salvage pathways of pyrimidine ribonucleotides

gomodel:YeastPathways_YEAST-RNT-SALV

Salvage pathways of pyrimidine ribonucleotides in Saccharomyces cerevisiae S288C recover uridine, cytidine, cytosine, and uracil through nucleosidase, deaminase, kinase, and uracil phosphoribosyltransferase reactions to regenerate UMP, CMP, CDP, UDP, CTP, and UTP in the SGD GO-CAM pyrimidine ribonucleotide salvage pathway.

Pathway type

nucleotide salvage

Organism scope

Saccharomyces cerevisiae S288C NCBITaxon:559292

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Pathway network

41 nodes · 82 asserted directed edges

Arrows show recorded subject → object relationships, not necessarily metabolic flow. Select a node for details or an arrow for evidence. Scroll, zoom or find a node to explore.

Reaction / activity
Chemical / cofactor
Protein / complex
Cell / process context
Solid arrow: mechanistic relation
Dashed arrow: membership, location or cofactor relation

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Components and activities

Declared biological components and source reaction directions
Node	Kind or role	Source direction
Saccharomyces cerevisiae S288C `NCBITaxon:559292`	taxon
uracil `CHEBI:17568`	small molecule
water `CHEBI:15377`	small molecule
pyrimidine ribonucleotide salvage `GO:0010138`	biological process
cytosine `CHEBI:16040`	small molecule
cytosol `GO:0005829`	cellular component
ADP(3-) `CHEBI:456216`	small molecule
hydron `CHEBI:15378`	small molecule
ammonium `CHEBI:28938`	small molecule
D-ribofuranose `CHEBI:47013`	small molecule
uridine `CHEBI:16704`	small molecule
URH1 Scer `SGD:S000002808`	protein
URK1 Scer `SGD:S000005295`	protein
GTP(4-) `CHEBI:37565`	small molecule
5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-) `CHEBI:58017`	small molecule
GDP(3-) `CHEBI:58189`	small molecule
cytidine `CHEBI:17562`	small molecule
YNK1 Scer `SGD:S000001550`	protein
CDP(3-) `CHEBI:58069`	small molecule
cytidine 5'-monophosphate(2-) `CHEBI:60377`	small molecule
ATP(4-) `CHEBI:30616`	small molecule
URA6 Scer `SGD:S000001507`	protein
FCY1 Scer `SGD:S000006266`	protein
CDD1 Scer `SGD:S000004235`	protein
CTP(4-) `CHEBI:37563`	small molecule
uridine 5'-monophosphate(2-) `CHEBI:57865`	small molecule
diphosphoric acid `CHEBI:29888`	small molecule
FUR1 Scer `SGD:S000001170`	protein
cytoplasm `GO:0005737`	cellular component
nucleus `GO:0005634`	cellular component
mitochondrial intermembrane space `GO:0005758`	cellular component
magnesium(2+) `CHEBI:18420`	cofactor
zinc(2+) `CHEBI:29105`	cofactor
CDP + ATP -> CTP + ADP `gomodel:CDPKIN-RXN`	molecular activity
cytosine + H₂O + H⁺ -> uracil + ammonium `gomodel:CYTDEAM-RXN`	molecular activity
cytidine + H⁺ + H₂O -> uridine + ammonium `gomodel:CYTIDEAM2-RXN`	molecular activity
cytidine + GTP -> CMP + GDP + H⁺ `gomodel:CYTIDINEKIN-RXN`	molecular activity
CMP + ATP <=> CDP + ADP `gomodel:RXN-11832`	molecular activity
cytidine + H₂O -> D-ribofuranose + cytosine `gomodel:RXN0-361`	molecular activity
UMP + diphosphate <- 5-phospho-α-D-ribose 1-diphosphate + uracil `gomodel:URACIL-PRIBOSYLTRANS-RXN`	molecular activity
uridine + H₂O -> D-ribofuranose + uracil `gomodel:URIDINE-NUCLEOSIDASE-RXN`	molecular activity
uridine + ATP -> UMP + ADP + H⁺ `gomodel:URIDINEKIN-RXN`	molecular activity

