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carboxin

CHEBI:3405 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

An anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxylic acid. A fungicide for control of bunts and smuts that is normally used as a seed treatment. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Chemical structure

Computed structure properties
Molecular formulaC12H13NO2S
Charge0
Average mass235.308 Da
Monoisotopic mass235.0667 Da
SourceChEBI
InChIKeyGYSSRZJIHXQEHQ-UHFFFAOYSA-N

SMILES

CC1=C(C(=O)Nc2ccccc2)SCCO1

InChI

InChI=1S/C12H13NO2S/c1-9-11(16-8-7-15-9)12(14)13-10-5-3-2-4-6-10/h2-6H,7-8H2,1H3,(H,13,14)

Also called

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
SourceNative IDLabelMinted CURIEVersion
CHEBI CHEBI:3405 carboxin antibioticmech:chebi-ebea524080 2026-08-30

Related pathway records

Evidence-qualified relationships to a pinned corpus revision.

PathwayMech: WikiPathways:WP296RELATED_PATHWAY_ACTIVITY
PMID:4336692 reports inhibition between succinate and coenzyme Q in mitochondria from Ustilago maydis and S. cerevisiae. The linked yeast TCA record contains succinate dehydrogenase. The evidence supports this activity connection, not inhibition of every TCA reaction or exact strain equivalence.
Source revision: aa305727458c44ab05614901334540e2c87a9f3a

Mechanism summary

Mode of action
ENERGY_METABOLISM_INHIBITION host shared target — Assigned from ChEBI role CHEBI:83072 (EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Resistance mechanisms

