pyruvate fermentation to acetoin III

gomodel:YeastPathways_PWY3O-440

Pyruvate fermentation to acetoin III in Saccharomyces cerevisiae S288C uses PDC1, PDC5, and PDC6 pyruvate decarboxylase activities to convert pyruvate through acetaldehyde to acetoin and carbon dioxide.

Pathway type

acetoin biosynthesis

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

23 nodes · 80 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
cytosol `GO:0005829`	cellular component
hydron `CHEBI:15378`	small molecule
acetoin biosynthetic process `GO:0045151`	biological process
PDC1 Scer `SGD:S000004034`	protein
pyruvate `CHEBI:15361`	small molecule
acetaldehyde `CHEBI:15343`	small molecule
acetoin `CHEBI:15688`	small molecule
carbon dioxide `CHEBI:16526`	small molecule
PDC6 Scer `SGD:S000003319`	protein
PDC5 Scer `SGD:S000004124`	protein
cytoplasm `GO:0005737`	cellular component
nucleus `GO:0005634`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
thiamine(1+) diphosphate(3-) `CHEBI:58937`	cofactor
pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	molecular activity
pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	molecular activity
2 acetaldehyde -> acetoin `gomodel:RXN3O-470`	molecular activity
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	molecular activity
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	molecular activity
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000854`	molecular activity
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000863`	molecular activity
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	molecular activity
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000899. Source location `./YeastPathways_PWY3O-440.json#/facts/0; endpoint types: /individuals/88/type; /individuals/95/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000824. Source location `./YeastPathways_PWY3O-440.json#/facts/1; endpoint types: /individuals/31/type; /individuals/33/type`
pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	causally_upstream_of	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN-6161 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000890. Source location `./YeastPathways_PWY3O-440.json#/facts/2; endpoint types: /individuals/10/type; /individuals/88/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000863`	part_of	acetoin biosynthetic process `GO:0045151`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000863 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440. Source location `./YeastPathways_PWY3O-440.json#/facts/3; endpoint types: /individuals/66/type; /individuals/30/type`
pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	causally_upstream_of	pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN-6161 RO:0002411 gomodel:RXN0-2022. Source location `./YeastPathways_PWY3O-440.json#/facts/4; endpoint types: /individuals/10/type; /individuals/11/type`
PDC1 Scer `SGD:S000004034`	enables	pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN-6161 RO:0002333 gomodel:YeastPathways_PWY3O-440/6690711d00000555. Source location `./YeastPathways_PWY3O-440.json#/facts/5; endpoint types: /individuals/10/type; /individuals/113/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	has_input	pyruvate `CHEBI:15361`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000877. Source location `./YeastPathways_PWY3O-440.json#/facts/6; endpoint types: /individuals/77/type; /individuals/78/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000878. Source location `./YeastPathways_PWY3O-440.json#/facts/7; endpoint types: /individuals/77/type; /individuals/79/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	has_input	pyruvate `CHEBI:15361`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000891. Source location `./YeastPathways_PWY3O-440.json#/facts/8; endpoint types: /individuals/88/type; /individuals/89/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	causally_upstream_of	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000876. Source location `./YeastPathways_PWY3O-440.json#/facts/9; endpoint types: /individuals/31/type; /individuals/77/type`
pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN0-2022 BFO:0000066 gomodel:reaction_RXN0-2022_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-440.json#/facts/10; endpoint types: /individuals/11/type; /individuals/28/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	has_input	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000893. Source location `./YeastPathways_PWY3O-440.json#/facts/11; endpoint types: /individuals/88/type; /individuals/91/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	has_output	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002234 gomodel:CHEBI_15343_RXN-6161. Source location `./YeastPathways_PWY3O-440.json#/facts/12; endpoint types: /individuals/31/type; /individuals/0/type`
PDC1 Scer `SGD:S000004034`	enables	2 acetaldehyde -> acetoin `gomodel:RXN3O-470`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN3O-470 RO:0002333 gomodel:YeastPathways_PWY3O-440/6690711d00000561. Source location `./YeastPathways_PWY3O-440.json#/facts/13; endpoint types: /individuals/12/type; /individuals/115/type`
2 acetaldehyde -> acetoin `gomodel:RXN3O-470`	part_of	acetoin biosynthetic process `GO:0045151`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN3O-470 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440. Source location `./YeastPathways_PWY3O-440.json#/facts/14; endpoint types: /individuals/12/type; /individuals/30/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	has_input	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000879. Source location `./YeastPathways_PWY3O-440.json#/facts/15; endpoint types: /individuals/77/type; /individuals/80/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	has_input	pyruvate `CHEBI:15361`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000834. Source location `./YeastPathways_PWY3O-440.json#/facts/16; endpoint types: /individuals/40/type; /individuals/41/type`