Mechanistic edges

Mechanistic edges and their cited evidence
Subject	Predicate and description	Object	Evidence
UMP + diphosphate <- 5-phospho-α-D-ribose 1-diphosphate + uracil `gomodel:URACIL-PRIBOSYLTRANS-RXN`	has_input	uracil `CHEBI:17568`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN RO:0002233 gomodel:CHEBI_17568_URIDINE-NUCLEOSIDASE-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/0; endpoint types: /individuals/40/type; /individuals/15/type`
uridine + H₂O -> D-ribofuranose + uracil `gomodel:URIDINE-NUCLEOSIDASE-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN RO:0002233 gomodel:CHEBI_15377_URIDINE-NUCLEOSIDASE-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/1; endpoint types: /individuals/41/type; /individuals/4/type`
UMP + diphosphate <- 5-phospho-α-D-ribose 1-diphosphate + uracil `gomodel:URACIL-PRIBOSYLTRANS-RXN`	part_of	pyrimidine ribonucleotide salvage `GO:0010138`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/2; endpoint types: /individuals/40/type; /individuals/119/type`
cytosine + H₂O + H⁺ -> uracil + ammonium `gomodel:CYTDEAM-RXN`	part_of	pyrimidine ribonucleotide salvage `GO:0010138`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTDEAM-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/3; endpoint types: /individuals/35/type; /individuals/119/type`
cytidine + H₂O -> D-ribofuranose + cytosine `gomodel:RXN0-361`	has_output	cytosine `CHEBI:16040`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN0-361 RO:0002234 gomodel:CHEBI_16040_RXN0-361. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/4; endpoint types: /individuals/39/type; /individuals/9/type`
UMP + diphosphate <- 5-phospho-α-D-ribose 1-diphosphate + uracil `gomodel:URACIL-PRIBOSYLTRANS-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN BFO:0000066 gomodel:reaction_URACIL-PRIBOSYLTRANS-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/5; endpoint types: /individuals/40/type; /individuals/116/type`
CMP + ATP <=> CDP + ADP `gomodel:RXN-11832`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN-11832 RO:0002234 gomodel:CHEBI_456216_RXN-11832. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/6; endpoint types: /individuals/38/type; /individuals/25/type`
cytosine + H₂O + H⁺ -> uracil + ammonium `gomodel:CYTDEAM-RXN`	has_input	cytosine `CHEBI:16040`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTDEAM-RXN RO:0002233 gomodel:CHEBI_16040_RXN0-361. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/7; endpoint types: /individuals/35/type; /individuals/9/type`
CMP + ATP <=> CDP + ADP `gomodel:RXN-11832`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN-11832 BFO:0000066 gomodel:reaction_RXN-11832_location_lociGO_0005829. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/8; endpoint types: /individuals/38/type; /individuals/114/type`
cytosine + H₂O + H⁺ -> uracil + ammonium `gomodel:CYTDEAM-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTDEAM-RXN RO:0002233 gomodel:CHEBI_15378_CYTDEAM-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/9; endpoint types: /individuals/35/type; /individuals/5/type`
cytosine + H₂O + H⁺ -> uracil + ammonium `gomodel:CYTDEAM-RXN`	has_output	ammonium `CHEBI:28938`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTDEAM-RXN RO:0002234 gomodel:CHEBI_28938_CYTDEAM-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/10; endpoint types: /individuals/35/type; /individuals/16/type`
uridine + ATP -> UMP + ADP + H⁺ `gomodel:URIDINEKIN-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINEKIN-RXN RO:0002234 gomodel:CHEBI_456216_URIDINEKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/11; endpoint types: /individuals/42/type; /individuals/26/type`
cytidine + H₂O -> D-ribofuranose + cytosine `gomodel:RXN0-361`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN0-361 BFO:0000066 gomodel:reaction_RXN0-361_location_lociGO_0005829. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/12; endpoint types: /individuals/39/type; /individuals/115/type`
CDP + ATP -> CTP + ADP `gomodel:CDPKIN-RXN`	part_of	pyrimidine ribonucleotide salvage `GO:0010138`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CDPKIN-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/13; endpoint types: /individuals/0/type; /individuals/119/type`
uridine + H₂O -> D-ribofuranose + uracil `gomodel:URIDINE-NUCLEOSIDASE-RXN`	has_output	D-ribofuranose `CHEBI:47013`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN RO:0002234 gomodel:CHEBI_47013_URIDINE-NUCLEOSIDASE-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/14; endpoint types: /individuals/41/type; /individuals/28/type`
uridine + H₂O -> D-ribofuranose + uracil `gomodel:URIDINE-NUCLEOSIDASE-RXN`	has_input	uridine `CHEBI:16704`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN RO:0002233 gomodel:CHEBI_16704_CYTIDEAM2-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/15; endpoint types: /individuals/41/type; /individuals/10/type`
