4-aminobutyrate degradation

gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY

4-aminobutyrate degradation in Saccharomyces cerevisiae S288C transaminates gamma-aminobutyric acid to 4-oxobutanoate and oxidizes 4-oxobutanoate to succinate in the SGD GO-CAM 4-aminobutyrate degradation pathway.

Pathway type

4 aminobutyrate degradation

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

17 nodes · 19 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
NAD(P)(+) `CHEBI:13390`	small molecule
succinate(2-) `CHEBI:30031`	small molecule
gamma-aminobutyric acid zwitterion `CHEBI:59888`	small molecule
cytosol `GO:0005829`	cellular component
GABA shunt `GO:0006540`	biological process
L-glutamate(1-) `CHEBI:29985`	small molecule
hydron `CHEBI:15378`	small molecule
water `CHEBI:15377`	small molecule
UGA2 Scer `SGD:S000000210`	protein
4-oxobutanoate `CHEBI:57706`	small molecule
NAD(P)H `CHEBI:13392`	small molecule
UGA1 Scer `SGD:S000003251`	protein
2-oxoglutarate(2-) `CHEBI:16810`	small molecule
cytoplasm `GO:0005737`	cellular component
pyridoxal 5'-phosphate(2-) `CHEBI:597326`	cofactor
2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde `gomodel:GABATRANSAM-RXN`	molecular activity
succinate semialdehyde + NAD(P)⁺ + H₂O -> succinate + NAD(P)H + 2 H⁺ `gomodel:RXN0-5293`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
succinate semialdehyde + NAD(P)⁺ + H₂O -> succinate + NAD(P)H + 2 H⁺ `gomodel:RXN0-5293`	has_input	NAD(P)(+) `CHEBI:13390`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:RXN0-5293 RO:0002233 gomodel:CHEBI_13390_RXN0-5293. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/0; endpoint types: /individuals/10/type; /individuals/0/type`
succinate semialdehyde + NAD(P)⁺ + H₂O -> succinate + NAD(P)H + 2 H⁺ `gomodel:RXN0-5293`	has_output	succinate(2-) `CHEBI:30031`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:RXN0-5293 RO:0002234 gomodel:CHEBI_30031_RXN0-5293. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/1; endpoint types: /individuals/10/type; /individuals/6/type`
2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde `gomodel:GABATRANSAM-RXN`	has_input	gamma-aminobutyric acid zwitterion `CHEBI:59888`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:GABATRANSAM-RXN RO:0002233 gomodel:CHEBI_59888_GABATRANSAM-RXN. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/2; endpoint types: /individuals/9/type; /individuals/8/type`
2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde `gomodel:GABATRANSAM-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:GABATRANSAM-RXN BFO:0000066 gomodel:reaction_GABATRANSAM-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/3; endpoint types: /individuals/9/type; /individuals/27/type`
succinate semialdehyde + NAD(P)⁺ + H₂O -> succinate + NAD(P)H + 2 H⁺ `gomodel:RXN0-5293`	part_of	GABA shunt `GO:0006540`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:RXN0-5293 BFO:0000050 gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY/YeastPathways_YEAST-4AMINOBUTMETAB-PWY. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/4; endpoint types: /individuals/10/type; /individuals/29/type`
succinate semialdehyde + NAD(P)⁺ + H₂O -> succinate + NAD(P)H + 2 H⁺ `gomodel:RXN0-5293`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:RXN0-5293 BFO:0000066 gomodel:reaction_RXN0-5293_location_lociGO_0005829. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/5; endpoint types: /individuals/10/type; /individuals/28/type`
2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde `gomodel:GABATRANSAM-RXN`	has_output	L-glutamate(1-) `CHEBI:29985`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:GABATRANSAM-RXN RO:0002234 gomodel:CHEBI_29985_GABATRANSAM-RXN. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/6; endpoint types: /individuals/9/type; /individuals/5/type`
succinate semialdehyde + NAD(P)⁺ + H₂O -> succinate + NAD(P)H + 2 H⁺ `gomodel:RXN0-5293`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:RXN0-5293 RO:0002234 gomodel:CHEBI_15378_RXN0-5293. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/7; endpoint types: /individuals/10/type; /individuals/3/type`
succinate semialdehyde + NAD(P)⁺ + H₂O -> succinate + NAD(P)H + 2 H⁺ `gomodel:RXN0-5293`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:RXN0-5293 RO:0002233 gomodel:CHEBI_15377_RXN0-5293. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/8; endpoint types: /individuals/10/type; /individuals/2/type`
