U4atac/U6atac x U5 tri-snRNP complex

GO:0071009 · Ribonucleoprotein · Ribonucleoprotein complex · Proposed

A spliceosomal snRNP complex that is formed by the association of the U4atac/U6atac and U5 snRNPs. [GO:0071009]

Synonyms: U4atac/U6atac.U5 snRNP complex

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
U4atac/U6atac snRNP	Protein complex	part of	`GO:0071002`				Base-paired minor-spliceosome snRNP subcomplex that associates with U5 snRNP to form the U4atac/U6atac x U5 tri-snRNP complex. `GO:0071009` GO:0071009 defines the U4atac/U6atac x U5 tri-snRNP complex as formed by the association of U4atac/U6atac and U5 snRNPs. `GO:0071002` GO:0071002 is the Gene Ontology cellular-component term for the U4atac/U6atac snRNP.
U5 snRNP	Protein complex	part of	`GO:0005682`				U5 small nuclear ribonucleoprotein subcomplex that associates with U4atac/U6atac snRNP in the minor spliceosomal tri-snRNP. `GO:0071009` GO:0071009 defines the U4atac/U6atac x U5 tri-snRNP complex as formed by the association of U4atac/U6atac and U5 snRNPs. `GO:0005682` GO:0005682 is the Gene Ontology cellular-component term for the U5 snRNP.

NCBITaxon:9606 Homo sapiens — COMMON: Human U4atac/U6atac.U5 tri-snRNPs were analyzed biochemically by Schneider, Will, Makarova and colleagues; broader eukaryotic distribution is left for follow-up curation. [DOI:10.1128/MCB.22.10.3219-3229.2002]

NCBITaxon:9606 Homo sapiens — Human minor spliceosomal tri-snRNP analyzed in a comparative U4/U6.U5 and U4atac/U6atac.U5 tri-snRNP composition study. [DOI:10.1128/MCB.22.10.3219-3229.2002]

The U4atac/U6atac x U5 tri-snRNP complex forms when the U4atac/U6atac snRNP associates with the U5 snRNP.

Subject	Predicate	Object	Evidence
U4atac/U6atac snRNP	contributes to assembly of	U4atac/U6atac x U5 tri-snRNP complex	`GO:0071009` GO:0071009 defines the complex as the product of U4atac/U6atac snRNP and U5 snRNP association.
U5 snRNP	contributes to assembly of	U4atac/U6atac x U5 tri-snRNP complex	`GO:0071009` GO:0071009 defines the complex as the product of U4atac/U6atac snRNP and U5 snRNP association.

CURATION_TODO (OPEN): Resolve exact source-neutral groundings for individual U4atac/U6atac.U5 tri-snRNP protein families observed in human minor spliceosomal tri-snRNPs. The first GO:0071009 record captures the GO-grounded U4atac/U6atac and U5 snRNP subcomplexes that define the minor tri-snRNP. Individual protein family boundaries, source-neutral groundings and similarity to human U4/U6.U5 tri-snRNP composition should be resolved before splitting the protein inventory.

GO:0071009 Gene Ontology cellular-component term for the U4atac/U6atac x U5 tri-snRNP complex and its GO exact synonym.
GO:0097526 Gene Ontology cellular-component parent term for spliceosomal tri-snRNP complex.
GO:0071002 Gene Ontology cellular-component term for the U4atac/U6atac snRNP.
GO:0005682 Gene Ontology cellular-component term for the U5 snRNP.
DOI:10.1128/MCB.22.10.3219-3229.2002 Schneider, Will, Makarova and colleagues 2002, Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions, Molecular and Cellular Biology.
PMID:11971955 PubMed identifier for Schneider, Will, Makarova and colleagues 2002 as reported by NCBI E-utilities.
DOI:10.1515/BC.2005.084 Will and Luehrmann 2005, Splicing of a rare class of introns by the U12-dependent spliceosome, Biological Chemistry.
PMID:16201866 PubMed identifier for Will and Luehrmann 2005 as reported by NCBI E-utilities.

2026-09-24T19:32:17Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-24T19:32:55Z codex · EXPANDED_RECORD — Added the GO exact synonym, spliceosomal tri-snRNP parentage, GO-grounded U4atac/U6atac and U5 snRNP components, human Schneider/Will/Makarova tri-snRNP evidence, an assembly graph and a protein-component grounding TODO.
2026-09-24T19:43:06Z codex · ADDRESS_REVIEW — #1519: narrowed the minor tri-snRNP TODO from broad U4/U6.U5 conservation to human U4/U6.U5 composition similarity.