galactose degradation

gomodel:YeastPathways_YEAST-GALACT-METAB-PWY

Galactose degradation in Saccharomyces cerevisiae S288C epimerizes beta-D-galactose to alpha-D-galactose, phosphorylates it, transfers UDP-glucose to form alpha-D-glucose 1-phosphate and UDP-galactose, regenerates UDP-glucose, and converts alpha-D-glucose 1-phosphate to D-glucose 6-phosphate in the SGD GO-CAM galactose degradation pathway.

Pathway type

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

27 nodes · 42 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
cytosol `GO:0005829`	cellular component
D-glucopyranose 6-phosphate `CHEBI:4170`	small molecule
PGM2 Scer `SGD:S000004711`	protein
galactose catabolic process `GO:0019388`	biological process
alpha-D-glucose 1-phosphate(2-) `CHEBI:58601`	small molecule
UDP-alpha-D-glucose(2-) `CHEBI:58885`	small molecule
alpha-D-galactose 1-phosphate(2-) `CHEBI:58336`	small molecule
hydron `CHEBI:15378`	small molecule
GAL10 Scer `SGD:S000000223`	protein
GAL1 Scer `SGD:S000000224`	protein
alpha-D-galactose `CHEBI:28061`	small molecule
ATP(4-) `CHEBI:30616`	small molecule
GAL7 Scer `SGD:S000000222`	protein
PGM1 Scer `SGD:S000001610`	protein
beta-D-galactose `CHEBI:27667`	small molecule
UDP-alpha-D-galactose(2-) `CHEBI:66914`	small molecule
ADP(3-) `CHEBI:456216`	small molecule
cytoplasm `GO:0005737`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
zinc(2+) `CHEBI:29105`	cofactor
NAD(1-) `CHEBI:57540`	cofactor
β-D-galactopyranose -> α-D-galactopyranose `gomodel:ALDOSE1EPIM-RXN`	molecular activity
α-D-galactopyranose + ATP -> α-D-galactose 1-phosphate + ADP + H⁺ `gomodel:GALACTOKIN-RXN`	molecular activity
UDP-α-D-glucose + α-D-galactose 1-phosphate -> UDP-α-D-galactose + α-D-glucopyranose 1-phosphate `gomodel:GALACTURIDYLYLTRANS-RXN`	molecular activity
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	molecular activity
UDP-α-D-glucose <=> UDP-α-D-galactose `gomodel:UDPGLUCEPIM-RXN`	molecular activity
phosphoglucomutase activity `gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
UDP-α-D-glucose <=> UDP-α-D-galactose `gomodel:UDPGLUCEPIM-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:UDPGLUCEPIM-RXN BFO:0000066 gomodel:reaction_UDPGLUCEPIM-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/0; endpoint types: /individuals/14/type; /individuals/47/type`
UDP-α-D-glucose + α-D-galactose 1-phosphate -> UDP-α-D-galactose + α-D-glucopyranose 1-phosphate `gomodel:GALACTURIDYLYLTRANS-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTURIDYLYLTRANS-RXN BFO:0000066 gomodel:reaction_GALACTURIDYLYLTRANS-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/1; endpoint types: /individuals/12/type; /individuals/45/type`
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	has_output	D-glucopyranose 6-phosphate `CHEBI:4170`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002234 gomodel:CHEBI_4170_PHOSPHOGLUCMUT-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/2; endpoint types: /individuals/13/type; /individuals/5/type`
PGM2 Scer `SGD:S000004711`	enables	phosphoglucomutase activity `gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632 RO:0002333 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000634. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/3; endpoint types: /individuals/49/type; /individuals/51/type`
α-D-galactopyranose + ATP -> α-D-galactose 1-phosphate + ADP + H⁺ `gomodel:GALACTOKIN-RXN`	part_of	galactose catabolic process `GO:0019388`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTOKIN-RXN BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/4; endpoint types: /individuals/11/type; /individuals/48/type`
phosphoglucomutase activity `gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632`	has_input	alpha-D-glucose 1-phosphate(2-) `CHEBI:58601`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632 RO:0002233 gomodel:CHEBI_58601_GALACTURIDYLYLTRANS-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/5; endpoint types: /individuals/49/type; /individuals/8/type`
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	has_input	alpha-D-glucose 1-phosphate(2-) `CHEBI:58601`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002233 gomodel:CHEBI_58601_GALACTURIDYLYLTRANS-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/6; endpoint types: /individuals/13/type; /individuals/8/type`
UDP-α-D-glucose <=> UDP-α-D-galactose `gomodel:UDPGLUCEPIM-RXN`	has_output	UDP-alpha-D-glucose(2-) `CHEBI:58885`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:UDPGLUCEPIM-RXN RO:0002234 gomodel:CHEBI_58885_UDPGLUCEPIM-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/7; endpoint types: /individuals/14/type; /individuals/9/type`
