glycerol biosynthesis

gomodel:YeastPathways_PWY3O-48

Glycerol biosynthesis in Saccharomyces cerevisiae S288C uses GPD1 and GPD2 glycerol-3-phosphate dehydrogenase activities with GPP1 and GPP2 glycerol-1-phosphatase activities to convert glycerone phosphate to glycerol via sn-glycerol 3-phosphate.

Pathway type

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

24 nodes · 44 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
sn-glycerol 3-phosphate(2-) `CHEBI:57597`	small molecule
cytosol `GO:0005829`	cellular component
NADH(2-) `CHEBI:57945`	small molecule
glycerol biosynthetic process `GO:0006114`	biological process
glycerol `CHEBI:17754`	small molecule
hydrogenphosphate `CHEBI:43474`	small molecule
water `CHEBI:15377`	small molecule
glycerol 1-phosphate(2-) `CHEBI:231935`	small molecule
GPD1 Scer `SGD:S000002180`	protein
NAD(1-) `CHEBI:57540`	small molecule
glycerone phosphate(2-) `CHEBI:57642`	small molecule
hydron `CHEBI:15378`	small molecule
GPD2 Scer `SGD:S000005420`	protein
GPP1 Scer `SGD:S000001315`	protein
GPP2 Scer `SGD:S000000864`	protein
cytoplasm `GO:0005737`	cellular component
peroxisome `GO:0005777`	cellular component
mitochondrion `GO:0005739`	cellular component
nucleus `GO:0005634`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	molecular activity
glycerol 1-phosphate + H₂O -> glycerol + phosphate `gomodel:GLYCEROL-1-PHOSPHATASE-RXN`	molecular activity
sn-glycerol 1-phosphatase activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000482`	molecular activity
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	has_output	sn-glycerol 3-phosphate(2-) `CHEBI:57597`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002234 gomodel:YeastPathways_PWY3O-48/6a4c244800000502. Source location `./YeastPathways_PWY3O-48.json#/facts/0; endpoint types: /individuals/45/type; /individuals/49/type`
sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	has_output	sn-glycerol 3-phosphate(2-) `CHEBI:57597`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:1.1.1.8-RXN RO:0002234 gomodel:CHEBI_57597_1.1.1.8-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/1; endpoint types: /individuals/28/type; /individuals/6/type`
sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:1.1.1.8-RXN BFO:0000066 gomodel:reaction_1.1.1.8-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-48.json#/facts/2; endpoint types: /individuals/28/type; /individuals/26/type`
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002233 gomodel:YeastPathways_PWY3O-48/6a4c244800000499. Source location `./YeastPathways_PWY3O-48.json#/facts/3; endpoint types: /individuals/45/type; /individuals/46/type`
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	part_of	glycerol biosynthetic process `GO:0006114`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 BFO:0000050 gomodel:YeastPathways_PWY3O-48/YeastPathways_PWY3O-48. Source location `./YeastPathways_PWY3O-48.json#/facts/4; endpoint types: /individuals/45/type; /individuals/29/type`
glycerol 1-phosphate + H₂O -> glycerol + phosphate `gomodel:GLYCEROL-1-PHOSPHATASE-RXN`	has_output	glycerol `CHEBI:17754`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN RO:0002234 gomodel:CHEBI_17754_GLYCEROL-1-PHOSPHATASE-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/5; endpoint types: /individuals/9/type; /individuals/2/type`
sn-glycerol 1-phosphatase activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000482`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 RO:0002234 gomodel:YeastPathways_PWY3O-48/6a4c244800000486. Source location `./YeastPathways_PWY3O-48.json#/facts/6; endpoint types: /individuals/30/type; /individuals/34/type`
sn-glycerol 1-phosphatase activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000482`	has_output	glycerol `CHEBI:17754`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 RO:0002234 gomodel:YeastPathways_PWY3O-48/6a4c244800000485. Source location `./YeastPathways_PWY3O-48.json#/facts/7; endpoint types: /individuals/30/type; /individuals/33/type`
glycerol 1-phosphate + H₂O -> glycerol + phosphate `gomodel:GLYCEROL-1-PHOSPHATASE-RXN`	part_of	glycerol biosynthetic process `GO:0006114`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-48/YeastPathways_PWY3O-48. Source location `./YeastPathways_PWY3O-48.json#/facts/8; endpoint types: /individuals/9/type; /individuals/29/type`
