All families / PF01757
PF01757: Acyl_transf_3
Acyltransferase domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF01757: Acyltransferase domain
IPR002656: integrated entry for Acyltransferase domain
Source description
This family includes a range of acyltransferase enzymes. This domain is found in a wide range of acyltransferase enzymes, including, mainly, bacterial proteins which catalyse the transfer of acyl groups, other than amino-acyl, from one compound to another, such as Glucans biosynthesis protein C (OPGC) or protein OatA from Listeria monocytogenes serovar 1/2a and Staphylococcus aureus, an integral membrane protein which is responsible for O-acetylation at the C6-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan, a modification that determines lysozyme resistance [InterPro reference PUB00097284,InterPro reference PUB00097283]. This domain is also present in eukaryotic proteins, namely O-acyltransferase like protein (OACYL) from mouse and RHY1 (Regulator of hypoxia-inducible factor 1) [InterPro reference PUB00097285] and NRF6 (Nose resistant to fluoxetine protein 6) from Caenorhabditis elegans [InterPro reference PUB00097286].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
11 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O05402 | Putative peptidoglycan O-acetyltransferase YrhL Bacillus subtilis (strain 168) | 634 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| O31559 | Putative membrane-bound acyltransferase YfiQ Bacillus subtilis (strain 168) | 362 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| O31660 | Putative membrane-bound acyltransferase YkrP Bacillus subtilis (strain 168) | 340 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P37669 | O-acetyltransferase WecH Escherichia coli (strain K12) | 331 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P75920 | Glucans biosynthesis protein C Escherichia coli (strain K12) | 385 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P75955 | Inner membrane protein YcfT Escherichia coli (strain K12) | 357 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q09225 | Nose resistant to fluoxetine protein 6 Caenorhabditis elegans | 822 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| Q2FV54 | O-acetyltransferase OatA Staphylococcus aureus (strain NCTC 8325 / PS 47) | 603 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8BML2 | O-acyltransferase like protein Mus musculus | 685 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q9X3P3 | Serine/alanine racemase Enterococcus gallinarum | 698 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
First 10 shown; the FASTA and family JSON contain all examples.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 79,491
- matches
- 80,016
- proteomes
- 17,243
- taxa
- 26,410
- structures
- 0
- alphafold models
- 51,499
- domain architectures
- 429
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.