mating projection tip membrane

GO:0070867 · Appendage · Membrane · Proposed

The portion of the plasma membrane surrounding the mating projection tip. [GO:0070867]

Part of: mating projection tip (GO:0043332); mating projection membrane (GO:0070250)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
mating projection tip lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Localized plasma-membrane lipid bilayer surrounding the apex of the pheromone-induced mating projection. `GO:0070867` GO:0070867 identifies the mating projection tip membrane as the plasma-membrane portion surrounding a mating projection tip.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — VARIABLE: Haploid budding-yeast cells extend pheromone-induced mating projections with polarized tips rather than carrying a mating projection tip membrane in every growth state. [DOI:10.1091/mbc.3.4.429]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which pheromone treatment induces mating projection formation and polarized Spa2p localization at projection tips. [DOI:10.1091/mbc.3.4.429]

Functions

mating-projection tip polarized growth — The mating projection tip membrane delimits the local plasma-membrane surface around the projection apex where pheromone-induced polarized growth occurs.
- GO:0070867 GO:0070867 identifies the membrane portion surrounding a mating projection tip.
- GO:0043332 GO:0043332 defines the mating projection tip as the apex and polarized-growth site of the mating projection.
- DOI:10.1091/mbc.3.4.429 Read et al. 1992 observed Spa2p segregation to Saccharomyces cerevisiae mating projection tips during mating projection formation.

Mechanism graphs

Mating projection tip membrane topology (FUNCTION)

The mating projection tip membrane is the local membrane portion that surrounds the projection apex and is part of the broader mating projection membrane.

Subject	Predicate	Object	Evidence
mating projection tip membrane	is part of	mating projection tip	`GO:0070867` GO:0070867 identifies the tip membrane as the membrane portion surrounding a mating projection tip. `GO:0043332` GO:0043332 identifies the mating projection tip.
mating projection tip membrane	is part of	mating projection membrane	`GO:0070867` GO:0070867 names the mating projection tip membrane as a portion of plasma membrane at the mating projection tip. `GO:0070250` GO:0070250 identifies the mating projection membrane.
mating projection tip	is part of	mating projection	`GO:0043332` GO:0043332 defines the mating projection tip as part of the mating projection.

Discussions

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of the mating projection tip membrane. GO:0070867 identifies the whole mating projection tip membrane, but the lipid-bilayer constituent is intentionally left as reviewed-label-only until an exact source-neutral lipid or membrane-domain CURIE is curated.

Evidence

GO:0070867 Gene Ontology cellular-component term for the mating projection tip membrane.
GO:0043332 Gene Ontology cellular-component term for the mating projection tip.
GO:0070250 Gene Ontology cellular-component term for the mating projection membrane.
GO:0005937 Gene Ontology cellular-component term for the mating projection.
DOI:10.1091/mbc.3.4.429 Read et al. 1992, 'Actin- and tubulin-dependent functions during Saccharomyces cerevisiae mating projection formation', Molecular Biology of the Cell.

Curation history

2026-09-30T05:04:34Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-30T05:05:30Z codex · EXPANDED_RECORD — Added mating-projection-tip and mating-projection-membrane parthood, a reviewed-label-only lipid-bilayer component, Saccharomyces scope, tip-membrane domain function evidence, a nonmechanistic tip-membrane topology graph, and a lipid-bilayer grounding TODO.
2026-09-30T05:26:38Z codex · ADDRESSED_REVIEW — Resolved #1810 by rewording the only function row from a membrane-domain restatement to a mating-projection-tip polarized-growth role.

Source: data/structures/appendage/mating_projection_tip_membrane.yaml