fatty acid oxidation pathway

gomodel:YeastPathways_YEAST-FAO-PWY

Fatty acid oxidation in Saccharomyces cerevisiae S288C connects acyl-CoA activation, acyl-CoA dehydrogenation, enoyl-CoA hydration, hydroxyacyl-CoA dehydrogenation, thiolysis, and auxiliary unsaturated fatty acid oxidation steps in the SGD GO-CAM fatty acid oxidation pathway.

Pathway type

fatty acid oxidation

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

50 nodes · 109 asserted directed edges

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
coenzyme A(4-) `CHEBI:57287`	small molecule
water `CHEBI:15377`	small molecule
3-oxo-fatty acyl-CoA `CHEBI:15489`	lipid
fatty acid oxidation `GO:0019395`	biological process
FAA4 Scer `SGD:S000004860`	protein
2,3,4-saturated fatty acid(1-) `CHEBI:71627`	lipid
cytosol `GO:0005829`	cellular component
saturated fatty acyl-CoA(4-) `CHEBI:77332`	small molecule
trans-2-enoyl-CoA `CHEBI:50998`	lipid
diphosphoric acid `CHEBI:29888`	small molecule
hydrogen peroxide `CHEBI:16240`	small molecule
FOX2 Scer `SGD:S000001717`	protein
cis-3-enoyl-CoA `CHEBI:27773`	lipid
adenosine 5'-monophosphate(2-) `CHEBI:456215`	small molecule
ATP(4-) `CHEBI:30616`	small molecule
ECI1 Scer `SGD:S000004274`	protein
FAA1 Scer `SGD:S000005844`	protein
hydron `CHEBI:15378`	small molecule
dioxygen `CHEBI:15379`	small molecule
POT1 Scer `SGD:S000001422`	protein
FAT1 Scer `SGD:S000000245`	protein
POX1 Scer `SGD:S000003173`	protein
DCI1 Scer `SGD:S000005706`	protein
NAD(1-) `CHEBI:57540`	small molecule
acetyl-CoA(4-) `CHEBI:57288`	small molecule
NADH(2-) `CHEBI:57945`	small molecule
FAA2 Scer `SGD:S000000817`	protein
FAA3 Scer `SGD:S000001271`	protein
lipid droplet `GO:0005811`	cellular component
peroxisome `GO:0005777`	cellular component
plasma membrane `GO:0005886`	cellular component
mitochondrial intermembrane space `GO:0005758`	cellular component
peroxisomal membrane `GO:0005778`	cellular component
cytoplasm `GO:0005737`	cellular component
(R)-3-hydroxyacyl-CoA(4-) `CHEBI:57319`	small molecule
(3E,5Z)-dienoyl-CoA(4-) `CHEBI:85110`	small molecule
6-saturated-trans,trans-2,4-dienoyl-CoA(4-) `CHEBI:85111`	small molecule
magnesium(2+) `CHEBI:18420`	cofactor
FAD(3-) `CHEBI:57692`	cofactor
a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	molecular activity
a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA `RHEA:45241`	molecular activity	left to right
a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA `RHEA:26528`	molecular activity	left to right
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	molecular activity
a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	molecular activity	left to right
a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	molecular activity
delta(3)-delta(2)-enoyl-CoA isomerase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775`	molecular activity
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	molecular activity
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	molecular activity
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	molecular activity
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA `RHEA:26528`	provides_input_for	a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ENOYL-COA-HYDRAT-RXN RO:0002413 gomodel:OHACYL-COA-DEHYDROG-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/0; endpoint types: /individuals/20/type; /individuals/22/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction`
a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	has_input	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ACYLCOASYN-RXN RO:0002233 gomodel:CHEBI_57287_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/1; endpoint types: /individuals/0/type; /individuals/11/type`
a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA `RHEA:26528`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ENOYL-COA-HYDRAT-RXN RO:0002233 gomodel:CHEBI_15377_ENOYL-COA-HYDRAT-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/2; endpoint types: /individuals/20/type; /individuals/1/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction`
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	has_input	3-oxo-fatty acyl-CoA `CHEBI:15489`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002233 gomodel:CHEBI_15489_OHACYL-COA-DEHYDROG-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/3; endpoint types: /individuals/21/type; /individuals/5/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/4; endpoint types: /individuals/143/type; /individuals/69/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	has_input	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006832. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/5; endpoint types: /individuals/124/type; /individuals/125/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	provides_input_for	a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002413 gomodel:RXN-11026. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/6; endpoint types: /individuals/106/type; /individuals/23/type`
