All families / PF01679
PF01679: Pmp3
Proteolipid membrane potential modulator
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF01679: Proteolipid membrane potential modulator
IPR000612: integrated entry for Proteolipid membrane potential modulator
Source description
Pmp3 is an evolutionarily conserved proteolipid in the plasma membrane which, in S. pombe, is transcriptionally regulated by the Spc1 stress MAPK (mitogen-activated protein kinases) pathway. It functions to modulate the membrane potential, particularly to resist high cellular cation concentration. In eukaryotic organisms, stress-activated mitogen-activated protein kinases play crucial roles in transmitting environmental signals that will regulate gene expression for allowing the cell to adapt to cellular stress. Pmp3-like proteins are highly conserved in bacteria, yeast, nematode and plants.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
11 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O82232 | PMP3 family protein At2g24040 Arabidopsis thaliana | 75 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P0AE42 | PMP3 family protein YqaE Escherichia coli (strain K12) | 52 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P14359 | Protein SNA3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 133 aa; version 3 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P56508 | Protein SNA2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 79 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P87284 | Plasma membrane proteolipid 3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 55 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q07549 | Protein SNA4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 140 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8H5T6 | Hydrophobic protein LTI6A Oryza sativa subsp. japonica | 56 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9FE70 | PMP3 family protein At1g57550 Arabidopsis thaliana | 52 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9M095 | PMP3 family protein At4g30650 Arabidopsis thaliana | 73 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9ZNQ7 | Hydrophobic protein RCI2A Arabidopsis thaliana | 54 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
First 10 shown; the FASTA and family JSON contain all examples.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 12,165
- matches
- 12,229
- proteomes
- 5,976
- taxa
- 10,614
- structures
- 2
- alphafold models
- 9,376
- domain architectures
- 139
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.