All families / PF02582
PF02582: DUF155
RMND1/Sif2-Sif3/Mrx10, DUF155
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF02582: RMND1/Sif2-Sif3/Mrx10, DUF155
IPR003734: integrated entry for RMND1/Sif2-Sif3/Mrx10, DUF155
Source description
This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homologue, Mrx10, are mitochondrial proteins required for mitochondrial translation [InterPro reference PUB00076329,InterPro reference PUB00076330]. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation [InterPro reference PUB00075393].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
7 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| P43620 | Sporulation protein RMD8 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 662 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q03441 | Sporulation protein RMD1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 430 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q05648 | MIOREX complex component 10 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 414 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8CI78 | Required for meiotic nuclear division protein 1 homolog Mus musculus | 450 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9C565 | Protein RETARDED ROOT GROWTH, mitochondrial Arabidopsis thaliana | 373 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q9FNB2 | Protein RETARDED ROOT GROWTH-LIKE Arabidopsis thaliana | 402 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q9NWS8 | Required for meiotic nuclear division protein 1 homolog Homo sapiens | 449 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 9,028
- matches
- 9,108
- proteomes
- 4,343
- taxa
- 10,538
- structures
- 0
- alphafold models
- 7,471
- domain architectures
- 131
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF155 (PF02582) | ProteinTraitsMech | Domain of unknown function DUF155 | P43620 Sporulation protein RMD8 | canonical example family classification |
| DUF155 (PF02582) | ProteinTraitsMech | Domain of unknown function DUF155 | Q03441 Sporulation protein RMD1 | canonical example family classification |
| DUF155 (PF02582) | ProteinTraitsMech | Domain of unknown function DUF155 | Q05648 MIOREX complex component 10 | canonical example family classification |
| DUF155 (PF02582) | ProteinTraitsMech | Domain of unknown function DUF155 | Q8CI78 Required for meiotic nuclear division protein 1 homolog | canonical example family classification |
| DUF155 (PF02582) | ProteinTraitsMech | Domain of unknown function DUF155 | Q9C565 Protein RETARDED ROOT GROWTH, mitochondrial | canonical example family classification |
| DUF155 (PF02582) | ProteinTraitsMech | Domain of unknown function DUF155 | Q9FNB2 Protein RETARDED ROOT GROWTH-LIKE | canonical example family classification |
| DUF155 (PF02582) | ProteinTraitsMech | Domain of unknown function DUF155 | Q9NWS8 Required for meiotic nuclear division protein 1 homolog | canonical example family classification |
| DUF155 (PF02582) | ProteinTraitsMech | Domain of unknown function DUF155 | trait identifier | |
| DUF155 (PF02582) | ProteinTraitsMech | RMND1/Sif2-Sif3/Mrx10, DUF155 | Q9C565 Protein RETARDED ROOT GROWTH, mitochondrial | canonical example family classification |
| DUF155 (PF02582) | ProteinTraitsMech | RMND1/Sif2-Sif3/Mrx10, DUF155 | Q9FNB2 Protein RETARDED ROOT GROWTH-LIKE | canonical example family classification |
| DUF155 (PF02582) | ProteinTraitsMech | RMND1/Sif2-Sif3/Mrx10, DUF155 | Q9NWS8 Required for meiotic nuclear division protein 1 homolog | canonical example family classification |
| DUF155 (PF02582) | ProteinTraitsMech | RMND1/Sif2-Sif3/Mrx10, DUF155 | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.