36 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

UNKNOWN 36
UNKNOWN
DeterminantARO IDOrganismGene familiesEvidence
Mosdi1(H245L) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review guo-2016-reference-context: Guy11 is retained as parent background, not a uniquely identified tested derivative. UniProtKB:G4NE45 / MGG_00167 and TaxID 242507 identify reference strain 70-15, not Guy11 or a tested derivative. The paper cites XP_003718958 without a version; UniProt links XP_003718958.1. Original and subsequent laboratory groups remain distinct. The 2019 Figure 4b correction is acknowledged; source alteration and phenotype remain unchanged without an inferred MIC, sequence or genome. Reference-only source identifiers: strain_taxon_id=NCBITaxon:242507; protein_accession=UniProtKB:G4NE45.		 — Magnaporthe oryzae NCBITaxon:318829
strain Guy11
PHIPO:0000377		 —
  • PMID:27558019 (PHI-base primary-literature antimicrobial interaction PHIG:9109; joined to this record by exact ChEBI identifier.)
  • DOI:10.1186/s13568-016-0232-x (Identifier-scope review: Results and Figure 2: parent and distinct laboratory subjects, 2019 correction DOI:10.1186/s13568-019-0814-5: Figure 4b image replacement, UniProtKB release 2026_03: G4NE45 entry 73, sequence version 1; reference strain and XP_003718958.1 cross-reference. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SDH2 transformant(Cbx02-SDH2(H267Y)) (transformant) [Ectopic] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.		 — Zymoseptoria tritici NCBITaxon:1047171
strain Unknown strain
UniProtKB:O42772
PHIPO:0000377		 —
  • PMID:9871122 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
Cell growth assay
SDH2(H253L) (amino acid mutation) [Ectopic] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.		 — Ustilago maydis NCBITaxon:5270
strain IMI103761
UniProtKB:P32420 KIS70918
PHIPO:0000377		 —
  • PMID:1423716 (PHI-base primary-literature antimicrobial interaction PHIG:9367; joined to this record by exact ChEBI identifier.)
Cell growth assay
SDHB transformant(Cbx1-SDHB(I269V)) (transformant) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review scalliet-2012-sdhb-reference-context: IPO323 is retained as parent background, not an exact tested-subject identity. UniProtKB:O42772 grounds a reference SDH2/SdhB protein with unresolved strain scope, not the imported allele. Original and subsequent laboratory subjects remain distinct. Whole-cell and biochemical IC50 values and resistance factors are not MICs; source notation is preserved. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:22536383 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1371/journal.pone.0035429 (Identifier-scope review: Results and Figure 5: parents and laboratory comparisons, Table 3: distinct whole-cell and mitochondrial measurements, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SDHB transformant(Cbx28-SDHB(H267Y)) (transformant) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review scalliet-2012-sdhb-reference-context: IPO323 is retained as parent background, not an exact tested-subject identity. UniProtKB:O42772 grounds a reference SDH2/SdhB protein with unresolved strain scope, not the imported allele. Original and subsequent laboratory subjects remain distinct. Whole-cell and biochemical IC50 values and resistance factors are not MICs; source notation is preserved. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:22536383 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1371/journal.pone.0035429 (Identifier-scope review: Results and Figure 5: parents and laboratory comparisons, Table 3: distinct whole-cell and mitochondrial measurements, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SDHB transformant(Cbx29-SDHB(H267L)) (transformant) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review scalliet-2012-sdhb-reference-context: IPO323 is retained as parent background, not an exact tested-subject identity. UniProtKB:O42772 grounds a reference SDH2/SdhB protein with unresolved strain scope, not the imported allele. Original and subsequent laboratory subjects remain distinct. Whole-cell and biochemical IC50 values and resistance factors are not MICs; source notation is preserved. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:22536383 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1371/journal.pone.0035429 (Identifier-scope review: Results and Figure 5: parents and laboratory comparisons, Table 3: distinct whole-cell and mitochondrial measurements, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SDHB transformant(Cbx56-SDHB(R265P)) (transformant) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review scalliet-2012-sdhb-reference-context: IPO323 is retained as parent background, not an exact tested-subject identity. UniProtKB:O42772 grounds a reference SDH2/SdhB protein with unresolved strain scope, not the imported allele. Original and subsequent laboratory subjects remain distinct. Whole-cell and biochemical IC50 values and resistance factors are not MICs; source notation is preserved. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:22536383 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1371/journal.pone.0035429 (Identifier-scope review: Results and Figure 5: parents and laboratory comparisons, Table 3: distinct whole-cell and mitochondrial measurements, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SDHC transformant(Izm1-SDHC(H152R)) (transformant) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review scalliet-2012-sdhcd-reference-context: The strain label denotes parent background. UniProtKB:F9X9V6 (SDH4/SdhD), UniProtKB:F9XH52 (SDH3/SdhC) and TaxID 336722 ground IPO323 reference context, not an exact experimental allele or derivative. Source alteration and phenotype remain unchanged without assigning an individual subject or converting assay endpoints. Reference-only source identifiers: strain_taxon_id=NCBITaxon:336722; protein_accession=UniProtKB:F9XH52.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:22536383 (PHI-base primary-literature antimicrobial interaction PHIG:9475; joined to this record by exact ChEBI identifier.)
