O-4108.json#/facts/94; endpoint types: /individuals/84/type; /individuals/88/type`
3-(4-hydroxyphenyl)pyruvate + H⁺ -> CO₂ + (4-hydroxyphenyl)acetaldehyde `gomodel:4.1.1.80-RXN`	provides_input_for	4-tyrosol + NAD⁺ <- (4-hydroxyphenyl)acetaldehyde + NADH + H⁺ `gomodel:RXN3O-4113`	gomodel:YeastPathways_PWY3O-4108 Source assertion: The model asserts gomodel:4.1.1.80-RXN RO:0002413 gomodel:RXN3O-4113. Source location `./YeastPathways_PWY3O-4108.json#/facts/95; endpoint types: /individuals/47/type; /individuals/15/type`
ARO8 Scer `SGD:S000003170`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P53090 Source assertion: UniProtKB:P53090 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P53090 Source assertion: UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2112/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH3 Scer `SGD:S000004688`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1101965); ECO:0000269 (PubMed:2188098); ECO:0000269 (PubMed:2943982)	mitochondrial matrix `GO:0005759`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH3 Scer `SGD:S000004688`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	mitochondrial inner membrane `GO:0005743`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates location Mitochondrion inner membrane (SL-0168). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH5 Scer `SGD:S000000349`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P38113 Source assertion: UniProtKB:P38113 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38113 Source assertion: UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH2 Scer `SGD:S000004918`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2937632)	cytoplasm `GO:0005737`	UniProtKB:P00331 Source assertion: UniProtKB:P00331 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00331 Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARO9 Scer `SGD:S000001179`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P38840 Source assertion: UniProtKB:P38840 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38840 Source assertion: UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1469/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH1 Scer `SGD:S000005446`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	cytoplasm `GO:0005737`	UniProtKB:P00330 Source assertion: UniProtKB:P00330 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00330 Source assertion: UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC1 Scer `SGD:S000004034`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC1 Scer `SGD:S000004034`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH4 Scer `SGD:S000003225`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	mitochondrion `GO:0005739`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC6 Scer `SGD:S000003319`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC5 Scer `SGD:S000004124`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC5 Scer `SGD:S000004124`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARO8 Scer `SGD:S000003170`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:23893908)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P53090 Source assertion: UniProtKB:P53090 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/comments/0/cofactors/0` UniProtKB:P53090 Source assertion: UniProtKB:P53090 has the exact SGD cross-reference SGD:S000003170. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2112/uniProtKBCrossReferences/0`
ADH3 Scer `SGD:S000004688`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/comments/0/cofactors/0; /results/161/comments/0/note` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/uniProtKBCrossReferences/0`
ADH5 Scer `SGD:S000000349`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P38113 Source assertion: UniProtKB:P38113 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/comments/0/cofactors/0; /results/3563/comments/0/note` UniProtKB:P38113 Source assertion: UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/uniProtKBCrossReferences/0`
ADH2 Scer `SGD:S000004918`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P00331 Source assertion: UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note` UniProtKB:P00331 Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0`
ARO9 Scer `SGD:S000001179`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:O84395)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P38840 Source assertion: UniProtKB:P38840 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/comments/0/cofactors/0` UniProtKB:P38840 Source assertion: UniProtKB:P38840 has the exact SGD cross-reference SGD:S000001179. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1469/uniProtKBCrossReferences/0`
ADH1 Scer `SGD:S000005446`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849)	zinc(2+) `CHEBI:29105`	UniProtKB:P00330 Source assertion: UniProtKB:P00330 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note` UniProtKB:P00330 Source assertion: UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/uniProtKBCrossReferences/0`
PDC1 Scer `SGD:S000004034`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	magnesium(2+) `CHEBI:18420`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/0/cofactors/0; /results/127/comments/0/note` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0`
PDC1 Scer `SGD:S000004034`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/1/cofactors/0; /results/127/comments/1/note` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0`
ADH4 Scer `SGD:S000003225`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	zinc(2+) `CHEBI:29105`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/0; /results/302/comments/0/note` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0`
ADH4 Scer `SGD:S000003225`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	iron(2+) `CHEBI:29033`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates CHEBI:29033 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/1; /results/302/comments/0/note` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0`
PDC6 Scer `SGD:S000003319`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	magnesium(2+) `CHEBI:18420`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/0/cofactors/0; /results/742/comments/0/note` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0`
PDC6 Scer `SGD:S000003319`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/1/cofactors/0; /results/742/comments/1/note` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0`
PDC5 Scer `SGD:S000004124`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	magnesium(2+) `CHEBI:18420`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/0/cofactors/0; /results/439/comments/0/note` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0`
PDC5 Scer `SGD:S000004124`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/1/cofactors/0; /results/439/comments/1/note` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY3O-4108 SGD GO-CAM L-tyrosine degradation III - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-08-04; member ./YeastPathways_PWY3O-4108.json)
UniProtKB:P53090 Reviewed UniProtKB P53090 location annotations (source version: UniProt release 2026_03)
UniProtKB:P07246 Reviewed UniProtKB P07246 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38113 Reviewed UniProtKB P38113 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00331 Reviewed UniProtKB P00331 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38840 Reviewed UniProtKB P38840 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00330 Reviewed UniProtKB P00330 location annotations (source version: UniProt release 2026_03)
UniProtKB:P06169 Reviewed UniProtKB P06169 location annotations (source version: UniProt release 2026_03)
UniProtKB:P10127 Reviewed UniProtKB P10127 location annotations (source version: UniProt release 2026_03)
UniProtKB:P26263 Reviewed UniProtKB P26263 location annotations (source version: UniProt release 2026_03)
UniProtKB:P16467 Reviewed UniProtKB P16467 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 10 activity location assignments and 10 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 13 independently supported location edges and quarantined 2 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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