preribosome

GO:0030684 · Ribonucleoprotein · Ribonucleoprotein complex · Proposed

Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. [GO:0030684]

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
pre-rRNA	Rna	part of	Reviewed label only (reviewed name; no accession asserted)				Precursor ribosomal RNA molecule incorporated into preribosomal particles during ribosome biogenesis. `GO:0030684` GO:0030684 defines a preribosome as a complex of pre-rRNAs, ribosomal proteins and associated proteins.

Preribosomes contain precursor ribosomal RNA.

Subject	Predicate	Object	Evidence
pre-rRNA	contributes constituents to	preribosome	`GO:0030684` GO:0030684 defines preribosomes as complexes that include pre-rRNAs.

CURATION_TODO (OPEN): Resolve exact source-neutral pre-rRNA, ribosomal-protein and associated assembly-factor boundaries for preribosomes. The first GO:0030684 record captures only the GO-defined pre-rRNA constituent. The Sequence Ontology search found SO:0002393 for the broader precursor_RNA class but no exact source-neutral pre-rRNA term, and the ribosomal-protein and associated-protein cohorts vary across preribosomal assembly states and need a narrower literature-backed boundary pass.

GO:0030684 Gene Ontology cellular-component term for preribosome.
GO:1990904 Gene Ontology cellular-component parent term for ribonucleoprotein complex.
SO:0002393 Sequence Ontology term for the broader precursor_RNA class, which covers RNAs that are not yet mature products but is not specific to precursor ribosomal RNA.
DOI:10.1128/MCB.19.12.7897 DOI for Kressler, Linder and de la Cruz 1999, 'Protein trans-Acting Factors Involved in Ribosome Biogenesis in Saccharomyces cerevisiae', verified through PubMed Central and NCBI E-utilities.
PMID:10567516 PubMed identifier for Kressler, Linder and de la Cruz 1999 as reported by NCBI E-utilities.

2026-09-25T04:54:14Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-25T04:55:06Z codex · EXPANDED_RECORD — Added ribonucleoprotein parentage, the reviewed-label-only pre-rRNA component, GO/PubMed evidence, a minimal pre-rRNA constituent graph and a TODO for exact preribosome component boundaries.
2026-09-25T05:06:35Z codex · TIGHTENED_GROUNDING — Added SO:0002393 evidence for the reviewed-label-only pre-rRNA grounding rationale.
2026-09-25T05:19:06Z codex · REVIEW_FIX — Resolved #1552 by adding SO:0002393 to the preribosome component-boundary TODO evidence.