tetrapyrrole biosynthesis

gomodel:YeastPathways_PWY3O-50

Tetrapyrrole biosynthesis in Saccharomyces cerevisiae S288C converts glycine and succinyl-CoA to 5-aminolevulinate, porphobilinogen, hydroxymethylbilane, and uroporphyrinogen III as a precursor route for heme and siroheme formation.

Pathway type

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

25 nodes · 32 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
5-ammoniolevulinate `CHEBI:356416`	small molecule
carbon dioxide `CHEBI:16526`	small molecule
uroporphyrinogen III(8-) `CHEBI:57308`	small molecule
HEM1 Scer `SGD:S000002640`	protein
HEM3 Scer `SGD:S000002364`	protein
cytosol `GO:0005829`	cellular component
HEM2 Scer `SGD:S000003008`	protein
water `CHEBI:15377`	small molecule
tetrapyrrole biosynthetic process `GO:0033014`	biological process
porphobilinogen(1-) `CHEBI:58126`	small molecule
ammonium `CHEBI:28938`	small molecule
hydron `CHEBI:15378`	small molecule
succinyl-CoA(5-) `CHEBI:57292`	small molecule
glycine zwitterion `CHEBI:57305`	small molecule
coenzyme A(4-) `CHEBI:57287`	small molecule
preuroporphyrinogen(8-) `CHEBI:57845`	small molecule
HEM4 Scer `SGD:S000005804`	protein
mitochondrial matrix `GO:0005759`	cellular component
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
dipyrromethane cofactor(4-) `CHEBI:60342`	cofactor
zinc(2+) `CHEBI:29105`	cofactor
glycine + succinyl-CoA + H⁺ -> CO₂ + 5-aminolevulinate + coenzyme A `gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN`	molecular activity
4 porphobilinogen + H₂O -> 4 ammonium + preuroporphyrinogen `gomodel:OHMETHYLBILANESYN-RXN`	molecular activity
2 5-aminolevulinate -> porphobilinogen + H⁺ + 2 H₂O `gomodel:PORPHOBILSYNTH-RXN`	molecular activity
preuroporphyrinogen -> uroporphyrinogen-III + H₂O `gomodel:UROGENIIISYN-RXN`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
glycine + succinyl-CoA + H⁺ -> CO₂ + 5-aminolevulinate + coenzyme A `gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN`	has_output	5-ammoniolevulinate `CHEBI:356416`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_356416_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/0; endpoint types: /individuals/50/type; /individuals/7/type`
glycine + succinyl-CoA + H⁺ -> CO₂ + 5-aminolevulinate + coenzyme A `gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN`	has_output	carbon dioxide `CHEBI:16526`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_16526_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/1; endpoint types: /individuals/50/type; /individuals/5/type`
preuroporphyrinogen -> uroporphyrinogen-III + H₂O `gomodel:UROGENIIISYN-RXN`	has_output	uroporphyrinogen III(8-) `CHEBI:57308`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:UROGENIIISYN-RXN RO:0002234 gomodel:CHEBI_57308_UROGENIIISYN-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/2; endpoint types: /individuals/16/type; /individuals/11/type`
HEM1 Scer `SGD:S000002640`	enables	glycine + succinyl-CoA + H⁺ -> CO₂ + 5-aminolevulinate + coenzyme A `gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002333 gomodel:YDR232W-MONOMER_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN_controller. Source location `./YeastPathways_PWY3O-50.json#/facts/3; endpoint types: /individuals/50/type; /individuals/18/type`
HEM3 Scer `SGD:S000002364`	enables	4 porphobilinogen + H₂O -> 4 ammonium + preuroporphyrinogen `gomodel:OHMETHYLBILANESYN-RXN`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:OHMETHYLBILANESYN-RXN RO:0002333 gomodel:YDL205C-MONOMER_OHMETHYLBILANESYN-RXN_controller. Source location `./YeastPathways_PWY3O-50.json#/facts/4; endpoint types: /individuals/14/type; /individuals/17/type`
HEM2 Scer `SGD:S000003008`	enables	2 5-aminolevulinate -> porphobilinogen + H⁺ + 2 H₂O `gomodel:PORPHOBILSYNTH-RXN`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:PORPHOBILSYNTH-RXN RO:0002333 gomodel:YGL040C-MONOMER_PORPHOBILSYNTH-RXN_controller. Source location `./YeastPathways_PWY3O-50.json#/facts/6; endpoint types: /individuals/15/type; /individuals/19/type`
preuroporphyrinogen -> uroporphyrinogen-III + H₂O `gomodel:UROGENIIISYN-RXN`	has_output	water `CHEBI:15377`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:UROGENIIISYN-RXN RO:0002234 gomodel:CHEBI_15377_UROGENIIISYN-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/7; endpoint types: /individuals/16/type; /individuals/2/type`
2 5-aminolevulinate -> porphobilinogen + H⁺ + 2 H₂O `gomodel:PORPHOBILSYNTH-RXN`	has_output	water `CHEBI:15377`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:PORPHOBILSYNTH-RXN RO:0002234 gomodel:CHEBI_15377_PORPHOBILSYNTH-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/8; endpoint types: /individuals/15/type; /individuals/1/type`
preuroporphyrinogen -> uroporphyrinogen-III + H₂O `gomodel:UROGENIIISYN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:UROGENIIISYN-RXN BFO:0000066 gomodel:reaction_UROGENIIISYN-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-50.json#/facts/9; endpoint types: /individuals/16/type; /individuals/49/type`
