sphingolipid biosynthesis (yeast)
gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1
Sphingolipid biosynthesis in Saccharomyces cerevisiae S288C connects long-chain base synthesis and phosphorylation, ceramide formation, ceramide hydrolysis, and inositol-phosphorylceramide remodeling reactions in the SGD GO-CAM yeast sphingolipid pathway.
- Pathway type
- sphingolipid biosynthesis
- Organism scope
Pathway network
85 nodes · 207 asserted directed edges
Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.
- Reaction / activity
- Chemical / cofactor
- Protein / complex
- Cell / process context
- Solid arrow: mechanistic relation
- Dashed arrow: membership, location or cofactor relation
Components and activities
| Node | Kind or role | Source direction |
|---|---|---|
Saccharomyces cerevisiae S288CNCBITaxon:559292 | taxon | |
cytosolGO:0005829 | cellular component | |
carbon dioxideCHEBI:16526 | small molecule | |
sphinganine 1-phosphate(1-)CHEBI:57939 | small molecule | |
waterCHEBI:15377 | small molecule | |
GDP-alpha-D-mannose(2-)CHEBI:57527 | small molecule | |
sphingolipid biosynthetic processGO:0030148 | biological process | |
N-acylphytosphingosineCHEBI:31998 | lipid | |
coenzyme A(4-)CHEBI:57287 | small molecule | |
hydronCHEBI:15378 | small molecule | |
1-phosphatidyl-1D-myo-inositolCHEBI:16749 | lipid | |
SUR2 ScerSGD:S000002705 | protein | |
YSR3 ScerSGD:S000001761 | protein | |
ATP(4-)CHEBI:30616 | small molecule | |
sphinganine(1+)CHEBI:57817 | lipid | |
L-serine zwitterionCHEBI:33384 | small molecule | |
3-dehydrosphinganinium(1+)CHEBI:58299 | small molecule | |
phytosphingosine 1-phosphate(1-)CHEBI:64795 | small molecule | |
1,2-diacyl-sn-glycerolCHEBI:17815 | lipid | |
inositol phosphomannosylinositol phosphoceramideCHEBI:62682 | lipid | |
phytosphingosine(1+)CHEBI:64124 | lipid | |
hydrogenphosphateCHEBI:43474 | small molecule | |
very long-chain fatty acyl-CoACHEBI:61910 | lipid | |
NADP(3-)CHEBI:58349 | small molecule | |
mannosylinositol phosphorylceramideCHEBI:25168 | lipid | |
ADP(3-)CHEBI:456216 | small molecule | |
AUR1 ScerSGD:S000001487 | protein | |
dioxygenCHEBI:15379 | small molecule | |
ferricytochrome b5CHEBI:18097 | protein | |
DPL1 ScerSGD:S000002702 | protein | |
ferrocytochrome b5CHEBI:16518 | protein | |
IPT1 ScerSGD:S000002479 | protein | |
2-hydroxy fatty acidCHEBI:10283 | lipid | |
TSC10 ScerSGD:S000000469 | protein | |
GDP(3-)CHEBI:58189 | small molecule | |
palmitoyl-CoA(4-)CHEBI:57379 | small molecule | |
LCB3 ScerSGD:S000003670 | protein | |
LCB2 ScerSGD:S000002469 | protein | |
LCB1 ScerSGD:S000004911 | protein | |
YPC1 ScerSGD:S000000387 | protein | |
CPX-1706 ScerSGD:S000218096 | complex | |
inositol phosphoceramideCHEBI:60245 | lipid | |
hexadecanalCHEBI:17600 | small molecule | |
LCB5 ScerSGD:S000004250 | protein | |
O-phosphonatoethanaminium(1-)CHEBI:58190 | small molecule | |
SCS7 ScerSGD:S000004885 | protein | |
LCB4 ScerSGD:S000005697 | protein | |
YDC1 ScerSGD:S000006008 | protein | |
CPX-1739 ScerSGD:S000218211 | complex | |
NADPH(4-)CHEBI:57783 | small molecule | |
Ceramide synthase LAG1UniProtKB:P38703 | protein | |
Ceramide synthase LAC1UniProtKB:P28496 | protein | |
Ceramide synthase subunit LIP1UniProtKB:Q03579 | protein | |
Mannosyl phosphorylinositol ceramide synthase SUR1UniProtKB:P33300 | protein | |
Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2UniProtKB:P35206 | protein | |
Golgi apparatusGO:0005794 | cellular component | |
endoplasmic reticulum membraneGO:0005789 | cellular component | |
Golgi cisterna membraneGO:0032580 | cellular component | |
Golgi membraneGO:0000139 | cellular component | |
cytoplasmGO:0005737 | cellular component | |
endoplasmic reticulumGO:0005783 | cellular component | |
membraneGO:0016020 | cellular component | |
plasma membraneGO:0005886 | cellular component | |
late endosome membraneGO:0031902 | cellular component | |
pyridoxal 5'-phosphate(2-)CHEBI:597326 | cofactor | |
zinc(2+)CHEBI:29105 | cofactor | |
D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN | molecular activity | |
a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN | molecular activity | |
sphinganine 1-phosphate + H2O -> D-erythro-sphinganine + phosphategomodel:DHS-PHOSPHATASE-RXN | molecular activity | |
D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | molecular activity | |
phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 | molecular activity | |
a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 | molecular activity | |
phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | molecular activity | |
phytosphingosine 1-phosphate + H2O -> phytosphingosine + phosphategomodel:RXN3O-504 | molecular activity | |
a (2'R)-2'-hydroxy-phytoceramide + a 1-phosphatidyl-1D-myo-inositol -> an inositol-phospho-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-581 | molecular activity | |
an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 | molecular activity | |
a mannosyl-inositol-phospho-α hydroxyphytoceramide + a 1-phosphatidyl-1D-myo-inositol -> a mannosyl-diphosphoinositol-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-680 | molecular activity | |
L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN | molecular activity | |
sphinganine 1-phosphate -> palmitaldehyde + O-phosphoethanolaminegomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN | molecular activity | |
D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN | molecular activity | |
serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 | molecular activity | |
dihydrosphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 | molecular activity | |
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 | molecular activity | |
sphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 | molecular activity | |
N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 | molecular activity | |