  • DOI:10.1371/journal.pone.0035429 (Identifier-scope review: Results and Figure 5: separate laboratory subjects and parent, Table 3: assay scope, UniProtKB release 2026_03: F9X9V6 entry 53 and F9XH52 entry 57, sequence versions 1; strain evidence and taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SDHC transformant(Izm7-SDHC(N86K)) (transformant) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review scalliet-2012-sdhcd-reference-context: The strain label denotes parent background. UniProtKB:F9X9V6 (SDH4/SdhD), UniProtKB:F9XH52 (SDH3/SdhC) and TaxID 336722 ground IPO323 reference context, not an exact experimental allele or derivative. Source alteration and phenotype remain unchanged without assigning an individual subject or converting assay endpoints. Reference-only source identifiers: strain_taxon_id=NCBITaxon:336722; protein_accession=UniProtKB:F9XH52.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:22536383 (PHI-base primary-literature antimicrobial interaction PHIG:9475; joined to this record by exact ChEBI identifier.)
  • DOI:10.1371/journal.pone.0035429 (Identifier-scope review: Results and Figure 5: separate laboratory subjects and parent, Table 3: assay scope, UniProtKB release 2026_03: F9X9V6 entry 53 and F9XH52 entry 57, sequence versions 1; strain evidence and taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SDHD transformant(Cbx67-SDHD(D129G)) (transformant) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review scalliet-2012-sdhcd-reference-context: The strain label denotes parent background. UniProtKB:F9X9V6 (SDH4/SdhD), UniProtKB:F9XH52 (SDH3/SdhC) and TaxID 336722 ground IPO323 reference context, not an exact experimental allele or derivative. Source alteration and phenotype remain unchanged without assigning an individual subject or converting assay endpoints. Reference-only source identifiers: strain_taxon_id=NCBITaxon:336722; protein_accession=UniProtKB:F9X9V6.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:22536383 (PHI-base primary-literature antimicrobial interaction PHIG:9472; joined to this record by exact ChEBI identifier.)
  • DOI:10.1371/journal.pone.0035429 (Identifier-scope review: Results and Figure 5: separate laboratory subjects and parent, Table 3: assay scope, UniProtKB release 2026_03: F9X9V6 entry 53 and F9XH52 entry 57, sequence versions 1; strain evidence and taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB transformant(JK19R1-SdhB(A11V)) (transformant) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review wang-2015-parent-and-reference-context: JK19 is the parent background, not one uniquely identified tested derivative. A7EGE3 and TaxID 665079 describe the ATCC 18683 / 1980 / Ss-1 reference, not that experimental subject. Table 2 reports EC50, not MIC. Source biological fields remain unchanged; exact subject protein, strain TaxID and genome remain unresolved. No activity measurement is added. Reference-only source identifiers: strain_taxon_id=NCBITaxon:665079; protein_accession=UniProtKB:A7EGE3.		 — Sclerotinia sclerotiorum NCBITaxon:5180
strain JK19
PHIPO:0000377		 —
  • PMID:25441450 (PHI-base primary-literature antimicrobial interaction PHIG:5032; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/mpp.12222 (Identifier-scope review: Results, Fungicide sensitivity and Table 2: parent and distinct tested groups, Fungal strain identity paragraph: JK19 parental context, UniProtKB release 2026_03: A7EGE3 entry 112, sequence version 1; ATCC 18683 / 1980 / Ss-1 reference taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(C137R) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(H267F) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(H267L) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(H267L) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review kilaru-2015-reference-context: IPO323 is retained as parent background, not a uniquely identified tested derivative. UniProtKB:O42772 is reference-only with unresolved strain scope. The paper's reference XP_003850753.1 / protein ID 74146 maps to UniProtKB:F9XG45 / MYCGRDRAFT_74146 in IPO323, not to an experimental allele. It is not a replacement subject accession. Source alteration and phenotype remain unchanged; no MIC or derivative identity is inferred. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:26092798 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1016/j.fgb.2015.03.018 (Identifier-scope review: Results and discussion sections 3.1, 3.3 and 3.4: reference accession, parent and separate derivatives, UniProtKB release 2026_03: O42772 entry 134 and F9XG45 entry 75, sequence versions 1; reference cross-references and strain evidence. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(H267N) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(H267N) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IRE30
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(H267Y) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IRE30
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(H267Y) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(I269V) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(N224I) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review piotrowska-2017-parent-reference-context: DK05 denotes parent background, not the tested descendants. UniProt proteins ground the parent SdhB/SdhC references, not experimental alleles. EC50-based resistance factors are not MICs. Source biological fields are retained; no exact descendant accession, genome or measurement is inferred. Reference-only source identifiers: protein_accession=UniProtKB:A0A1S6KZ79.		 — Ramularia collo-cygni NCBITaxon:112498
strain DK05
PHIPO:0000377		 —
  • PMID:27644008 (PHI-base primary-literature antimicrobial interaction PHIG:3434; joined to this record by exact ChEBI identifier.)