glycine + succinyl-CoA + H⁺ -> CO₂ + 5-aminolevulinate + coenzyme A `gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN`	part_of	tetrapyrrole biosynthetic process `GO:0033014`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-50/YeastPathways_PWY3O-50. Source location `./YeastPathways_PWY3O-50.json#/facts/10; endpoint types: /individuals/50/type; /individuals/51/type`
2 5-aminolevulinate -> porphobilinogen + H⁺ + 2 H₂O `gomodel:PORPHOBILSYNTH-RXN`	has_output	porphobilinogen(1-) `CHEBI:58126`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:PORPHOBILSYNTH-RXN RO:0002234 gomodel:CHEBI_58126_PORPHOBILSYNTH-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/11; endpoint types: /individuals/15/type; /individuals/13/type`
4 porphobilinogen + H₂O -> 4 ammonium + preuroporphyrinogen `gomodel:OHMETHYLBILANESYN-RXN`	has_input	porphobilinogen(1-) `CHEBI:58126`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:OHMETHYLBILANESYN-RXN RO:0002233 gomodel:CHEBI_58126_PORPHOBILSYNTH-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/12; endpoint types: /individuals/14/type; /individuals/13/type`
4 porphobilinogen + H₂O -> 4 ammonium + preuroporphyrinogen `gomodel:OHMETHYLBILANESYN-RXN`	has_output	ammonium `CHEBI:28938`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:OHMETHYLBILANESYN-RXN RO:0002234 gomodel:CHEBI_28938_OHMETHYLBILANESYN-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/13; endpoint types: /individuals/14/type; /individuals/6/type`
glycine + succinyl-CoA + H⁺ -> CO₂ + 5-aminolevulinate + coenzyme A `gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_15378_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/14; endpoint types: /individuals/50/type; /individuals/3/type`
glycine + succinyl-CoA + H⁺ -> CO₂ + 5-aminolevulinate + coenzyme A `gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN`	has_input	succinyl-CoA(5-) `CHEBI:57292`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57292_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/15; endpoint types: /individuals/50/type; /individuals/9/type`
glycine + succinyl-CoA + H⁺ -> CO₂ + 5-aminolevulinate + coenzyme A `gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN`	has_input	glycine zwitterion `CHEBI:57305`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002233 gomodel:CHEBI_57305_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/16; endpoint types: /individuals/50/type; /individuals/10/type`
2 5-aminolevulinate -> porphobilinogen + H⁺ + 2 H₂O `gomodel:PORPHOBILSYNTH-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:PORPHOBILSYNTH-RXN BFO:0000066 gomodel:reaction_PORPHOBILSYNTH-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-50.json#/facts/17; endpoint types: /individuals/15/type; /individuals/48/type`
4 porphobilinogen + H₂O -> 4 ammonium + preuroporphyrinogen `gomodel:OHMETHYLBILANESYN-RXN`	part_of	tetrapyrrole biosynthetic process `GO:0033014`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:OHMETHYLBILANESYN-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-50/YeastPathways_PWY3O-50. Source location `./YeastPathways_PWY3O-50.json#/facts/18; endpoint types: /individuals/14/type; /individuals/51/type`
glycine + succinyl-CoA + H⁺ -> CO₂ + 5-aminolevulinate + coenzyme A `gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN`	has_output	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN RO:0002234 gomodel:CHEBI_57287_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/19; endpoint types: /individuals/50/type; /individuals/8/type`
4 porphobilinogen + H₂O -> 4 ammonium + preuroporphyrinogen `gomodel:OHMETHYLBILANESYN-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:OHMETHYLBILANESYN-RXN RO:0002233 gomodel:CHEBI_15377_OHMETHYLBILANESYN-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/20; endpoint types: /individuals/14/type; /individuals/0/type`
4 porphobilinogen + H₂O -> 4 ammonium + preuroporphyrinogen `gomodel:OHMETHYLBILANESYN-RXN`	has_output	preuroporphyrinogen(8-) `CHEBI:57845`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:OHMETHYLBILANESYN-RXN RO:0002234 gomodel:CHEBI_57845_OHMETHYLBILANESYN-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/21; endpoint types: /individuals/14/type; /individuals/12/type`
HEM4 Scer `SGD:S000005804`	enables	preuroporphyrinogen -> uroporphyrinogen-III + H₂O `gomodel:UROGENIIISYN-RXN`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:UROGENIIISYN-RXN RO:0002333 gomodel:YOR278W-MONOMER_UROGENIIISYN-RXN_controller. Source location `./YeastPathways_PWY3O-50.json#/facts/22; endpoint types: /individuals/16/type; /individuals/20/type`
2 5-aminolevulinate -> porphobilinogen + H⁺ + 2 H₂O `gomodel:PORPHOBILSYNTH-RXN`	part_of	tetrapyrrole biosynthetic process `GO:0033014`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:PORPHOBILSYNTH-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-50/YeastPathways_PWY3O-50. Source location `./YeastPathways_PWY3O-50.json#/facts/23; endpoint types: /individuals/15/type; /individuals/51/type`
