ethanol degradation

gomodel:YeastPathways_PWY3O-4300

Ethanol degradation in Saccharomyces cerevisiae S288C uses alcohol dehydrogenase, aldehyde dehydrogenase, and acetyl-CoA ligase activities to oxidize ethanol through acetaldehyde and acetate to acetyl-CoA.

Pathway type

alcohol degradation

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

32 nodes · 68 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
ACS2 Scer `SGD:S000004143`	protein
hydron `CHEBI:15378`	small molecule
acetaldehyde `CHEBI:15343`	small molecule
ADH2 Scer `SGD:S000004918`	protein
NADH(2-) `CHEBI:57945`	small molecule
acetate `CHEBI:30089`	small molecule
ethanol catabolic process `GO:0006068`	biological process
diphosphoric acid `CHEBI:29888`	small molecule
ethanol `CHEBI:16236`	small molecule
NAD(1-) `CHEBI:57540`	small molecule
acetyl-CoA(4-) `CHEBI:57288`	small molecule
adenosine 5'-monophosphate(2-) `CHEBI:456215`	small molecule
cytosol `GO:0005829`	cellular component
ATP(4-) `CHEBI:30616`	small molecule
coenzyme A(4-) `CHEBI:57287`	small molecule
ALD2 Scer `SGD:S000004780`	protein
ADH1 Scer `SGD:S000005446`	protein
ADH3 Scer `SGD:S000004688`	protein
water `CHEBI:15377`	small molecule
ACS1 Scer `SGD:S000000050`	protein
cytoplasm `GO:0005737`	cellular component
nucleus `GO:0005634`	cellular component
mitochondrion `GO:0005739`	cellular component
mitochondrial matrix `GO:0005759`	cellular component
mitochondrial inner membrane `GO:0005743`	cellular component
zinc(2+) `CHEBI:29105`	cofactor
acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	molecular activity
ethanol + NAD⁺ <=> acetaldehyde + NADH + H⁺ `gomodel:ALCOHOL-DEHYDROG-RXN`	molecular activity
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	molecular activity
acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003312`	molecular activity
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003332`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
ACS2 Scer `SGD:S000004143`	enables	acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002333 gomodel:YeastPathways_PWY3O-4300/6a4c244800003300. Source location `./YeastPathways_PWY3O-4300.json#/facts/0; endpoint types: /individuals/48/type; /individuals/54/type`
ethanol + NAD⁺ <=> acetaldehyde + NADH + H⁺ `gomodel:ALCOHOL-DEHYDROG-RXN`	has_output	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_15343_ALCOHOL-DEHYDROG-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/3; endpoint types: /individuals/1/type; /individuals/2/type`
ADH2 Scer `SGD:S000004918`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003312`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002333 gomodel:YeastPathways_PWY3O-4300/6a4c244800003321. Source location `./YeastPathways_PWY3O-4300.json#/facts/4; endpoint types: /individuals/66/type; /individuals/71/type`
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	provides_input_for	acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 RO:0002413 gomodel:YeastPathways_PWY3O-4300/6a4c244800003293. Source location `./YeastPathways_PWY3O-4300.json#/facts/5; endpoint types: /individuals/17/type; /individuals/48/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003332`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003336. Source location `./YeastPathways_PWY3O-4300.json#/facts/6; endpoint types: /individuals/82/type; /individuals/86/type`
ethanol + NAD⁺ <=> acetaldehyde + NADH + H⁺ `gomodel:ALCOHOL-DEHYDROG-RXN`	provides_input_for	acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002413 gomodel:RXN66-3. Source location `./YeastPathways_PWY3O-4300.json#/facts/7; endpoint types: /individuals/1/type; /individuals/17/type`
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	has_output	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 RO:0002234 gomodel:CHEBI_57945_RXN66-3. Source location `./YeastPathways_PWY3O-4300.json#/facts/8; endpoint types: /individuals/17/type; /individuals/16/type`
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	has_output	acetate `CHEBI:30089`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 RO:0002234 gomodel:CHEBI_30089_RXN66-3. Source location `./YeastPathways_PWY3O-4300.json#/facts/9; endpoint types: /individuals/17/type; /individuals/8/type`
acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	has_input	acetate `CHEBI:30089`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002233 gomodel:CHEBI_30089_RXN66-3. Source location `./YeastPathways_PWY3O-4300.json#/facts/10; endpoint types: /individuals/0/type; /individuals/8/type`
acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002234 gomodel:CHEBI_29888_ACETATE--COA-LIGASE-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/13; endpoint types: /individuals/0/type; /individuals/7/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003332`	has_input	ethanol `CHEBI:16236`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003334. Source location `./YeastPathways_PWY3O-4300.json#/facts/14; endpoint types: /individuals/82/type; /individuals/84/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003332`	has_input	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003333. Source location `./YeastPathways_PWY3O-4300.json#/facts/15; endpoint types: /individuals/82/type; /individuals/83/type`