cytidine + H₂O -> D-ribofuranose + cytosine `gomodel:RXN0-361`	has_output	D-ribofuranose `CHEBI:47013`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN0-361 RO:0002234 gomodel:CHEBI_47013_RXN0-361. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/16; endpoint types: /individuals/39/type; /individuals/27/type`
uridine + ATP -> UMP + ADP + H⁺ `gomodel:URIDINEKIN-RXN`	part_of	pyrimidine ribonucleotide salvage `GO:0010138`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINEKIN-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/17; endpoint types: /individuals/42/type; /individuals/119/type`
cytidine + GTP -> CMP + GDP + H⁺ `gomodel:CYTIDINEKIN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDINEKIN-RXN BFO:0000066 gomodel:reaction_CYTIDINEKIN-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/18; endpoint types: /individuals/37/type; /individuals/113/type`
URH1 Scer `SGD:S000002808`	enables	uridine + H₂O -> D-ribofuranose + uracil `gomodel:URIDINE-NUCLEOSIDASE-RXN`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN RO:0002333 gomodel:YDR400W-MONOMER_URIDINE-NUCLEOSIDASE-RXN_controller. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/19; endpoint types: /individuals/41/type; /individuals/44/type`
cytosine + H₂O + H⁺ -> uracil + ammonium `gomodel:CYTDEAM-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTDEAM-RXN RO:0002233 gomodel:CHEBI_15377_CYTDEAM-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/20; endpoint types: /individuals/35/type; /individuals/1/type`
uridine + ATP -> UMP + ADP + H⁺ `gomodel:URIDINEKIN-RXN`	has_input	uridine `CHEBI:16704`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINEKIN-RXN RO:0002233 gomodel:CHEBI_16704_CYTIDEAM2-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/21; endpoint types: /individuals/42/type; /individuals/10/type`
URH1 Scer `SGD:S000002808`	enables	cytidine + H₂O -> D-ribofuranose + cytosine `gomodel:RXN0-361`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN0-361 RO:0002333 gomodel:YDR400W-MONOMER_RXN0-361_controller. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/22; endpoint types: /individuals/39/type; /individuals/43/type`
CDP + ATP -> CTP + ADP `gomodel:CDPKIN-RXN`	has_output	ADP(3-) `CHEBI:456216`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CDPKIN-RXN RO:0002234 gomodel:CHEBI_456216_CDPKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/23; endpoint types: /individuals/0/type; /individuals/24/type`
URK1 Scer `SGD:S000005295`	enables	cytidine + GTP -> CMP + GDP + H⁺ `gomodel:CYTIDINEKIN-RXN`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDINEKIN-RXN RO:0002333 gomodel:YNR012W-MONOMER_CYTIDINEKIN-RXN_controller. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/24; endpoint types: /individuals/37/type; /individuals/49/type`
cytidine + GTP -> CMP + GDP + H⁺ `gomodel:CYTIDINEKIN-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDINEKIN-RXN RO:0002234 gomodel:CHEBI_15378_CYTIDINEKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/25; endpoint types: /individuals/37/type; /individuals/7/type`
cytidine + GTP -> CMP + GDP + H⁺ `gomodel:CYTIDINEKIN-RXN`	has_input	GTP(4-) `CHEBI:37565`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDINEKIN-RXN RO:0002233 gomodel:CHEBI_37565_CYTIDINEKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/26; endpoint types: /individuals/37/type; /individuals/23/type`
UMP + diphosphate <- 5-phospho-α-D-ribose 1-diphosphate + uracil `gomodel:URACIL-PRIBOSYLTRANS-RXN`	has_input	5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-) `CHEBI:58017`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN RO:0002233 gomodel:CHEBI_58017_URACIL-PRIBOSYLTRANS-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/27; endpoint types: /individuals/40/type; /individuals/31/type`
cytidine + GTP -> CMP + GDP + H⁺ `gomodel:CYTIDINEKIN-RXN`	has_output	GDP(3-) `CHEBI:58189`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDINEKIN-RXN RO:0002234 gomodel:CHEBI_58189_CYTIDINEKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/28; endpoint types: /individuals/37/type; /individuals/33/type`
cytidine + H₂O -> D-ribofuranose + cytosine `gomodel:RXN0-361`	has_input	cytidine `CHEBI:17562`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN0-361 RO:0002233 gomodel:CHEBI_17562_RXN0-361. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/29; endpoint types: /individuals/39/type; /individuals/13/type`
uridine + ATP -> UMP + ADP + H⁺ `gomodel:URIDINEKIN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINEKIN-RXN BFO:0000066 gomodel:reaction_URIDINEKIN-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/30; endpoint types: /individuals/42/type; /individuals/118/type`
YNK1 Scer `SGD:S000001550`	enables	CDP + ATP -> CTP + ADP `gomodel:CDPKIN-RXN`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CDPKIN-RXN RO:0002333 gomodel:YKL067W-MONOMER_CDPKIN-RXN_controller. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/31; endpoint types: /individuals/0/type; /individuals/47/type`
