trans spliceosomal complex

GO:0071023 · Ribonucleoprotein · Ribonucleoprotein complex · Proposed

A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates. [GO:0071023]

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Role
SL snRNP	Protein complex	part of	`GO:0071024`	Spliced leader small nuclear ribonucleoprotein constituent of trans spliceosomal complexes. `GO:0071023` Gene Ontology asserts the SL snRNP as part of the trans spliceosomal complex. `GO:0071024` GO:0071024 is the Gene Ontology cellular-component term for the SL snRNP.
U2 snRNP	Protein complex	part of	`GO:0005686`	U2 small nuclear ribonucleoprotein constituent of trans spliceosomal complexes. `GO:0071023` Gene Ontology asserts the U2 snRNP as part of the trans spliceosomal complex. `GO:0005686` GO:0005686 is the Gene Ontology cellular-component term for the U2 snRNP.
U4 snRNP	Protein complex	part of	`GO:0005687`	U4 small nuclear ribonucleoprotein constituent of trans spliceosomal complexes. `GO:0071023` Gene Ontology asserts the U4 snRNP as part of the trans spliceosomal complex. `GO:0005687` GO:0005687 is the Gene Ontology cellular-component term for the U4 snRNP.
U5 snRNP	Protein complex	part of	`GO:0005682`	U5 small nuclear ribonucleoprotein constituent of trans spliceosomal complexes. `GO:0071023` Gene Ontology asserts the U5 snRNP as part of the trans spliceosomal complex. `GO:0005682` GO:0005682 is the Gene Ontology cellular-component term for the U5 snRNP.
U6 snRNP	Protein complex	part of	`GO:0005688`	U6 small nuclear ribonucleoprotein constituent of trans spliceosomal complexes. `GO:0071023` Gene Ontology asserts the U6 snRNP as part of the trans spliceosomal complex. `GO:0005688` GO:0005688 is the Gene Ontology cellular-component term for the U6 snRNP.

Mechanism graphs

SL and spliceosomal snRNPs define the trans spliceosomal complex (ASSEMBLY)

The trans spliceosomal complex is a spliceosomal complex whose GO-asserted parts include SL, U2, U4, U5 and U6 snRNPs.

Subject	Predicate	Object	Evidence
SL snRNP	contributes constituents to	trans spliceosomal complex	`GO:0071023` Gene Ontology asserts SL snRNP as part of GO:0071023.
U2 snRNP	contributes constituents to	trans spliceosomal complex	`GO:0071023` Gene Ontology asserts U2 snRNP as part of GO:0071023.
U4 snRNP	contributes constituents to	trans spliceosomal complex	`GO:0071023` Gene Ontology asserts U4 snRNP as part of GO:0071023.
U5 snRNP	contributes constituents to	trans spliceosomal complex	`GO:0071023` Gene Ontology asserts U5 snRNP as part of GO:0071023.
U6 snRNP	contributes constituents to	trans spliceosomal complex	`GO:0071023` Gene Ontology asserts U6 snRNP as part of GO:0071023.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral component boundaries for SL snRNP proteins, trans-splicing substrate RNAs and non-snRNP proteins in trans spliceosomal complexes. The first GO:0071023 record captures the GO-asserted SL, U2, U4, U5 and U6 snRNP subcomplexes. Individual SL RNP proteins, spliceosomal proteins and substrate RNAs should be resolved before expanding the component list beyond this GO-grounded boundary.

Evidence

GO:0071023 Gene Ontology cellular-component term for trans spliceosomal complex.
GO:0005681 Gene Ontology cellular-component parent term for spliceosomal complex.
GO:0071024 Gene Ontology cellular-component term for the SL snRNP.
GO:0005686 Gene Ontology cellular-component term for the U2 snRNP.
GO:0005687 Gene Ontology cellular-component term for the U4 snRNP.
GO:0005682 Gene Ontology cellular-component term for the U5 snRNP.
GO:0005688 Gene Ontology cellular-component term for the U6 snRNP.

Curation history

2026-09-25T10:48:14Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-25T10:49:12Z codex · EXPANDED_RECORD — Added spliceosomal-complex parentage, GO-grounded SL, U2, U4, U5 and U6 snRNP components, a conservative snRNP contribution graph and a TODO for exact trans-spliceosomal RNA and protein-family boundaries.

Source: data/structures/ribonucleoprotein/trans_spliceosomal_complex.yaml