leucine degradation

gomodel:YeastPathways_PWY3O-4112

Leucine degradation in Saccharomyces cerevisiae S288C uses branched-chain amino acid aminotransferase, 4-methyl-2-oxopentanoate decarboxylase, and alcohol dehydrogenase activities to convert L-leucine through 4-methyl-2-oxopentanoate and 3-methylbutanal to isoamylol.

Pathway type

leucine degradation

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

38 nodes · 81 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
cytosol `GO:0005829`	cellular component
NADH(2-) `CHEBI:57945`	small molecule
ADH1 Scer `SGD:S000005446`	protein
L-leucine catabolic process `GO:0006552`	biological process
L-leucine zwitterion `CHEBI:57427`	small molecule
4-methyl-2-oxopentanoate `CHEBI:17865`	small molecule
NAD(1-) `CHEBI:57540`	small molecule
3-methylbutanal `CHEBI:16638`	small molecule
isoamylol `CHEBI:15837`	small molecule
ARO10 Scer `SGD:S000002788`	protein
BAT2 Scer `SGD:S000003909`	protein
L-glutamate(1-) `CHEBI:29985`	small molecule
2-oxoglutarate(2-) `CHEBI:16810`	small molecule
SFA1 Scer `SGD:S000002327`	protein
carbon dioxide `CHEBI:16526`	small molecule
BAT1 Scer `SGD:S000001251`	protein
ADH3 Scer `SGD:S000004688`	protein
ADH4 Scer `SGD:S000003225`	protein
ADH5 Scer `SGD:S000000349`	protein
ADH2 Scer `SGD:S000004918`	protein
cytoplasm `GO:0005737`	cellular component
mitochondrion `GO:0005739`	cellular component
mitochondrial matrix `GO:0005759`	cellular component
mitochondrial inner membrane `GO:0005743`	cellular component
zinc(2+) `CHEBI:29105`	cofactor
magnesium(2+) `CHEBI:18420`	cofactor
thiamine(1+) diphosphate(3-) `CHEBI:58937`	cofactor
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
iron(2+) `CHEBI:29033`	cofactor
L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN`	molecular activity
4-methyl-2-oxopentanoate -> 3-methylbutanal + CO₂ `gomodel:RXN3O-4108`	molecular activity
3-methylbutanal + NADH -> 3-methylbutanol + NAD⁺ `gomodel:RXN3O-4109`	molecular activity
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001175`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001189`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001207`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001224`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001240`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001255`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
4-methyl-2-oxopentanoate -> 3-methylbutanal + CO₂ `gomodel:RXN3O-4108`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4108 BFO:0000066 gomodel:reaction_RXN3O-4108_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4112.json#/facts/0; endpoint types: /individuals/10/type; /individuals/31/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001255`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 BFO:0000066 gomodel:YeastPathways_PWY3O-4112/6a4c244800001261. Source location `./YeastPathways_PWY3O-4112.json#/facts/1; endpoint types: /individuals/99/type; /individuals/104/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001240`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 BFO:0000066 gomodel:YeastPathways_PWY3O-4112/6a4c244800001247. Source location `./YeastPathways_PWY3O-4112.json#/facts/2; endpoint types: /individuals/86/type; /individuals/91/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001224`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001225. Source location `./YeastPathways_PWY3O-4112.json#/facts/3; endpoint types: /individuals/73/type; /individuals/74/type`
ADH1 Scer `SGD:S000005446`	enables	3-methylbutanal + NADH -> 3-methylbutanol + NAD⁺ `gomodel:RXN3O-4109`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4109 RO:0002333 gomodel:YOL086C-MONOMER_RXN3O-4109_controller. Source location `./YeastPathways_PWY3O-4112.json#/facts/4; endpoint types: /individuals/11/type; /individuals/13/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001224`	part_of	L-leucine catabolic process `GO:0006552`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112. Source location `./YeastPathways_PWY3O-4112.json#/facts/5; endpoint types: /individuals/73/type; /individuals/33/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001175`	has_input	L-leucine zwitterion `CHEBI:57427`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001177. Source location `./YeastPathways_PWY3O-4112.json#/facts/6; endpoint types: /individuals/34/type; /individuals/36/type`
L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN`	has_output	4-methyl-2-oxopentanoate `CHEBI:17865`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN RO:0002234 gomodel:CHEBI_17865_BRANCHED-CHAINAMINOTRANSFERLEU-RXN. Source location `./YeastPathways_PWY3O-4112.json#/facts/7; endpoint types: /individuals/0/type; /individuals/5/type`
