new spindle pole body SIN signaling complex

GO:0160067 · Cytoskeleton · Multiprotein complex · Proposed

A SIN signaling complex associated with the new mitotic spindle pole body during anaphase and characterized by the presence activated (GTP bound) GTPase (Spg1 in fission yeast) to activate SIN signaling. [GO:0160067]

Synonyms: new spindle pole body SIN signalling complex

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Taxonomic distribution

• NCBITaxon:4896 Schizosaccharomyces pombe — COMMON: Fission yeast is the system in which the new-SPB SIN signaling complex was defined in anaphase; no broader fungal distribution is asserted here. [DOI:10.1038/emboj.2010.317]

Canonical examples

• NCBITaxon:4896 Schizosaccharomyces pombe — Reference fission-yeast system for the anaphase SIN configuration with activated GTP-bound Spg1 at the new spindle pole body. [DOI:10.1038/emboj.2010.317]

Functions

• new-SPB SIN activation — The new-SPB SIN signaling complex is the anaphase SIN state in which activated GTP-bound Spg1 at the newly formed mitotic spindle pole body activates septation-initiation signaling.
  • GO:0160067 GO:0160067 defines this complex by association with the new mitotic spindle pole body during anaphase and activation of SIN signaling.
  • DOI:10.1038/emboj.2010.317 Johnson and Gould 2011 studied regulation of fission-yeast Sid4 and Plo1 kinase localization at spindle pole bodies.

Discussions

• INTERPRETATION (RESOLVED): Keep the new spindle pole body SIN signaling complex as the narrower fission-yeast anaphase GO child rather than the broad SIN/MEN complex or old-SPB interphase SIN state. GO:0160067 is an is-a child of the broader GO:0160065 SIN/MEN signaling complex and is defined by the new-SPB anaphase SIN state with activated GTP-bound Spg1. It is distinct from GO:0160066, the old-SPB interphase SIN signaling complex, and from GO:1990334, the narrower two-component GAP complex. No part_of link to the new mitotic SPB is asserted here because GO:0160067 says the complex is associated with that SPB rather than declaring a proper-parthood relation.
• CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the activated Spg1 and associated new-SPB SIN constituents. This first GO-backed record captures the anaphase new-SPB SIN signaling complex without guessing InterPro, Pfam, NCBIfam, UniProtKB, or Complex Portal groundings for fission-yeast-specific protein names.

Evidence

• GO:0160067 Gene Ontology cellular-component term for the new spindle pole body SIN signaling complex, with the British spelling as an exact synonym.
• GO:0160065 Gene Ontology parent term for the broader SIN/MEN signaling complex.
• GO:0071958 Gene Ontology cellular-component term for the new mitotic spindle pole body named in the GO:0160067 definition.
• DOI:10.1038/emboj.2010.317 Johnson and Gould 2011 studied regulation of fission-yeast SIN scaffold Sid4 and Plo1 kinase localization at spindle pole bodies.

Curation history

• 2026-09-29T20:04:32Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
• 2026-09-29T20:05:42Z codex · EXPANDED_RECORD — Added the GO exact synonym, SIN/MEN parentage, fission-yeast scope, a new-SPB SIN-activation function, GO and literature evidence, and boundary/component discussions.

Source: data/structures/cytoskeleton/new_spindle_pole_body_sin_signaling_complex.yaml