2 acetaldehyde -> acetoin `gomodel:RXN3O-470`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN3O-470 BFO:0000066 gomodel:reaction_RXN3O-470_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-440.json#/facts/17; endpoint types: /individuals/12/type; /individuals/29/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	causally_upstream_of	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000890. Source location `./YeastPathways_PWY3O-440.json#/facts/18; endpoint types: /individuals/40/type; /individuals/88/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000863`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000863 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000868. Source location `./YeastPathways_PWY3O-440.json#/facts/19; endpoint types: /individuals/66/type; /individuals/69/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	causally_upstream_of	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000876. Source location `./YeastPathways_PWY3O-440.json#/facts/20; endpoint types: /individuals/40/type; /individuals/77/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000863`	has_input	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000863 RO:0002233 gomodel:CHEBI_15343_RXN-6161. Source location `./YeastPathways_PWY3O-440.json#/facts/21; endpoint types: /individuals/66/type; /individuals/0/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	part_of	acetoin biosynthetic process `GO:0045151`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440. Source location `./YeastPathways_PWY3O-440.json#/facts/22; endpoint types: /individuals/88/type; /individuals/30/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	has_output	acetoin `CHEBI:15688`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000895. Source location `./YeastPathways_PWY3O-440.json#/facts/23; endpoint types: /individuals/88/type; /individuals/93/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	causally_upstream_of	pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002411 gomodel:RXN0-2022. Source location `./YeastPathways_PWY3O-440.json#/facts/24; endpoint types: /individuals/40/type; /individuals/11/type`
pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN0-2022 RO:0002234 gomodel:CHEBI_16526_RXN0-2022. Source location `./YeastPathways_PWY3O-440.json#/facts/25; endpoint types: /individuals/11/type; /individuals/9/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000854`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000854 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000859. Source location `./YeastPathways_PWY3O-440.json#/facts/26; endpoint types: /individuals/59/type; /individuals/62/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000829. Source location `./YeastPathways_PWY3O-440.json#/facts/27; endpoint types: /individuals/31/type; /individuals/36/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000894. Source location `./YeastPathways_PWY3O-440.json#/facts/28; endpoint types: /individuals/88/type; /individuals/92/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	part_of	acetoin biosynthetic process `GO:0045151`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440. Source location `./YeastPathways_PWY3O-440.json#/facts/29; endpoint types: /individuals/77/type; /individuals/30/type`
pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	part_of	acetoin biosynthetic process `GO:0045151`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN-6161 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440. Source location `./YeastPathways_PWY3O-440.json#/facts/30; endpoint types: /individuals/10/type; /individuals/30/type`
pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	has_output	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN-6161 RO:0002234 gomodel:CHEBI_15343_RXN-6161. Source location `./YeastPathways_PWY3O-440.json#/facts/31; endpoint types: /individuals/10/type; /individuals/0/type`
pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN-6161 RO:0002234 gomodel:CHEBI_16526_RXN-6161. Source location `./YeastPathways_PWY3O-440.json#/facts/32; endpoint types: /individuals/10/type; /individuals/8/type`
PDC6 Scer `SGD:S000003319`	enables	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000898. Source location `./YeastPathways_PWY3O-440.json#/facts/33; endpoint types: /individuals/88/type; /individuals/94/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	has_output	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002234 gomodel:CHEBI_15343_RXN-6161. Source location `./YeastPathways_PWY3O-440.json#/facts/34; endpoint types: /individuals/40/type; /individuals/0/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000880. Source location `./YeastPathways_PWY3O-440.json#/facts/35; endpoint types: /individuals/77/type; /individuals/81/type`
pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	has_input	pyruvate `CHEBI:15361`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN0-2022 RO:0002233 gomodel:CHEBI_15361_RXN0-2022. Source location `./YeastPathways_PWY3O-440.json#/facts/36; endpoint types: /individuals/11/type; /individuals/3/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	has_output	acetoin `CHEBI:15688`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000881. Source location `./YeastPathways_PWY3O-440.json#/facts/37; endpoint types: /individuals/77/type; /individuals/82/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	has_input	pyruvate `CHEBI:15361`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000823. Source location `./YeastPathways_PWY3O-440.json#/facts/38; endpoint types: /individuals/31/type; /individuals/32/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000825. Source location `./YeastPathways_PWY3O-440.json#/facts/39; endpoint types: /individuals/31/type; /individuals/34/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000885. Source location `./YeastPathways_PWY3O-440.json#/facts/40; endpoint types: /individuals/77/type; /individuals/84/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	causally_upstream_of	pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002411 gomodel:RXN0-2022. Source location `./YeastPathways_PWY3O-440.json#/facts/41; endpoint types: /individuals/31/type; /individuals/11/type`
pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN-6161 BFO:0000066 gomodel:reaction_RXN-6161_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-440.json#/facts/42; endpoint types: /individuals/10/type; /individuals/27/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000890 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000892. Source location `./YeastPathways_PWY3O-440.json#/facts/43; endpoint types: /individuals/88/type; /individuals/90/type`
PDC5 Scer `SGD:S000004124`	enables	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000876 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000882. Source location `./YeastPathways_PWY3O-440.json#/facts/44; endpoint types: /individuals/77/type; /individuals/83/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000863`	has_output	acetoin `CHEBI:15688`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000863 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000864. Source location `./YeastPathways_PWY3O-440.json#/facts/45; endpoint types: /individuals/66/type; /individuals/67/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002233 gomodel:YeastPathways_PWY3O-440/6a46ef0600000835. Source location `./YeastPathways_PWY3O-440.json#/facts/46; endpoint types: /individuals/40/type; /individuals/42/type`
2 acetaldehyde -> acetoin `gomodel:RXN3O-470`	has_output	acetoin `CHEBI:15688`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN3O-470 RO:0002234 gomodel:CHEBI_15688_RXN3O-470. Source location `./YeastPathways_PWY3O-440.json#/facts/47; endpoint types: /individuals/12/type; /individuals/7/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 BFO:0000066 gomodel:YeastPathways_PWY3O-440/6a46ef0600000840. Source location `./YeastPathways_PWY3O-440.json#/facts/48; endpoint types: /individuals/40/type; /individuals/45/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	part_of	acetoin biosynthetic process `GO:0045151`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440. Source location `./YeastPathways_PWY3O-440.json#/facts/49; endpoint types: /individuals/40/type; /individuals/30/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000854`	has_output	acetoin `CHEBI:15688`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000854 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000855. Source location `./YeastPathways_PWY3O-440.json#/facts/50; endpoint types: /individuals/59/type; /individuals/60/type`
PDC6 Scer `SGD:S000003319`	enables	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000838. Source location `./YeastPathways_PWY3O-440.json#/facts/51; endpoint types: /individuals/40/type; /individuals/44/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000854`	has_input	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000854 RO:0002233 gomodel:CHEBI_15343_RXN-6161. Source location `./YeastPathways_PWY3O-440.json#/facts/52; endpoint types: /individuals/59/type; /individuals/0/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	causally_upstream_of	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000890`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000890. Source location `./YeastPathways_PWY3O-440.json#/facts/53; endpoint types: /individuals/31/type; /individuals/88/type`
pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	causally_upstream_of	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000876`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN-6161 RO:0002411 gomodel:YeastPathways_PWY3O-440/6a46ef0600000876. Source location `./YeastPathways_PWY3O-440.json#/facts/54; endpoint types: /individuals/10/type; /individuals/77/type`
PDC6 Scer `SGD:S000003319`	enables	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000863`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000863 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000867. Source location `./YeastPathways_PWY3O-440.json#/facts/55; endpoint types: /individuals/66/type; /individuals/68/type`
pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	has_input	pyruvate `CHEBI:15361`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN-6161 RO:0002233 gomodel:CHEBI_15361_RXN-6161. Source location `./YeastPathways_PWY3O-440.json#/facts/56; endpoint types: /individuals/10/type; /individuals/2/type`
2 acetaldehyde -> acetoin `gomodel:RXN3O-470`	has_input	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN3O-470 RO:0002233 gomodel:CHEBI_15343_RXN-6161. Source location `./YeastPathways_PWY3O-440.json#/facts/57; endpoint types: /individuals/12/type; /individuals/0/type`
PDC5 Scer `SGD:S000004124`	enables	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000826. Source location `./YeastPathways_PWY3O-440.json#/facts/58; endpoint types: /individuals/31/type; /individuals/35/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000833`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000833 RO:0002234 gomodel:YeastPathways_PWY3O-440/6a46ef0600000836. Source location `./YeastPathways_PWY3O-440.json#/facts/59; endpoint types: /individuals/40/type; /individuals/43/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000822`	part_of	acetoin biosynthetic process `GO:0045151`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000822 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440. Source location `./YeastPathways_PWY3O-440.json#/facts/60; endpoint types: /individuals/31/type; /individuals/30/type`
PDC1 Scer `SGD:S000004034`	enables	pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN0-2022 RO:0002333 gomodel:YeastPathways_PWY3O-440/6690711d00000568. Source location `./YeastPathways_PWY3O-440.json#/facts/61; endpoint types: /individuals/11/type; /individuals/118/type`
pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000854`	part_of	acetoin biosynthetic process `GO:0045151`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000854 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440. Source location `./YeastPathways_PWY3O-440.json#/facts/62; endpoint types: /individuals/59/type; /individuals/30/type`
pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN0-2022 RO:0002233 gomodel:CHEBI_15378_RXN0-2022. Source location `./YeastPathways_PWY3O-440.json#/facts/63; endpoint types: /individuals/11/type; /individuals/5/type`
pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	part_of	acetoin biosynthetic process `GO:0045151`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN0-2022 BFO:0000050 gomodel:YeastPathways_PWY3O-440/YeastPathways_PWY3O-440. Source location `./YeastPathways_PWY3O-440.json#/facts/64; endpoint types: /individuals/11/type; /individuals/30/type`
pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	has_input	acetaldehyde `CHEBI:15343`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN0-2022 RO:0002233 gomodel:CHEBI_15343_RXN0-2022. Source location `./YeastPathways_PWY3O-440.json#/facts/65; endpoint types: /individuals/11/type; /individuals/1/type`
pyruvate + H⁺ -> acetaldehyde + CO₂ `gomodel:RXN-6161`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN-6161 RO:0002233 gomodel:CHEBI_15378_RXN-6161. Source location `./YeastPathways_PWY3O-440.json#/facts/66; endpoint types: /individuals/10/type; /individuals/4/type`
pyruvate + acetaldehyde + H⁺ -> acetoin + CO₂ `gomodel:RXN0-2022`	has_output	acetoin `CHEBI:15688`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:RXN0-2022 RO:0002234 gomodel:CHEBI_15688_RXN0-2022. Source location `./YeastPathways_PWY3O-440.json#/facts/67; endpoint types: /individuals/11/type; /individuals/6/type`
PDC5 Scer `SGD:S000004124`	enables	pyruvate decarboxylase activity `gomodel:YeastPathways_PWY3O-440/6a46ef0600000854`	gomodel:YeastPathways_PWY3O-440 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-440/6a46ef0600000854 RO:0002333 gomodel:YeastPathways_PWY3O-440/6a46ef0600000857. Source location `./YeastPathways_PWY3O-440.json#/facts/68; endpoint types: /individuals/59/type; /individuals/61/type`
PDC1 Scer `SGD:S000004034`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC1 Scer `SGD:S000004034`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/127/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC6 Scer `SGD:S000003319`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/742/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC5 Scer `SGD:S000004124`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC5 Scer `SGD:S000004124`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/439/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PDC1 Scer `SGD:S000004034`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	magnesium(2+) `CHEBI:18420`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/0/cofactors/0; /results/127/comments/0/note` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0`
PDC1 Scer `SGD:S000004034`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10651824) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000269 (PubMed:10651824)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P06169 Source assertion: UniProtKB:P06169 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/comments/1/cofactors/0; /results/127/comments/1/note` UniProtKB:P06169 Source assertion: UniProtKB:P06169 has the exact SGD cross-reference SGD:S000004034. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/127/uniProtKBCrossReferences/0`
PDC6 Scer `SGD:S000003319`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	magnesium(2+) `CHEBI:18420`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/0/cofactors/0; /results/742/comments/0/note` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0`
PDC6 Scer `SGD:S000003319`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P26263 Source assertion: UniProtKB:P26263 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/comments/1/cofactors/0; /results/742/comments/1/note` UniProtKB:P26263 Source assertion: UniProtKB:P26263 has the exact SGD cross-reference SGD:S000003319. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/742/uniProtKBCrossReferences/0`
PDC5 Scer `SGD:S000004124`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 Mg(2+) per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	magnesium(2+) `CHEBI:18420`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/0/cofactors/0; /results/439/comments/0/note` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0`
PDC5 Scer `SGD:S000004124`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P06169) Binds 1 thiamine pyrophosphate per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P06169)	thiamine(1+) diphosphate(3-) `CHEBI:58937`	UniProtKB:P16467 Source assertion: UniProtKB:P16467 annotates CHEBI:58937 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/comments/1/cofactors/0; /results/439/comments/1/note` UniProtKB:P16467 Source assertion: UniProtKB:P16467 has the exact SGD cross-reference SGD:S000004124. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/439/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY3O-440 SGD GO-CAM pyruvate fermentation to acetoin III - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-06; member ./YeastPathways_PWY3O-440.json)
UniProtKB:P06169 Reviewed UniProtKB P06169 location annotations (source version: UniProt release 2026_03)
UniProtKB:P26263 Reviewed UniProtKB P26263 location annotations (source version: UniProt release 2026_03)
UniProtKB:P16467 Reviewed UniProtKB P16467 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 9 activity location assignments and 3 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 5 independently supported location edges and quarantined 0 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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