CMP + ATP <=> CDP + ADP `gomodel:RXN-11832`	has_output	CDP(3-) `CHEBI:58069`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN-11832 RO:0002234 gomodel:CHEBI_58069_RXN-11832. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/32; endpoint types: /individuals/38/type; /individuals/32/type`
cytidine + H₂O -> D-ribofuranose + cytosine `gomodel:RXN0-361`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN0-361 RO:0002233 gomodel:CHEBI_15377_RXN0-361. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/33; endpoint types: /individuals/39/type; /individuals/3/type`
cytidine + H⁺ + H₂O -> uridine + ammonium `gomodel:CYTIDEAM2-RXN`	has_output	ammonium `CHEBI:28938`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDEAM2-RXN RO:0002234 gomodel:CHEBI_28938_CYTIDEAM2-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/34; endpoint types: /individuals/36/type; /individuals/17/type`
cytidine + H₂O -> D-ribofuranose + cytosine `gomodel:RXN0-361`	part_of	pyrimidine ribonucleotide salvage `GO:0010138`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN0-361 BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/35; endpoint types: /individuals/39/type; /individuals/119/type`
cytidine + GTP -> CMP + GDP + H⁺ `gomodel:CYTIDINEKIN-RXN`	has_output	cytidine 5'-monophosphate(2-) `CHEBI:60377`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDINEKIN-RXN RO:0002234 gomodel:CHEBI_60377_CYTIDINEKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/36; endpoint types: /individuals/37/type; /individuals/34/type`
uridine + H₂O -> D-ribofuranose + uracil `gomodel:URIDINE-NUCLEOSIDASE-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN BFO:0000066 gomodel:reaction_URIDINE-NUCLEOSIDASE-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/37; endpoint types: /individuals/41/type; /individuals/117/type`
CMP + ATP <=> CDP + ADP `gomodel:RXN-11832`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN-11832 RO:0002233 gomodel:CHEBI_30616_RXN-11832. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/38; endpoint types: /individuals/38/type; /individuals/20/type`
cytosine + H₂O + H⁺ -> uracil + ammonium `gomodel:CYTDEAM-RXN`	has_output	uracil `CHEBI:17568`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTDEAM-RXN RO:0002234 gomodel:CHEBI_17568_CYTDEAM-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/39; endpoint types: /individuals/35/type; /individuals/14/type`
cytidine + H⁺ + H₂O -> uridine + ammonium `gomodel:CYTIDEAM2-RXN`	part_of	pyrimidine ribonucleotide salvage `GO:0010138`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDEAM2-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/40; endpoint types: /individuals/36/type; /individuals/119/type`
cytidine + H⁺ + H₂O -> uridine + ammonium `gomodel:CYTIDEAM2-RXN`	has_output	uridine `CHEBI:16704`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDEAM2-RXN RO:0002234 gomodel:CHEBI_16704_CYTIDEAM2-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/41; endpoint types: /individuals/36/type; /individuals/10/type`
CDP + ATP -> CTP + ADP `gomodel:CDPKIN-RXN`	has_input	CDP(3-) `CHEBI:58069`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CDPKIN-RXN RO:0002233 gomodel:CHEBI_58069_RXN-11832. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/42; endpoint types: /individuals/0/type; /individuals/32/type`
CMP + ATP <=> CDP + ADP `gomodel:RXN-11832`	has_input	cytidine 5'-monophosphate(2-) `CHEBI:60377`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN-11832 RO:0002233 gomodel:CHEBI_60377_CYTIDINEKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/43; endpoint types: /individuals/38/type; /individuals/34/type`
cytidine + GTP -> CMP + GDP + H⁺ `gomodel:CYTIDINEKIN-RXN`	part_of	pyrimidine ribonucleotide salvage `GO:0010138`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDINEKIN-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/44; endpoint types: /individuals/37/type; /individuals/119/type`
cytidine + H⁺ + H₂O -> uridine + ammonium `gomodel:CYTIDEAM2-RXN`	has_input	hydron `CHEBI:15378`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDEAM2-RXN RO:0002233 gomodel:CHEBI_15378_CYTIDEAM2-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/45; endpoint types: /individuals/36/type; /individuals/6/type`
URA6 Scer `SGD:S000001507`	enables URA6-mediated CMP phosphorylation is disputed: UniProt's CAUTION reports positive results in PMID:1333436/Ref.8 and negative results in PMID:2172245/8391780. Retain the native branch as a qualified biochemical possibility, not an established physiological substrate assignment.	CMP + ATP <=> CDP + ADP `gomodel:RXN-11832`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN-11832 RO:0002333 gomodel:YKL024C-MONOMER_RXN-11832_controller. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/46; endpoint types: /individuals/38/type; /individuals/46/type` UniProtKB:P15700 Source assertion: URA6-mediated CMP phosphorylation is disputed: UniProt's CAUTION reports positive results in PMID:1333436/Ref.8 and negative results in PMID:2172245/8391780. Retain the native branch as a qualified biochemical possibility, not an established physiological substrate assignment. Source location `https://rest.uniprot.org/uniprotkb/P15700.json [sha256:0558d409b3620b20cc57c77b6e3cf019b4606d9c0402d6568ceb0e6440aa4385] #/comments/9/texts/0`