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | molecular activity |
Mechanistic edges
| Subject | Predicate and description | Object | Evidence |
|---|---|---|---|
L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN | has_output | carbon dioxideCHEBI:16526 |
|
sphinganine 1-phosphate + H2O -> D-erythro-sphinganine + phosphategomodel:DHS-PHOSPHATASE-RXN | has_input | sphinganine 1-phosphate(1-)CHEBI:57939 |
|
N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 | has_input | waterCHEBI:15377 |
|
sphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 | provides_input_for | phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 |
|
an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 | has_input | GDP-alpha-D-mannose(2-)CHEBI:57527 |
|
serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 | occurs_in | cytosolGO:0005829 |
|
N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 | provides_input_for | phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 |
|
sphinganine 1-phosphate + H2O -> D-erythro-sphinganine + phosphategomodel:DHS-PHOSPHATASE-RXN | part_of | sphingolipid biosynthetic processGO:0030148 |
|
serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 | provides_input_for | D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN |
|
a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 | has_output | N-acylphytosphingosineCHEBI:31998 |
|
phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 | has_output | coenzyme A(4-)CHEBI:57287 |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | has_output | hydronCHEBI:15378 |
|
a mannosyl-inositol-phospho-α hydroxyphytoceramide + a 1-phosphatidyl-1D-myo-inositol -> a mannosyl-diphosphoinositol-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-680 | has_input | 1-phosphatidyl-1D-myo-inositolCHEBI:16749 |
|
SUR2 ScerSGD:S000002705 | enables | D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | part_of | sphingolipid biosynthetic processGO:0030148 |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 | provides_input_for | dihydrosphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 |
|
L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN | provides_input_for | D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN |
|
phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 | provides_input_for | a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 |
|
a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 | has_input | N-acylphytosphingosineCHEBI:31998 |
|
D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | provides_input_for | phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 |
|
a (2'R)-2'-hydroxy-phytoceramide + a 1-phosphatidyl-1D-myo-inositol -> an inositol-phospho-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-581 | provides_input_for | an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 |
|
YSR3 ScerSGD:S000001761 | enables | dihydrosphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 | has_input | ATP(4-)CHEBI:30616 |
|
a (2'R)-2'-hydroxy-phytoceramide + a 1-phosphatidyl-1D-myo-inositol -> an inositol-phospho-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-581 | has_input | 1-phosphatidyl-1D-myo-inositolCHEBI:16749 |
|
phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 | part_of | sphingolipid biosynthetic processGO:0030148 |
|
serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 | has_output | carbon dioxideCHEBI:16526 |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 | provides_input_for | sphinganine 1-phosphate -> palmitaldehyde + O-phosphoethanolaminegomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | provides_input_for | sphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | provides_input_for | a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN |
|
dihydrosphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 | has_output | sphinganine(1+)CHEBI:57817 |
|
serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 | has_input | L-serine zwitterionCHEBI:33384 |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 | has_output | sphinganine 1-phosphate(1-)CHEBI:57939 |
|
an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 | part_of | sphingolipid biosynthetic processGO:0030148 |
|
serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 | has_output | 3-dehydrosphinganinium(1+)CHEBI:58299 |
|
a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 | has_output | waterCHEBI:15377 |
|
phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | has_output | phytosphingosine 1-phosphate(1-)CHEBI:64795 |
|
a (2'R)-2'-hydroxy-phytoceramide + a 1-phosphatidyl-1D-myo-inositol -> an inositol-phospho-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-581 | has_output | 1,2-diacyl-sn-glycerolCHEBI:17815 |
|
phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | provides_input_for | sphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 |
|
an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 | has_output | hydronCHEBI:15378 |
|
a mannosyl-inositol-phospho-α hydroxyphytoceramide + a 1-phosphatidyl-1D-myo-inositol -> a mannosyl-diphosphoinositol-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-680 | has_output | inositol phosphomannosylinositol phosphoceramideCHEBI:62682 |
|
D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | has_output | phytosphingosine(1+)CHEBI:64124 |
|
sphinganine 1-phosphate + H2O -> D-erythro-sphinganine + phosphategomodel:DHS-PHOSPHATASE-RXN | has_output | hydrogenphosphateCHEBI:43474 |
|
phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 | has_input | very long-chain fatty acyl-CoACHEBI:61910 |
|
phytosphingosine 1-phosphate + H2O -> phytosphingosine + phosphategomodel:RXN3O-504 | has_output | hydrogenphosphateCHEBI:43474 |
|
a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN | has_input | N-acylphytosphingosineCHEBI:31998 |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | has_input | ATP(4-)CHEBI:30616 |
|