UDP-α-D-glucose <=> UDP-α-D-galactose `gomodel:UDPGLUCEPIM-RXN`	part_of	galactose catabolic process `GO:0019388`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:UDPGLUCEPIM-RXN BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/8; endpoint types: /individuals/14/type; /individuals/48/type`
α-D-galactopyranose + ATP -> α-D-galactose 1-phosphate + ADP + H⁺ `gomodel:GALACTOKIN-RXN`	has_output	alpha-D-galactose 1-phosphate(2-) `CHEBI:58336`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTOKIN-RXN RO:0002234 gomodel:CHEBI_58336_GALACTOKIN-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/9; endpoint types: /individuals/11/type; /individuals/7/type`
β-D-galactopyranose -> α-D-galactopyranose `gomodel:ALDOSE1EPIM-RXN`	part_of	galactose catabolic process `GO:0019388`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:ALDOSE1EPIM-RXN BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/10; endpoint types: /individuals/0/type; /individuals/48/type`
α-D-galactopyranose + ATP -> α-D-galactose 1-phosphate + ADP + H⁺ `gomodel:GALACTOKIN-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTOKIN-RXN RO:0002234 gomodel:CHEBI_15378_GALACTOKIN-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/11; endpoint types: /individuals/11/type; /individuals/1/type`
GAL10 Scer `SGD:S000000223`	enables	β-D-galactopyranose -> α-D-galactopyranose `gomodel:ALDOSE1EPIM-RXN`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:ALDOSE1EPIM-RXN RO:0002333 gomodel:YBR019C-MONOMER_ALDOSE1EPIM-RXN_controller. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/12; endpoint types: /individuals/0/type; /individuals/16/type`
GAL1 Scer `SGD:S000000224`	enables	α-D-galactopyranose + ATP -> α-D-galactose 1-phosphate + ADP + H⁺ `gomodel:GALACTOKIN-RXN`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTOKIN-RXN RO:0002333 gomodel:YBR020W-MONOMER_GALACTOKIN-RXN_controller. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/13; endpoint types: /individuals/11/type; /individuals/18/type`
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN BFO:0000066 gomodel:reaction_PHOSPHOGLUCMUT-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/14; endpoint types: /individuals/13/type; /individuals/46/type`
phosphoglucomutase activity `gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632`	has_output	D-glucopyranose 6-phosphate `CHEBI:4170`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632 RO:0002234 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000633. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/15; endpoint types: /individuals/49/type; /individuals/50/type`
α-D-galactopyranose + ATP -> α-D-galactose 1-phosphate + ADP + H⁺ `gomodel:GALACTOKIN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTOKIN-RXN BFO:0000066 gomodel:reaction_GALACTOKIN-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/16; endpoint types: /individuals/11/type; /individuals/44/type`
β-D-galactopyranose -> α-D-galactopyranose `gomodel:ALDOSE1EPIM-RXN`	has_output	alpha-D-galactose `CHEBI:28061`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:ALDOSE1EPIM-RXN RO:0002234 gomodel:CHEBI_28061_ALDOSE1EPIM-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/17; endpoint types: /individuals/0/type; /individuals/3/type`
α-D-galactopyranose + ATP -> α-D-galactose 1-phosphate + ADP + H⁺ `gomodel:GALACTOKIN-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTOKIN-RXN RO:0002233 gomodel:CHEBI_30616_GALACTOKIN-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/18; endpoint types: /individuals/11/type; /individuals/4/type`
GAL7 Scer `SGD:S000000222`	enables	UDP-α-D-glucose + α-D-galactose 1-phosphate -> UDP-α-D-galactose + α-D-glucopyranose 1-phosphate `gomodel:GALACTURIDYLYLTRANS-RXN`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTURIDYLYLTRANS-RXN RO:0002333 gomodel:YBR018C-MONOMER_GALACTURIDYLYLTRANS-RXN_controller. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/19; endpoint types: /individuals/12/type; /individuals/15/type`
UDP-α-D-glucose + α-D-galactose 1-phosphate -> UDP-α-D-galactose + α-D-glucopyranose 1-phosphate `gomodel:GALACTURIDYLYLTRANS-RXN`	has_output	alpha-D-glucose 1-phosphate(2-) `CHEBI:58601`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTURIDYLYLTRANS-RXN RO:0002234 gomodel:CHEBI_58601_GALACTURIDYLYLTRANS-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/20; endpoint types: /individuals/12/type; /individuals/8/type`
PGM1 Scer `SGD:S000001610`	enables	α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN RO:0002333 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6690711d00000510. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/21; endpoint types: /individuals/13/type; /individuals/58/type`
