U2-type spliceosomal complex

GO:0005684 · Ribonucleoprotein · Ribonucleoprotein complex · Proposed

Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. [GO:0005684]

Synonyms: major (U2-type) spliceosomal complex; major spliceosomal complex; GT-AG spliceosome

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
U2-type spliceosomal snRNPs	Protein complex	part of	Reviewed label only (reviewed name; no accession asserted)				State-variable small nuclear ribonucleoprotein constituents of U2-type spliceosomal complexes. `GO:0005684` GO:0005684 is the Gene Ontology cellular-component term for the snRNP-based complexes that form during U2-type spliceosomal splicing.

Mechanism graphs

U2-type spliceosomal complexes use state-variable snRNPs (ASSEMBLY)

U2-type spliceosomal complexes are the series of snRNP-based spliceosomal complexes that form during major-spliceosome splicing of introns with canonical consensus sequences.

Subject	Predicate	Object	Evidence
U2-type spliceosomal snRNPs	contributes state-dependent constituents to	U2-type spliceosomal complex	`GO:0005684` GO:0005684 describes U2-type spliceosomal complexes as the snRNP-based complexes that form during U2-splicing.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral snRNP membership for each U2-type spliceosomal state. The first GO:0005684 parent record captures only the state-variable snRNP cohort supported by GO. Child records for the U2-type prespliceosome, precatalytic complex, catalytic complexes and post-spliceosomal states should carry the exact U1, U2, U4, U5 and U6 snRNP constituent boundaries that apply to those specific states.

Evidence

GO:0005684 Gene Ontology cellular-component term for U2-type spliceosomal complex and its GO synonyms.
GO:0005681 Gene Ontology cellular-component parent term for spliceosomal complex.

Curation history

2026-09-25T06:53:22Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-25T06:54:35Z codex · EXPANDED_RECORD — Added GO exact and narrow synonyms, spliceosomal-complex parentage, a reviewed-label-only state-variable U2-type snRNP cohort, a conservative parent-level snRNP graph and a TODO for exact state-specific U2-type snRNP boundaries.

Source: data/structures/ribonucleoprotein/u2_type_spliceosomal_complex.yaml