4 porphobilinogen + H₂O -> 4 ammonium + preuroporphyrinogen `gomodel:OHMETHYLBILANESYN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:OHMETHYLBILANESYN-RXN BFO:0000066 gomodel:reaction_OHMETHYLBILANESYN-RXN_location_lociGO_0005829. Source location `./YeastPathways_PWY3O-50.json#/facts/24; endpoint types: /individuals/14/type; /individuals/47/type`
preuroporphyrinogen -> uroporphyrinogen-III + H₂O `gomodel:UROGENIIISYN-RXN`	part_of	tetrapyrrole biosynthetic process `GO:0033014`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:UROGENIIISYN-RXN BFO:0000050 gomodel:YeastPathways_PWY3O-50/YeastPathways_PWY3O-50. Source location `./YeastPathways_PWY3O-50.json#/facts/25; endpoint types: /individuals/16/type; /individuals/51/type`
preuroporphyrinogen -> uroporphyrinogen-III + H₂O `gomodel:UROGENIIISYN-RXN`	has_input	preuroporphyrinogen(8-) `CHEBI:57845`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:UROGENIIISYN-RXN RO:0002233 gomodel:CHEBI_57845_OHMETHYLBILANESYN-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/26; endpoint types: /individuals/16/type; /individuals/12/type`
2 5-aminolevulinate -> porphobilinogen + H⁺ + 2 H₂O `gomodel:PORPHOBILSYNTH-RXN`	has_input	5-ammoniolevulinate `CHEBI:356416`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:PORPHOBILSYNTH-RXN RO:0002233 gomodel:CHEBI_356416_5-AMINOLEVULINIC-ACID-SYNTHASE-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/27; endpoint types: /individuals/15/type; /individuals/7/type`
2 5-aminolevulinate -> porphobilinogen + H⁺ + 2 H₂O `gomodel:PORPHOBILSYNTH-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_PWY3O-50 Source assertion: The model asserts gomodel:PORPHOBILSYNTH-RXN RO:0002234 gomodel:CHEBI_15378_PORPHOBILSYNTH-RXN. Source location `./YeastPathways_PWY3O-50.json#/facts/28; endpoint types: /individuals/15/type; /individuals/4/type`
HEM1 Scer `SGD:S000002640`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:3023841); ECO:0000269 (PubMed:6381051)	mitochondrial matrix `GO:0005759`	UniProtKB:P09950 Source assertion: UniProtKB:P09950 annotates location Mitochondrion matrix (SL-0170). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/233/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P09950 Source assertion: UniProtKB:P09950 has the exact SGD cross-reference SGD:S000002640. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/233/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
HEM1 Scer `SGD:S000002640`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:6381051)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P09950 Source assertion: UniProtKB:P09950 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/233/comments/0/cofactors/0` UniProtKB:P09950 Source assertion: UniProtKB:P09950 has the exact SGD cross-reference SGD:S000002640. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/233/uniProtKBCrossReferences/0`
HEM3 Scer `SGD:S000002364`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The source describes a covalently attached cofactor moiety. Keep that bound-state qualification; no free cosubstrate consumption is inferred. UniProt evidence: not specified Binds 1 dipyrromethane group covalently. UniProt note evidence: ECO:0000305 (PubMed:1508149)	dipyrromethane cofactor(4-) `CHEBI:60342`	UniProtKB:P28789 Source assertion: UniProtKB:P28789 annotates CHEBI:60342 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4526/comments/0/cofactors/0; /results/4526/comments/0/note` UniProtKB:P28789 Source assertion: UniProtKB:P28789 has the exact SGD cross-reference SGD:S000002364. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/4526/uniProtKBCrossReferences/0`
HEM2 Scer `SGD:S000003008`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:10386874) Binds 1 zinc ion per monomer. UniProt note evidence: ECO:0000269 (PubMed:10386874)	zinc(2+) `CHEBI:29105`	UniProtKB:P05373 Source assertion: UniProtKB:P05373 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/104/comments/0/cofactors/0; /results/104/comments/0/note` UniProtKB:P05373 Source assertion: UniProtKB:P05373 has the exact SGD cross-reference SGD:S000003008. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/104/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_PWY3O-50 SGD GO-CAM tetrapyrrole biosynthesis - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2023-12-14; member ./YeastPathways_PWY3O-50.json)
UniProtKB:P09950 Reviewed UniProtKB P09950 location annotations (source version: UniProt release 2026_03)
UniProtKB:P28789 UniProtKB P28789 cofactor annotations (source version: 2026_03)
UniProtKB:P05373 UniProtKB P05373 cofactor annotations (source version: 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 4 activity location assignments and 4 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 1 independently supported location edges and quarantined 1 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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