spliceosomal complex

GO:0005681 · Ribonucleoprotein · Ribonucleoprotein complex · Proposed

Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. [GO:0005681]

Synonyms: spliceosome complex; spliceosome

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
spliceosomal snRNP complex	Protein complex	part of	`GO:0097525`				Small ribonucleoprotein complex constituent involved in formation of spliceosomal complexes. `GO:0005681` GO:0005681 defines spliceosomal complexes as containing small nuclear ribonucleoproteins. `GO:0097525` GO:0097525 is the Gene Ontology cellular-component term for spliceosomal snRNP complex.
spliceosomal substrate, intermediate and product RNAs	Rna	part of	Reviewed label only (reviewed name; no accession asserted)				RNA substrates, intermediates or products carried by a spliceosomal complex during the splicing cycle. `GO:0005681` GO:0005681 defines spliceosomal complexes as containing the RNA substrates, splicing intermediates and final RNA products that distinguish states in the splicing cycle.

Mechanism graphs

snRNP and state-dependent RNAs define spliceosomal complexes (ASSEMBLY)

Spliceosomal complexes are ribonucleoprotein states that contain spliceosomal snRNP complexes and carry substrate, intermediate or product RNAs through a spliceosomal splicing cycle.

Subject	Predicate	Object	Evidence
spliceosomal snRNP complex	contributes constituents to	spliceosomal complex	`GO:0005681` GO:0005681 defines spliceosomal complexes as containing small nuclear ribonucleoproteins. `GO:0097525` GO:0097525 defines spliceosomal snRNP complexes as small ribonucleoprotein complexes involved in spliceosome formation.
spliceosomal substrate, intermediate and product RNAs	is carried by	spliceosomal complex	`GO:0005681` GO:0005681 defines spliceosomal complexes as containing substrate, intermediate or product RNAs.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral component boundaries for individual spliceosomal-complex states. The first GO:0005681 record captures the generic GO-defined spliceosomal snRNP and RNA cohorts. U2-type, U12-type and other spliceosomal states vary in their U-series snRNPs, substrate or product RNAs and additional proteins, so their exact constituent boundaries should be resolved on the specific state records.

Evidence

GO:0005681 Gene Ontology cellular-component term for spliceosomal complex and its exact and broad synonyms.
GO:0140513 Gene Ontology cellular-component parent term for nuclear protein-containing complex.
GO:1990904 Gene Ontology cellular-component parent term for ribonucleoprotein complex.
GO:0097525 Gene Ontology cellular-component term for spliceosomal snRNP complex.

Curation history

2026-09-25T06:14:54Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-25T06:15:33Z codex · EXPANDED_RECORD — Added GO synonymy, nuclear and ribonucleoprotein parentage, a GO-grounded spliceosomal snRNP component, a reviewed-label-only RNA substrate/product cohort, a conservative generic assembly graph and a TODO for state-specific spliceosomal component boundaries.
2026-09-25T06:30:13Z codex · REVIEW_FIX — #1556: renamed the reviewed-label-only spliceosomal RNA cohort and its graph/TODO anchors so they explicitly include splicing intermediate RNAs.

Source: data/structures/ribonucleoprotein/spliceosomal_complex.yaml