All families / PF04394
PF04394: DUF536
Protein of unknown function, DUF536
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF04394: Protein of unknown function, DUF536
IPR007489: integrated entry for Protein of unknown function, DUF536
Source description
This family aligns the C-terminal region from several bacterial proteins of unknown function that may be involved in a theta-type replication mechanism [InterPro reference PUB00019474,InterPro reference PUB00099934,InterPro reference PUB00099935].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A0A0H2ZKY7 | Regulator of chromosome segregation Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) | 163 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8DQ15 | Regulator of chromosome segregation Streptococcus pneumoniae (strain ATCC BAA-255 / R6) | 163 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q9L8I7 | Plasmid partition protein Par Staphylococcus aureus | 245 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 398
- matches
- 398
- proteomes
- 318
- taxa
- 534
- structures
- 1
- alphafold models
- 263
- domain architectures
- 7
Classification basis
short name matches duf; name says unknown function; description says unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF536 (PF04394) | ProteinTraitsMech | Regulator of chromosome segregation-like, C-terminal domain | trait identifier | |
| DUF536 (PF04394) | ProteinTraitsMech | Winged helix-turn-helix DNA-binding | Q8DQ15 Regulator of chromosome segregation | canonical example family classification |
| DUF536 (PF04394) | ProteinTraitsMech | Protein of unknown function, DUF536 | A0A0H2ZKY7 Regulator of chromosome segregation | canonical example family classification |
| DUF536 (PF04394) | ProteinTraitsMech | Protein of unknown function, DUF536 | Q8DQ15 Regulator of chromosome segregation | canonical example family classification |
| DUF536 (PF04394) | ProteinTraitsMech | Protein of unknown function, DUF536 | Q9L8I7 Plasmid partition protein Par | canonical example family classification |
| DUF536 (PF04394) | ProteinTraitsMech | Protein of unknown function, DUF536 | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.