β-D-galactopyranose -> α-D-galactopyranose `gomodel:ALDOSE1EPIM-RXN`	has_input	beta-D-galactose `CHEBI:27667`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:ALDOSE1EPIM-RXN RO:0002233 gomodel:CHEBI_27667_ALDOSE1EPIM-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/22; endpoint types: /individuals/0/type; /individuals/2/type`
UDP-α-D-glucose + α-D-galactose 1-phosphate -> UDP-α-D-galactose + α-D-glucopyranose 1-phosphate `gomodel:GALACTURIDYLYLTRANS-RXN`	has_input	alpha-D-galactose 1-phosphate(2-) `CHEBI:58336`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTURIDYLYLTRANS-RXN RO:0002233 gomodel:CHEBI_58336_GALACTOKIN-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/23; endpoint types: /individuals/12/type; /individuals/7/type`
UDP-α-D-glucose + α-D-galactose 1-phosphate -> UDP-α-D-galactose + α-D-glucopyranose 1-phosphate `gomodel:GALACTURIDYLYLTRANS-RXN`	has_output	UDP-alpha-D-galactose(2-) `CHEBI:66914`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTURIDYLYLTRANS-RXN RO:0002234 gomodel:CHEBI_66914_GALACTURIDYLYLTRANS-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/24; endpoint types: /individuals/12/type; /individuals/10/type`
phosphoglucomutase activity `gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632`	part_of	galactose catabolic process `GO:0019388`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632 BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/25; endpoint types: /individuals/49/type; /individuals/48/type`
phosphoglucomutase activity `gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000632 BFO:0000066 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/6a4c244800000636. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/26; endpoint types: /individuals/49/type; /individuals/52/type`
α-D-galactopyranose + ATP -> α-D-galactose 1-phosphate + ADP + H⁺ `gomodel:GALACTOKIN-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTOKIN-RXN RO:0002234 gomodel:CHEBI_456216_GALACTOKIN-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/27; endpoint types: /individuals/11/type; /individuals/6/type`
UDP-α-D-glucose + α-D-galactose 1-phosphate -> UDP-α-D-galactose + α-D-glucopyranose 1-phosphate `gomodel:GALACTURIDYLYLTRANS-RXN`	part_of	galactose catabolic process `GO:0019388`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTURIDYLYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/28; endpoint types: /individuals/12/type; /individuals/48/type`
α-D-glucopyranose 1-phosphate <=> D-glucopyranose 6-phosphate `gomodel:PHOSPHOGLUCMUT-RXN`	part_of	galactose catabolic process `GO:0019388`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:PHOSPHOGLUCMUT-RXN BFO:0000050 gomodel:YeastPathways_YEAST-GALACT-METAB-PWY/YeastPathways_YEAST-GALACT-METAB-PWY. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/29; endpoint types: /individuals/13/type; /individuals/48/type`
UDP-α-D-glucose <=> UDP-α-D-galactose `gomodel:UDPGLUCEPIM-RXN`	has_input	UDP-alpha-D-galactose(2-) `CHEBI:66914`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:UDPGLUCEPIM-RXN RO:0002233 gomodel:CHEBI_66914_GALACTURIDYLYLTRANS-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/30; endpoint types: /individuals/14/type; /individuals/10/type`
β-D-galactopyranose -> α-D-galactopyranose `gomodel:ALDOSE1EPIM-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:ALDOSE1EPIM-RXN BFO:0000066 gomodel:reaction_ALDOSE1EPIM-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/31; endpoint types: /individuals/0/type; /individuals/43/type`
GAL10 Scer `SGD:S000000223`	enables	UDP-α-D-glucose <=> UDP-α-D-galactose `gomodel:UDPGLUCEPIM-RXN`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:UDPGLUCEPIM-RXN RO:0002333 gomodel:YBR019C-MONOMER_UDPGLUCEPIM-RXN_controller. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/32; endpoint types: /individuals/14/type; /individuals/17/type`
α-D-galactopyranose + ATP -> α-D-galactose 1-phosphate + ADP + H⁺ `gomodel:GALACTOKIN-RXN`	has_input	alpha-D-galactose `CHEBI:28061`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTOKIN-RXN RO:0002233 gomodel:CHEBI_28061_ALDOSE1EPIM-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/33; endpoint types: /individuals/11/type; /individuals/3/type`
UDP-α-D-glucose + α-D-galactose 1-phosphate -> UDP-α-D-galactose + α-D-glucopyranose 1-phosphate `gomodel:GALACTURIDYLYLTRANS-RXN`	has_input	UDP-alpha-D-glucose(2-) `CHEBI:58885`	gomodel:YeastPathways_YEAST-GALACT-METAB-PWY Source assertion: The model asserts gomodel:GALACTURIDYLYLTRANS-RXN RO:0002233 gomodel:CHEBI_58885_UDPGLUCEPIM-RXN. Source location `./YeastPathways_YEAST-GALACT-METAB-PWY.json#/facts/34; endpoint types: /individuals/12/type; /individuals/9/type`