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	has_input	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 RO:0002233 gomodel:CHEBI_57540_RXN66-3. Source location `./YeastPathways_PWY3O-4300.json#/facts/16; endpoint types: /individuals/17/type; /individuals/14/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003312`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003315. Source location `./YeastPathways_PWY3O-4300.json#/facts/17; endpoint types: /individuals/66/type; /individuals/69/type`
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 RO:0002234 gomodel:CHEBI_15378_RXN66-3. Source location `./YeastPathways_PWY3O-4300.json#/facts/19; endpoint types: /individuals/17/type; /individuals/5/type`
ethanol + NAD⁺ <=> acetaldehyde + NADH + H⁺ `gomodel:ALCOHOL-DEHYDROG-RXN`	part_of	ethanol catabolic process `GO:0006068`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ALCOHOL-DEHYDROG-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300. Source location `./YeastPathways_PWY3O-4300.json#/facts/21; endpoint types: /individuals/1/type; /individuals/45/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003312`	has_output	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002234 gomodel:CHEBI_15343_ALCOHOL-DEHYDROG-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/22; endpoint types: /individuals/66/type; /individuals/2/type`
ethanol + NAD⁺ <=> acetaldehyde + NADH + H⁺ `gomodel:ALCOHOL-DEHYDROG-RXN`	has_input	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002233 gomodel:CHEBI_57540_ALCOHOL-DEHYDROG-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/24; endpoint types: /individuals/1/type; /individuals/13/type`
acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	has_output	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003298. Source location `./YeastPathways_PWY3O-4300.json#/facts/25; endpoint types: /individuals/48/type; /individuals/53/type`
acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	has_output	adenosine 5'-monophosphate(2-) `CHEBI:456215`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002234 gomodel:CHEBI_456215_ACETATE--COA-LIGASE-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/26; endpoint types: /individuals/0/type; /individuals/10/type`
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	provides_input_for	acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 RO:0002413 gomodel:ACETATE--COA-LIGASE-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/27; endpoint types: /individuals/17/type; /individuals/0/type`
acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	has_output	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002234 gomodel:CHEBI_57288_ACETATE--COA-LIGASE-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/28; endpoint types: /individuals/0/type; /individuals/12/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003332`	part_of	ethanol catabolic process `GO:0006068`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300. Source location `./YeastPathways_PWY3O-4300.json#/facts/29; endpoint types: /individuals/82/type; /individuals/45/type`
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	has_input	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 RO:0002233 gomodel:CHEBI_15343_ALCOHOL-DEHYDROG-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/30; endpoint types: /individuals/17/type; /individuals/2/type`
acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ACETATE--COA-LIGASE-RXN BFO:0000066 gomodel:reaction_ACETATE--COA-LIGASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4300.json#/facts/31; endpoint types: /individuals/0/type; /individuals/42/type`
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	part_of	ethanol catabolic process `GO:0006068`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300. Source location `./YeastPathways_PWY3O-4300.json#/facts/32; endpoint types: /individuals/17/type; /individuals/45/type`
acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003295. Source location `./YeastPathways_PWY3O-4300.json#/facts/33; endpoint types: /individuals/48/type; /individuals/50/type`
acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	has_input	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002233 gomodel:CHEBI_57287_ACETATE--COA-LIGASE-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/34; endpoint types: /individuals/0/type; /individuals/11/type`
acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003296. Source location `./YeastPathways_PWY3O-4300.json#/facts/35; endpoint types: /individuals/48/type; /individuals/51/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003332`	has_output	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002234 gomodel:CHEBI_15343_ALCOHOL-DEHYDROG-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/37; endpoint types: /individuals/82/type; /individuals/2/type`
acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002233 gomodel:CHEBI_30616_ACETATE--COA-LIGASE-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/39; endpoint types: /individuals/0/type; /individuals/9/type`
ethanol + NAD⁺ <=> acetaldehyde + NADH + H⁺ `gomodel:ALCOHOL-DEHYDROG-RXN`	has_output	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_57945_ALCOHOL-DEHYDROG-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/40; endpoint types: /individuals/1/type; /individuals/15/type`
ethanol + NAD⁺ <=> acetaldehyde + NADH + H⁺ `gomodel:ALCOHOL-DEHYDROG-RXN`	has_input	ethanol `CHEBI:16236`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002233 gomodel:CHEBI_16236_ALCOHOL-DEHYDROG-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/41; endpoint types: /individuals/1/type; /individuals/6/type`
acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	has_input	acetate `CHEBI:30089`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002233 gomodel:CHEBI_30089_RXN66-3. Source location `./YeastPathways_PWY3O-4300.json#/facts/42; endpoint types: /individuals/48/type; /individuals/8/type`
ALD2 Scer `SGD:S000004780`	enables	acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 RO:0002333 gomodel:YeastPathways_PWY3O-4300/6690711d00000772. Source location `./YeastPathways_PWY3O-4300.json#/facts/43; endpoint types: /individuals/17/type; /individuals/130/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003332`	has_output	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003335. Source location `./YeastPathways_PWY3O-4300.json#/facts/44; endpoint types: /individuals/82/type; /individuals/85/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003312`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 BFO:0000066 gomodel:YeastPathways_PWY3O-4300/6a4c244800003322. Source location `./YeastPathways_PWY3O-4300.json#/facts/46; endpoint types: /individuals/66/type; /individuals/72/type`
acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	part_of	ethanol catabolic process `GO:0006068`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ACETATE--COA-LIGASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300. Source location `./YeastPathways_PWY3O-4300.json#/facts/47; endpoint types: /individuals/0/type; /individuals/45/type`
acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 BFO:0000066 gomodel:YeastPathways_PWY3O-4300/6a4c244800003301. Source location `./YeastPathways_PWY3O-4300.json#/facts/48; endpoint types: /individuals/48/type; /individuals/55/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003332`	provides_input_for	acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002413 gomodel:RXN66-3. Source location `./YeastPathways_PWY3O-4300.json#/facts/49; endpoint types: /individuals/82/type; /individuals/17/type`
ADH1 Scer `SGD:S000005446`	enables	ethanol + NAD⁺ <=> acetaldehyde + NADH + H⁺ `gomodel:ALCOHOL-DEHYDROG-RXN`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002333 gomodel:YOL086C-MONOMER_ALCOHOL-DEHYDROG-RXN_controller. Source location `./YeastPathways_PWY3O-4300.json#/facts/50; endpoint types: /individuals/1/type; /individuals/19/type`
ADH3 Scer `SGD:S000004688`	enables	alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003332`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003332 RO:0002333 gomodel:YeastPathways_PWY3O-4300/6a4c244800003339. Source location `./YeastPathways_PWY3O-4300.json#/facts/52; endpoint types: /individuals/82/type; /individuals/87/type`
ethanol + NAD⁺ <=> acetaldehyde + NADH + H⁺ `gomodel:ALCOHOL-DEHYDROG-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ALCOHOL-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_15378_ALCOHOL-DEHYDROG-RXN. Source location `./YeastPathways_PWY3O-4300.json#/facts/53; endpoint types: /individuals/1/type; /individuals/4/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003312`	provides_input_for	acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002413 gomodel:RXN66-3. Source location `./YeastPathways_PWY3O-4300.json#/facts/54; endpoint types: /individuals/66/type; /individuals/17/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003312`	has_input	ethanol `CHEBI:16236`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003314. Source location `./YeastPathways_PWY3O-4300.json#/facts/56; endpoint types: /individuals/66/type; /individuals/68/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003312`	has_output	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003316. Source location `./YeastPathways_PWY3O-4300.json#/facts/57; endpoint types: /individuals/66/type; /individuals/70/type`