D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN | has_output | NADP(3-)CHEBI:58349 |
|
YSR3 ScerSGD:S000001761 | enables | sphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 |
|
phytosphingosine 1-phosphate + H2O -> phytosphingosine + phosphategomodel:RXN3O-504 | provides_input_for | phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 |
|
a mannosyl-inositol-phospho-α hydroxyphytoceramide + a 1-phosphatidyl-1D-myo-inositol -> a mannosyl-diphosphoinositol-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-680 | has_input | mannosylinositol phosphorylceramideCHEBI:25168 |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | has_output | ADP(3-)CHEBI:456216 |
|
D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | has_input | hydronCHEBI:15378 |
|
an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 | provides_input_for | a mannosyl-inositol-phospho-α hydroxyphytoceramide + a 1-phosphatidyl-1D-myo-inositol -> a mannosyl-diphosphoinositol-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-680 |
|
a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN | part_of | sphingolipid biosynthetic processGO:0030148 |
|
D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | provides_input_for | sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 |
|
a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN | provides_input_for | sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 |
|
a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN | provides_input_for | phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 |
|
phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | part_of | sphingolipid biosynthetic processGO:0030148 |
|
AUR1 ScerSGD:S000001487 | enables | a (2'R)-2'-hydroxy-phytoceramide + a 1-phosphatidyl-1D-myo-inositol -> an inositol-phospho-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-581 |
|
N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 | part_of | sphingolipid biosynthetic processGO:0030148 |
|
sphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 | has_input | phytosphingosine 1-phosphate(1-)CHEBI:64795 |
|
D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN | provides_input_for | sphinganine 1-phosphate + H2O -> D-erythro-sphinganine + phosphategomodel:DHS-PHOSPHATASE-RXN |
|
D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | has_input | dioxygenCHEBI:15379 |
|
phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 | has_output | N-acylphytosphingosineCHEBI:31998 |
|
a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 | has_output | ferricytochrome b5CHEBI:18097 |
|
a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 | provides_input_for | a (2'R)-2'-hydroxy-phytoceramide + a 1-phosphatidyl-1D-myo-inositol -> an inositol-phospho-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-581 |
|
DPL1 ScerSGD:S000002702 | enables | sphinganine 1-phosphate -> palmitaldehyde + O-phosphoethanolaminegomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN |
|
D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | has_input | sphinganine(1+)CHEBI:57817 |
|
D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | has_input | ferrocytochrome b5CHEBI:16518 |
|
serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 | has_output | coenzyme A(4-)CHEBI:57287 |
|
sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | provides_input_for | N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 |
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L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN | part_of | sphingolipid biosynthetic processGO:0030148 |
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sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | has_output | phytosphingosine 1-phosphate(1-)CHEBI:64795 |
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sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 | part_of | sphingolipid biosynthetic processGO:0030148 |
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D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN | has_output | hydronCHEBI:15378 |
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phytosphingosine 1-phosphate + H2O -> phytosphingosine + phosphategomodel:RXN3O-504 | has_input | phytosphingosine 1-phosphate(1-)CHEBI:64795 |
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phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | has_input | phytosphingosine(1+)CHEBI:64124 |
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L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN | has_input | hydronCHEBI:15378 |
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IPT1 ScerSGD:S000002479 | enables | a mannosyl-inositol-phospho-α hydroxyphytoceramide + a 1-phosphatidyl-1D-myo-inositol -> a mannosyl-diphosphoinositol-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-680 |
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D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN | has_input | hydronCHEBI:15378 |
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N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 | has_output | 2-hydroxy fatty acidCHEBI:10283 |
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D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN | has_output | sphinganine(1+)CHEBI:57817 |
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TSC10 ScerSGD:S000000469 | enables | D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN |
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phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | provides_input_for | N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 |
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an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 | has_output | GDP(3-)CHEBI:58189 |
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L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN | has_input | palmitoyl-CoA(4-)CHEBI:57379 |