UGA2 Scer `SGD:S000000210`	enables	succinate semialdehyde + NAD(P)⁺ + H₂O -> succinate + NAD(P)H + 2 H⁺ `gomodel:RXN0-5293`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:RXN0-5293 RO:0002333 gomodel:YBR006W-MONOMER_RXN0-5293_controller. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/9; endpoint types: /individuals/10/type; /individuals/11/type`
2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde `gomodel:GABATRANSAM-RXN`	has_output	4-oxobutanoate `CHEBI:57706`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:GABATRANSAM-RXN RO:0002234 gomodel:CHEBI_57706_GABATRANSAM-RXN. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/10; endpoint types: /individuals/9/type; /individuals/7/type`
succinate semialdehyde + NAD(P)⁺ + H₂O -> succinate + NAD(P)H + 2 H⁺ `gomodel:RXN0-5293`	has_output	NAD(P)H `CHEBI:13392`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:RXN0-5293 RO:0002234 gomodel:CHEBI_13392_RXN0-5293. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/11; endpoint types: /individuals/10/type; /individuals/1/type`
2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde `gomodel:GABATRANSAM-RXN`	part_of	GABA shunt `GO:0006540`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:GABATRANSAM-RXN BFO:0000050 gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY/YeastPathways_YEAST-4AMINOBUTMETAB-PWY. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/12; endpoint types: /individuals/9/type; /individuals/29/type`
UGA1 Scer `SGD:S000003251`	enables	2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde `gomodel:GABATRANSAM-RXN`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:GABATRANSAM-RXN RO:0002333 gomodel:YGR019W-MONOMER_GABATRANSAM-RXN_controller. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/13; endpoint types: /individuals/9/type; /individuals/12/type`
succinate semialdehyde + NAD(P)⁺ + H₂O -> succinate + NAD(P)H + 2 H⁺ `gomodel:RXN0-5293`	has_input	4-oxobutanoate `CHEBI:57706`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:RXN0-5293 RO:0002233 gomodel:CHEBI_57706_GABATRANSAM-RXN. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/14; endpoint types: /individuals/10/type; /individuals/7/type`
2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde `gomodel:GABATRANSAM-RXN`	has_input	2-oxoglutarate(2-) `CHEBI:16810`	gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY Source assertion: The model asserts gomodel:GABATRANSAM-RXN RO:0002233 gomodel:CHEBI_16810_GABATRANSAM-RXN. Source location `./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json#/facts/15; endpoint types: /individuals/9/type; /individuals/4/type`
UGA2 Scer `SGD:S000000210`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P38067 Source assertion: UniProtKB:P38067 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1267/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38067 Source assertion: UniProtKB:P38067 has the exact SGD cross-reference SGD:S000000210. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1267/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
UGA1 Scer `SGD:S000003251`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11914276)	cytoplasm `GO:0005737`	UniProtKB:P17649 Source assertion: UniProtKB:P17649 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/468/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P17649 Source assertion: UniProtKB:P17649 has the exact SGD cross-reference SGD:S000003251. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/468/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
UGA1 Scer `SGD:S000003251`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:17355287)	pyridoxal 5'-phosphate(2-) `CHEBI:597326`	UniProtKB:P17649 Source assertion: UniProtKB:P17649 annotates CHEBI:597326 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/468/comments/0/cofactors/0` UniProtKB:P17649 Source assertion: UniProtKB:P17649 has the exact SGD cross-reference SGD:S000003251. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/468/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_YEAST-4AMINOBUTMETAB-PWY SGD GO-CAM 4-aminobutyrate degradation - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-04-22; member ./YeastPathways_YEAST-4AMINOBUTMETAB-PWY.json)
UniProtKB:P38067 Reviewed UniProtKB P38067 location annotations (source version: UniProt release 2026_03)
UniProtKB:P17649 Reviewed UniProtKB P17649 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 2 activity location assignments and 2 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 2 independently supported location edges and quarantined 0 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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