All families / PF02678
PF02678: Pirin
Pirin
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
Source description
This family consists of Pirin proteins from both eukaryotes and prokaryotes. The function of Pirin is unknown but the gene coding for this protein is known to be expressed in all tissues in the human body although it is expressed most strongly in the liver and heart. Pirin is known to be a nuclear protein, exclusively localised within the nucleoplasma and predominantly concentrated within dot-like subnuclear structures [InterPro reference PUB00016051]. A tomato homologue of human Pirin has been found to be induced during programmed cell death [InterPro reference PUB00020125]. Human Pirin interacts with Bcl-3 and NFI [InterPro reference PUB00020126] and hence is probably involved in the regulation of DNA transcription and replication. It appears to be an Fe(II)-containing member of the Cupin superfamily.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
8 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O00625 | Pirin Homo sapiens | 290 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR9 sibling references |
| P42624 | Pirin-like protein YhaK Escherichia coli (strain K12) | 233 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P46852 | Quercetin 2,3-dioxygenase Escherichia coli (strain K12) | 231 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR9 sibling references |
| Q9D711 | Pirin Mus musculus | 290 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9LPS9 | Pirin-like protein At1g50590 Arabidopsis thaliana | 310 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q9LX45 | Putative pirin-like protein At3g59260 Arabidopsis thaliana | 271 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9LX49 | Pirin-1 Arabidopsis thaliana | 287 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9ZW82 | Pirin-like protein 2 Arabidopsis thaliana | 321 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 36,769
- matches
- 36,808
- proteomes
- 15,924
- taxa
- 24,583
- structures
- 22
- alphafold models
- 23,663
- domain architectures
- 112
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.