FAA4 Scer `SGD:S000004860`	enables	long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002333 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006839. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/7; endpoint types: /individuals/124/type; /individuals/130/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	has_input	2,3,4-saturated fatty acid(1-) `CHEBI:71627`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006854. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/8; endpoint types: /individuals/143/type; /individuals/145/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	has_output	saturated fatty acyl-CoA(4-) `CHEBI:77332`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002234 gomodel:CHEBI_77332_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/10; endpoint types: /individuals/124/type; /individuals/17/type`
delta(3)-delta(2)-enoyl-CoA isomerase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775`	has_output	trans-2-enoyl-CoA `CHEBI:50998`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006777. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/11; endpoint types: /individuals/76/type; /individuals/78/type`
a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ACYLCOASYN-RXN BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/12; endpoint types: /individuals/0/type; /individuals/69/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	has_output	saturated fatty acyl-CoA(4-) `CHEBI:77332`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002234 gomodel:CHEBI_77332_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/13; endpoint types: /individuals/106/type; /individuals/17/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006857. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/14; endpoint types: /individuals/143/type; /individuals/148/type`
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	provides_input_for	a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002413 gomodel:ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/15; endpoint types: /individuals/21/type; /individuals/0/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	has_input	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006788. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/16; endpoint types: /individuals/87/type; /individuals/88/type`
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	has_output	saturated fatty acyl-CoA(4-) `CHEBI:77332`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002234 gomodel:CHEBI_77332_KETOACYLCOATHIOL-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/17; endpoint types: /individuals/21/type; /individuals/18/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	has_output	saturated fatty acyl-CoA(4-) `CHEBI:77332`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002234 gomodel:CHEBI_77332_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/18; endpoint types: /individuals/87/type; /individuals/17/type`
a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	has_output	hydrogen peroxide `CHEBI:16240`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:RXN-11026 RO:0002234 gomodel:CHEBI_16240_RXN-11026. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/19; endpoint types: /individuals/23/type; /individuals/6/type`
delta(3)-delta(2)-enoyl-CoA isomerase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/20; endpoint types: /individuals/76/type; /individuals/69/type`
FOX2 Scer `SGD:S000001717`	enables	a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA `RHEA:26528`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ENOYL-COA-HYDRAT-RXN RO:0002333 gomodel:YKR009C-MONOMER_ENOYL-COA-HYDRAT-RXN_controller. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/21; endpoint types: /individuals/20/type; /individuals/26/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction`
a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA `RHEA:45241`	has_input	(3E,5Z)-dienoyl-CoA(4-) `CHEBI:85110`	UniProtKB:Q08558 Source assertion: UniProtKB:Q08558 annotates (3E,5Z)-dienoyl-CoA to (2E,4E)-dienoyl-CoA isomerization (RHEA:45240); DCI1 is distinct from the retained ECI1 monoene isomerase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2894/comments/1/reaction`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	has_output	adenosine 5'-monophosphate(2-) `CHEBI:456215`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006791. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/23; endpoint types: /individuals/87/type; /individuals/91/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006813. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/24; endpoint types: /individuals/106/type; /individuals/109/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/27; endpoint types: /individuals/124/type; /individuals/69/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006855. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/28; endpoint types: /individuals/143/type; /individuals/146/type`
a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA `RHEA:26528`	has_input	trans-2-enoyl-CoA `CHEBI:50998`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ENOYL-COA-HYDRAT-RXN RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6690711d00000514. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/29; endpoint types: /individuals/20/type; /individuals/164/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006834. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/31; endpoint types: /individuals/124/type; /individuals/127/type`
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/32; endpoint types: /individuals/21/type; /individuals/69/type`