sn-glycerol 1-phosphatase activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000482`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 RO:0002233 gomodel:YeastPathways_PWY3O-48/6a4c244800000483. Source location `./YeastPathways_PWY3O-48.json#/facts/9; endpoint types: /individuals/30/type; /individuals/31/type`
sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	has_input	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:1.1.1.8-RXN RO:0002233 gomodel:CHEBI_57945_1.1.1.8-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/10; endpoint types: /individuals/28/type; /individuals/8/type`
sn-glycerol 1-phosphatase activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000482`	has_input	glycerol 1-phosphate(2-) `CHEBI:231935`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 RO:0002233 gomodel:YeastPathways_PWY3O-48/6a4c244800000484. Source location `./YeastPathways_PWY3O-48.json#/facts/11; endpoint types: /individuals/30/type; /individuals/32/type`
GPD1 Scer `SGD:S000002180`	enables	sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:1.1.1.8-RXN RO:0002333 gomodel:YDL022W-MONOMER_1.1.1.8-RXN_controller. Source location `./YeastPathways_PWY3O-48.json#/facts/12; endpoint types: /individuals/28/type; /individuals/10/type`
glycerol 1-phosphate + H₂O -> glycerol + phosphate `gomodel:GLYCEROL-1-PHOSPHATASE-RXN`	has_output	hydrogenphosphate `CHEBI:43474`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN RO:0002234 gomodel:CHEBI_43474_GLYCEROL-1-PHOSPHATASE-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/13; endpoint types: /individuals/9/type; /individuals/4/type`
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	causally_upstream_of	sn-glycerol 1-phosphatase activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000482`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002411 gomodel:YeastPathways_PWY3O-48/6a4c244800000482. Source location `./YeastPathways_PWY3O-48.json#/facts/14; endpoint types: /individuals/45/type; /individuals/30/type`
glycerol 1-phosphate + H₂O -> glycerol + phosphate `gomodel:GLYCEROL-1-PHOSPHATASE-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN RO:0002233 gomodel:CHEBI_15377_GLYCEROL-1-PHOSPHATASE-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/15; endpoint types: /individuals/9/type; /individuals/0/type`
sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	causally_upstream_of	sn-glycerol 1-phosphatase activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000482`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:1.1.1.8-RXN RO:0002411 gomodel:YeastPathways_PWY3O-48/6a4c244800000482. Source location `./YeastPathways_PWY3O-48.json#/facts/16; endpoint types: /individuals/28/type; /individuals/30/type`
glycerol 1-phosphate + H₂O -> glycerol + phosphate `gomodel:GLYCEROL-1-PHOSPHATASE-RXN`	has_input	glycerol 1-phosphate(2-) `CHEBI:231935`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN RO:0002233 gomodel:CHEBI_231935_GLYCEROL-1-PHOSPHATASE-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/17; endpoint types: /individuals/9/type; /individuals/3/type`
sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	part_of	glycerol biosynthetic process `GO:0006114`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:1.1.1.8-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-48/YeastPathways_PWY3O-48. Source location `./YeastPathways_PWY3O-48.json#/facts/18; endpoint types: /individuals/28/type; /individuals/29/type`
glycerol 1-phosphate + H₂O -> glycerol + phosphate `gomodel:GLYCEROL-1-PHOSPHATASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN BFO:0000066 gomodel:reaction_GLYCEROL-1-PHOSPHATASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-48.json#/facts/19; endpoint types: /individuals/9/type; /individuals/27/type`
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002234 gomodel:YeastPathways_PWY3O-48/6a4c244800000503. Source location `./YeastPathways_PWY3O-48.json#/facts/20; endpoint types: /individuals/45/type; /individuals/50/type`
sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	causally_upstream_of	glycerol 1-phosphate + H₂O -> glycerol + phosphate `gomodel:GLYCEROL-1-PHOSPHATASE-RXN`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:1.1.1.8-RXN RO:0002411 gomodel:GLYCEROL-1-PHOSPHATASE-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/21; endpoint types: /individuals/28/type; /individuals/9/type`