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D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN | has_output | ADP(3-)CHEBI:456216 |
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sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 | has_output | ADP(3-)CHEBI:456216 |
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phytosphingosine 1-phosphate + H2O -> phytosphingosine + phosphategomodel:RXN3O-504 | part_of | sphingolipid biosynthetic processGO:0030148 |
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a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 | part_of | sphingolipid biosynthetic processGO:0030148 |
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sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | provides_input_for | phytosphingosine 1-phosphate + H2O -> phytosphingosine + phosphategomodel:RXN3O-504 |
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D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | has_output | waterCHEBI:15377 |
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phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | provides_input_for | phytosphingosine 1-phosphate + H2O -> phytosphingosine + phosphategomodel:RXN3O-504 |
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dihydrosphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 | part_of | sphingolipid biosynthetic processGO:0030148 |
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a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 | has_input | hydronCHEBI:15378 |
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sphinganine 1-phosphate + H2O -> D-erythro-sphinganine + phosphategomodel:DHS-PHOSPHATASE-RXN | has_output | sphinganine(1+)CHEBI:57817 |
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D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN | has_input | 3-dehydrosphinganinium(1+)CHEBI:58299 |
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L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN | occurs_in | cytosolGO:0005829 |
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L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN | has_input | L-serine zwitterionCHEBI:33384 |
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a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 | has_input | dioxygenCHEBI:15379 |
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D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN | provides_input_for | D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN |
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LCB3 ScerSGD:S000003670 | enables | phytosphingosine 1-phosphate + H2O -> phytosphingosine + phosphategomodel:RXN3O-504 |
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sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 | has_input | phytosphingosine(1+)CHEBI:64124 |
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D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN | part_of | sphingolipid biosynthetic processGO:0030148 |
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D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN | has_output | sphinganine 1-phosphate(1-)CHEBI:57939 |
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N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 | provides_input_for | sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 |
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phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | provides_input_for | a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN |
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serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 | part_of | sphingolipid biosynthetic processGO:0030148 |
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phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | has_output | hydronCHEBI:15378 |
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LCB3 ScerSGD:S000003670 | enables | sphinganine 1-phosphate + H2O -> D-erythro-sphinganine + phosphategomodel:DHS-PHOSPHATASE-RXN |
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LCB2 ScerSGD:S000002469 | enables | serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 |
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LCB1 ScerSGD:S000004911 | enables | L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN |
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a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 | has_input | ferrocytochrome b5CHEBI:16518 |
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sphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 | has_output | phytosphingosine(1+)CHEBI:64124 |
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L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN | has_output | 3-dehydrosphinganinium(1+)CHEBI:58299 |
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D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN | provides_input_for | sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 |
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YPC1 ScerSGD:S000000387 | enables | N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 |
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CPX-1706 ScerSGD:S000218096 | enables | phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 |
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phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | has_input | ATP(4-)CHEBI:30616 |
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sphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 | has_output | hydrogenphosphateCHEBI:43474 |
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a (2'R)-2'-hydroxy-phytoceramide + a 1-phosphatidyl-1D-myo-inositol -> an inositol-phospho-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-581 | part_of | sphingolipid biosynthetic processGO:0030148 |