  • DOI:10.1002/ps.4442 (Identifier-scope review: Accepted manuscript p. 9: DK05 parent identity; pp. 16-17 and Table 3: separate descendants and EC50-based resistance factors, UniProtKB release 2026_03: A0A1S6KZ79 entry 35 and A0A1S6KZ87 entry 22, sequence versions 1; DK 05 Rcc 001 ss2 strain comments, KU758973 / AQT27052.1 and KU758974 / AQT27053.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(P155L, H267Y) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IRE30
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(R265P) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(S221P) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(S221P) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IRE30
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhB(S221T) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhb-reference-context: The retained strain label is parent background, not a uniquely identified tested derivative. UniProtKB:O42772 grounds a reference SDH2/SdhB protein; its strain scope is unresolved. Field-strain deposits do not identify the resistant derivatives. Grouped EC50 evidence is not an individual MIC; source alterations and assay wording remain unnormalized. Reference-only source identifiers: protein_accession=UniProtKB:O42772.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:4137; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: field strains, parents and derivative groups, Declared deposits, UniProtKB release 2026_03: O42772 entry 134, sequence version 1; AF042062 / AAB97419.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhC(H142Q) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review piotrowska-2017-parent-reference-context: DK05 denotes parent background, not the tested descendants. UniProt proteins ground the parent SdhB/SdhC references, not experimental alleles. EC50-based resistance factors are not MICs. Source biological fields are retained; no exact descendant accession, genome or measurement is inferred. Reference-only source identifiers: protein_accession=UniProtKB:A0A1S6KZ87.		 — Ramularia collo-cygni NCBITaxon:112498
strain DK05
PHIPO:0000377		 —
  • PMID:27644008 (PHI-base primary-literature antimicrobial interaction PHIG:3435; joined to this record by exact ChEBI identifier.)
  • DOI:10.1002/ps.4442 (Identifier-scope review: Accepted manuscript p. 9: DK05 parent identity; pp. 16-17 and Table 3: separate descendants and EC50-based resistance factors, UniProtKB release 2026_03: A0A1S6KZ79 entry 35 and A0A1S6KZ87 entry 22, sequence versions 1; DK 05 Rcc 001 ss2 strain comments, KU758973 / AQT27052.1 and KU758974 / AQT27053.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhC(H142R) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review piotrowska-2017-parent-reference-context: DK05 denotes parent background, not the tested descendants. UniProt proteins ground the parent SdhB/SdhC references, not experimental alleles. EC50-based resistance factors are not MICs. Source biological fields are retained; no exact descendant accession, genome or measurement is inferred. Reference-only source identifiers: protein_accession=UniProtKB:A0A1S6KZ87.		 — Ramularia collo-cygni NCBITaxon:112498
strain DK05
PHIPO:0000377		 —
  • PMID:27644008 (PHI-base primary-literature antimicrobial interaction PHIG:3435; joined to this record by exact ChEBI identifier.)
  • DOI:10.1002/ps.4442 (Identifier-scope review: Accepted manuscript p. 9: DK05 parent identity; pp. 16-17 and Table 3: separate descendants and EC50-based resistance factors, UniProtKB release 2026_03: A0A1S6KZ79 entry 35 and A0A1S6KZ87 entry 22, sequence versions 1; DK 05 Rcc 001 ss2 strain comments, KU758973 / AQT27052.1 and KU758974 / AQT27053.1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhC(L85P) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhcd-reference-context: The retained strain label is parent background. UniProtKB:F9X9V6 (SDH4/SdhD), UniProtKB:F9XH52 (SDH3/SdhC) and TaxID 336722 identify IPO323 reference context, not a tested derivative or IRE30. Grouped phenotypes cannot resolve an individual allele sequence; field-strain proteins and experimental subjects remain separate. Reference-only source identifiers: strain_taxon_id=NCBITaxon:336722; protein_accession=UniProtKB:F9XH52.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:9475; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: separate backgrounds and derivative groups, UniProtKB release 2026_03: F9X9V6 entry 53 and F9XH52 entry 57, sequence versions 1; strain evidence and taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhC(N86K) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhcd-reference-context: The retained strain label is parent background. UniProtKB:F9X9V6 (SDH4/SdhD), UniProtKB:F9XH52 (SDH3/SdhC) and TaxID 336722 identify IPO323 reference context, not a tested derivative or IRE30. Grouped phenotypes cannot resolve an individual allele sequence; field-strain proteins and experimental subjects remain separate. Reference-only source identifiers: strain_taxon_id=NCBITaxon:336722; protein_accession=UniProtKB:F9XH52.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:9475; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: separate backgrounds and derivative groups, UniProtKB release 2026_03: F9X9V6 entry 53 and F9XH52 entry 57, sequence versions 1; strain evidence and taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhD(D129E) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhcd-reference-context: The retained strain label is parent background. UniProtKB:F9X9V6 (SDH4/SdhD), UniProtKB:F9XH52 (SDH3/SdhC) and TaxID 336722 identify IPO323 reference context, not a tested derivative or IRE30. Grouped phenotypes cannot resolve an individual allele sequence; field-strain proteins and experimental subjects remain separate. Reference-only source identifiers: strain_taxon_id=NCBITaxon:336722; protein_accession=UniProtKB:F9X9V6.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IRE30