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 RO:0002233 gomodel:CHEBI_15377_RXN66-3. Source location `./YeastPathways_PWY3O-4300.json#/facts/58; endpoint types: /individuals/17/type; /individuals/3/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003312`	has_input	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003313. Source location `./YeastPathways_PWY3O-4300.json#/facts/59; endpoint types: /individuals/66/type; /individuals/67/type`
ethanol + NAD⁺ <=> acetaldehyde + NADH + H⁺ `gomodel:ALCOHOL-DEHYDROG-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ALCOHOL-DEHYDROG-RXN BFO:0000066 gomodel:reaction_ALCOHOL-DEHYDROG-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4300.json#/facts/61; endpoint types: /individuals/1/type; /individuals/43/type`
ACS1 Scer `SGD:S000000050`	enables	acetate + ATP + coenzyme A -> acetyl-CoA + AMP + diphosphate `gomodel:ACETATE--COA-LIGASE-RXN`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:ACETATE--COA-LIGASE-RXN RO:0002333 gomodel:YAL054C-MONOMER_ACETATE--COA-LIGASE-RXN_controller. Source location `./YeastPathways_PWY3O-4300.json#/facts/64; endpoint types: /individuals/0/type; /individuals/18/type`
alcohol dehydrogenase (NAD+) activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003312`	part_of	ethanol catabolic process `GO:0006068`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003312 BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300. Source location `./YeastPathways_PWY3O-4300.json#/facts/67; endpoint types: /individuals/66/type; /individuals/45/type`
acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	has_input	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002233 gomodel:YeastPathways_PWY3O-4300/6a4c244800003294. Source location `./YeastPathways_PWY3O-4300.json#/facts/69; endpoint types: /individuals/48/type; /individuals/49/type`
acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	part_of	ethanol catabolic process `GO:0006068`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 BFO:0000050 gomodel:YeastPathways_PWY3O-4300/YeastPathways_PWY3O-4300. Source location `./YeastPathways_PWY3O-4300.json#/facts/71; endpoint types: /individuals/48/type; /individuals/45/type`
acetaldehyde + NAD⁺ + H₂O -> acetate + NADH + 2 H⁺ `gomodel:RXN66-3`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:RXN66-3 BFO:0000066 gomodel:reaction_RXN66-3_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-4300.json#/facts/72; endpoint types: /individuals/17/type; /individuals/44/type`
acetyl-CoA synthetase activity `gomodel:YeastPathways_PWY3O-4300/6a4c244800003293`	has_output	adenosine 5'-monophosphate(2-) `CHEBI:456215`	gomodel:YeastPathways_PWY3O-4300 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-4300/6a4c244800003293 RO:0002234 gomodel:YeastPathways_PWY3O-4300/6a4c244800003297. Source location `./YeastPathways_PWY3O-4300.json#/facts/73; endpoint types: /individuals/48/type; /individuals/52/type`
ACS2 Scer `SGD:S000004143`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source Source qualification: Predominantly nuclear	cytoplasm `GO:0005737`	UniProtKB:P52910 Source assertion: UniProtKB:P52910 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2080/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P52910 Source assertion: UniProtKB:P52910 has the exact SGD cross-reference SGD:S000004143. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2080/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ACS2 Scer `SGD:S000004143`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source Source qualification: Predominantly nuclear	nucleus `GO:0005634`	UniProtKB:P52910 Source assertion: UniProtKB:P52910 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2080/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P52910 Source assertion: UniProtKB:P52910 has the exact SGD cross-reference SGD:S000004143. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2080/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH2 Scer `SGD:S000004918`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:2937632)	cytoplasm `GO:0005737`	UniProtKB:P00331 Source assertion: UniProtKB:P00331 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00331 Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/23/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ALD2 Scer `SGD:S000004780`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11914276)	cytoplasm `GO:0005737`	UniProtKB:P47771 Source assertion: UniProtKB:P47771 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3891/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P47771 Source assertion: UniProtKB:P47771 has the exact SGD cross-reference SGD:S000004780. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3891/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH1 Scer `SGD:S000005446`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	cytoplasm `GO:0005737`	UniProtKB:P00330 Source assertion: UniProtKB:P00330 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P00330 Source assertion: UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/22/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH3 Scer `SGD:S000004688`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:1101965); ECO:0000269 (PubMed:2188098); ECO:0000269 (PubMed:2943982)	mitochondrial matrix `GO:0005759`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH3 Scer `SGD:S000004688`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:2937632)	mitochondrial inner membrane `GO:0005743`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates location Mitochondrion inner membrane (SL-0168). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/161/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ACS1 Scer `SGD:S000000050`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	cytoplasm `GO:0005737`	UniProtKB:Q01574 Source assertion: UniProtKB:Q01574 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q01574 Source assertion: UniProtKB:Q01574 has the exact SGD cross-reference SGD:S000000050. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ACS1 Scer `SGD:S000000050`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	mitochondrion `GO:0005739`	UniProtKB:Q01574 Source assertion: UniProtKB:Q01574 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q01574 Source assertion: UniProtKB:Q01574 has the exact SGD cross-reference SGD:S000000050. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ACS1 Scer `SGD:S000000050`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	nucleus `GO:0005634`	UniProtKB:Q01574 Source assertion: UniProtKB:Q01574 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/comments/1/subcellularLocations/3; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q01574 Source assertion: UniProtKB:Q01574 has the exact SGD cross-reference SGD:S000000050. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2393/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ADH2 Scer `SGD:S000004918`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P00331 Source assertion: UniProtKB:P00331 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/comments/0/cofactors/0; /results/23/comments/0/note` UniProtKB:P00331 Source assertion: UniProtKB:P00331 has the exact SGD cross-reference SGD:S000004918. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/23/uniProtKBCrossReferences/0`
ADH1 Scer `SGD:S000005446`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000269 (PubMed:25157460); ECO:0000269 (PubMed:26743849)	zinc(2+) `CHEBI:29105`	UniProtKB:P00330 Source assertion: UniProtKB:P00330 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/comments/0/cofactors/0; /results/22/comments/0/note` UniProtKB:P00330 Source assertion: UniProtKB:P00330 has the exact SGD cross-reference SGD:S000005446. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/22/uniProtKBCrossReferences/0`
ADH3 Scer `SGD:S000004688`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00330) Binds 2 Zn(2+) ions per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00330)	zinc(2+) `CHEBI:29105`	UniProtKB:P07246 Source assertion: UniProtKB:P07246 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/comments/0/cofactors/0; /results/161/comments/0/note` UniProtKB:P07246 Source assertion: UniProtKB:P07246 has the exact SGD cross-reference SGD:S000004688. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/161/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY3O-4300 SGD GO-CAM ethanol degradation - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-15; member ./YeastPathways_PWY3O-4300.json)
UniProtKB:P52910 Reviewed UniProtKB P52910 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00331 Reviewed UniProtKB P00331 location annotations (source version: UniProt release 2026_03)
UniProtKB:P10127 Reviewed UniProtKB P10127 location annotations (source version: UniProt release 2026_03)
UniProtKB:P47771 Reviewed UniProtKB P47771 location annotations (source version: UniProt release 2026_03)
UniProtKB:P00330 Reviewed UniProtKB P00330 location annotations (source version: UniProt release 2026_03)
UniProtKB:P07246 Reviewed UniProtKB P07246 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q01574 Reviewed UniProtKB Q01574 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38113 Reviewed UniProtKB P38113 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:53:32Z Codex; review-catalytic-function; Reconciled native GO-CAM chemistry with independently reviewed enzyme specificity, direction, physiological scope and source cautions; superseded facts remain in the function review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 8 activity location assignments and 8 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 12 independently supported location edges and quarantined 2 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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