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a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN | has_input | waterCHEBI:15377 |
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an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 | has_input | inositol phosphoceramideCHEBI:60245 |
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phytosphingosine 1-phosphate + H2O -> phytosphingosine + phosphategomodel:RXN3O-504 | has_input | waterCHEBI:15377 |
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serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 | has_input | palmitoyl-CoA(4-)CHEBI:57379 |
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sphinganine 1-phosphate -> palmitaldehyde + O-phosphoethanolaminegomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN | has_output | hexadecanalCHEBI:17600 |
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LCB5 ScerSGD:S000004250 | enables | sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 |
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a mannosyl-inositol-phospho-α hydroxyphytoceramide + a 1-phosphatidyl-1D-myo-inositol -> a mannosyl-diphosphoinositol-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-680 | part_of | sphingolipid biosynthetic processGO:0030148 |
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phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 | occurs_in | cytosolGO:0005829 |
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serine C-palmitoyltransferase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006208 | has_input | hydronCHEBI:15378 |
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sphinganine 1-phosphate -> palmitaldehyde + O-phosphoethanolaminegomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN | has_output | O-phosphonatoethanaminium(1-)CHEBI:58190 |
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sphinganine 1-phosphate -> palmitaldehyde + O-phosphoethanolaminegomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN | part_of | sphingolipid biosynthetic processGO:0030148 |
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N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 | has_output | phytosphingosine(1+)CHEBI:64124 |
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D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | part_of | sphingolipid biosynthetic processGO:0030148 |
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D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN | provides_input_for | dihydrosphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 |
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an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 | has_output | mannosylinositol phosphorylceramideCHEBI:25168 |
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SCS7 ScerSGD:S000004885 | enables | a phytoceramide + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> a (2'R)-2'-hydroxy-phytoceramide + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-4042 |
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LCB4 ScerSGD:S000005697 | enables | phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 |
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a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN | has_output | 2-hydroxy fatty acidCHEBI:10283 |
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LCB4 ScerSGD:S000005697 | enables | D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN |
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LCB5 ScerSGD:S000004250 | enables | sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006292 |
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L-serine + palmitoyl-CoA + H+ -> CO2 + 3-dehydrosphinganine + coenzyme Agomodel:SERINE-C-PALMITOYLTRANSFERASE-RXN | has_output | coenzyme A(4-)CHEBI:57287 |
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dihydrosphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 | has_input | sphinganine 1-phosphate(1-)CHEBI:57939 |
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N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 | has_input | N-acylphytosphingosineCHEBI:31998 |
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a (2'R)-2'-hydroxy-phytoceramide + a 1-phosphatidyl-1D-myo-inositol -> an inositol-phospho-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-581 | has_input | N-acylphytosphingosineCHEBI:31998 |
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sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 | has_input | sphinganine(1+)CHEBI:57817 |
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a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN | provides_input_for | phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 |
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D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN | part_of | sphingolipid biosynthetic processGO:0030148 |
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YDC1 ScerSGD:S000006008 | enables | a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN |
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N-acylsphingosine amidohydrolase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006275 | provides_input_for | phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 |
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D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN | has_input | ATP(4-)CHEBI:30616 |
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sphinganine 1-phosphate + H2O -> D-erythro-sphinganine + phosphategomodel:DHS-PHOSPHATASE-RXN | has_input | waterCHEBI:15377 |
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D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN | has_input | sphinganine(1+)CHEBI:57817 |
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phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 | has_output | hydronCHEBI:15378 |
