intermediate layer of spindle pole body

GO:0005821 · Cytoskeleton · Multiprotein complex · Proposed

The layer of the spindle pole body between the central plaque and the outer plaque. [GO:0005821]

Part of: spindle pole body (GO:0005816)

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast is a characterized fungal model for the layered spindle pole body that includes an intermediate layer between the central and outer plaques. [DOI:10.1146/annurev.cellbio.20.022003.114106]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast reference system in which layered SPB architecture and plaque topology have been characterized. [DOI:10.1146/annurev.cellbio.20.022003.114106]

The intermediate layer is the spindle-pole-body layer between the central and outer plaques.

Subject	Predicate	Object	Evidence
intermediate layer of spindle pole body	is part of	spindle pole body	`GO:0005821` GO:0005821 identifies the intermediate layer as a layer of the spindle pole body.
intermediate layer of spindle pole body	lies between	central plaque of spindle pole body	`GO:0005821` GO:0005821 defines the intermediate layer as the SPB layer between the central and outer plaques.
intermediate layer of spindle pole body	lies between	outer plaque of spindle pole body	`GO:0005821` GO:0005821 defines the intermediate layer as the SPB layer between the central and outer plaques.

INTERPRETATION (RESOLVED): Keep the SPB intermediate layer distinct from the central and outer plaques. GO:0005821 denotes the layer between the central and outer plaques of the spindle pole body, while GO:0005823 denotes the nuclear-envelope-embedded central plaque and GO:0005824 denotes the cytoplasmic outer plaque.
CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for SPB intermediate-layer constituents. The first GO-backed intermediate-layer record captures the named SPB layer without guessing exact InterPro, Pfam, NCBIfam, or Complex Portal groundings for budding-yeast proteins in the layer.

GO:0005821 Gene Ontology cellular-component term for the intermediate layer of the spindle pole body.
GO:0005816 Gene Ontology cellular-component term for the spindle pole body that includes the intermediate layer.
GO:0005823 Gene Ontology cellular-component term for the central plaque of the spindle pole body.
GO:0005824 Gene Ontology cellular-component term for the outer plaque of the spindle pole body.
DOI:10.1146/annurev.cellbio.20.022003.114106 Jaspersen and Winey 2004, The budding yeast spindle pole body: structure, duplication, and function, Annual Review of Cell and Developmental Biology.

2026-09-29T09:41:57Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-29T09:42:43Z codex · EXPANDED_RECORD — Added spindle-pole-body parthood, Saccharomyces scope, GO and literature evidence, a nonmechanistic intermediate-layer topology graph, and boundary/component discussions.