3-methylbutanal + NADH -> 3-methylbutanol + NAD⁺ `gomodel:RXN3O-4109`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4109 RO:0002233 gomodel:CHEBI_57945_RXN3O-4109. Source location `./YeastPathways_PWY3O-4112.json#/facts/8; endpoint types: /individuals/11/type; /individuals/9/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001189`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001190. Source location `./YeastPathways_PWY3O-4112.json#/facts/9; endpoint types: /individuals/47/type; /individuals/48/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001240`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001243. Source location `./YeastPathways_PWY3O-4112.json#/facts/10; endpoint types: /individuals/86/type; /individuals/89/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001240`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001241. Source location `./YeastPathways_PWY3O-4112.json#/facts/11; endpoint types: /individuals/86/type; /individuals/87/type`
4-methyl-2-oxopentanoate -> 3-methylbutanal + CO₂ `gomodel:RXN3O-4108`	has_input	4-methyl-2-oxopentanoate `CHEBI:17865`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4108 RO:0002233 gomodel:CHEBI_17865_BRANCHED-CHAINAMINOTRANSFERLEU-RXN. Source location `./YeastPathways_PWY3O-4112.json#/facts/12; endpoint types: /individuals/10/type; /individuals/5/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001189`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001192. Source location `./YeastPathways_PWY3O-4112.json#/facts/13; endpoint types: /individuals/47/type; /individuals/50/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001175`	has_output	4-methyl-2-oxopentanoate `CHEBI:17865`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 RO:0002234 gomodel:CHEBI_17865_BRANCHED-CHAINAMINOTRANSFERLEU-RXN. Source location `./YeastPathways_PWY3O-4112.json#/facts/14; endpoint types: /individuals/34/type; /individuals/5/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001255`	part_of	L-leucine catabolic process `GO:0006552`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112. Source location `./YeastPathways_PWY3O-4112.json#/facts/15; endpoint types: /individuals/99/type; /individuals/33/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001255`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001258. Source location `./YeastPathways_PWY3O-4112.json#/facts/16; endpoint types: /individuals/99/type; /individuals/102/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001255`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001256. Source location `./YeastPathways_PWY3O-4112.json#/facts/17; endpoint types: /individuals/99/type; /individuals/100/type`
4-methyl-2-oxopentanoate -> 3-methylbutanal + CO₂ `gomodel:RXN3O-4108`	has_output	3-methylbutanal `CHEBI:16638`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4108 RO:0002234 gomodel:CHEBI_16638_RXN3O-4108. Source location `./YeastPathways_PWY3O-4112.json#/facts/18; endpoint types: /individuals/10/type; /individuals/3/type`
L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN`	has_input	L-leucine zwitterion `CHEBI:57427`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN RO:0002233 gomodel:CHEBI_57427_BRANCHED-CHAINAMINOTRANSFERLEU-RXN. Source location `./YeastPathways_PWY3O-4112.json#/facts/19; endpoint types: /individuals/0/type; /individuals/7/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001207`	has_output	isoamylol `CHEBI:15837`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001209. Source location `./YeastPathways_PWY3O-4112.json#/facts/20; endpoint types: /individuals/60/type; /individuals/62/type`
ARO10 Scer `SGD:S000002788`	enables	4-methyl-2-oxopentanoate -> 3-methylbutanal + CO₂ `gomodel:RXN3O-4108`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4108 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6690711d00000770. Source location `./YeastPathways_PWY3O-4112.json#/facts/21; endpoint types: /individuals/10/type; /individuals/112/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001207`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001210. Source location `./YeastPathways_PWY3O-4112.json#/facts/22; endpoint types: /individuals/60/type; /individuals/63/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001224`	has_output	isoamylol `CHEBI:15837`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001226. Source location `./YeastPathways_PWY3O-4112.json#/facts/23; endpoint types: /individuals/73/type; /individuals/75/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001189`	has_output	isoamylol `CHEBI:15837`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001191. Source location `./YeastPathways_PWY3O-4112.json#/facts/24; endpoint types: /individuals/47/type; /individuals/49/type`