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sphinganine 1-phosphate -> palmitaldehyde + O-phosphoethanolaminegomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN | has_input | sphinganine 1-phosphate(1-)CHEBI:57939 |
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D-erythro-sphinganine + 2 a ferrocytochrome b5 + oxygen + 2 H+ -> phytosphingosine + 2 a ferricytochrome b5 + H2Ogomodel:RXN3O-1380 | has_output | ferricytochrome b5CHEBI:18097 |
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sphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 | part_of | sphingolipid biosynthetic processGO:0030148 |
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phytosphingosine + ATP -> phytosphingosine 1-phosphate + ADP + H+gomodel:RXN3O-458 | has_output | ADP(3-)CHEBI:456216 |
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a mannosyl-inositol-phospho-α hydroxyphytoceramide + a 1-phosphatidyl-1D-myo-inositol -> a mannosyl-diphosphoinositol-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-680 | has_output | 1,2-diacyl-sn-glycerolCHEBI:17815 |
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D-erythro-sphinganine + ATP -> sphinganine 1-phosphate + ADP + H+gomodel:SPHINGANINE-KINASE-RXN | provides_input_for | sphinganine 1-phosphate -> palmitaldehyde + O-phosphoethanolaminegomodel:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN |
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CPX-1739 ScerSGD:S000218211 | enables | an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 |
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dihydrosphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 | has_input | waterCHEBI:15377 |
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phytosphingosine + a very long chain fatty acyl-CoA -> a phytoceramide + coenzyme A + H+gomodel:RXN3O-328 | has_input | phytosphingosine(1+)CHEBI:64124 |
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sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 | provides_input_for | sphinganine 1-phosphate + H2O -> D-erythro-sphinganine + phosphategomodel:DHS-PHOSPHATASE-RXN |
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D-erythro-sphinganine + NADP+ <- 3-dehydrosphinganine + NADPH + H+gomodel:3-DEHYDROSPHINGANINE-REDUCTASE-RXN | has_input | NADPH(4-)CHEBI:57783 |
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a (2'R)-2'-hydroxy-phytoceramide + H2O <=> phytosphingosine + a 2-hydroxy fatty acidgomodel:CERAMIDASE-YEAST-RXN | has_output | phytosphingosine(1+)CHEBI:64124 |
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phytosphingosine 1-phosphate + H2O -> phytosphingosine + phosphategomodel:RXN3O-504 | has_output | phytosphingosine(1+)CHEBI:64124 |
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dihydrosphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006227 | has_output | hydrogenphosphateCHEBI:43474 |
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a (2'R)-2'-hydroxy-phytoceramide + a 1-phosphatidyl-1D-myo-inositol -> an inositol-phospho-α hydroxyphytoceramide + a 1,2-diacyl-sn-glycerolgomodel:RXN3O-581 | has_output | inositol phosphoceramideCHEBI:60245 |
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sphingosine-1-phosphate phosphatase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006260 | has_input | waterCHEBI:15377 |
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sphingosine kinase activitygomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1/6a4c244800006241 | has_output | hydronCHEBI:15378 |
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CPX-1706 ScerSGD:S000218096 | has_part ECO:0000353: physical interaction evidence; source stoichiometry minValue: 1, maxValue: 1 | Ceramide synthase LAG1UniProtKB:P38703 |
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CPX-1706 ScerSGD:S000218096 | has_part ECO:0000353: physical interaction evidence; source stoichiometry minValue: 1, maxValue: 1 | Ceramide synthase LAC1UniProtKB:P28496 |
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CPX-1706 ScerSGD:S000218096 | has_part ECO:0000353: physical interaction evidence; source stoichiometry minValue: 2, maxValue: 2 | Ceramide synthase subunit LIP1UniProtKB:Q03579 |
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CPX-1739 ScerSGD:S000218211 | has_part ECO:0000353: physical interaction evidence; stoichiometry unspecified | Mannosyl phosphorylinositol ceramide synthase SUR1UniProtKB:P33300 |
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CPX-1739 ScerSGD:S000218211 | has_part ECO:0000353: physical interaction evidence; stoichiometry unspecified | Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2UniProtKB:P35206 |
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CPX-1739 ScerSGD:S000218211 | located_in Complex location from the independent composition source; original GO-CAM activity locations are retained with their own provenance. | Golgi apparatusGO:0005794 |
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SUR2 ScerSGD:S000002705 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8868422) Topology: Multi-pass membrane protein. | endoplasmic reticulum membraneGO:0005789 |
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YSR3 ScerSGD:S000001761 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10477278); ECO:0000269 (PubMed:10563329); ECO:0000269 (PubMed:9353337) Topology: Multi-pass membrane protein. | endoplasmic reticulum membraneGO:0005789 |
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AUR1 ScerSGD:S000001487 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10888667); ECO:0000269 (PubMed:19726565) Topology: Multi-pass membrane protein. | Golgi cisterna membraneGO:0032580 |
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DPL1 ScerSGD:S000002702 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:18487605) Topology: Single-pass type I membrane protein. Source qualification: Localizes to the cortical and the perinuclear ER | endoplasmic reticulum membraneGO:0005789 |
