DUFMech

All families / PF03478

PF03478: Beta-prop_KIB1-4

KIB1-4 beta-propeller

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF03478: KIB1-4 beta-propeller
IPR005174: integrated entry for KIB1-4 beta-propeller

Source description

This entry represents the beta-propeller domain found in F-box proteins KIB1-4, from Arabidopsis thaliana, and similar plant proteins. This domain adopts a beta-propeller structure with 6 blades and is often found in association with F-box domain (PF00646 (Pfam entry)). KIB1-4 are ubiquitin ligases that act as essential positive regulators in brassinosteroid signalling, mediating the ubiquitination, substrate interaction and degradation of GSK3 kinase BIN2 [InterPro reference PUB00094297].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

13 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O65451Probable F-box protein At4g22030
Arabidopsis thaliana		626 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P0C2F5Uncharacterized protein At1g65760
Arabidopsis thaliana		362 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q1PEZ8F-box protein At2g26160
Arabidopsis thaliana		331 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q39090Protein UNUSUAL FLORAL ORGANS
Arabidopsis thaliana		442 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q84V03Protein PHOTOPERIODIC CONTROL OF HYPOCOTYL 1
Arabidopsis thaliana		778 aa; version 2
UniProt 2026_03		PTM REGISTRY MIRROR
5 sibling references
Q9C6X9Probable F-box protein At1g44080
Arabidopsis thaliana		347 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9FLV8Putative F-box/kelch-repeat protein At5g24040
Arabidopsis thaliana		373 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9LVG8Putative F-box protein At5g60060
Arabidopsis thaliana		374 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9SHX9Putative F-box protein At1g65770
Arabidopsis thaliana		360 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q9SMZ3F-box only protein 13
Arabidopsis thaliana		457 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
29,927
matches
32,016
proteomes
382
taxa
1,130
structures
0
alphafold models
24,983
domain architectures
744

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF03478.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.