a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA `RHEA:26528`	has_output	(R)-3-hydroxyacyl-CoA(4-) `CHEBI:57319`	UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction`
ECI1 Scer `SGD:S000004274`	enables	delta(3)-delta(2)-enoyl-CoA isomerase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775 RO:0002333 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006779. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/34; endpoint types: /individuals/76/type; /individuals/79/type`
a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	has_output	adenosine 5'-monophosphate(2-) `CHEBI:456215`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ACYLCOASYN-RXN RO:0002234 gomodel:CHEBI_456215_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/35; endpoint types: /individuals/0/type; /individuals/10/type`
a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:RXN-11026 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/36; endpoint types: /individuals/23/type; /individuals/69/type`
FAA1 Scer `SGD:S000005844`	enables	a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ACYLCOASYN-RXN RO:0002333 gomodel:YOR317W-MONOMER_ACYLCOASYN-RXN_controller. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/37; endpoint types: /individuals/0/type; /individuals/29/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	has_input	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006853. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/38; endpoint types: /individuals/143/type; /individuals/144/type`
a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_15378_OHACYL-COA-DEHYDROG-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/39; endpoint types: /individuals/22/type; /individuals/2/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction`
a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ACYLCOASYN-RXN RO:0002234 gomodel:CHEBI_29888_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/40; endpoint types: /individuals/0/type; /individuals/8/type`
a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA `RHEA:45241`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ENOYL-COA-DELTA-ISOM-RXN BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/41; endpoint types: /individuals/19/type; /individuals/69/type` UniProtKB:Q08558 Source assertion: UniProtKB:Q08558 annotates (3E,5Z)-dienoyl-CoA to (2E,4E)-dienoyl-CoA isomerization (RHEA:45240); DCI1 is distinct from the retained ECI1 monoene isomerase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2894/comments/1/reaction`
a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	provides_input_for	a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA `RHEA:26528`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:RXN-11026 RO:0002413 gomodel:ENOYL-COA-HYDRAT-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/42; endpoint types: /individuals/23/type; /individuals/20/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction`
a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	has_input	dioxygen `CHEBI:15379`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:RXN-11026 RO:0002233 gomodel:CHEBI_15379_RXN-11026. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/44; endpoint types: /individuals/23/type; /individuals/3/type`
a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	has_output	3-oxo-fatty acyl-CoA `CHEBI:15489`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_15489_OHACYL-COA-DEHYDROG-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/45; endpoint types: /individuals/22/type; /individuals/5/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction`
a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	has_input	2,3,4-saturated fatty acid(1-) `CHEBI:71627`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ACYLCOASYN-RXN RO:0002233 gomodel:CHEBI_71627_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/46; endpoint types: /individuals/0/type; /individuals/16/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	provides_input_for	a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002413 gomodel:RXN-11026. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/47; endpoint types: /individuals/143/type; /individuals/23/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	has_input	2,3,4-saturated fatty acid(1-) `CHEBI:71627`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006812. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/48; endpoint types: /individuals/106/type; /individuals/108/type`
POT1 Scer `SGD:S000001422`	enables	a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002333 gomodel:YIL160C-MONOMER_KETOACYLCOATHIOL-RXN_controller. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/49; endpoint types: /individuals/21/type; /individuals/25/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006790. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/50; endpoint types: /individuals/87/type; /individuals/90/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	has_input	2,3,4-saturated fatty acid(1-) `CHEBI:71627`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006789. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/51; endpoint types: /individuals/87/type; /individuals/89/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	has_input	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006811. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/52; endpoint types: /individuals/106/type; /individuals/107/type`