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IPT1 ScerSGD:S000002479 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14583628) Topology: Multi-pass membrane protein. | Golgi membraneGO:0000139 |
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TSC10 ScerSGD:S000000469 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:19141869) Topology: Multi-pass membrane protein. | endoplasmic reticulum membraneGO:0005789 |
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LCB3 ScerSGD:S000003670 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10477278); ECO:0000269 (PubMed:10563329); ECO:0000269 (PubMed:9353337) Topology: Multi-pass membrane protein. | endoplasmic reticulum membraneGO:0005789 |
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LCB2 ScerSGD:S000002469 | located_in Physical protein location from reviewed UniProt. evidence code not specified by source | cytoplasmGO:0005737 |
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LCB2 ScerSGD:S000002469 | located_in Physical protein location from reviewed UniProt. evidence code not specified by source | endoplasmic reticulumGO:0005783 |
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LCB2 ScerSGD:S000002469 | located_in Physical protein location from reviewed UniProt. ECO:0000305 Topology: Multi-pass membrane protein. | membraneGO:0016020 |
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LCB1 ScerSGD:S000004911 | located_in Physical protein location from reviewed UniProt. evidence code not specified by source | cytoplasmGO:0005737 |
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LCB1 ScerSGD:S000004911 | located_in Physical protein location from reviewed UniProt. evidence code not specified by source Topology: Multi-pass membrane protein. | endoplasmic reticulum membraneGO:0005789 |
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YPC1 ScerSGD:S000000387 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10900202); ECO:0000269 (PubMed:24866405) Topology: Multi-pass membrane protein. Source qualification: Localizes to the cortical ER | endoplasmic reticulum membraneGO:0005789 |
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LCB5 ScerSGD:S000004250 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12493772) Topology: Peripheral membrane protein. | Golgi membraneGO:0000139 |
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SCS7 ScerSGD:S000004885 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095) Topology: Multi-pass membrane protein. | endoplasmic reticulum membraneGO:0005789 |
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LCB4 ScerSGD:S000005697 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12459470); ECO:0000269 (PubMed:16141212) Topology: Peripheral membrane protein. Source qualification: LCB4 is synthesized in the cytosol, palmitoylated at the Golgi apparatus by AKR1, and then transported to the plasma membrane (PM) via the late Sec pathway. Most of the LCB4 is delivered further to the cortical ER (cER), which is closely adjacent to the PM. In stationary phase, G1 cell cycle arrest causes ER-localized LCB4 to be transported to the Golgi apparatus via the early Sec pathway, and finally to the vacuole via the MVB pathway, where it is degraded | plasma membraneGO:0005886 |
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LCB4 ScerSGD:S000005697 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12493772) Topology: Peripheral membrane protein. Source qualification: LCB4 is synthesized in the cytosol, palmitoylated at the Golgi apparatus by AKR1, and then transported to the plasma membrane (PM) via the late Sec pathway. Most of the LCB4 is delivered further to the cortical ER (cER), which is closely adjacent to the PM. In stationary phase, G1 cell cycle arrest causes ER-localized LCB4 to be transported to the Golgi apparatus via the early Sec pathway, and finally to the vacuole via the MVB pathway, where it is degraded | endoplasmic reticulum membraneGO:0005789 |
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LCB4 ScerSGD:S000005697 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12459470) Topology: Peripheral membrane protein. Source qualification: LCB4 is synthesized in the cytosol, palmitoylated at the Golgi apparatus by AKR1, and then transported to the plasma membrane (PM) via the late Sec pathway. Most of the LCB4 is delivered further to the cortical ER (cER), which is closely adjacent to the PM. In stationary phase, G1 cell cycle arrest causes ER-localized LCB4 to be transported to the Golgi apparatus via the early Sec pathway, and finally to the vacuole via the MVB pathway, where it is degraded | late endosome membraneGO:0031902 |
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LCB4 ScerSGD:S000005697 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12459470) Topology: Peripheral membrane protein. Source qualification: LCB4 is synthesized in the cytosol, palmitoylated at the Golgi apparatus by AKR1, and then transported to the plasma membrane (PM) via the late Sec pathway. Most of the LCB4 is delivered further to the cortical ER (cER), which is closely adjacent to the PM. In stationary phase, G1 cell cycle arrest causes ER-localized LCB4 to be transported to the Golgi apparatus via the early Sec pathway, and finally to the vacuole via the MVB pathway, where it is degraded | Golgi membraneGO:0000139 |
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YDC1 ScerSGD:S000006008 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10900202) Topology: Multi-pass membrane protein. | endoplasmic reticulum membraneGO:0005789 |
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Ceramide synthase LAG1UniProtKB:P38703 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:34492164) Topology: Multi-pass membrane protein. Source qualification: Localized to both cortical and nuclear endoplasmic reticulum | endoplasmic reticulum membraneGO:0005789 |
