All families / PF03007
PF03007: WS_DGAT_cat
Wax ester synthase/diacylglycerol acyltransferase catalytic domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF03007: Wax ester synthase/diacylglycerol acyltransferase catalytic domain
IPR004255: integrated entry for Wax ester synthase/diacylglycerol acyltransferase catalytic domain
Source description
This domain is found in wax ester synthases/diacylglycerol O-acyltransferases (WS/DAGs), largely found in bacteria, plants and animals. They catalyse the condensation of a fatty alcohol and a fatty acyl-Coenzyme A (acyl-CoA) and they can also catalyse the transesterification of acyl-CoAs with diacylglycerols. These are bifunctional enzymes (WS/DAGs) that share low overall sequence similarity but all WS/DGATs share a conserved HHXXXDG motif, which is also found in other acyltransferases [InterPro reference PUB00099698,InterPro reference PUB00100087]. This entry represents the N-terminal catalytic domain of WS/DAGs which contains the conserved HHXXXDG motif. It consists of a mixed beta-sheet flanked by four alpha-helices and a small antiparallel beta-sheet [InterPro reference PUB00100087].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
8 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q5KS41 | Wax ester synthase/diacylglycerol acyltransferase 11 Arabidopsis thaliana | 486 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q93ZR6 | Wax ester synthase/diacylglycerol acyltransferase 1 Arabidopsis thaliana | 481 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q94CK0 | Wax ester synthase/diacylglycerol acyltransferase 7 Arabidopsis thaliana | 480 aa; version 1 UniProt 2026_03 | UNIPROT FETCH9 sibling references |
| Q9C7H4 | Wax ester synthase/diacylglycerol acyltransferase 2 Arabidopsis thaliana | 479 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9FFE8 | Wax ester synthase/diacylglycerol acyltransferase 8 Arabidopsis thaliana | 488 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9FK04 | Wax ester synthase/diacylglycerol acyltransferase 10 Arabidopsis thaliana | 483 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9M3B1 | Wax ester synthase/diacylglycerol acyltransferase 6 Arabidopsis thaliana | 518 aa; version 1 UniProt 2026_03 | UNIPROT FETCH9 sibling references |
| Q9M3B3 | Wax ester synthase/diacylglycerol acyltransferase 4 Arabidopsis thaliana | 522 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 15,050
- matches
- 15,215
- proteomes
- 4,055
- taxa
- 6,769
- structures
- 2
- alphafold models
- 10,311
- domain architectures
- 107
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.