radial spoke neck

GO:0120343 · Cytoskeleton · Multiprotein complex · Proposed

The radial spoke neck is a complex that connects the spoke stalk to the head. [GO:0120343]

Part of: radial spoke (GO:0001534)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
radial spoke neck proteins	Protein	part of	Reviewed label only (reviewed name; no accession asserted)			UNKNOWN	Protein constituents of the connector subcomplex that joins the radial-spoke stalk to the head. `GO:0120343` GO:0120343 identifies the radial spoke neck as a protein-containing complex that connects the radial-spoke stalk to the head. `DOI:10.1242/jcs.245233` Poghosyan et al. 2020 refined the Chlamydomonas radial-spoke architecture and assigned proteins to the neck region.

NCBITaxon:3055 Chlamydomonas reinhardtii — COMMON: Chlamydomonas flagellar axonemes carry radial spokes with neck subcomplexes resolved by cryo-EM. [DOI:10.1242/jcs.245233]

NCBITaxon:3055 Chlamydomonas reinhardtii — Green-algal model whose radial-spoke necks connect the head and stalk in 9+2 flagellar axonemes. [DOI:10.1242/jcs.245233]

radial spoke neck head-stalk linkage — The radial spoke neck forms the connector between the stalk and head portions of the axonemal radial spoke.
- GO:0120343 GO:0120343 defines the neck by its connection between the radial-spoke stalk and head.
- DOI:10.1242/jcs.245233 Poghosyan et al. 2020 describe the Chlamydomonas radial spoke as a complex in the ciliary motility transducer apparatus and assign neck-region proteins.

Radial-spoke-neck proteins form the connector subcomplex between the radial-spoke stalk and the head.

Subject	Predicate	Object	Evidence
radial spoke neck proteins	contribute to	radial spoke neck	`GO:0120343` GO:0120343 identifies the radial spoke neck as a protein-containing complex.
radial spoke neck	is part of	radial spoke	`GO:0120343` GO:0120343 places the radial spoke neck as part of the radial spoke.
radial spoke neck	connects to	radial spoke head	`GO:0120343` GO:0120343 defines the neck by its connection between the radial-spoke stalk and head.
radial spoke neck	connects to	radial spoke stalk	`GO:0120343` GO:0120343 defines the neck by its connection between the radial-spoke stalk and head.

INTERPRETATION (RESOLVED): Keep the radial spoke neck distinct from the whole radial spoke and adjacent head and stalk subcomplexes. GO:0120343 denotes the connector subcomplex between the radial-spoke stalk and head, GO:0001534 denotes the complete radial spoke, GO:0001535 denotes the radial spoke head, and GO:0001536 denotes the radial spoke stalk.
CURATION_TODO (OPEN): Resolve exact source-neutral groundings and copy numbers for Chlamydomonas radial-spoke-neck RSP proteins. Poghosyan et al. 2020 assigned individual Chlamydomonas RSP densities to the neck region, but this first child-subcomplex record keeps a reviewed-label-only aggregate instead of guessing exact InterPro, Pfam, NCBIfam, or UniProtKB groundings and cross-species boundaries.

GO:0120343 Gene Ontology cellular-component term for the radial spoke neck.
GO:0032991 Gene Ontology cellular-component term for protein-containing complex.
GO:0001534 Gene Ontology cellular-component term for the containing radial spoke.
GO:0001535 Gene Ontology cellular-component term for the radial spoke head.
GO:0001536 Gene Ontology cellular-component term for the radial spoke stalk.
DOI:10.1126/science.1128618 Nicastro et al. 2006, 'The molecular architecture of axonemes revealed by cryoelectron tomography', Science.
DOI:10.1242/jcs.245233 Poghosyan et al. 2020, 'The structure and symmetry of the radial spoke protein complex in Chlamydomonas flagella', Journal of Cell Science.

2026-09-30T01:44:32Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-30T01:45:31Z codex · EXPANDED_RECORD — Added protein-complex parentage, radial-spoke parthood, a reviewed-label-only neck-protein constituent, Chlamydomonas scope and canonical example, a head-stalk-linkage function, GO/DOI evidence, a nonmechanistic topology graph, and boundary and component-grounding discussions.