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:9472; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: separate backgrounds and derivative groups, UniProtKB release 2026_03: F9X9V6 entry 53 and F9XH52 entry 57, sequence versions 1; strain evidence and taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhD(D129E) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhcd-reference-context: The retained strain label is parent background. UniProtKB:F9X9V6 (SDH4/SdhD), UniProtKB:F9XH52 (SDH3/SdhC) and TaxID 336722 identify IPO323 reference context, not a tested derivative or IRE30. Grouped phenotypes cannot resolve an individual allele sequence; field-strain proteins and experimental subjects remain separate. Reference-only source identifiers: strain_taxon_id=NCBITaxon:336722; protein_accession=UniProtKB:F9X9V6.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:9472; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: separate backgrounds and derivative groups, UniProtKB release 2026_03: F9X9V6 entry 53 and F9XH52 entry 57, sequence versions 1; strain evidence and taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhD(D129T) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhcd-reference-context: The retained strain label is parent background. UniProtKB:F9X9V6 (SDH4/SdhD), UniProtKB:F9XH52 (SDH3/SdhC) and TaxID 336722 identify IPO323 reference context, not a tested derivative or IRE30. Grouped phenotypes cannot resolve an individual allele sequence; field-strain proteins and experimental subjects remain separate. Reference-only source identifiers: strain_taxon_id=NCBITaxon:336722; protein_accession=UniProtKB:F9X9V6.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:9472; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: separate backgrounds and derivative groups, UniProtKB release 2026_03: F9X9V6 entry 53 and F9XH52 entry 57, sequence versions 1; strain evidence and taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
SdhD(I127V) (amino acid mutation) [Not assayed] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review fraaije-2012-sdhcd-reference-context: The retained strain label is parent background. UniProtKB:F9X9V6 (SDH4/SdhD), UniProtKB:F9XH52 (SDH3/SdhC) and TaxID 336722 identify IPO323 reference context, not a tested derivative or IRE30. Grouped phenotypes cannot resolve an individual allele sequence; field-strain proteins and experimental subjects remain separate. Reference-only source identifiers: strain_taxon_id=NCBITaxon:336722; protein_accession=UniProtKB:F9X9V6.		 — Zymoseptoria tritici NCBITaxon:1047171
strain IPO323
PHIPO:0000377		 —
  • PMID:21933337 (PHI-base primary-literature antimicrobial interaction PHIG:9472; joined to this record by exact ChEBI identifier.)
  • DOI:10.1111/j.1364-3703.2011.00746.x (Identifier-scope review: Results and Tables 1, 3 and 4: separate backgrounds and derivative groups, UniProtKB release 2026_03: F9X9V6 entry 53 and F9XH52 entry 57, sequence versions 1; strain evidence and taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
sdhB transformant(CR9-sdhB(H249L)) (transformant) [Ectopic] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review shima-2009-parent-reference-context: RIB40 is retained as parent background, not a unique tested transformant. The authors' primary follow-up distinguishes the earlier donor subjects from wild-type RIB40; donor deposits do not identify later transformants. Q2TWM0, Q2U3V9 and TaxID 510516 describe the RIB40 reference genome, not experimental alleles. The 2009 full text remains unavailable; this is a follow-up-supported identity review, not complete phenotype validation. Source alteration and phenotype remain unchanged; no experimental accession, genome or measurement is inferred. Reference-only source identifiers: strain_taxon_id=NCBITaxon:510516; protein_accession=UniProtKB:Q2TWM0.		 — Aspergillus oryzae NCBITaxon:5062
strain RIB40
PHIPO:0000377		 —
  • PMID:18992352 (PHI-base primary-literature antimicrobial interaction PHIG:8700; joined to this record by exact ChEBI identifier.)
  • DOI:10.1271/bbb.100687 (Identifier-scope review: Shima 2011 final published follow-up p. 181: wild-type RIB40; p. 182 Table 1: previous-study subjects distinct from RIB40; p. 184 reference 15: Shima 2009, UniProtKB release 2026_03: Q2TWM0 entry 127 and Q2U3V9 entry 98, sequence versions 1; RIB40 reference genome loci AO090010000505 and AO090020000596, TaxID 510516 under species 5062. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
sdhC transformant(CR6-sdhC(T90I)) (transformant) [Ectopic] associated with resistance to carboxin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review shima-2009-parent-reference-context: RIB40 is retained as parent background, not a unique tested transformant. The authors' primary follow-up distinguishes the earlier donor subjects from wild-type RIB40; donor deposits do not identify later transformants. Q2TWM0, Q2U3V9 and TaxID 510516 describe the RIB40 reference genome, not experimental alleles. The 2009 full text remains unavailable; this is a follow-up-supported identity review, not complete phenotype validation. Source alteration and phenotype remain unchanged; no experimental accession, genome or measurement is inferred. Reference-only source identifiers: strain_taxon_id=NCBITaxon:510516; protein_accession=UniProtKB:Q2U3V9.		 — Aspergillus oryzae NCBITaxon:5062
strain RIB40
PHIPO:0000377		 —
  • PMID:18992352 (PHI-base primary-literature antimicrobial interaction PHIG:8701; joined to this record by exact ChEBI identifier.)
  • DOI:10.1271/bbb.100687 (Identifier-scope review: Shima 2011 final published follow-up p. 181: wild-type RIB40; p. 182 Table 1: previous-study subjects distinct from RIB40; p. 184 reference 15: Shima 2009, UniProtKB release 2026_03: Q2TWM0 entry 127 and Q2U3V9 entry 98, sequence versions 1; RIB40 reference genome loci AO090010000505 and AO090020000596, TaxID 510516 under species 5062. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay

Curation history

  1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Seeded from data/raw/ inventories (CHEBI)

  2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  4. RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  5. RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  6. RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  7. RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  8. RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  9. ADD_PATHWAY_LINKS 2026-10-05 · codex · LLM-assisted

    Added reviewed PathwayMech relationships and any supported protein example from curation/pathway_links.yaml; organism and evidence limits are recorded in each basis.

  10. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Scoped 26 imported carboxin associations: reference proteins and IPO323 TaxID are not tested-derivative identifiers. Retained species, source background labels, alterations and phenotypes; field deposits remain separate. EC50/IC50 evidence is not converted to MIC.

  11. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Scoped two imported carboxin associations from Kilaru 2015 and Guo 2016: reference proteins and the 70-15 TaxID are not tested-derivative identities. Retained parent background labels, species, alterations and phenotypes. No exact derivative, MIC or genome inferred; Guo 2019 correction noted.

  12. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after eleven additional identifier-scope corrections; biological fields, activities and decisions unchanged.

  13. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after seventeen additional identifier-scope corrections; biological fields, activities and decisions unchanged.

  14. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after one yeast identity-scope correction; biological fields, activities and prior decisions unchanged.

  15. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after twelve reference-scope corrections; biological fields, activities and prior decisions unchanged.

  16. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Scoped source protein and reference-strain identifiers to provenance, not exact experimental subjects, after primary-paper review. Parent labels and source biological fields preserved; no new allele, measurement or genome inferred.

  17. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after six identifier-scope corrections; previous decisions, biological fields and activities unchanged.

  18. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after eight subject-identity corrections; previous decisions, biological fields and activities unchanged.

  19. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Darlington subject correction; prior review decisions, biological fields and activities unchanged.

  20. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Nakayama reference-scope review; prior decisions, biological fields and activities unchanged.

  21. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Duan reference-scope review; prior decisions, biological fields and activities unchanged.

  22. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Separated DK05 parent reference proteins from experimental descendant context. Source background label, alteration, phenotype and activities preserved; no experimental accession or measurement inferred.

  23. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Xu subject and species corrections; prior decisions, biological fields and activities unchanged.

  24. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Scoped RIB40 reference proteins and strain TaxID to provenance after primary follow-up identity review. Parent label, source alteration, phenotype and activities preserved; donor deposits not assigned to later experimental subjects.

  25. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Mehrabi parent-reference review; prior decisions, biological fields and activities unchanged.

  26. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Huang parent-reference review; prior decisions, biological fields and activities unchanged.

  27. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-09 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the HDF1 subject-reference review; prior decisions, biological fields and activities unchanged.

  28. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-09 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Fouche parent-cohort review; prior decisions, biological fields and activities unchanged.

  29. REVIEWED_RESISTANCE_REFERENCE_CONTEXT 2026-10-09 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the SDH8 reference-alias correction; prior decisions, biological fields and activities unchanged.

  30. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-09 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after the Posteraro subject-context review; previous decisions, biological fields and activities unchanged.

  31. RECONCILED_BRANCH_CURATION 2026-10-11 · codex · LLM-assisted

    Integrated main's reviewed PathwayMech links with the resistance-grounding checkpoint; retained both committed event histories and all resistance and activity evidence.

  32. REVIEWED_RESISTANCE_REFERENCE_CONTEXT 2026-10-12 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after four reference-identifier scope corrections; previous decisions, biological fields and activities unchanged.

  33. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-13 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after one Neurospora subject-context correction; previous decisions, biological fields and activities unchanged.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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