All families / PF04239
PF04239: DUF421
YetF C-terminal domain
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF04239: YetF C-terminal domain
IPR007353: integrated entry for YetF C-terminal domain
Source description
This domain is found at the C-terminal end of the YetF protein, which contains three N-terminal transmembrane helices.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
6 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O31533 | UPF0702 transmembrane protein YetF Bacillus subtilis (strain 168) | 231 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| O32050 | UPF0702 transmembrane protein YrbG Bacillus subtilis (strain 168) | 218 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| P49853 | UPF0702 transmembrane protein YkjA Bacillus subtilis (strain 168) | 243 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| P75839 | UPF0702 transmembrane protein YcaP Escherichia coli (strain K12) | 230 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| P96696 | UPF0702 transmembrane protein YdfR Bacillus subtilis (strain 168) | 225 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| P96697 | UPF0702 transmembrane protein YdfS Bacillus subtilis (strain 168) | 235 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 14,102
- matches
- 14,140
- proteomes
- 7,086
- taxa
- 10,446
- structures
- 1
- alphafold models
- 8,907
- domain architectures
- 17
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF421 (PF04239) | ProteinTraitsMech | YetF, C-terminal domain | O31533 UPF0702 transmembrane protein YetF | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF, C-terminal domain | O32050 UPF0702 transmembrane protein YrbG | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF, C-terminal domain | P49853 UPF0702 transmembrane protein YkjA | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF, C-terminal domain | P75839 UPF0702 transmembrane protein YcaP | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF, C-terminal domain | P96696 UPF0702 transmembrane protein YdfR | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF, C-terminal domain | P96697 UPF0702 transmembrane protein YdfS | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF, C-terminal domain | trait identifier | |
| DUF421 (PF04239) | ProteinTraitsMech | YetF-like, N-terminal transmembrane domain | O31533 UPF0702 transmembrane protein YetF | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF-like, N-terminal transmembrane domain | P49853 UPF0702 transmembrane protein YkjA | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF-like, N-terminal transmembrane domain | P96697 UPF0702 transmembrane protein YdfS | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF C-terminal domain | O31533 UPF0702 transmembrane protein YetF | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF C-terminal domain | P49853 UPF0702 transmembrane protein YkjA | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF C-terminal domain | P96696 UPF0702 transmembrane protein YdfR | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF C-terminal domain | trait identifier | |
| DUF421 (PF04239) | ProteinTraitsMech | YetF N-terminal transmembrane domain | O31533 UPF0702 transmembrane protein YetF | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF N-terminal transmembrane domain | P49853 UPF0702 transmembrane protein YkjA | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | YetF N-terminal transmembrane domain | P96697 UPF0702 transmembrane protein YdfS | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | UPF0702, alpha/beta domain superfamily | O31533 UPF0702 transmembrane protein YetF | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | UPF0702, alpha/beta domain superfamily | O32050 UPF0702 transmembrane protein YrbG | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | UPF0702, alpha/beta domain superfamily | P49853 UPF0702 transmembrane protein YkjA | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | UPF0702, alpha/beta domain superfamily | P75839 UPF0702 transmembrane protein YcaP | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | UPF0702, alpha/beta domain superfamily | P96696 UPF0702 transmembrane protein YdfR | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | UPF0702, alpha/beta domain superfamily | P96697 UPF0702 transmembrane protein YdfS | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | bsu07140 like domains | O31533 UPF0702 transmembrane protein YetF | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | bsu07140 like domains | O32050 UPF0702 transmembrane protein YrbG | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | bsu07140 like domains | P49853 UPF0702 transmembrane protein YkjA | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | bsu07140 like domains | P75839 UPF0702 transmembrane protein YcaP | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | bsu07140 like domains | P96696 UPF0702 transmembrane protein YdfR | canonical example family classification |
| DUF421 (PF04239) | ProteinTraitsMech | bsu07140 like domains | P96697 UPF0702 transmembrane protein YdfS | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.