L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN`	part_of	L-leucine catabolic process `GO:0006552`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112. Source location `./YeastPathways_PWY3O-4112.json#/facts/25; endpoint types: /individuals/0/type; /individuals/33/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001189`	part_of	L-leucine catabolic process `GO:0006552`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112. Source location `./YeastPathways_PWY3O-4112.json#/facts/26; endpoint types: /individuals/47/type; /individuals/33/type`
BAT2 Scer `SGD:S000003909`	enables	L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001175`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001179. Source location `./YeastPathways_PWY3O-4112.json#/facts/27; endpoint types: /individuals/34/type; /individuals/38/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001175`	part_of	L-leucine catabolic process `GO:0006552`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112. Source location `./YeastPathways_PWY3O-4112.json#/facts/28; endpoint types: /individuals/34/type; /individuals/33/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001189`	has_input	3-methylbutanal `CHEBI:16638`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108. Source location `./YeastPathways_PWY3O-4112.json#/facts/29; endpoint types: /individuals/47/type; /individuals/3/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001175`	has_output	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001178. Source location `./YeastPathways_PWY3O-4112.json#/facts/30; endpoint types: /individuals/34/type; /individuals/37/type`
4-methyl-2-oxopentanoate -> 3-methylbutanal + CO₂ `gomodel:RXN3O-4108`	part_of	L-leucine catabolic process `GO:0006552`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4108 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112. Source location `./YeastPathways_PWY3O-4112.json#/facts/31; endpoint types: /individuals/10/type; /individuals/33/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001175`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 BFO:0000066 gomodel:YeastPathways_PWY3O-4112/6a4c244800001181. Source location `./YeastPathways_PWY3O-4112.json#/facts/32; endpoint types: /individuals/34/type; /individuals/39/type`
3-methylbutanal + NADH -> 3-methylbutanol + NAD⁺ `gomodel:RXN3O-4109`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4109 BFO:0000066 gomodel:reaction_RXN3O-4109_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4112.json#/facts/33; endpoint types: /individuals/11/type; /individuals/32/type`
L-isoleucine:2-oxoglutarate transaminase activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001175`	has_input	2-oxoglutarate(2-) `CHEBI:16810`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001175 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001176. Source location `./YeastPathways_PWY3O-4112.json#/facts/34; endpoint types: /individuals/34/type; /individuals/35/type`
SFA1 Scer `SGD:S000002327`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001255`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001260. Source location `./YeastPathways_PWY3O-4112.json#/facts/35; endpoint types: /individuals/99/type; /individuals/103/type`
4-methyl-2-oxopentanoate -> 3-methylbutanal + CO₂ `gomodel:RXN3O-4108`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4108 RO:0002234 gomodel:CHEBI_16526_RXN3O-4108. Source location `./YeastPathways_PWY3O-4112.json#/facts/36; endpoint types: /individuals/10/type; /individuals/2/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001240`	part_of	L-leucine catabolic process `GO:0006552`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112. Source location `./YeastPathways_PWY3O-4112.json#/facts/38; endpoint types: /individuals/86/type; /individuals/33/type`
L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN`	has_input	2-oxoglutarate(2-) `CHEBI:16810`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN RO:0002233 gomodel:CHEBI_16810_BRANCHED-CHAINAMINOTRANSFERLEU-RXN. Source location `./YeastPathways_PWY3O-4112.json#/facts/39; endpoint types: /individuals/0/type; /individuals/4/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001240`	has_input	3-methylbutanal `CHEBI:16638`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108. Source location `./YeastPathways_PWY3O-4112.json#/facts/40; endpoint types: /individuals/86/type; /individuals/3/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001240`	has_output	isoamylol `CHEBI:15837`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001242. Source location `./YeastPathways_PWY3O-4112.json#/facts/41; endpoint types: /individuals/86/type; /individuals/88/type`