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	has_input	glycerone phosphate(2-) `CHEBI:57642`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002233 gomodel:YeastPathways_PWY3O-48/6a4c244800000501. Source location `./YeastPathways_PWY3O-48.json#/facts/22; endpoint types: /individuals/45/type; /individuals/48/type`
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002233 gomodel:YeastPathways_PWY3O-48/6a4c244800000500. Source location `./YeastPathways_PWY3O-48.json#/facts/23; endpoint types: /individuals/45/type; /individuals/47/type`
sn-glycerol 1-phosphatase activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000482`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 BFO:0000066 gomodel:YeastPathways_PWY3O-48/6a4c244800000489. Source location `./YeastPathways_PWY3O-48.json#/facts/24; endpoint types: /individuals/30/type; /individuals/36/type`
sn-glycerol 1-phosphatase activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000482`	part_of	glycerol biosynthetic process `GO:0006114`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 BFO:0000050 gomodel:YeastPathways_PWY3O-48/YeastPathways_PWY3O-48. Source location `./YeastPathways_PWY3O-48.json#/facts/25; endpoint types: /individuals/30/type; /individuals/29/type`
sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:1.1.1.8-RXN RO:0002233 gomodel:CHEBI_15378_1.1.1.8-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/26; endpoint types: /individuals/28/type; /individuals/1/type`
sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	has_output	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:1.1.1.8-RXN RO:0002234 gomodel:CHEBI_57540_1.1.1.8-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/27; endpoint types: /individuals/28/type; /individuals/5/type`
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 BFO:0000066 gomodel:YeastPathways_PWY3O-48/6a4c244800000506. Source location `./YeastPathways_PWY3O-48.json#/facts/28; endpoint types: /individuals/45/type; /individuals/52/type`
sn-glycerol 3-phosphate + NAD⁺ <- glycerone phosphate + NADH + H⁺ `gomodel:1.1.1.8-RXN`	has_input	glycerone phosphate(2-) `CHEBI:57642`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:1.1.1.8-RXN RO:0002233 gomodel:CHEBI_57642_1.1.1.8-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/29; endpoint types: /individuals/28/type; /individuals/7/type`
GPD2 Scer `SGD:S000005420`	enables	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002333 gomodel:YeastPathways_PWY3O-48/6a4c244800000504. Source location `./YeastPathways_PWY3O-48.json#/facts/30; endpoint types: /individuals/45/type; /individuals/51/type`
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000498`	causally_upstream_of	glycerol 1-phosphate + H₂O -> glycerol + phosphate `gomodel:GLYCEROL-1-PHOSPHATASE-RXN`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000498 RO:0002411 gomodel:GLYCEROL-1-PHOSPHATASE-RXN. Source location `./YeastPathways_PWY3O-48.json#/facts/31; endpoint types: /individuals/45/type; /individuals/9/type`
GPP1 Scer `SGD:S000001315`	enables	glycerol 1-phosphate + H₂O -> glycerol + phosphate `gomodel:GLYCEROL-1-PHOSPHATASE-RXN`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:GLYCEROL-1-PHOSPHATASE-RXN RO:0002333 gomodel:YIL053W-MONOMER_GLYCEROL-1-PHOSPHATASE-RXN_controller. Source location `./YeastPathways_PWY3O-48.json#/facts/32; endpoint types: /individuals/9/type; /individuals/11/type`
GPP2 Scer `SGD:S000000864`	enables	sn-glycerol 1-phosphatase activity `gomodel:YeastPathways_PWY3O-48/6a4c244800000482`	gomodel:YeastPathways_PWY3O-48 Source assertion: The model asserts gomodel:YeastPathways_PWY3O-48/6a4c244800000482 RO:0002333 gomodel:YeastPathways_PWY3O-48/6a4c244800000487. Source location `./YeastPathways_PWY3O-48.json#/facts/33; endpoint types: /individuals/30/type; /individuals/35/type`
GPD1 Scer `SGD:S000002180`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:15210723)	cytoplasm `GO:0005737`	UniProtKB:Q00055 Source assertion: UniProtKB:Q00055 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q00055 Source assertion: UniProtKB:Q00055 has the exact SGD cross-reference SGD:S000002180. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GPD1 Scer `SGD:S000002180`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095); ECO:0000269 (PubMed:15210723)	peroxisome `GO:0005777`	UniProtKB:Q00055 Source assertion: UniProtKB:Q00055 annotates location Peroxisome (SL-0204). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q00055 Source assertion: UniProtKB:Q00055 has the exact SGD cross-reference SGD:S000002180. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2362/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GPD2 Scer `SGD:S000005420`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	cytoplasm `GO:0005737`	UniProtKB:P41911 Source assertion: UniProtKB:P41911 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P41911 Source assertion: UniProtKB:P41911 has the exact SGD cross-reference SGD:S000005420. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GPD2 Scer `SGD:S000005420`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	mitochondrion `GO:0005739`	UniProtKB:P41911 Source assertion: UniProtKB:P41911 annotates location Mitochondrion (SL-0173). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P41911 Source assertion: UniProtKB:P41911 has the exact SGD cross-reference SGD:S000005420. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1828/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GPP1 Scer `SGD:S000001315`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P41277 Source assertion: UniProtKB:P41277 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1798/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P41277 Source assertion: UniProtKB:P41277 has the exact SGD cross-reference SGD:S000001315. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1798/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GPP1 Scer `SGD:S000001315`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P41277 Source assertion: UniProtKB:P41277 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1798/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P41277 Source assertion: UniProtKB:P41277 has the exact SGD cross-reference SGD:S000001315. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1798/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GPP2 Scer `SGD:S000000864`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P40106 Source assertion: UniProtKB:P40106 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1669/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P40106 Source assertion: UniProtKB:P40106 has the exact SGD cross-reference SGD:S000000864. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1669/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GPP2 Scer `SGD:S000000864`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P40106 Source assertion: UniProtKB:P40106 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1669/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P40106 Source assertion: UniProtKB:P40106 has the exact SGD cross-reference SGD:S000000864. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1669/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
GPP1 Scer `SGD:S000001315`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000305 (PubMed:8662716)	magnesium(2+) `CHEBI:18420`	UniProtKB:P41277 Source assertion: UniProtKB:P41277 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1798/comments/0/cofactors/0` UniProtKB:P41277 Source assertion: UniProtKB:P41277 has the exact SGD cross-reference SGD:S000001315. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1798/uniProtKBCrossReferences/0`
GPP2 Scer `SGD:S000000864`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000305 (PubMed:8662716)	magnesium(2+) `CHEBI:18420`	UniProtKB:P40106 Source assertion: UniProtKB:P40106 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1669/comments/0/cofactors/0` UniProtKB:P40106 Source assertion: UniProtKB:P40106 has the exact SGD cross-reference SGD:S000000864. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1669/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY3O-48 SGD GO-CAM glycerol biosynthesis - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-07; member ./YeastPathways_PWY3O-48.json)
UniProtKB:Q00055 Reviewed UniProtKB Q00055 location annotations (source version: UniProt release 2026_03)
UniProtKB:P41911 Reviewed UniProtKB P41911 location annotations (source version: UniProt release 2026_03)
UniProtKB:P41277 Reviewed UniProtKB P41277 location annotations (source version: UniProt release 2026_03)
UniProtKB:P40106 Reviewed UniProtKB P40106 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 4 activity location assignments and 4 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 8 independently supported location edges and quarantined 0 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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