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	provides_input_for	long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002413 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/53; endpoint types: /individuals/21/type; /individuals/124/type`
FOX2 Scer `SGD:S000001717`	enables	a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002333 gomodel:YKR009C-MONOMER_OHACYL-COA-DEHYDROG-RXN_controller. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/54; endpoint types: /individuals/22/type; /individuals/27/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction`
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	provides_input_for	long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002413 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/55; endpoint types: /individuals/21/type; /individuals/87/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	provides_input_for	a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002413 gomodel:RXN-11026. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/56; endpoint types: /individuals/87/type; /individuals/23/type`
FAT1 Scer `SGD:S000000245`	enables	long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002333 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006858. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/57; endpoint types: /individuals/143/type; /individuals/149/type`
a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	has_input	saturated fatty acyl-CoA(4-) `CHEBI:77332`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:RXN-11026 RO:0002233 gomodel:CHEBI_77332_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/58; endpoint types: /individuals/23/type; /individuals/17/type`
POX1 Scer `SGD:S000003173`	enables	a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:RXN-11026 RO:0002333 gomodel:YGL205W-MONOMER_RXN-11026_controller. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/59; endpoint types: /individuals/23/type; /individuals/24/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006836. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/60; endpoint types: /individuals/124/type; /individuals/129/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006792. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/61; endpoint types: /individuals/87/type; /individuals/92/type`
a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	provides_input_for	a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ACYLCOASYN-RXN RO:0002413 gomodel:RXN-11026. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/62; endpoint types: /individuals/0/type; /individuals/23/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	provides_input_for	a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002413 gomodel:RXN-11026. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/64; endpoint types: /individuals/124/type; /individuals/23/type`
a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA `RHEA:26528`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ENOYL-COA-HYDRAT-RXN BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/65; endpoint types: /individuals/20/type; /individuals/69/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 annotates (3R)-hydroxyacyl-CoA hydration/dehydration (RHEA:26526). FOX2 uses the R intermediate; the imported S assignment is corrected. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/1/reaction`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	has_output	adenosine 5'-monophosphate(2-) `CHEBI:456215`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006856. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/66; endpoint types: /individuals/143/type; /individuals/147/type`
delta(3)-delta(2)-enoyl-CoA isomerase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775`	provides_input_for	a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775 RO:0002413 gomodel:OHACYL-COA-DEHYDROG-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/67; endpoint types: /individuals/76/type; /individuals/22/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction`
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	has_input	coenzyme A(4-) `CHEBI:57287`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002233 gomodel:CHEBI_57287_KETOACYLCOATHIOL-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/69; endpoint types: /individuals/21/type; /individuals/12/type`
DCI1 Scer `SGD:S000005706`	enables	a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA `RHEA:45241`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ENOYL-COA-DELTA-ISOM-RXN RO:0002333 gomodel:YOR180C-MONOMER_ENOYL-COA-DELTA-ISOM-RXN_controller. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/70; endpoint types: /individuals/19/type; /individuals/28/type` UniProtKB:Q08558 Source assertion: UniProtKB:Q08558 annotates (3E,5Z)-dienoyl-CoA to (2E,4E)-dienoyl-CoA isomerization (RHEA:45240); DCI1 is distinct from the retained ECI1 monoene isomerase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2894/comments/1/reaction`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006815. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/71; endpoint types: /individuals/106/type; /individuals/111/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	has_output	adenosine 5'-monophosphate(2-) `CHEBI:456215`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006835. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/72; endpoint types: /individuals/124/type; /individuals/128/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	has_output	adenosine 5'-monophosphate(2-) `CHEBI:456215`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006814. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/75; endpoint types: /individuals/106/type; /individuals/110/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/76; endpoint types: /individuals/106/type; /individuals/69/type`