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Ceramide synthase LAC1UniProtKB:P28496 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10198056); ECO:0000269 (PubMed:14562095) Topology: Multi-pass membrane protein. Source qualification: The specific interaction of LAC1 and LIP1 at the lumen of the ER may be important for the enzymatic activity of the complex | endoplasmic reticulum membraneGO:0005789 |
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Ceramide synthase subunit LIP1UniProtKB:Q03579 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:15692566) Topology: Single-pass type II membrane protein. Source qualification: The specific interaction of LAC1 and LIP1 at the lumen of the ER may be important for the enzymatic activity of the complex | endoplasmic reticulum membraneGO:0005789 |
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Mannosyl phosphorylinositol ceramide synthase SUR1UniProtKB:P33300 | located_in Physical protein location from reviewed UniProt. ECO:0000305 Topology: Multi-pass membrane protein. | membraneGO:0016020 |
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Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2UniProtKB:P35206 | located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:7854312) Topology: Multi-pass membrane protein. | endoplasmic reticulum membraneGO:0005789 |
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an inositol-phospho-α hydroxyphytoceramide + GDP-α-D-mannose -> a mannosyl-inositol-phospho-α hydroxyphytoceramide + GDP + H+gomodel:RXN3O-663 | occurs_in Functional compartment explicitly described by Complex Portal. ECO:0000353: physical interaction evidence. | Golgi apparatusGO:0005794 |
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DPL1 ScerSGD:S000002702 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:20696404) | pyridoxal 5'-phosphate(2-)CHEBI:597326 |
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LCB2 ScerSGD:S000002469 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified | pyridoxal 5'-phosphate(2-)CHEBI:597326 |
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LCB1 ScerSGD:S000004911 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified | pyridoxal 5'-phosphate(2-)CHEBI:597326 |
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SCS7 ScerSGD:S000004885 | has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000305 (PubMed:26515067) Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center. UniProt note evidence: ECO:0000269 (PubMed:26515067) | zinc(2+)CHEBI:29105 |
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References
gomodel:YeastPathways_SPHINGOLIPID-SYN-PWY-1SGD GO-CAM sphingolipid biosynthesis (yeast) - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-21; member ./YeastPathways_SPHINGOLIPID-SYN-PWY-1.json)SGD:S000218096Complex Portal CPX-1706: Acyl-CoA ceramide synthase complex (source version: Inspected API snapshot 2026-10-05; release dates 2014-10-16)SGD:S000218211Complex Portal CPX-1739: Mannosyl phosphorylinositol ceramide synthase SUR1-CSG2 (source version: Inspected API snapshot 2026-10-05; release dates 2014-10-16)UniProtKB:P38992Reviewed UniProtKB P38992 location annotations (source version: UniProt release 2026_03)UniProtKB:P23501Reviewed UniProtKB P23501 location annotations (source version: UniProt release 2026_03)UniProtKB:P36107Reviewed UniProtKB P36107 location annotations (source version: UniProt release 2026_03)UniProtKB:Q05567Reviewed UniProtKB Q05567 location annotations (source version: UniProt release 2026_03)UniProtKB:P38954Reviewed UniProtKB P38954 location annotations (source version: UniProt release 2026_03)UniProtKB:P38342Reviewed UniProtKB P38342 location annotations (source version: UniProt release 2026_03)UniProtKB:P47013Reviewed UniProtKB P47013 location annotations (source version: UniProt release 2026_03)UniProtKB:P40970Reviewed UniProtKB P40970 location annotations (source version: UniProt release 2026_03)UniProtKB:P25045Reviewed UniProtKB P25045 location annotations (source version: UniProt release 2026_03)UniProtKB:P38298Reviewed UniProtKB P38298 location annotations (source version: UniProt release 2026_03)UniProtKB:Q06147Reviewed UniProtKB Q06147 location annotations (source version: UniProt release 2026_03)UniProtKB:Q03529Reviewed UniProtKB Q03529 location annotations (source version: UniProt release 2026_03)UniProtKB:Q12246Reviewed UniProtKB Q12246 location annotations (source version: UniProt release 2026_03)UniProtKB:Q02896Reviewed UniProtKB Q02896 location annotations (source version: UniProt release 2026_03)UniProtKB:P38703Reviewed UniProtKB P38703 location annotations (source version: UniProt release 2026_03)UniProtKB:P28496Reviewed UniProtKB P28496 location annotations (source version: UniProt release 2026_03)UniProtKB:Q03579Reviewed UniProtKB Q03579 location annotations (source version: UniProt release 2026_03)UniProtKB:P33300Reviewed UniProtKB P33300 location annotations (source version: UniProt release 2026_03)UniProtKB:P35206Reviewed UniProtKB P35206 location annotations (source version: UniProt release 2026_03)
Curation history
- Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger. Reviewed exact Complex Portal composition, source evidence grades, and independent physical complex locations.
- Codex; review-complex-composition; Reviewed exact Complex Portal composition, source evidence grades, and independent physical complex locations; reused existing proteins through reviewed UniProt SGD cross-references.
- Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
Reviewed all 20 activity location assignments and 19 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 26 independently supported location edges and quarantined 17 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence