7SK snRNP

GO:0120259 · Ribonucleoprotein · Ribonucleoprotein complex · Proposed

A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb. [GO:0120259]

Synonyms: snRNP 7SK

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
7SK RNA	Rna	part of	`SO:0002340`				7SK RNA constituent named in the 7SK snRNP definition and grounded to the 7SK RNA Sequence Ontology term. `GO:0120259` GO:0120259 defines the 7SK snRNP as containing 7SK snRNA. `SO:0002340` SO:0002340 is the Sequence Ontology RNA_7SK term and lists 7SK RNA as an exact synonym.

Mechanism graphs

7SK RNA is a 7SK snRNP constituent (ASSEMBLY)

The 7SK snRNP contains 7SK RNA.

Subject	Predicate	Object	Evidence
7SK RNA	contributes constituents to	7SK snRNP	`GO:0120259` GO:0120259 defines the 7SK snRNP as containing 7SK snRNA.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral protein components that form the 7SK snRNP. The first GO:0120259 record captures 7SK RNA, which defines the 7SK snRNP in GO. Protein-family and subcomplex boundaries should be resolved before expanding this component list.

Evidence

GO:0120259 Gene Ontology cellular-component term for the 7SK snRNP and its exact synonym.
GO:0030532 Gene Ontology cellular-component parent term for small nuclear ribonucleoprotein complex.
SO:0002340 Sequence Ontology term for RNA_7SK and its 7SK RNA exact synonym.
DOI:10.1016/j.molcel.2008.01.003 DOI for He, Jahchan, Hong, Li, Bayfield, Maraia, Luo and Zhou 2008 as reported by NCBI E-utilities.
PMID:18249148 PubMed identifier for He, Jahchan, Hong, Li, Bayfield, Maraia, Luo and Zhou 2008 as reported by NCBI E-utilities.
DOI:10.1093/nar/gkx262 DOI for Brogie and Price 2017, Reconstitution of a functional 7SK snRNP, as reported by NCBI E-utilities.
PMID:28431135 PubMed identifier for Brogie and Price 2017 as reported by NCBI E-utilities.

Curation history

2026-09-25T03:39:26Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-25T03:40:06Z codex · EXPANDED_RECORD — Added the GO exact synonym, small nuclear RNP parentage, the SO-grounded 7SK RNA component, QuickGO/PubMed evidence, a minimal 7SK RNA constituent graph and a protein-component grounding TODO.
2026-09-25T03:54:43Z codex · REVIEW_FIX — Tightened the SO:0002340 evidence note to attribute the 7SK RNA synonym to the Sequence Ontology term rather than the OLS lookup route.

Source: data/structures/ribonucleoprotein/7sk_snrnp.yaml