FCY1 Scer `SGD:S000006266`	enables	cytosine + H₂O + H⁺ -> uracil + ammonium `gomodel:CYTDEAM-RXN`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTDEAM-RXN RO:0002333 gomodel:YPR062W-MONOMER_CYTDEAM-RXN_controller. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/47; endpoint types: /individuals/35/type; /individuals/51/type`
uridine + ATP -> UMP + ADP + H⁺ `gomodel:URIDINEKIN-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINEKIN-RXN RO:0002233 gomodel:CHEBI_30616_URIDINEKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/48; endpoint types: /individuals/42/type; /individuals/21/type`
cytidine + H⁺ + H₂O -> uridine + ammonium `gomodel:CYTIDEAM2-RXN`	has_input	water `CHEBI:15377`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDEAM2-RXN RO:0002233 gomodel:CHEBI_15377_CYTIDEAM2-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/49; endpoint types: /individuals/36/type; /individuals/2/type`
cytidine + H⁺ + H₂O -> uridine + ammonium `gomodel:CYTIDEAM2-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDEAM2-RXN BFO:0000066 gomodel:reaction_CYTIDEAM2-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/50; endpoint types: /individuals/36/type; /individuals/112/type`
cytosine + H₂O + H⁺ -> uracil + ammonium `gomodel:CYTDEAM-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTDEAM-RXN BFO:0000066 gomodel:reaction_CYTDEAM-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/51; endpoint types: /individuals/35/type; /individuals/111/type`
CDD1 Scer `SGD:S000004235`	enables	cytidine + H⁺ + H₂O -> uridine + ammonium `gomodel:CYTIDEAM2-RXN`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDEAM2-RXN RO:0002333 gomodel:YLR245C-MONOMER_CYTIDEAM2-RXN_controller. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/52; endpoint types: /individuals/36/type; /individuals/48/type`
CDP + ATP -> CTP + ADP `gomodel:CDPKIN-RXN`	has_output	CTP(4-) `CHEBI:37563`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CDPKIN-RXN RO:0002234 gomodel:CHEBI_37563_CDPKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/53; endpoint types: /individuals/0/type; /individuals/22/type`
cytidine + GTP -> CMP + GDP + H⁺ `gomodel:CYTIDINEKIN-RXN`	has_input	cytidine `CHEBI:17562`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDINEKIN-RXN RO:0002233 gomodel:CHEBI_17562_CYTIDINEKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/54; endpoint types: /individuals/37/type; /individuals/12/type`
CDP + ATP -> CTP + ADP `gomodel:CDPKIN-RXN`	has_input	ATP(4-) `CHEBI:30616`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CDPKIN-RXN RO:0002233 gomodel:CHEBI_30616_CDPKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/55; endpoint types: /individuals/0/type; /individuals/19/type`
URK1 Scer `SGD:S000005295`	enables	uridine + ATP -> UMP + ADP + H⁺ `gomodel:URIDINEKIN-RXN`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINEKIN-RXN RO:0002333 gomodel:YNR012W-MONOMER_URIDINEKIN-RXN_controller. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/56; endpoint types: /individuals/42/type; /individuals/50/type`
uridine + H₂O -> D-ribofuranose + uracil `gomodel:URIDINE-NUCLEOSIDASE-RXN`	has_output	uracil `CHEBI:17568`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN RO:0002234 gomodel:CHEBI_17568_URIDINE-NUCLEOSIDASE-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/57; endpoint types: /individuals/41/type; /individuals/15/type`
CMP + ATP <=> CDP + ADP `gomodel:RXN-11832`	part_of	pyrimidine ribonucleotide salvage `GO:0010138`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:RXN-11832 BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/58; endpoint types: /individuals/38/type; /individuals/119/type`
uridine + ATP -> UMP + ADP + H⁺ `gomodel:URIDINEKIN-RXN`	has_output	hydron `CHEBI:15378`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINEKIN-RXN RO:0002234 gomodel:CHEBI_15378_URIDINEKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/59; endpoint types: /individuals/42/type; /individuals/8/type`
UMP + diphosphate <- 5-phospho-α-D-ribose 1-diphosphate + uracil `gomodel:URACIL-PRIBOSYLTRANS-RXN`	has_output	uridine 5'-monophosphate(2-) `CHEBI:57865`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN RO:0002234 gomodel:CHEBI_57865_URACIL-PRIBOSYLTRANS-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/60; endpoint types: /individuals/40/type; /individuals/29/type`
uridine + H₂O -> D-ribofuranose + uracil `gomodel:URIDINE-NUCLEOSIDASE-RXN`	part_of	pyrimidine ribonucleotide salvage `GO:0010138`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINE-NUCLEOSIDASE-RXN BFO:0000050 gomodel:YeastPathways_YEAST-RNT-SALV/YeastPathways_YEAST-RNT-SALV. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/61; endpoint types: /individuals/41/type; /individuals/119/type`
