DUFMech

All families / PF01931

PF01931: NTPase_I-T

Protein of unknown function DUF84

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF01931: Protein of unknown function DUF84
IPR026533: integrated entry for Protein of unknown function DUF84

Source description

NTPase_I-T is a family of NTPases with supreme activity against ITP and XTP. Active site analysis and structure comparison of YjjX strongly suggested that it is an NTP binding protein with nucleoside triphosphatase activity. YjjX exhibits a mixed alpha-beta fold [InterPro reference PUB00038960,InterPro reference PUB00037841].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

4 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
P39411Inosine/xanthosine triphosphatase
Escherichia coli (strain K12)
170 aa; version 2
UniProt 2026_03
PTM REGISTRY MIRROR
7 sibling references
Q3UPH1Protein PRRC1
Mus musculus
443 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q57709Probable inosine/xanthosine triphosphatase
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
179 aa; version 4
UniProt 2026_03
UNIPROT FETCH
8 sibling references
Q96M27Protein PRRC1
Homo sapiens
445 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
3,984
matches
4,030
proteomes
3,631
taxa
7,463
structures
4
alphafold models
2,998
domain architectures
24

Classification basis

name matches duf; name says unknown function; pfam previous unknown name

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
NTPase_I-T (PF01931)ProteinTraitsMechITPase activityP39411
Inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechITPase activityQ57709
Probable inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechnucleotide metabolic processQ57709
Probable inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechthiamine metabolic processP39411
Inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechthiamine metabolic processQ57709
Probable inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechinosine/xanthosine triphosphataseP39411
Inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechinosine/xanthosine triphosphataseP39411
Inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechinosine/xanthosine triphosphataseQ57709
Probable inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechNon-canonical purine NTP phosphatase/PRRC1P39411
Inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechNon-canonical purine NTP phosphatase/PRRC1Q3UPH1
Protein PRRC1
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechNon-canonical purine NTP phosphatase/PRRC1Q57709
Probable inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechNon-canonical purine NTP phosphatase/PRRC1Q96M27
Protein PRRC1
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechNon-canonical purine NTP phosphatase/PRRC1
trait identifier
NTPase_I-T (PF01931)ProteinTraitsMechProtein of unknown function DUF84P39411
Inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechProtein of unknown function DUF84Q3UPH1
Protein PRRC1
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechProtein of unknown function DUF84Q57709
Probable inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechProtein of unknown function DUF84Q96M27
Protein PRRC1
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechProtein of unknown function DUF84
trait identifier
NTPase_I-T (PF01931)ProteinTraitsMechInosine triphosphate pyrophosphatase-likeQ57709
Probable inosine/xanthosine triphosphatase
canonical example family classification
NTPase_I-T (PF01931)ProteinTraitsMechCATH homologous superfamily 3.90.950.10Q57709
Probable inosine/xanthosine triphosphatase
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF01931.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.