multimeric ribonuclease P complex

GO:0030681 · Ribonucleoprotein · Ribonucleoprotein complex · Proposed

A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species. [GO:0030681]

Synonyms: multimeric RNase P complex

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
RNase P RNA	Rna	part of	`SO:0000386`				RNA constituent of multimeric RNase P ribonucleoproteins that is grounded to the Sequence Ontology RNase_P_RNA term. `GO:0030681` GO:0030681 defines the multimeric ribonuclease P complex as generally containing a single RNA molecule. `SO:0000386` SO:0000386 is the Sequence Ontology term for RNase_P_RNA.
multimeric RNase P protein subunits	Protein	part of	Reviewed label only (reviewed name; no accession asserted)				Protein constituents that accompany RNase P RNA in multimeric ribonuclease P complexes. `GO:0030681` GO:0030681 defines multimeric ribonuclease P complexes as generally containing several protein molecules.

Functions

ribonuclease P activity GO:0004526 — The multimeric ribonuclease P complex removes 5-prime extra nucleotides from precursor tRNA by endonucleolytic RNA cleavage.
- GO:0004526 GO:0004526 is the Gene Ontology molecular-function term for ribonuclease P activity.
- GO:0030677 GO:0030677 defines ribonuclease P complexes as catalyzing pre-tRNA leader-sequence cleavage.
tRNA 5'-leader removal GO:0001682 — RNase P complexes generate mature tRNA 5-prime ends by cleaving 5-prime leader sequences from pre-tRNAs.
- GO:0001682 GO:0001682 is the Gene Ontology biological-process term for tRNA 5'-leader removal.
- GO:0030677 GO:0030677 defines ribonuclease P complexes by their cleavage of precursor tRNAs to generate mature 5-prime tRNA ends.

Mechanism graphs

RNase P RNA and protein subunits form multimeric RNase P (ASSEMBLY)

Multimeric ribonuclease P complexes generally contain a single RNase P RNA and several protein molecules.

Subject	Predicate	Object	Evidence
RNase P RNA	contributes constituents to	multimeric ribonuclease P complex	`GO:0030681` GO:0030681 defines the complex as generally containing a single RNA molecule.
multimeric RNase P protein subunits	contributes constituents to	multimeric ribonuclease P complex	`GO:0030681` GO:0030681 defines the complex as generally containing several protein molecules.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral protein-family boundaries for multimeric RNase P complexes. The first GO:0030681 record captures the GO-defined single-RNA, several-protein composition at cohort granularity. Exact protein families and the boundary between archaeal multimeric RNase P and organellar variants should be resolved before assigning protein groundings.

Evidence

GO:0030681 Gene Ontology cellular-component term for the multimeric ribonuclease P complex and its exact synonym.
GO:0030677 Gene Ontology cellular-component parent term for the ribonuclease P complex.
SO:0000386 Sequence Ontology term for RNase_P_RNA.
GO:0004526 Gene Ontology molecular-function term for ribonuclease P activity.
GO:0001682 Gene Ontology biological-process term for tRNA 5'-leader removal.

Curation history

2026-09-25T12:28:22Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-25T12:29:04Z codex · EXPANDED_RECORD — Added RNase P parentage, GO exact synonymy, SO-grounded RNase P RNA plus reviewed-label-only multimeric RNase P protein components, conservative function terms, an assembly graph and a TODO for exact multimeric protein-family boundaries.

Source: data/structures/ribonucleoprotein/multimeric_ribonuclease_p_complex.yaml