Gin4 complex

GO:1990317 · Cytoskeleton · Multiprotein complex · Proposed

A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved. [GO:1990317]

Part of: cellular bud neck septin ring (GO:0000144)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: GO:1990317 defines the Gin4 complex by its Saccharomyces cerevisiae BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1 composition; no broader fungal distribution is asserted here. [GO:1990317]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which GO:1990317 defines the Gin4 complex as a BNI5/CDC3/CDC10/CDC11/CDC12/GIN4/NAP1/SHS1 complex involved in mitotic septin ring formation. [GO:1990317]

Functions

mitotic septin ring assembly support — The Gin4 complex participates in septin ring formation during mitosis.
- GO:1990317 GO:1990317 defines the complex by its involvement in septin ring formation during mitosis.
- GO:0000921 GO:1990317 has a capable_of_part_of relation to GO:0000921 septin ring assembly in OLS.

Mechanism graphs

Gin4 complex links to septin ring assembly (ASSEMBLY)

The Gin4 complex is modeled as part of the cellular bud neck septin ring and as participating in septin ring assembly.

Subject	Predicate	Object	Evidence
Gin4 complex	is part of	cellular bud neck septin ring	`GO:1990317` GO:1990317 links the Gin4 complex to the cellular bud neck septin ring by parthood. `GO:0000144` GO:0000144 identifies the cellular bud neck septin ring.
Gin4 complex	participates in	septin ring assembly	`GO:1990317` GO:1990317 defines the Gin4 complex by its involvement in septin ring formation during mitosis. `GO:0000921` GO:0000921 identifies the septin ring assembly process.

Discussions

INTERPRETATION (RESOLVED): Keep the Gin4 complex distinct from the cellular bud neck septin ring and from the septin ring assembly process. GO:1990317 denotes a Saccharomyces protein complex involved in septin ring formation. GO:0000144 denotes the higher-order cellular bud neck septin ring that contains it, and GO:0000921 denotes the biological process of septin ring assembly rather than a cellular structure.
CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the BNI5/CDC3/CDC10/CDC11/CDC12/GIN4/NAP1/SHS1 Gin4-complex participants. The initial Gin4 complex record uses the exact GO cellular-component identity without guessing InterPro, Pfam, NCBIfam, UniProtKB, or Complex Portal accessions for the Saccharomyces-specific protein names in the GO definition.

Evidence

GO:1990317 Gene Ontology cellular-component term for the Saccharomyces Gin4 complex, with a GO definition that names the BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1 participants.
GO:1902554 OLS reports GO:1902554 serine/threonine protein kinase complex as the direct GO:1990317 parent.
GO:0000144 GO:1990317 is related to the cellular bud neck septin ring, GO:0000144, by GO parthood.
GO:0000921 GO:1990317 is related to GO:0000921 septin ring assembly by a capable_of_part_of relation.

Curation history

2026-09-30T19:04:33Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-30T19:06:15Z codex · EXPANDED_RECORD — Added kinase-complex parentage, cellular bud neck septin ring parthood, Saccharomyces scope, septin-ring assembly function, a nonmechanistic GO relation graph, and boundary and component-grounding discussions.

Source: data/structures/cytoskeleton/gin4_complex.yaml