UMP + diphosphate <- 5-phospho-α-D-ribose 1-diphosphate + uracil `gomodel:URACIL-PRIBOSYLTRANS-RXN`	has_output	diphosphoric acid `CHEBI:29888`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN RO:0002234 gomodel:CHEBI_29888_URACIL-PRIBOSYLTRANS-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/62; endpoint types: /individuals/40/type; /individuals/18/type`
CDP + ATP -> CTP + ADP `gomodel:CDPKIN-RXN`	occurs_in	cytosol `GO:0005829`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CDPKIN-RXN BFO:0000066 gomodel:reaction_CDPKIN-RXN_location_lociGO_0005829. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/63; endpoint types: /individuals/0/type; /individuals/110/type`
cytidine + H⁺ + H₂O -> uridine + ammonium `gomodel:CYTIDEAM2-RXN`	has_input	cytidine `CHEBI:17562`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:CYTIDEAM2-RXN RO:0002233 gomodel:CHEBI_17562_CYTIDEAM2-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/64; endpoint types: /individuals/36/type; /individuals/11/type`
FUR1 Scer `SGD:S000001170`	enables	UMP + diphosphate <- 5-phospho-α-D-ribose 1-diphosphate + uracil `gomodel:URACIL-PRIBOSYLTRANS-RXN`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URACIL-PRIBOSYLTRANS-RXN RO:0002333 gomodel:YHR128W-MONOMER_URACIL-PRIBOSYLTRANS-RXN_controller. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/65; endpoint types: /individuals/40/type; /individuals/45/type`
uridine + ATP -> UMP + ADP + H⁺ `gomodel:URIDINEKIN-RXN`	has_output	uridine 5'-monophosphate(2-) `CHEBI:57865`	gomodel:YeastPathways_YEAST-RNT-SALV Source assertion: The model asserts gomodel:URIDINEKIN-RXN RO:0002234 gomodel:CHEBI_57865_URIDINEKIN-RXN. Source location `./YeastPathways_YEAST-RNT-SALV.json#/facts/66; endpoint types: /individuals/42/type; /individuals/30/type`
URH1 Scer `SGD:S000002808`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:Q04179 Source assertion: UniProtKB:Q04179 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2585/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q04179 Source assertion: UniProtKB:Q04179 has the exact SGD cross-reference SGD:S000002808. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2585/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
URH1 Scer `SGD:S000002808`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:Q04179 Source assertion: UniProtKB:Q04179 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2585/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q04179 Source assertion: UniProtKB:Q04179 has the exact SGD cross-reference SGD:S000002808. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/2585/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
URK1 Scer `SGD:S000005295`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:P27515 Source assertion: UniProtKB:P27515 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/761/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P27515 Source assertion: UniProtKB:P27515 has the exact SGD cross-reference SGD:S000005295. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/761/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
URK1 Scer `SGD:S000005295`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:P27515 Source assertion: UniProtKB:P27515 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/761/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P27515 Source assertion: UniProtKB:P27515 has the exact SGD cross-reference SGD:S000005295. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/761/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
YNK1 Scer `SGD:S000001550`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12472466) Source qualification: Localizes predominantly to the cytoplasm. A small fraction is present in the mitochondrial intermembrane space	cytoplasm `GO:0005737`	UniProtKB:P36010 Source assertion: UniProtKB:P36010 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P36010 Source assertion: UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
YNK1 Scer `SGD:S000001550`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:12472466); ECO:0000269 (PubMed:16823961); ECO:0000269 (PubMed:22984289) Source qualification: Localizes predominantly to the cytoplasm. A small fraction is present in the mitochondrial intermembrane space	mitochondrial intermembrane space `GO:0005758`	UniProtKB:P36010 Source assertion: UniProtKB:P36010 annotates location Mitochondrion intermembrane space (SL-0169). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P36010 Source assertion: UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/1183/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
URA6 Scer `SGD:S000001507`	located_in Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:1333436); ECO:0000269 (PubMed:8391780) Source qualification: Predominantly cytoplasmic	cytoplasm `GO:0005737`	UniProtKB:P15700 Source assertion: UniProtKB:P15700 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P15700 Source assertion: UniProtKB:P15700 has the exact SGD cross-reference SGD:S000001507. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
