prospore membrane spindle pole body attachment site

GO:0070057 · Spore · Subcellular region · Proposed

The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus. [GO:0070057]

Synonyms: forespore membrane SPB attachment site; forespore membrane spindle pole body attachment site; prospore membrane SPB attachment site

Part of: prospore membrane (GO:0005628)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
prospore membrane attachment-site lipid bilayer	Lipid	part of				ESSENTIAL	Local prospore-membrane bilayer region that forms the patch where the spindle pole body is anchored. `GO:0070057` GO:0070057 defines the attachment site as a region of the prospore membrane.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding-yeast prospore membranes extend from spindle-pole-body attachment sites during meiotic spore formation. [DOI:10.1093/emboj/19.14.3657]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which spindle pole bodies organize meiotic outer plaques that mediate prospore membrane assembly. [DOI:10.1093/emboj/19.14.3657]

Functions

spindle pole body-prospore membrane attachment — Marks the region of the prospore membrane that remains anchored to a spindle pole body while the membrane extends around the spore nucleus.
- GO:0070057 GO:0070057 defines the membrane region to which the spindle pole body is anchored.
- DOI:10.1093/emboj/19.14.3657 Knop and Strasser 2000 studied the spindle-pole-body role in mediating Saccharomyces prospore membrane assembly.

Mechanism graphs

The spindle-pole-body attachment site positions prospore outgrowth (ASSEMBLY)

The attachment site is the prospore membrane region to which the spindle pole body is anchored as the membrane extends during budding-yeast sporulation.

Subject	Predicate	Object	Evidence
prospore membrane spindle pole body attachment site	is part of	prospore membrane	`GO:0070057` GO:0070057 defines the spindle-pole-body attachment site as a prospore membrane region.
prospore membrane spindle pole body attachment site	anchors	spindle pole body	`GO:0070057` GO:0070057 defines a prospore membrane region to which the spindle pole body is anchored. `DOI:10.1093/emboj/19.14.3657` Knop and Strasser 2000 analyzed spindle-pole-body control of prospore membrane assembly.
prospore membrane	extends from	prospore membrane spindle pole body attachment site	`GO:0070057` GO:0070057 states that the prospore membrane extends from the SPB attachment site to surround the spore nucleus.
prospore membrane	extends around	haploid meiotic nucleus	`GO:0070057` GO:0070057 states that the prospore membrane extends from the SPB attachment site to surround the spore nucleus.

Discussions

CURATION_TODO (OPEN): Resolve the molecular and spatial boundary between the membrane attachment site and the meiotic outer plaque. This first attachment-site record keeps the meiotic outer plaque and spindle pole body out of components, mirroring the parent prospore membrane curation. The exact Saccharomyces proteins at the membrane-facing attachment site need a focused curation pass.

Evidence

GO:0070057 Gene Ontology cellular-component term for the prospore membrane spindle pole body attachment site.
GO:0005628 Gene Ontology cellular-component term for the prospore membrane that contains the attachment site.
GO:0016020 Gene Ontology cellular-component parent term for membrane.
GO:0005816 Gene Ontology cellular-component term for the spindle pole body.
DOI:10.1093/emboj/19.14.3657 Knop and Strasser 2000, Role of the spindle pole body of yeast in mediating assembly of the prospore membrane during meiosis, The EMBO Journal.

Curation history

2026-09-15T08:59:11Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-15T09:00:07Z codex · EXPANDED_RECORD — Added GO exact synonyms, membrane parentage, prospore-membrane parthood, a lipid constituent, Saccharomyces scope, an SPB-attachment function, GO/DOI evidence, a nonmechanistic topology graph, and a meiotic-outer-plaque boundary TODO.
2026-09-15T09:11:17Z codex · ADDRESSED_REVIEW — Resolved review issues #955 and #956 by adding the spore nucleus to the graph and flipping the SPB anchoring edge to the attachment site.

Source: data/structures/spore/prospore_membrane_spindle_pole_body_attachment_site.yaml