UDP-N-acetylglucosamine biosynthesis

gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY

UDP-N-acetylglucosamine biosynthesis converts beta-D-fructofuranose 6-phosphate and L-glutamine to UDP-N-acetyl-alpha-D-glucosamine through D-glucosamine 6-phosphate and N-acetylglucosamine phosphate intermediates in Saccharomyces cerevisiae S288C.

Pathway type

amino sugar biosynthesis

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

25 nodes · 35 asserted directed edges

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Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
N-acetyl-D-glucosamine 6-phosphate `CHEBI:15784`	small molecule
QRI1 Scer `SGD:S000002261`	protein
cytosol `GO:0005829`	cellular component
acetyl-CoA `CHEBI:15351`	small molecule
GNA1 Scer `SGD:S000001877`	protein
D-glucosamine 6-phosphate `CHEBI:12962`	small molecule
UDP-N-acetylglucosamine biosynthetic process `GO:0006048`	biological process
L-glutamic acid `CHEBI:16015`	small molecule
hydron `CHEBI:15378`	small molecule
UDP-N-acetyl-alpha-D-glucosamine `CHEBI:16264`	small molecule
N-acetyl-alpha-D-glucosamine 1-phosphate `CHEBI:16446`	small molecule
GFA1 Scer `SGD:S000001587`	protein
beta-D-fructofuranose 6-phosphate `CHEBI:16084`	small molecule
L-glutamine zwitterion `CHEBI:58359`	small molecule
PCM1 Scer `SGD:S000000784`	protein
diphosphoric acid `CHEBI:29888`	small molecule
UTP `CHEBI:15713`	small molecule
coenzyme A `CHEBI:15346`	small molecule
cytoplasm `GO:0005737`	cellular component
nucleus `GO:0005634`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	molecular activity
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity `gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN`	molecular activity
UDP-N-acetylglucosamine diphosphorylase activity `gomodel:NAG1P-URIDYLTRANS-RXN`	molecular activity
phosphoacetylglucosamine mutase activity `gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	has_output	N-acetyl-D-glucosamine 6-phosphate `CHEBI:15784`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002234 gomodel:CHEBI_57513_GLUCOSAMINEPNACETYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/0; endpoint types: /individuals/13/type; /individuals/8/type`
QRI1 Scer `SGD:S000002261`	enables	UDP-N-acetylglucosamine diphosphorylase activity `gomodel:NAG1P-URIDYLTRANS-RXN`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002333 gomodel:YDL103C-MONOMER_NAG1P-URIDYLTRANS-RXN_controller. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/1; endpoint types: /individuals/15/type; /individuals/17/type`
UDP-N-acetylglucosamine diphosphorylase activity `gomodel:NAG1P-URIDYLTRANS-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:NAG1P-URIDYLTRANS-RXN BFO:0000066 gomodel:reaction_NAG1P-URIDYLTRANS-RXN_location_lociGO_0005829. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/2; endpoint types: /individuals/15/type; /individuals/47/type`
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity `gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN BFO:0000066 gomodel:reaction_L-GLN-FRUCT-6-P-AMINOTRANS-RXN_location_lociGO_0005829. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/3; endpoint types: /individuals/14/type; /individuals/46/type`
phosphoacetylglucosamine mutase activity `gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN`	provides_input_for	UDP-N-acetylglucosamine diphosphorylase activity `gomodel:NAG1P-URIDYLTRANS-RXN`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN RO:0002413 gomodel:NAG1P-URIDYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/4; endpoint types: /individuals/16/type; /individuals/15/type`
phosphoacetylglucosamine mutase activity `gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN BFO:0000066 gomodel:reaction_PHOSACETYLGLUCOSAMINEMUT-RXN_location_lociGO_0005829. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/5; endpoint types: /individuals/16/type; /individuals/48/type`
glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN BFO:0000066 gomodel:reaction_GLUCOSAMINEPNACETYLTRANS-RXN_location_lociGO_0005829. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/6; endpoint types: /individuals/13/type; /individuals/45/type`
glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	has_input	acetyl-CoA `CHEBI:15351`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002233 gomodel:CHEBI_57288_GLUCOSAMINEPNACETYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/7; endpoint types: /individuals/13/type; /individuals/7/type`
GNA1 Scer `SGD:S000001877`	enables	glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002333 gomodel:YFL017C-MONOMER_GLUCOSAMINEPNACETYLTRANS-RXN_controller. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/8; endpoint types: /individuals/13/type; /individuals/19/type`
glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	has_input	D-glucosamine 6-phosphate `CHEBI:12962`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002233 gomodel:CHEBI_15873_L-GLN-FRUCT-6-P-AMINOTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/9; endpoint types: /individuals/13/type; /individuals/2/type`
glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	part_of	UDP-N-acetylglucosamine biosynthetic process `GO:0006048`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY/YeastPathways_UDPNAGSYN-YEAST-PWY. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/10; endpoint types: /individuals/13/type; /individuals/49/type`
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity `gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN`	has_output	L-glutamic acid `CHEBI:16015`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002234 gomodel:CHEBI_29985_L-GLN-FRUCT-6-P-AMINOTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/11; endpoint types: /individuals/14/type; /individuals/4/type`
UDP-N-acetylglucosamine diphosphorylase activity `gomodel:NAG1P-URIDYLTRANS-RXN`	part_of	UDP-N-acetylglucosamine biosynthetic process `GO:0006048`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:NAG1P-URIDYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY/YeastPathways_UDPNAGSYN-YEAST-PWY. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/12; endpoint types: /individuals/15/type; /individuals/49/type`
glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002234 gomodel:CHEBI_15378_GLUCOSAMINEPNACETYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/13; endpoint types: /individuals/13/type; /individuals/0/type`
UDP-N-acetylglucosamine diphosphorylase activity `gomodel:NAG1P-URIDYLTRANS-RXN`	has_output	UDP-N-acetyl-alpha-D-glucosamine `CHEBI:16264`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002234 gomodel:CHEBI_57705_NAG1P-URIDYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/14; endpoint types: /individuals/15/type; /individuals/10/type`
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity `gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN`	provides_input_for	glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002413 gomodel:GLUCOSAMINEPNACETYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/15; endpoint types: /individuals/14/type; /individuals/13/type`
UDP-N-acetylglucosamine diphosphorylase activity `gomodel:NAG1P-URIDYLTRANS-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_15378_NAG1P-URIDYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/16; endpoint types: /individuals/15/type; /individuals/1/type`
phosphoacetylglucosamine mutase activity `gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN`	has_output	N-acetyl-alpha-D-glucosamine 1-phosphate `CHEBI:16446`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN RO:0002234 gomodel:CHEBI_57776_PHOSACETYLGLUCOSAMINEMUT-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/17; endpoint types: /individuals/16/type; /individuals/11/type`
GFA1 Scer `SGD:S000001587`	enables	L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity `gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002333 gomodel:YKL104C-MONOMER_L-GLN-FRUCT-6-P-AMINOTRANS-RXN_controller. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/18; endpoint types: /individuals/14/type; /individuals/20/type`
phosphoacetylglucosamine mutase activity `gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN`	part_of	UDP-N-acetylglucosamine biosynthetic process `GO:0006048`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN BFO:0000050 gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY/YeastPathways_UDPNAGSYN-YEAST-PWY. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/19; endpoint types: /individuals/16/type; /individuals/49/type`
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity `gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN`	has_input	beta-D-fructofuranose 6-phosphate `CHEBI:16084`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002233 gomodel:CHEBI_57634_L-GLN-FRUCT-6-P-AMINOTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/20; endpoint types: /individuals/14/type; /individuals/9/type`
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity `gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN`	has_input	L-glutamine zwitterion `CHEBI:58359`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002233 gomodel:CHEBI_58359_L-GLN-FRUCT-6-P-AMINOTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/21; endpoint types: /individuals/14/type; /individuals/12/type`
PCM1 Scer `SGD:S000000784`	enables	phosphoacetylglucosamine mutase activity `gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN RO:0002333 gomodel:YEL058W-MONOMER_PHOSACETYLGLUCOSAMINEMUT-RXN_controller. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/22; endpoint types: /individuals/16/type; /individuals/18/type`
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity `gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN`	part_of	UDP-N-acetylglucosamine biosynthetic process `GO:0006048`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN BFO:0000050 gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY/YeastPathways_UDPNAGSYN-YEAST-PWY. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/23; endpoint types: /individuals/14/type; /individuals/49/type`
glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	provides_input_for	phosphoacetylglucosamine mutase activity `gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002413 gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/24; endpoint types: /individuals/13/type; /individuals/16/type`
phosphoacetylglucosamine mutase activity `gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN`	has_input	N-acetyl-D-glucosamine 6-phosphate `CHEBI:15784`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:PHOSACETYLGLUCOSAMINEMUT-RXN RO:0002233 gomodel:CHEBI_57513_GLUCOSAMINEPNACETYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/25; endpoint types: /individuals/16/type; /individuals/8/type`
UDP-N-acetylglucosamine diphosphorylase activity `gomodel:NAG1P-URIDYLTRANS-RXN`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002234 gomodel:CHEBI_29888_NAG1P-URIDYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/26; endpoint types: /individuals/15/type; /individuals/3/type`
UDP-N-acetylglucosamine diphosphorylase activity `gomodel:NAG1P-URIDYLTRANS-RXN`	has_input	UTP `CHEBI:15713`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_46398_NAG1P-URIDYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/27; endpoint types: /individuals/15/type; /individuals/5/type`
UDP-N-acetylglucosamine diphosphorylase activity `gomodel:NAG1P-URIDYLTRANS-RXN`	has_input	N-acetyl-alpha-D-glucosamine 1-phosphate `CHEBI:16446`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:NAG1P-URIDYLTRANS-RXN RO:0002233 gomodel:CHEBI_57776_PHOSACETYLGLUCOSAMINEMUT-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/28; endpoint types: /individuals/15/type; /individuals/11/type`
L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity `gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN`	has_output	D-glucosamine 6-phosphate `CHEBI:12962`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:L-GLN-FRUCT-6-P-AMINOTRANS-RXN RO:0002234 gomodel:CHEBI_15873_L-GLN-FRUCT-6-P-AMINOTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/29; endpoint types: /individuals/14/type; /individuals/2/type`
glucosamine 6-phosphate N-acetyltransferase activity `gomodel:GLUCOSAMINEPNACETYLTRANS-RXN`	has_output	coenzyme A `CHEBI:15346`	gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY Source assertion: The model asserts gomodel:GLUCOSAMINEPNACETYLTRANS-RXN RO:0002234 gomodel:CHEBI_57287_GLUCOSAMINEPNACETYLTRANS-RXN. Source location `./YeastPathways_UDPNAGSYN-YEAST-PWY.json#/facts/30; endpoint types: /individuals/13/type; /individuals/6/type`
QRI1 Scer `SGD:S000002261`	located_in Physical protein location from reviewed UniProt. ECO:0000305	cytoplasm `GO:0005737`	UniProtKB:P43123 Source assertion: UniProtKB:P43123 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1848/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P43123 Source assertion: UniProtKB:P43123 has the exact SGD cross-reference SGD:S000002261. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1848/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PCM1 Scer `SGD:S000000784`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P38628 Source assertion: UniProtKB:P38628 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1398/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38628 Source assertion: UniProtKB:P38628 has the exact SGD cross-reference SGD:S000000784. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1398/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PCM1 Scer `SGD:S000000784`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P38628 Source assertion: UniProtKB:P38628 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1398/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38628 Source assertion: UniProtKB:P38628 has the exact SGD cross-reference SGD:S000000784. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1398/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PCM1 Scer `SGD:S000000784`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:Q9P4V2) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:Q9P4V2)	magnesium(2+) `CHEBI:18420`	UniProtKB:P38628 Source assertion: UniProtKB:P38628 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1398/comments/0/cofactors/0; /results/1398/comments/0/note` UniProtKB:P38628 Source assertion: UniProtKB:P38628 has the exact SGD cross-reference SGD:S000000784. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1398/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_UDPNAGSYN-YEAST-PWY GO-CAM UDP-N-acetylglucosamine biosynthesis model YeastPathways_UDPNAGSYN-YEAST-PWY (source version: Pinned Noctua JSON archive; model date 2026-08-03; member ./YeastPathways_UDPNAGSYN-YEAST-PWY.json)
UniProtKB:P43123 Reviewed UniProtKB P43123 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38628 Reviewed UniProtKB P38628 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 4 activity location assignments and 4 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 3 independently supported location edges and quarantined 0 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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