PGM2 Scer `SGD:S000004711`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:8385141)	cytoplasm `GO:0005737`	UniProtKB:P37012 Source assertion: UniProtKB:P37012 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1251/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P37012 Source assertion: UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1251/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PGM1 Scer `SGD:S000001610`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P33401 Source assertion: UniProtKB:P33401 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1085/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P33401 Source assertion: UniProtKB:P33401 has the exact SGD cross-reference SGD:S000001610. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1085/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
PGM2 Scer `SGD:S000004711`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805) Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor. UniProt note evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805)	magnesium(2+) `CHEBI:18420`	UniProtKB:P37012 Source assertion: UniProtKB:P37012 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/comments/0/cofactors/0; /results/1251/comments/0/note` UniProtKB:P37012 Source assertion: UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/uniProtKBCrossReferences/0`
PGM2 Scer `SGD:S000004711`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805) Binds 1 magnesium ion per subunit. Can also use Zn(2+) as cofactor. UniProt note evidence: ECO:0000269 (PubMed:1100398); ECO:0000269 (PubMed:4628805)	zinc(2+) `CHEBI:29105`	UniProtKB:P37012 Source assertion: UniProtKB:P37012 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/comments/0/cofactors/1; /results/1251/comments/0/note` UniProtKB:P37012 Source assertion: UniProtKB:P37012 has the exact SGD cross-reference SGD:S000004711. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1251/uniProtKBCrossReferences/0`
GAL10 Scer `SGD:S000000223`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	NAD(1-) `CHEBI:57540`	UniProtKB:P04397 Source assertion: UniProtKB:P04397 annotates CHEBI:57540 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/84/comments/0/cofactors/0` UniProtKB:P04397 Source assertion: UniProtKB:P04397 has the exact SGD cross-reference SGD:S000000223. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/84/uniProtKBCrossReferences/0`
GAL7 Scer `SGD:S000000222`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P09148) Binds 1 zinc ion per subunit. Zinc binding seems to play a structural role. UniProt note evidence: ECO:0000250 (UniProtKB:P09148)	zinc(2+) `CHEBI:29105`	UniProtKB:P08431 Source assertion: UniProtKB:P08431 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3254/comments/0/cofactors/0; /results/3254/comments/0/note` UniProtKB:P08431 Source assertion: UniProtKB:P08431 has the exact SGD cross-reference SGD:S000000222. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3254/uniProtKBCrossReferences/0`
PGM1 Scer `SGD:S000001610`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 (UniProtKB:P00949) Binds 1 Mg(2+) ion per subunit. UniProt note evidence: ECO:0000250 (UniProtKB:P00949)	magnesium(2+) `CHEBI:18420`	UniProtKB:P33401 Source assertion: UniProtKB:P33401 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1085/comments/0/cofactors/0; /results/1085/comments/0/note` UniProtKB:P33401 Source assertion: UniProtKB:P33401 has the exact SGD cross-reference SGD:S000001610. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1085/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_YEAST-GALACT-METAB-PWY SGD GO-CAM galactose degradation - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2026-07-08; member ./YeastPathways_YEAST-GALACT-METAB-PWY.json)
UniProtKB:P37012 Reviewed UniProtKB P37012 location annotations (source version: UniProt release 2026_03)
UniProtKB:P33401 Reviewed UniProtKB P33401 location annotations (source version: UniProt release 2026_03)
UniProtKB:P04397 UniProtKB P04397 cofactor annotations (source version: 2026_03)
UniProtKB:P08431 UniProtKB P08431 cofactor annotations (source version: 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 6 activity location assignments and 5 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 2 independently supported location edges and quarantined 0 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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