a 2,3,4-saturated fatty acyl CoA + oxygen -> a trans-2-enoyl-CoA + hydrogen peroxide `gomodel:RXN-11026`	has_output	trans-2-enoyl-CoA `CHEBI:50998`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:RXN-11026 RO:0002234 gomodel:YeastPathways_YEAST-FAO-PWY/6690711d00000512. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/77; endpoint types: /individuals/23/type; /individuals/162/type`
a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	has_input	NAD(1-) `CHEBI:57540`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002233 gomodel:CHEBI_57540_OHACYL-COA-DEHYDROG-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/78; endpoint types: /individuals/22/type; /individuals/14/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction`
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	has_output	acetyl-CoA(4-) `CHEBI:57288`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002234 gomodel:CHEBI_57288_KETOACYLCOATHIOL-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/79; endpoint types: /individuals/21/type; /individuals/13/type`
a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/80; endpoint types: /individuals/22/type; /individuals/69/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction`
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	provides_input_for	long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002413 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/81; endpoint types: /individuals/21/type; /individuals/143/type`
a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	has_output	NADH(2-) `CHEBI:57945`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002234 gomodel:CHEBI_57945_OHACYL-COA-DEHYDROG-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/82; endpoint types: /individuals/22/type; /individuals/15/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction`
a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	has_input	(R)-3-hydroxyacyl-CoA(4-) `CHEBI:57319`	UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 BFO:0000066 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006798. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/84; endpoint types: /individuals/87/type; /individuals/94/type`
delta(3)-delta(2)-enoyl-CoA isomerase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775`	has_input	cis-3-enoyl-CoA `CHEBI:27773`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006775 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006776. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/85; endpoint types: /individuals/76/type; /individuals/77/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831`	has_input	2,3,4-saturated fatty acid(1-) `CHEBI:71627`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006831 RO:0002233 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006833. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/86; endpoint types: /individuals/124/type; /individuals/126/type`
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	provides_input_for	long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:KETOACYLCOATHIOL-RXN RO:0002413 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/87; endpoint types: /individuals/21/type; /individuals/106/type`
a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	has_output	saturated fatty acyl-CoA(4-) `CHEBI:77332`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ACYLCOASYN-RXN RO:0002234 gomodel:CHEBI_77332_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/88; endpoint types: /individuals/0/type; /individuals/17/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	part_of	fatty acid oxidation `GO:0019395`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 BFO:0000050 gomodel:YeastPathways_YEAST-FAO-PWY/YeastPathways_YEAST-FAO-PWY. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/90; endpoint types: /individuals/87/type; /individuals/69/type`
FAA2 Scer `SGD:S000000817`	enables	long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006787 RO:0002333 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006795. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/91; endpoint types: /individuals/87/type; /individuals/93/type`
FAA3 Scer `SGD:S000001271`	enables	long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006810 RO:0002333 gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006816. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/92; endpoint types: /individuals/106/type; /individuals/112/type`
a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA `RHEA:45241`	has_output	6-saturated-trans,trans-2,4-dienoyl-CoA(4-) `CHEBI:85111`	UniProtKB:Q08558 Source assertion: UniProtKB:Q08558 annotates (3E,5Z)-dienoyl-CoA to (2E,4E)-dienoyl-CoA isomerization (RHEA:45240); DCI1 is distinct from the retained ECI1 monoene isomerase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2894/comments/1/reaction`