L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN`	has_output	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN RO:0002234 gomodel:CHEBI_29985_BRANCHED-CHAINAMINOTRANSFERLEU-RXN. Source location `./YeastPathways_PWY3O-4112.json#/facts/42; endpoint types: /individuals/0/type; /individuals/6/type`
BAT1 Scer `SGD:S000001251`	enables	L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate `gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:BRANCHED-CHAINAMINOTRANSFERLEU-RXN RO:0002333 gomodel:YHR208W-MONOMER_BRANCHED-CHAINAMINOTRANSFERLEU-RXN_controller. Source location `./YeastPathways_PWY3O-4112.json#/facts/43; endpoint types: /individuals/0/type; /individuals/12/type`
ADH3 Scer `SGD:S000004688`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001207`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001215. Source location `./YeastPathways_PWY3O-4112.json#/facts/44; endpoint types: /individuals/60/type; /individuals/64/type`
3-methylbutanal + NADH -> 3-methylbutanol + NAD⁺ `gomodel:RXN3O-4109`	has_output	isoamylol `CHEBI:15837`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4109 RO:0002234 gomodel:CHEBI_15837_RXN3O-4109. Source location `./YeastPathways_PWY3O-4112.json#/facts/45; endpoint types: /individuals/11/type; /individuals/1/type`
3-methylbutanal + NADH -> 3-methylbutanol + NAD⁺ `gomodel:RXN3O-4109`	part_of	L-leucine catabolic process `GO:0006552`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4109 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112. Source location `./YeastPathways_PWY3O-4112.json#/facts/46; endpoint types: /individuals/11/type; /individuals/33/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001207`	part_of	L-leucine catabolic process `GO:0006552`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 BFO:0000050 gomodel:YeastPathways_PWY3O-4112/YeastPathways_PWY3O-4112. Source location `./YeastPathways_PWY3O-4112.json#/facts/47; endpoint types: /individuals/60/type; /individuals/33/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001255`	has_output	isoamylol `CHEBI:15837`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001257. Source location `./YeastPathways_PWY3O-4112.json#/facts/48; endpoint types: /individuals/99/type; /individuals/101/type`
3-methylbutanal + NADH -> 3-methylbutanol + NAD⁺ `gomodel:RXN3O-4109`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4109 RO:0002234 gomodel:CHEBI_57540_RXN3O-4109. Source location `./YeastPathways_PWY3O-4112.json#/facts/49; endpoint types: /individuals/11/type; /individuals/8/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001255`	has_input	3-methylbutanal `CHEBI:16638`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001255 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108. Source location `./YeastPathways_PWY3O-4112.json#/facts/50; endpoint types: /individuals/99/type; /individuals/3/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001207`	has_input	3-methylbutanal `CHEBI:16638`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108. Source location `./YeastPathways_PWY3O-4112.json#/facts/51; endpoint types: /individuals/60/type; /individuals/3/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001189`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 BFO:0000066 gomodel:YeastPathways_PWY3O-4112/6a4c244800001199. Source location `./YeastPathways_PWY3O-4112.json#/facts/52; endpoint types: /individuals/47/type; /individuals/52/type`
ADH4 Scer `SGD:S000003225`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001224`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001231. Source location `./YeastPathways_PWY3O-4112.json#/facts/53; endpoint types: /individuals/73/type; /individuals/77/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001224`	has_input	3-methylbutanal `CHEBI:16638`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108. Source location `./YeastPathways_PWY3O-4112.json#/facts/54; endpoint types: /individuals/73/type; /individuals/3/type`
ADH5 Scer `SGD:S000000349`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001240`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001240 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001245. Source location `./YeastPathways_PWY3O-4112.json#/facts/55; endpoint types: /individuals/86/type; /individuals/90/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001207`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001207 RO:0002233 gomodel:YeastPathways_PWY3O-4112/6a4c244800001208. Source location `./YeastPathways_PWY3O-4112.json#/facts/57; endpoint types: /individuals/60/type; /individuals/61/type`
3-methylbutanal + NADH -> 3-methylbutanol + NAD⁺ `gomodel:RXN3O-4109`	has_input	3-methylbutanal `CHEBI:16638`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:RXN3O-4109 RO:0002233 gomodel:CHEBI_16638_RXN3O-4108. Source location `./YeastPathways_PWY3O-4112.json#/facts/59; endpoint types: /individuals/11/type; /individuals/3/type`
ADH2 Scer `SGD:S000004918`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001189`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001189 RO:0002333 gomodel:YeastPathways_PWY3O-4112/6a4c244800001198. Source location `./YeastPathways_PWY3O-4112.json#/facts/60; endpoint types: /individuals/47/type; /individuals/51/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4112/6a4c244800001224`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4112 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4112/6a4c244800001224 RO:0002234 gomodel:YeastPathways_PWY3O-4112/6a4c244800001227. Source location `./YeastPathways_PWY3O-4112.json#/facts/61; endpoint types: /individuals/73/type; /individuals/76/type`
ADH1 Scer `SGD:S000005446`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	cytoplasm `GO:0005737`	UniProtKB:P00330 Source assertion: UniProtKB:P00330 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00330 Source assertion: UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ARO10 Scer `SGD:S000002788`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2752/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2752/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
BAT2 Scer `SGD:S000003909`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21267457); ECO:0000269 (PubMed:8798704)	cytoplasm `GO:0005737`	UniProtKB:P47176 Source assertion: UniProtKB:P47176 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1987/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P47176 Source assertion: UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1987/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
SFA1 Scer `SGD:S000002327`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P32771 Source assertion: UniProtKB:P32771 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P32771 Source assertion: UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
SFA1 Scer `SGD:S000002327`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:16823961)	mitochondrion `GO:0005739`	UniProtKB:P32771 Source assertion: UniProtKB:P32771 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P32771 Source assertion: UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/990/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
BAT1 Scer `SGD:S000001251`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21267457); ECO:0000269 (PubMed:8798704)	mitochondrial matrix `GO:0005759`	UniProtKB:P38891 Source assertion: UniProtKB:P38891 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1497/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38891 Source assertion: UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1497/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH3 Scer `SGD:S000004688`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1101965); ECO:0000269 (PubMed:2188098); ECO:0000269 (PubMed:2943982)	mitochondrial matrix `GO:0005759`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH3 Scer `SGD:S000004688`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	mitochondrial inner membrane `GO:0005743`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates location Mitochondrion inner membrane (SL-0168). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH4 Scer `SGD:S000003225`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	mitochondrion `GO:0005739`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/302/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH5 Scer `SGD:S000000349`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P38113 Source assertion: UniProtKB:P38113 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38113 Source assertion: UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3563/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH2 Scer `SGD:S000004918`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2937632)	cytoplasm `GO:0005737`	UniProtKB:P00331 Source assertion: UniProtKB:P00331 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00331 Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH1 Scer `SGD:S000005446`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849)	zinc(2+) `CHEBI:29105`	UniProtKB:P00330 Source assertion: UniProtKB:P00330 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note` UniProtKB:P00330 Source assertion: UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/uniProtKBCrossReferences/0`
ARO10 Scer `SGD:S000002788`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250	magnesium(2+) `CHEBI:18420`	UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/0/cofactors/0; /results/2752/comments/0/note` UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0`