URA6 Scer `SGD:S000001507`	located_in Physical protein location from reviewed UniProt. ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:1333436); ECO:0000269 (PubMed:8391780) Source qualification: Predominantly cytoplasmic	nucleus `GO:0005634`	UniProtKB:P15700 Source assertion: UniProtKB:P15700 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:P15700 Source assertion: UniProtKB:P15700 has the exact SGD cross-reference SGD:S000001507. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/422/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FCY1 Scer `SGD:S000006266`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	cytoplasm `GO:0005737`	UniProtKB:Q12178 Source assertion: UniProtKB:Q12178 annotates location Cytoplasm (SL-0086). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3006/comments/1/subcellularLocations/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q12178 Source assertion: UniProtKB:Q12178 has the exact SGD cross-reference SGD:S000006266. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3006/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
FCY1 Scer `SGD:S000006266`	located_in Physical protein location from reviewed UniProt. ECO:0000269 (PubMed:14562095)	nucleus `GO:0005634`	UniProtKB:Q12178 Source assertion: UniProtKB:Q12178 annotates location Nucleus (SL-0191). Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3006/comments/1/subcellularLocations/1; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d` UniProtKB:Q12178 Source assertion: UniProtKB:Q12178 has the exact SGD cross-reference SGD:S000006266. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_subcellular_location%2Ccc_function%2Ccc_caution%2Corganism_id#/results/3006/uniProtKBCrossReferences/0; sha256=95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d`
YNK1 Scer `SGD:S000001550`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:5793714)	magnesium(2+) `CHEBI:18420`	UniProtKB:P36010 Source assertion: UniProtKB:P36010 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1183/comments/0/cofactors/0` UniProtKB:P36010 Source assertion: UniProtKB:P36010 has the exact SGD cross-reference SGD:S000001550. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/1183/uniProtKBCrossReferences/0`
URA6 Scer `SGD:S000001507`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. Reviewed source qualification: The dispute concerns nucleoside substrate specificity, not magnesium dependence; keep the metal assertion without expanding substrate scope. UniProt evidence: ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:16240436); ECO:0000269 (PubMed:8391780) Binds 1 Mg(2+) ion per monomer. UniProt note evidence: ECO:0000255 (HAMAP-Rule:MF_03172); ECO:0000269 (PubMed:16240436); ECO:0000269 (PubMed:8391780)	magnesium(2+) `CHEBI:18420`	UniProtKB:P15700 Source assertion: UniProtKB:P15700 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/422/comments/0/cofactors/0; /results/422/comments/0/note` UniProtKB:P15700 Source assertion: UniProtKB:P15700 has the exact SGD cross-reference SGD:S000001507. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/422/uniProtKBCrossReferences/0`
FCY1 Scer `SGD:S000006266`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000269 (PubMed:12637534); ECO:0000269 (PubMed:12906827); ECO:0000269 (PubMed:15879217)	zinc(2+) `CHEBI:29105`	UniProtKB:Q12178 Source assertion: UniProtKB:Q12178 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3006/comments/0/cofactors/0` UniProtKB:Q12178 Source assertion: UniProtKB:Q12178 has the exact SGD cross-reference SGD:S000006266. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3006/uniProtKBCrossReferences/0`
CDD1 Scer `SGD:S000004235`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: not specified	zinc(2+) `CHEBI:29105`	UniProtKB:Q06549 Source assertion: UniProtKB:Q06549 annotates CHEBI:29105 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2769/comments/0/cofactors/0` UniProtKB:Q06549 Source assertion: UniProtKB:Q06549 has the exact SGD cross-reference SGD:S000004235. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/2769/uniProtKBCrossReferences/0`
FUR1 Scer `SGD:S000001170`	has_cofactor UniProtKB reviewed (Swiss-Prot) annotation. UniProt evidence: ECO:0000250 Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP. UniProt note evidence: ECO:0000250	magnesium(2+) `CHEBI:18420`	UniProtKB:P18562 Source assertion: UniProtKB:P18562 annotates CHEBI:18420 as a cofactor of this protein. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3318/comments/0/cofactors/0; /results/3318/comments/0/note` UniProtKB:P18562 Source assertion: UniProtKB:P18562 has the exact SGD cross-reference SGD:S000001170. Source location `https://rest.uniprot.org/uniprotkb/stream?query=taxonomy_id%3A559292+AND+reviewed%3Atrue&format=json&fields=accession%2Cprotein_name%2Cxref_sgd%2Ccc_cofactor%2Corganism_id%2Ccc_caution [sha256:1378282d22c5518215707964664b55946f468ba74a227a6ea1bbf27db69ddbc4] #/results/3318/uniProtKBCrossReferences/0`