a (3R)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + NADH + H(+) `RHEA:32712`	provides_input_for	a 2,3,4-saturated fatty acyl CoA + acetyl-CoA <- a 3-oxoacyl-CoA + coenzyme A `gomodel:KETOACYLCOATHIOL-RXN`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:OHACYL-COA-DEHYDROG-RXN RO:0002413 gomodel:KETOACYLCOATHIOL-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/94; endpoint types: /individuals/22/type; /individuals/21/type` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 oxidizes (3R)-3-hydroxyacyl-CoA with NAD+ to 3-oxoacyl-CoA and NADH (RHEA:32711), supporting the R intermediate shared with its hydratase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2412/comments/2/reaction`
a 2,3,4-saturated fatty acid + ATP + coenzyme A -> a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate `gomodel:ACYLCOASYN-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:ACYLCOASYN-RXN RO:0002233 gomodel:CHEBI_30616_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/95; endpoint types: /individuals/0/type; /individuals/9/type`
long-chain fatty acid-CoA ligase activity `gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852`	has_output	saturated fatty acyl-CoA(4-) `CHEBI:77332`	gomodel:YeastPathways_YEAST-FAO-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-FAO-PWY/6a4c244800006852 RO:0002234 gomodel:CHEBI_77332_ACYLCOASYN-RXN. Source location `./YeastPathways_YEAST-FAO-PWY.json#/facts/96; endpoint types: /individuals/143/type; /individuals/17/type`
FAA4 Scer `SGD:S000004860`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:21820081); ECO:0000269 (PubMed:24868093)	lipid droplet `GO:0005811`	UniProtKB:P47912 Source assertion: UniProtKB:P47912 annotates location Lipid droplet (SL-0154). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1993/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P47912 Source assertion: UniProtKB:P47912 has the exact SGD cross-reference SGD:S000004860. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1993/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FOX2 Scer `SGD:S000001717`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	peroxisome `GO:0005777`	UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 annotates location Peroxisome (SL-0204). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2412/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q02207 Source assertion: UniProtKB:Q02207 has the exact SGD cross-reference SGD:S000001717. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2412/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
ECI1 Scer `SGD:S000004274`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10381339); ECO:0000269 (PubMed:11302517); ECO:0000269 (PubMed:9837886) Source qualification: This location is DCI1 dependent	peroxisome `GO:0005777`	UniProtKB:Q05871 Source assertion: UniProtKB:Q05871 annotates location Peroxisome (SL-0204). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2689/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q05871 Source assertion: UniProtKB:Q05871 has the exact SGD cross-reference SGD:S000004274. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2689/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FAA1 Scer `SGD:S000005844`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10515935); ECO:0000269 (PubMed:21820081); ECO:0000269 (PubMed:24868093)	lipid droplet `GO:0005811`	UniProtKB:P30624 Source assertion: UniProtKB:P30624 annotates location Lipid droplet (SL-0154). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/826/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P30624 Source assertion: UniProtKB:P30624 has the exact SGD cross-reference SGD:S000005844. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/826/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FAA1 Scer `SGD:S000005844`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:27136724)	plasma membrane `GO:0005886`	UniProtKB:P30624 Source assertion: UniProtKB:P30624 annotates location Cell membrane (SL-0039). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/826/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P30624 Source assertion: UniProtKB:P30624 has the exact SGD cross-reference SGD:S000005844. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/826/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
POT1 Scer `SGD:S000001422`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:7754706); ECO:0000269 (PubMed:8125978)	peroxisome `GO:0005777`	UniProtKB:P27796 Source assertion: UniProtKB:P27796 annotates location Peroxisome (SL-0204). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/771/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P27796 Source assertion: UniProtKB:P27796 has the exact SGD cross-reference SGD:S000001422. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/771/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
