fluconazole

CHEBI:46081 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

triazole antifungalARO:3007499

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:26878 CHEBI:26878
CHEBI:38582 CHEBI:38582
CHEBI:87071 CHEBI:87071
CHEBI:87101 CHEBI:87101
ARO:3007499 ARO:3007499

Chemical structure

Computed structure properties
Molecular formula	C13H12F2N6O
Charge	0
Average mass	306.276 Da
Monoisotopic mass	306.10407 Da
Source	ChEBI
InChIKey	RFHAOTPXVQNOHP-UHFFFAOYSA-N

SMILES

OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F

InChI

InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2

Also called

Biozole (BRAND_NAME)— chebi
Diflucan (BRAND_NAME)— chebi
Triflucan (BRAND_NAME)— chebi
fluconazol (INN)— chebi
fluconazolum (INN)— chebi
2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazol-1-yl)propan-2-ol (EXACT_SYNONYM)— chebi
2,4-difluoro-α,α-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol (EXACT_SYNONYM)— chebi
2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL (EXACT_SYNONYM)— chebi
Elazor (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3007508
beilstein:4269710
cas:86386-73-4
drugbank:DB00196
drugcentral:1187
hmdb:HMDB0014342
kegg.drug:D00322
lincs.smallmolecule:LSM-2106
patent:GB2099818
patent:US4404216
pdb-ccd:TPF
reaxys:7311650
wikipedia.en:Fluconazole
chembl:CHEMBL106
pubchem.compound:3365

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:35718 CHEBI:35718
CHEBI:86327 CHEBI:86327

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3007508`	fluconazole	`antibioticmech:aro-77ffa56cc7`	2026-08-30
CHEBI	`CHEBI:46081`	fluconazole	`antibioticmech:chebi-83d44cb0ba`	2026-08-30

Mechanism summary

Mode of action: ERGOSTEROL_PATHWAY_INHIBITION host shared target — Assigned from ChEBI role CHEBI:75282 (ergosterol biosynthesis inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.
Clinical status: APPROVED

