DUFMech

All families / PF04473

PF04473: DUF553

Transglutaminase-like domain

Curation status
SEEDED
Seed status
KNOWN HISTORICAL DUF
Characterization
UNSCORED

Grounding

PF04473: Transglutaminase-like domain
IPR007562: integrated entry for Transglutaminase-like domain

Source description

This family of uncharacterised archaeal proteins are related to Transglutaminase-like domains. This family has previously been called DUF553 and UPF0252.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

4 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O58405UPF0252 protein PH0672
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)		309 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
O59045UPF0252 protein PH1321
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)		337 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q58678UPF0252 protein MJ1282
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)		352 aa; version 1
UniProt 2026_03		UNIPROT FETCH
4 sibling references
Q60294UPF0252 protein MJECL39
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)		351 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
232
matches
232
proteomes
187
taxa
505
structures
0
alphafold models
184
domain architectures
20

Classification basis

short name matches duf

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF553 (PF04473)ProteinTraitsMechS-layer protein, outer domainQ58678
UPF0252 protein MJ1282		canonical example family classification
DUF553 (PF04473)ProteinTraitsMechTransglutaminase-like domainQ58678
UPF0252 protein MJ1282		canonical example family classification
DUF553 (PF04473)ProteinTraitsMechTransglutaminase-like domainQ60294
UPF0252 protein MJECL39		canonical example family classification
DUF553 (PF04473)ProteinTraitsMechTransglutaminase-like domain
trait identifier
DUF553 (PF04473)ProteinTraitsMechTransglutaminase-like domainO58405
UPF0252 protein PH0672		canonical example family classification
DUF553 (PF04473)ProteinTraitsMechTransglutaminase-like domainO59045
UPF0252 protein PH1321		canonical example family classification
DUF553 (PF04473)ProteinTraitsMechTransglutaminase-like domainQ58678
UPF0252 protein MJ1282		canonical example family classification
DUF553 (PF04473)ProteinTraitsMechTransglutaminase-like domain
trait identifier
DUF553 (PF04473)ProteinTraitsMechS-layer like family, outer domainQ58678
UPF0252 protein MJ1282		canonical example family classification
DUF553 (PF04473)ProteinTraitsMechCATH homologous superfamily 3.10.620.30Q60294
UPF0252 protein MJECL39		canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF04473.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.