DUFMech

All families / PF04258

PF04258: Peptidase_A22B

Signal peptide peptidase

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF04258: Signal peptide peptidase
IPR064098: integrated entry for Signal peptide peptidase

Source description

The members of this family are membrane proteins. In some proteins this region is found associated with PF02225 (Pfam entry). This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with PF01080 (Pfam entry).

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

20 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A2A6C4Signal peptide peptidase-like 2C
Mus musculus		690 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
O81062Signal peptide peptidase
Arabidopsis thaliana		344 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P34248Intramembrane protease YPF1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)		587 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P49049Intramembrane protease 2
Caenorhabditis elegans		468 aa; version 1
UniProt 2026_03		UNIPROT FETCH
3 sibling references
Q0WMJ8Signal peptide peptidase-like 4
Arabidopsis thaliana		540 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
4 sibling references
Q3TD49Signal peptide peptidase-like 2B
Mus musculus		578 aa; version 2
UniProt 2026_03		UNIPROT FETCH
4 sibling references
Q4V3B8Signal peptide peptidase-like 3
Arabidopsis thaliana		540 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
5 sibling references
Q86P97Signal peptide peptidase-like
Drosophila melanogaster		422 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q8IUH8Signal peptide peptidase-like 2C
Homo sapiens		684 aa; version 3
UniProt 2026_03		PTM REGISTRY MIRROR
5 sibling references
Q8TCT6Signal peptide peptidase-like 3
Homo sapiens		384 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
13,660
matches
14,137
proteomes
3,348
taxa
8,908
structures
2
alphafold models
11,659
domain architectures
192

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF04258.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.