Resistance mechanisms

76 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

UNKNOWN 34

UNKNOWN
Determinant	ARO ID	Organism	Gene families	Evidence
Candida albicans TAC1 with mutations conferring resistance to fluconazole	ARO:3009241	not organism-specific	—	ARO:3009241 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida albicans Upc2 with mutations conferring resistance to fluconazole	ARO:3009637	not organism-specific	—	ARO:3009637 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
CnAFR1 (unknown) [Overexpression] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Cryptococcus neoformans `NCBITaxon:5207` strain BYP22 `UniProtKB:Q8X0Z3` `PHIPO:0000653`	—	PMID:12519188 (PHI-base primary-literature antimicrobial interaction PHIG:8831; joined to this record by exact ChEBI identifier.) Cell growth assay
Cryptococcus neoformans AIF1 mutations conferring resistance against fluconazole	ARO:3009379	not organism-specific	—	ARO:3009379 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
DOX::ERG11+(DOX repressible promoter) (other) [Knockdown] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida glabrata `NCBITaxon:5478` strain ATCC 2001 `NCBITaxon:284593` `UniProtKB:P50859` CAGL0E04334g-T `PHIPO:0000653`	—	PMID:11600353 (PHI-base primary-literature antimicrobial interaction PHIG:3694; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11 transformant(Darlington-ERG11(Y132H, I471T)) (transformant) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain CAI4 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:11036010 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11 transformant(JEY162-ERG11(824-955bpdelta + D275V) (transformant) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida tropicalis `NCBITaxon:5482` strain 1909 `UniProtKB:P14263` CTRG_05283-t43_1 `PHIPO:0000653`	—	PMID:23629718 (PHI-base primary-literature antimicrobial interaction PHIG:8774; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11 transformant(MRL862-ERG11(Y145F)) (transformant) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Cryptococcus neoformans `NCBITaxon:5207` strain H99 `UniProtKB:Q870D1` `PHIPO:0000653`	—	PMID:22155829 (PHI-base primary-literature antimicrobial interaction PHIG:1668; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(D278N G464S) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(D446E) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(E266D G464S) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(F145L E266D) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(F145L) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(F449V) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(G307S G450E) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(G448E) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(G450E) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(G464S) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(I483V G450E) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(K143R E266D) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(K143R) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(M258L G464S) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(S405F) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(Y132F F145L) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(Y132F K143R) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(Y132F) (amino acid mutation) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000653`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG3 transformant(JEY162-ERG3(S258F)) (transformant) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida tropicalis `NCBITaxon:5482` strain 1909 `UniProtKB:N0A5G3` `PHIPO:0000653`	—	PMID:23629718 (PHI-base primary-literature antimicrobial interaction PHIG:8773; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG3delta (deletion) associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:Q59VG6` C1_04770C_A-T `PHIPO:0000653`	—	PMID:28630186 (PHI-base primary-literature antimicrobial interaction PHIG:1133; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG3delta (deletion) associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida parapsilosis `NCBITaxon:5480` strain Unknown strain `NCBITaxon:578454` `UniProtKB:G8B7T4` `PHIPO:0000653`	—	PMID:28630186 (PHI-base primary-literature antimicrobial interaction PHIG:8772; joined to this record by exact ChEBI identifier.) Cell growth assay
Efg1delta (deletion) associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SN152 `NCBITaxon:237561` `UniProtKB:Q59X67` CR_07890W_A-T `PHIPO:0000653`	—	PMID:39464835 (PHI-base primary-literature antimicrobial interaction PHIG:5984; joined to this record by exact ChEBI identifier.) Microscopy
MRR1 transformant(JEY355-MRR1(V877F)) (transformant) [Not assayed] associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:Q5A4G2` C3_05920W_A-T `PHIPO:0000653`	—	PMID:23629718 (PHI-base primary-literature antimicrobial interaction PHIG:8769; joined to this record by exact ChEBI identifier.) Cell growth assay
Sdh8delta (deletion) associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:A0A1D8PGP5` `PHIPO:0000653`	—	PMID:39403939 (PHI-base primary-literature antimicrobial interaction PHIG:10398; joined to this record by exact ChEBI identifier.) Macroscopic observation (qualitative observation)
Sla1delta (deletion) associated with resistance to fluconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SN152 `NCBITaxon:237561` `UniProtKB:Q5ALV2` C2_01640W_A-T `PHIPO:0000653`	—	PMID:39464835 (PHI-base primary-literature antimicrobial interaction PHIG:10399; joined to this record by exact ChEBI identifier.) Microscopy
antifungal susceptible Upc2	ARO:3009638	not organism-specific	—	ARO:3009638 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_ALTERATION 24