References

gomodel:YeastPathways_YEAST-RNT-SALV SGD GO-CAM salvage pathways of pyrimidine ribonucleotides - imported from: Saccharomyces Genome Database (source version: Pinned Noctua JSON archive; model date 2024-07-15; member ./YeastPathways_YEAST-RNT-SALV.json)
UniProtKB:Q04179 Reviewed UniProtKB Q04179 location annotations (source version: UniProt release 2026_03)
UniProtKB:P27515 Reviewed UniProtKB P27515 location annotations (source version: UniProt release 2026_03)
UniProtKB:P36010 Reviewed UniProtKB P36010 location annotations (source version: UniProt release 2026_03)
UniProtKB:P15700 Reviewed UniProtKB P15700 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q12178 Reviewed UniProtKB Q12178 location annotations (source version: UniProt release 2026_03)
UniProtKB:Q06549 UniProtKB Q06549 cofactor annotations (source version: 2026_03)
UniProtKB:P18562 UniProtKB P18562 cofactor annotations (source version: 2026_03)

Curation history

2026-10-05T06:05:08Z Codex; review-causal-graph; Reviewed every native GO-CAM fact; preserved precise input/output, causal, location, membership and complex-part relations with traceable structured source evidence. Kept distinct generic physical instances and recorded source-scope exclusions in the cohort review ledger.
2026-10-05T06:53:32Z Codex; review-catalytic-function; Reconciled native GO-CAM chemistry with independently reviewed enzyme specificity, direction, physiological scope and source cautions; superseded facts remain in the function review ledger.
2026-10-05T06:43:56Z Codex
- EDIT — Audit causal activity compartments and preserve scoped protein location evidence
  Reviewed all 9 activity location assignments and 7 mapped physical proteins against reviewed S288C UniProt release2026_03 location/function/caution batch SHA256 95f72dcc644358c480e0e59f996cf88533558b5fa4256460a030e0a1eaf9678d. Added 10 independently supported location edges and quarantined 0 generic cytosol source assertions. Mapped physical protein locations via exact SGD cross-references; retained source ECO grades, molecular form and conditional notes. Physical protein location alone never generates activity location. Explicitly inspected functional assertions support bounded activity projections. Every original activity location and exclusion is recorded in reports/causal_graph_review/gocam-location-review.json. No independent location annotation is treated as an evidence gap, not a negative result. Cytoplasm is not narrowed to cytosol. Microsome fractions are not projected as in-vivo organelles. Semantic validation passed all85 records;4 independent source-role acceptance tests passed.
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