POT1 Scer `SGD:S000001422`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22984289)	mitochondrial intermembrane space `GO:0005758`	UniProtKB:P27796 Source assertion: UniProtKB:P27796 annotates location Mitochondrion intermembrane space (SL-0169). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/771/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P27796 Source assertion: UniProtKB:P27796 has the exact SGD cross-reference SGD:S000001422. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/771/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FAT1 Scer `SGD:S000000245`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10515935); ECO:0000269 (PubMed:21820081); ECO:0000269 (PubMed:24868093)	lipid droplet `GO:0005811`	UniProtKB:P38225 Source assertion: UniProtKB:P38225 annotates location Lipid droplet (SL-0154). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38225 Source assertion: UniProtKB:P38225 has the exact SGD cross-reference SGD:S000000245. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FAT1 Scer `SGD:S000000245`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:17679730) Topology: Multi-pass membrane protein.	plasma membrane `GO:0005886`	UniProtKB:P38225 Source assertion: UniProtKB:P38225 annotates location Cell membrane (SL-0039). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38225 Source assertion: UniProtKB:P38225 has the exact SGD cross-reference SGD:S000000245. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FAT1 Scer `SGD:S000000245`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:22493507) Topology: Multi-pass membrane protein.	peroxisomal membrane `GO:0005778`	UniProtKB:P38225 Source assertion: UniProtKB:P38225 annotates location Peroxisome membrane (SL-0203). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/comments/1/subcellularLocations/2; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38225 Source assertion: UniProtKB:P38225 has the exact SGD cross-reference SGD:S000000245. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FAT1 Scer `SGD:S000000245`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:11330068)	peroxisome `GO:0005777`	UniProtKB:P38225 Source assertion: UniProtKB:P38225 annotates location Peroxisome (SL-0204). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/comments/1/subcellularLocations/3; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P38225 Source assertion: UniProtKB:P38225 has the exact SGD cross-reference SGD:S000000245. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1321/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
POX1 Scer `SGD:S000003173`	located_in Physical protein location from reviewed UniProt. evidence code not specified by source	peroxisome `GO:0005777`	UniProtKB:P13711 Source assertion: UniProtKB:P13711 annotates location Peroxisome (SL-0204). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3301/comments/0/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P13711 Source assertion: UniProtKB:P13711 has the exact SGD cross-reference SGD:S000003173. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3301/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
DCI1 Scer `SGD:S000005706`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:10381339); ECO:0000269 (PubMed:10455114); ECO:0000269 (PubMed:10639339)	peroxisome `GO:0005777`	UniProtKB:Q08558 Source assertion: UniProtKB:Q08558 annotates location Peroxisome (SL-0204). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2894/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q08558 Source assertion: UniProtKB:Q08558 has the exact SGD cross-reference SGD:S000005706. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2894/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FAA2 Scer `SGD:S000000817`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:7988550) Source qualification: Imported via the peroxisome targeting signal type 1 (PTS1)-dependent protein import pathway	cytoplasm `GO:0005737`	UniProtKB:P39518 Source assertion: UniProtKB:P39518 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1562/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P39518 Source assertion: UniProtKB:P39518 has the exact SGD cross-reference SGD:S000000817. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1562/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FAA2 Scer `SGD:S000000817`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8670886) Topology: Peripheral membrane protein. Orientation: Matrix side. Source qualification: Imported via the peroxisome targeting signal type 1 (PTS1)-dependent protein import pathway	peroxisomal membrane `GO:0005778`	UniProtKB:P39518 Source assertion: UniProtKB:P39518 annotates location Peroxisome membrane (SL-0203). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1562/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P39518 Source assertion: UniProtKB:P39518 has the exact SGD cross-reference SGD:S000000817. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1562/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FAA3 Scer `SGD:S000001271`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	plasma membrane `GO:0005886`	UniProtKB:P39002 Source assertion: UniProtKB:P39002 annotates location Cell membrane (SL-0039). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1536/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P39002 Source assertion: UniProtKB:P39002 has the exact SGD cross-reference SGD:S000001271. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1536/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA `RHEA:45241`	occurs_in Activity compartment supported by an inspected functional annotation. ECO:0000269 (PubMed:10381339); ECO:0000269 (PubMed:10455114); ECO:0000269 (PubMed:11302517). Alternative isoenzymes may function elsewhere.	peroxisome `GO:0005777`	UniProtKB:Q08558 Source assertion: UniProtKB:Q08558 describes the corresponding catalytic function in the peroxisome; this projection applies to the activity enabled by SGD:S000005706. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2894/comments/0/texts/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q08558 Source assertion: UniProtKB:Q08558 annotates (3E,5Z)-dienoyl-CoA to (2E,4E)-dienoyl-CoA isomerization (RHEA:45240); DCI1 is distinct from the retained ECI1 monoene isomerase activity. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_catalytic_activity%2Ccc_function%2Ccc_caution%2Corganism_id [sha256:9600fe7f1e55a4f51554b244607a706b1604904dc71de8960b2f399bf75b0c7c] #/results/2894/comments/1/reaction`