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Aspergillus fumigatus Cyp51A with mutations conferring resistance to fluconazole	ARO:3009519	not organism-specific	—	ARO:3009519 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida albicans Cyp51 with mutations conferring resistance to fluconazole	ARO:3009523	not organism-specific	—	ARO:3009523 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida albicans Cyp51a with mutations conferring resistance to fluconazole	ARO:3009504	not organism-specific	—	ARO:3009504 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida albicans Erg11 with mutations conferring resistance to fluconazole	ARO:3009414	not organism-specific	—	ARO:3009414 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida albicans FKS1 beta-1,3-glucan with mutations conferring resistance to fluconazole	ARO:3009559	not organism-specific	—	ARO:3009559 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida auris ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance to fluconazole	ARO:3009213	not organism-specific	—	ARO:3009213 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida dubliniensis ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance to fluconazole	ARO:3009578	not organism-specific	—	ARO:3009578 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida glabrata ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance to fluconazole	ARO:3009397	not organism-specific	—	ARO:3009397 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida glabrata FKS1 with mutations conferring resistance to fluconazole	ARO:3009422	not organism-specific	—	ARO:3009422 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida glabrata FKS2 with mutations conferring resistance to fluconazole	ARO:3009412	not organism-specific	—	ARO:3009412 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida orthopsilosis ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance to fluconazole	ARO:3009579	not organism-specific	—	ARO:3009579 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida parapsilosis Erg11 lanosterol 14-alpha-demethylase with mutations associated with resistance to fluconazole	ARO:3009222	not organism-specific	—	ARO:3009222 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida parapsilosis Erg3 C-5 sterol desaturase with mutations conferring resistance to fluconazole	ARO:3009242	not organism-specific	—	ARO:3009242 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida parapsilosis FSK1 beta-1,3-glucan synthase with mutations associated with resistance to fluconazole	ARO:3009611	not organism-specific	—	ARO:3009611 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida spp. ERG11 with mutations conferring resistance to azole antibiotics	ARO:3007524	not organism-specific	—	ARO:3007524 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida spp. Upc2 with mutations conferring resistance to azole antibiotics	ARO:3007551	not organism-specific	—	ARO:3007551 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida spp. cyp51A1 with mutations conferring resistance to triazoles and imidazole antibiotics	ARO:3007666	not organism-specific	—	ARO:3007666 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida tropicalis Erg11 lanosterol 14-alpha-demethylase with mutations conferring resistance to fluconazole	ARO:3009226	not organism-specific	—	ARO:3009226 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Cryptococcus neoformans Erg11 lanosterol 14-alpha-demethylase with mutations conferring resistance to fluconazole	ARO:3009228	not organism-specific	—	ARO:3009228 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Histoplasma capsulatum Cyp51 with mutations conferring resistance to fluconazole	ARO:3009528	not organism-specific	—	ARO:3009528 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Histoplasma capsulatum Erg11 lanosterol 14-alpha-demethylase with mutations conferring resistance to fluconazole	ARO:3009224	not organism-specific	—	ARO:3009224 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Pichia kudriavzevii ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance to fluconazole	ARO:3009396	not organism-specific	—	ARO:3009396 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Saccharomyces cerevisiae ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance to fluconazole	ARO:3009588	not organism-specific	—	ARO:3009588 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
antifungal resistance-associated MSH	ARO:3009134	not organism-specific	—	ARO:3009134 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)

ANTIBIOTIC_EFFLUX 18

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
Candida albicans CDR1 with mutations conferring resistance to antifungals	ARO:3007553	not organism-specific	—	ARO:3007553 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida albicans CDR1 with mutations conferring resistance to fluconazole	ARO:3009436	not organism-specific	—	ARO:3009436 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida albicans CDR2 with mutations conferring resistance to azoles	ARO:3007554	not organism-specific	—	ARO:3007554 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida albicans CDR2 with mutations conferring resistance to fluconazole	ARO:3009444	not organism-specific	—	ARO:3009444 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida albicans MDR1 with mutations conferring resistance to fluconazole	ARO:3009447	not organism-specific	—	ARO:3009447 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida albicans mrr2 with mutations associated with resistance to fluconazole	ARO:3009239	not organism-specific	—	ARO:3009239 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida glabrata CDR1 with mutations conferring resistance to fluconazole	ARO:3009438	not organism-specific	—	ARO:3009438 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida glabrata Yor1 with mutations conferring resistance to fluconazole	ARO:3009468	not organism-specific	—	ARO:3009468 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Candida tropicalis CDR1 with mutations conferring resistance to fluconazole	ARO:3009442	not organism-specific	—	ARO:3009442 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Cryptococcus neoformans AFR1 with mutations conferring resistance against fluconazole	ARO:3009343	not organism-specific	—	ARO:3009343 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Cryptococcus neoformans PDR5 with mutations conferring resistance to fluconazole	ARO:3009462	not organism-specific	—	ARO:3009462 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Cryptococcus spp. AFR1	ARO:3007566	not organism-specific	—	ARO:3007566 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Debaryomyces hansenii CDR1 with mutations conferring resistance to fluconazole	ARO:3009443	not organism-specific	—	ARO:3009443 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mdr1 with mutations associated with resistance to fluconazole	ARO:3009250	not organism-specific	—	ARO:3009250 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mdr3 with mutations associated with resistance to fluconazole	ARO:3009254	not organism-specific	—	ARO:3009254 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mfs1 with mutations associated with resistance to fluconazole	ARO:3009261	not organism-specific	—	ARO:3009261 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mfs2 with mutations associated with resistance to fluconazole	ARO:3009266	not organism-specific	—	ARO:3009266 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)
fungal MDR	ARO:3009425	not organism-specific	—	ARO:3009425 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007508 (fluconazole); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
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Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.