ARO10 Scer `SGD:S000002788`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/comments/1/cofactors/0; /results/2752/comments/1/note` UniProtKB:Q06408 Source assertion: UniProtKB:Q06408 has the exact SGD cross-reference SGD:S000002788. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2752/uniProtKBCrossReferences/0`
BAT2 Scer `SGD:S000003909`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P47176 Source assertion: UniProtKB:P47176 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/comments/0/cofactors/0` UniProtKB:P47176 Source assertion: UniProtKB:P47176 has the exact SGD cross-reference SGD:S000003909. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1987/uniProtKBCrossReferences/0`
SFA1 Scer `SGD:S000002327`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06525) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06525)	zinc(2+) `CHEBI:29105`	UniProtKB:P32771 Source assertion: UniProtKB:P32771 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/comments/0/cofactors/0; /results/990/comments/0/note` UniProtKB:P32771 Source assertion: UniProtKB:P32771 has the exact SGD cross-reference SGD:S000002327. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/990/uniProtKBCrossReferences/0`
BAT1 Scer `SGD:S000001251`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: Disputed growth phenotypes do not address PLP binding; retain the similarity-based PLP annotation. UniProt evidence: ECO:0000250 (UniProtKB:P0AB80)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P38891 Source assertion: UniProtKB:P38891 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/comments/0/cofactors/0` UniProtKB:P38891 Source assertion: UniProtKB:P38891 has the exact SGD cross-reference SGD:S000001251. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1497/uniProtKBCrossReferences/0`
ADH3 Scer `SGD:S000004688`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/comments/0/cofactors/0; /results/161/comments/0/note` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/uniProtKBCrossReferences/0`
ADH4 Scer `SGD:S000003225`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	zinc(2+) `CHEBI:29105`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/0; /results/302/comments/0/note` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0`
ADH4 Scer `SGD:S000003225`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:3282541) Zinc. May bind iron when zinc levels are limiting. UniProt note evidence: ECO:0000269 (PubMed:3282541)	iron(2+) `CHEBI:29033`	UniProtKB:P10127 Source assertion: UniProtKB:P10127 annotates CHEBI:29033 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/comments/0/cofactors/1; /results/302/comments/0/note` UniProtKB:P10127 Source assertion: UniProtKB:P10127 has the exact SGD cross-reference SGD:S000003225. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/302/uniProtKBCrossReferences/0`
ADH5 Scer `SGD:S000000349`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P38113 Source assertion: UniProtKB:P38113 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/comments/0/cofactors/0; /results/3563/comments/0/note` UniProtKB:P38113 Source assertion: UniProtKB:P38113 has the exact SGD cross-reference SGD:S000000349. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3563/uniProtKBCrossReferences/0`
ADH2 Scer `SGD:S000004918`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P00331 Source assertion: UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note` UniProtKB:P00331 Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY3O-4112 SGD GO-CAM leucine degradation - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-10; member ./YeastPathways_PWY3O-4112.json)
UniProtKB:P00330 Reviewed UniProtKB P00330 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q06408 Reviewed UniProtKB Q06408 location annotations (source version: UniProt release 2026_03)
UniProtKB:P47176 Reviewed UniProtKB P47176 location annotations (source version: UniProt release 2026_03)
UniProtKB:P32771 Reviewed UniProtKB P32771 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38891 Reviewed UniProtKB P38891 location annotations (source version: UniProt release 2026_03)
UniProtKB:P07246 Reviewed UniProtKB P07246 location annotations (source version: UniProt release 2026_03)
UniProtKB:P10127 Reviewed UniProtKB P10127 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38113 Reviewed UniProtKB P38113 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00331 Reviewed UniProtKB P00331 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 9 activity location assignments and 9 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 11 independently supported location edges and quarantined 3 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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