FAA4 Scer `SGD:S000004860`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250	magnesium(2+) `CHEBI:18420`	UniProtKB:P47912 Source assertion: UniProtKB:P47912 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1993/comments/0/cofactors/0` UniProtKB:P47912 Source assertion: UniProtKB:P47912 has the exact SGD cross-reference SGD:S000004860. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1993/uniProtKBCrossReferences/0`
FAA1 Scer `SGD:S000005844`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:8206942)	magnesium(2+) `CHEBI:18420`	UniProtKB:P30624 Source assertion: UniProtKB:P30624 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/826/comments/0/cofactors/0` UniProtKB:P30624 Source assertion: UniProtKB:P30624 has the exact SGD cross-reference SGD:S000005844. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/826/uniProtKBCrossReferences/0`
POX1 Scer `SGD:S000003173`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	FAD(3-) `CHEBI:57692`	UniProtKB:P13711 Source assertion: UniProtKB:P13711 annotates CHEBI:57692 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3301/comments/0/cofactors/0` UniProtKB:P13711 Source assertion: UniProtKB:P13711 has the exact SGD cross-reference SGD:S000003173. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3301/uniProtKBCrossReferences/0`
FAA2 Scer `SGD:S000000817`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P30624)	magnesium(2+) `CHEBI:18420`	UniProtKB:P39518 Source assertion: UniProtKB:P39518 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1562/comments/0/cofactors/0` UniProtKB:P39518 Source assertion: UniProtKB:P39518 has the exact SGD cross-reference SGD:S000000817. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1562/uniProtKBCrossReferences/0`
FAA3 Scer `SGD:S000001271`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P30624)	magnesium(2+) `CHEBI:18420`	UniProtKB:P39002 Source assertion: UniProtKB:P39002 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1536/comments/0/cofactors/0` UniProtKB:P39002 Source assertion: UniProtKB:P39002 has the exact SGD cross-reference SGD:S000001271. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1536/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_YEAST-FAO-PWY SGD GO-CAM fatty acid oxidation pathway - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-22; member ./YeastPathways_YEAST-FAO-PWY.json)
UniProtKB:P47912 Reviewed UniProtKB P47912 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q02207 Reviewed UniProtKB Q02207 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q05871 Reviewed UniProtKB Q05871 location annotations (source version: UniProt release 2026_03)
UniProtKB:P30624 Reviewed UniProtKB P30624 location annotations (source version: UniProt release 2026_03)
UniProtKB:P27796 Reviewed UniProtKB P27796 location annotations (source version: UniProt release 2026_03)
UniProtKB:P38225 Reviewed UniProtKB P38225 location annotations (source version: UniProt release 2026_03)
UniProtKB:P13711 Reviewed UniProtKB P13711 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q08558 Reviewed UniProtKB Q08558 location annotations (source version: UniProt release 2026_03)
UniProtKB:P39518 Reviewed UniProtKB P39518 location annotations (source version: UniProt release 2026_03)
UniProtKB:P39002 Reviewed UniProtKB P39002 location annotations (source version: UniProt release 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T07:05:26Z Codex; edited; Correct FOX2 stereochemistry and distinguish DCI1 dienoyl auxiliary chemistry from ECI1 monoene isomerization.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 11 activity location assignments and 10 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 17 independently supported location edges and quarantined 10 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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2026-10-05T07:05:26Z Codex
- EDIT — Correct FOX2 stereochemistry and distinguish DCI1 dienoyl auxiliary chemistry from ECI1 monoene isomerization.
  User-authorized full causal graph curation. Correct FOX2 stereochemistry and distinguish DCI1 dienoyl auxiliary chemistry from ECI1 monoene isomerization. Independent UniProt release2026_03 annotations, Rhea139 and ChEBI255 were inspected; primary literature was checked for the taxon/function distinctions. Exact source pointers and superseded edge assertions are retained in reports/causal_graph_review/gocam-chemical-corrections.json. Native schema validation and focused biochemical regression tests were run. Shared final rendering and full gates are performed by the coordinating agent.
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